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Erschienen in: Im Fokus Onkologie 5/2020

30.10.2020 | Zytostatische Therapie | Allgemeine Onkologie

Neurologische Komplikationen von Tumortherapien

Chemotherapie-induzierte Polyneuropathien bleiben herausfordernd

verfasst von: Christoph Oster, Prof. Dr. med. Martin Glas

Erschienen in: Im Fokus Onkologie | Ausgabe 5/2020

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Die medikamentöse Tumortherapie ist fester Bestandteil in der Behandlung maligner Tumoren. Bei steigenden Überlebensraten der Patienten wird die Vermeidung therapiebedingter Nebenwirkungen in der onkologischen Behandlung immer wichtiger. Eine häufige Nebenwirkung zytotoxischer Therapien ist die Chemotherapie-induzierte Polyneuropathie (CIPN). Sie stellt das behandelnde Team vor viele Herausforderungen. Eine Standardtherapie gibt es bislang nicht. Wichtig ist daher die Früherkennung, Prävention und eine medikamentös suffiziente Schmerztherapie.
Literatur
1.
Zurück zum Zitat Zukas AM, Schiff D. Neurological complications of new chemotherapy agents. Neuro Oncol. 2018;20(1):24-36 Zukas AM, Schiff D. Neurological complications of new chemotherapy agents. Neuro Oncol. 2018;20(1):24-36
2.
Zurück zum Zitat Chan A et al. Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview. Support Care Cancer. 2019;27(10):3729-37 Chan A et al. Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview. Support Care Cancer. 2019;27(10):3729-37
3.
Zurück zum Zitat Seretny M et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014;155(12):2461-70 Seretny M et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014;155(12):2461-70
4.
Zurück zum Zitat Bulls HWet al. A longitudinal examination of associations between age and chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer. Gynecol Oncol. 2019;152(2):310-5 Bulls HWet al. A longitudinal examination of associations between age and chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer. Gynecol Oncol. 2019;152(2):310-5
5.
Zurück zum Zitat Kautio AL et al. Oxaliplatin scale and National Cancer Institute-Common Toxicity Criteria in the assessment of chemotherapy-induced peripheral neuropathy. Anticancer Res. 2011;31(10):3493-6 Kautio AL et al. Oxaliplatin scale and National Cancer Institute-Common Toxicity Criteria in the assessment of chemotherapy-induced peripheral neuropathy. Anticancer Res. 2011;31(10):3493-6
6.
Zurück zum Zitat Robinson-Papp J et al. Optimizing measures of HIV-associated neuropathy. Muscle Nerve. 2015;51(1):56-64 Robinson-Papp J et al. Optimizing measures of HIV-associated neuropathy. Muscle Nerve. 2015;51(1):56-64
7.
Zurück zum Zitat Park SB et al. Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies. Curr Med Chem. 2008;15(29):3081-94 Park SB et al. Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies. Curr Med Chem. 2008;15(29):3081-94
8.
Zurück zum Zitat Ibrahim EY, Ehrlich BE. Prevention of chemotherapy-induced peripheral neuropathy: A review of recent findings. Crit Rev Oncol Hematol. 2020;145:102831 Ibrahim EY, Ehrlich BE. Prevention of chemotherapy-induced peripheral neuropathy: A review of recent findings. Crit Rev Oncol Hematol. 2020;145:102831
9.
Zurück zum Zitat Weaver BA. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 2014;25(18):2677-81 Weaver BA. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 2014;25(18):2677-81
10.
Zurück zum Zitat Gornstein EL, Schwarz TL. Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects. Exp Neurol. 2017;288:153-66 Gornstein EL, Schwarz TL. Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects. Exp Neurol. 2017;288:153-66
11.
Zurück zum Zitat Addington J, Freimer M. Chemotherapy-induced peripheral neuropathy: an update on the current understanding. F1000Res. 2016;5:F1000 Faculty Rev-1466 Addington J, Freimer M. Chemotherapy-induced peripheral neuropathy: an update on the current understanding. F1000Res. 2016;5:F1000 Faculty Rev-1466
12.
Zurück zum Zitat Cavaletti G et al. Carboplatin toxic effects on the peripheral nervous system of the rat. Ann Oncol. 1998;9(4):443-7 Cavaletti G et al. Carboplatin toxic effects on the peripheral nervous system of the rat. Ann Oncol. 1998;9(4):443-7
13.
Zurück zum Zitat Grolleau F et al. A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol. 2001;85(5):2293-7 Grolleau F et al. A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol. 2001;85(5):2293-7
14.
Zurück zum Zitat Gadgil S et al. A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN). PLoS One. 2019;14(8):e0221787 Gadgil S et al. A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN). PLoS One. 2019;14(8):e0221787
15.
Zurück zum Zitat Hershman DL et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32(18):1941-67 Hershman DL et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32(18):1941-67
16.
Zurück zum Zitat Gamelin L et al. Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer. Clin Cancer Res. 2004;10(12 Pt 1):4055-61 Gamelin L et al. Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer. Clin Cancer Res. 2004;10(12 Pt 1):4055-61
17.
Zurück zum Zitat Hochster HS et al. Use of calcium and magnesium salts to reduce oxaliplatin-related neurotoxicity. J Clin Oncol. 2007;25(25):4028-29 Hochster HS et al. Use of calcium and magnesium salts to reduce oxaliplatin-related neurotoxicity. J Clin Oncol. 2007;25(25):4028-29
18.
Zurück zum Zitat Durand JP et al. Efficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trial. Ann Oncol. 2012;23(1):200-5 Durand JP et al. Efficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trial. Ann Oncol. 2012;23(1):200-5
19.
Zurück zum Zitat Smith EM et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309(13):1359-67 Smith EM et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013;309(13):1359-67
20.
Zurück zum Zitat Magnowska M al. Effectiveness of gabapentin pharmacotherapy in chemotherapy-induced peripheral neuropathy. Ginekol Pol. 2018;89(4):200-4 Magnowska M al. Effectiveness of gabapentin pharmacotherapy in chemotherapy-induced peripheral neuropathy. Ginekol Pol. 2018;89(4):200-4
21.
Zurück zum Zitat de Andrade DC et al. Pregabalin for the Prevention of Oxaliplatin-Induced Painful Neuropathy: A Randomized, Double-Blind Trial. Oncologist. 2017;22(10):1154-e105 de Andrade DC et al. Pregabalin for the Prevention of Oxaliplatin-Induced Painful Neuropathy: A Randomized, Double-Blind Trial. Oncologist. 2017;22(10):1154-e105
22.
Zurück zum Zitat Stock W et al. An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia. Clin Pharmacol Ther. 2017;101(3):391-5 Stock W et al. An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia. Clin Pharmacol Ther. 2017;101(3):391-5
23.
Zurück zum Zitat Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004;4(8):604-16 Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004;4(8):604-16
24.
Zurück zum Zitat Janes K et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014;289(30):21082-97 Janes K et al. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014;289(30):21082-97
25.
Zurück zum Zitat Leblanc AF et al. OAT P1B2 deficiency protects against paclitaxel-induced neurotoxicity. J Clin Invest. 2018;128(2):816-25 Leblanc AF et al. OAT P1B2 deficiency protects against paclitaxel-induced neurotoxicity. J Clin Invest. 2018;128(2):816-25
Metadaten
Titel
Neurologische Komplikationen von Tumortherapien
Chemotherapie-induzierte Polyneuropathien bleiben herausfordernd
verfasst von
Christoph Oster
Prof. Dr. med. Martin Glas
Publikationsdatum
30.10.2020
Verlag
Springer Medizin
Erschienen in
Im Fokus Onkologie / Ausgabe 5/2020
Print ISSN: 1435-7402
Elektronische ISSN: 2192-5674
DOI
https://doi.org/10.1007/s15015-020-2575-z

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