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Archives of Virology

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05.09.2018 | Brief Report

Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity

verfasst von: Jingjing Liu, Ling Xue, Shunlin Hu, Hao Cheng, Yonghuan Deng, Zenglei Hu, Xiaoquan Wang, Xiufan Liu

Erschienen in: Archives of Virology | Ausgabe 12/2018

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Abstract

A chimeric Newcastle disease virus (NDV) vector (NDV/AI4-TFHN) was constructed with the replacement of the ectodomains of the fusion and hemagglutinin-neuraminidase proteins by those from avian paramyxovirus type 2. The chimeric virus induced high antibody response in chickens pre-immunized with NDV. A recombinant vaccine candidate, NDV/AI4-TFHN-H9, expressing the hemagglutinin of H9N2 avian influenza virus, was generated, on the basis of the chimeric NDV vector mentioned above. The NDV/AI4-TFHN-H9 vaccine elicited H9-specific hemagglutination inhibition antibodies in chickens pre-immunized with NDV vaccine, and reduced the numbers of chickens shedding virus after H9N2 challenge. NDV/AI4-TFHN-H9 could serve as an alternative vaccine for the prevention of H9N2 infection in commercial poultry flocks.

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Titel: Chimeric Newcastle disease virus-vectored vaccine protects chickens against H9N2 avian influenza virus in the presence of pre-existing NDV immunity
verfasst von: Jingjing Liu
Ling Xue
Shunlin Hu
Hao Cheng
Yonghuan Deng
Zenglei Hu
Xiaoquan Wang
Xiufan Liu
Publikationsdatum: 05.09.2018
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 12/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-4016-2

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