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01.01.2012 | Original paper

Cholecystectomy and risk of pancreatic cancer: a meta-analysis of observational studies

verfasst von: Genlai Lin, Zhaochong Zeng, Xiaolin Wang, Zheng Wu, Jian Wang, Chenggang Wang, Qiao Sun, Yixing Chen, Hongbo Quan

Erschienen in: Cancer Causes & Control | Ausgabe 1/2012

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Abstract

Objective

Data from epidemiological studies related to the association of cholecystectomy and pancreatic cancer (PaC) risk are inconsistent. We conducted a meta-analysis of observational studies to explore this relationship.

Methods

We identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 30 June 2011, and by searching the reference lists of pertinent articles. Summary relative risks with their 95% confidence intervals were calculated with a random-effects model. Between-study heterogeneity was assessed using Cochran’s Q statistic and the I ².

Results

A total of 18 studies (10 case–control studies, eight cohort studies) were included in this meta-analysis. Analysis of these 18 studies found that cholecystectomy was associated with a 23% excess risk of PaC (SRR = 1.23, 95% CI = 1.12–1.35), with moderate heterogeneity among these studies (p _{heterogeneity} = 0.006, I ² = 51.0%). Sub-grouped analyses revealed that the increased risk of PaC was independent of geographic location, gender, study design and confounders. There was no publication bias in the current meta-analysis.

Conclusions

The results of this meta-analysis suggest that individuals with a history of cholecystectomy may have an increased risk of pancreatic cancer.

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Titel: Cholecystectomy and risk of pancreatic cancer: a meta-analysis of observational studies
verfasst von: Genlai Lin
Zhaochong Zeng
Xiaolin Wang
Zheng Wu
Jian Wang
Chenggang Wang
Qiao Sun
Yixing Chen
Hongbo Quan
Publikationsdatum: 01.01.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 1/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-011-9856-y

Springer Medizin

Cholecystectomy and risk of pancreatic cancer: a meta-analysis of observational studies