nach oben

International Archives of Occupational and Environmental Health

Erschienen in:

01.07.2009 | Original Article

Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates

verfasst von: Sirivarasai Jintana, Kaojarern Sming, Yoovathaworn Krongtong, Sura Thanyachai

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 7/2009

Einloggen, um Zugang zu erhalten

Abstract

Objective

Biological monitoring is an essential component for assessing the exposure of individuals to organophosphate pesticides. The aim of this study was to determine cholinesterase activity, pesticide exposure and health effects in the exposed population.

Methods

A total of 90 individuals occupationally exposed to OPs and 30 controls were recruited in this study. Erythrocyte acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were measured in two periods of low- and high-exposure.

Results

There were statistically significant decrease in AChE and BuChE activities in the high-exposure period (20.73 ± 0.99 U/gHb and 3.73 ± 0.19 U/mL, respectively, P < 0.001) compared to the low-exposure period (29.81 ± 1.19 U/gHb and 4.92 ± 0.19 U/mL, respectively). All enzyme activities in the exposed group were statistically lower than in the control group. Analysis of the relation between cholinesterase activity and symptoms showed significant evidences.

Conclusions

The results suggested the association between occupational pesticide exposure and inhibition of cholinesterases. Thus, medical monitoring of cholinesterase inhibition and intervention programs regarding safety practices during field work are important issues aimed at minimizing adverse health effects of pesticide.

Blanco LE, Aragon A, Lundberg I, Liden C, Wesseling C, Nise G (2005) Determinants of dermal exposure among Nicaraguan subsistence farmers during pesticide applications with backpack sprayers. Ann Occup Hyg 49:17–24PubMed

Ciesielski S, Loomis DP, Mims SR, Auer A (1994) Pesticide exposure, cholinesterase expression, and symptoms among north Carolina migrant farmworkers. Am J Public Health 84:446–451PubMedCrossRef

Ecobichon DJ (2001) Toxic effects of pesticides. In: Klassen CD (ed) Casarette & Doull’s Toxicology: the basic science of poison. 6th edn. McGrew Hill, New York

Ellman GL, Courtney DK, Andres V, Featherstone RM (1961) A new rapid colorimetric method determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95. doi:10.1016/0006-2952(61)90145-9 PubMedCrossRef

Gomes J, Lioyd OL, Revitt DM (1999) The influence of personal protection, environmental hygiene and exposure to pesticides on the health of immigrant farm workers in a desert country. Int Arch Occup Environ Health 72:40–45. doi:10.1007/s004200050332 PubMedCrossRef

Jors E, Morant RC, Aguilar GC, Huici O, Lander F, Baelum J (2006) Occupational pesticide intoxications among farmers in Bolivia: a cross-sectional study. Environ Health 5:1–10. doi:10.1186/1476-069X-5-10 CrossRef

Kamanyire R, Karalliedde L (2004) Organophosphate toxicity and occupational exposure. Occup Med 54:69–75CrossRef

Karalliedde L (1999) Organophosphorus poisoning and anesthesia. Anaesthesia 7:88–95

Kishi M, Hirschhorn N, Djajadisastra M, Satterlee LN, Strowman S, Dilts R (1995) Relationship of pesticide spraying to signs and symptoms in Indonesian farmers. Scand J Work Environ Health 21:124–133PubMed

Kwong TC (2002) Organophosphate pesticides: biochemistry and clinical toxicology. Ther Drug Monit 24:144–149PubMedCrossRef

London L, Meyers JE (1995) Critical issues for agricultural safety in South Africa. Am J Ind Med 27:1–14. doi:10.1002/ajim.4700270102 PubMedCrossRef

Lopez-Carillo L, Lopez-Cervantes M (1993) Effect of exposure to organophosphate pesticides on serum cholinesterase levels. Arch Environ Health 48:359–363PubMed

Maroni M, Colosio C, Ferioli A, Fait A (2000) Organophosphate pesticide. Toxicology 143:9–37. doi:10.1016/S0300-483X(99)00152-3 CrossRef

Ohayo-Mitoko GJA, Kromhout H, Simwa JM, Boleij SM, Heederik D (2000) Self- reported symptoms and inhibition of acetylcholinesterase activity among Kenya agricultural workers. Occup Environ Med 57:195–200. doi:10.1136/oem.57.3.195 PubMedCrossRef

Sivyoganathan C, Gnanachandran S, Lewis J, Fernando M (1995) Protective measures use and symptoms among agripesticide applicators in Sri Lanka. Sco Sci Med 40:431–436. doi:10.1016/0277-9536(94)00143-H CrossRef

Thailand Development Research Institute (TDRI) (1996) The potential of the development of contract farming. Research report: The case of cotton production in Thailand

Thetkathuek A, Keifer M, Fungladda W, Kaewkungwal J, Padungtod C, Wilson B (2005) Spectrophotometric determination of plasma and red blood cell cholinesterase activity of 53 fruit farm workers pre-and post-exposed chlorpyrifos for one fruit crop. Chem Pharm Bull (Tokyo) 53:422–424. doi:10.1248/cpb.53.422 CrossRef

Vale JA (1998) Toxicokinetic and toxicodynamic aspects of organophosphorus (OP) insecticide poisoning. Toxicol Lett 102–103:649–652. doi:10.1016/S0378-4274(98)00277-X PubMedCrossRef

Wessels D, Barr DB, Mendola P (2003) Use of biomarker to indicate exposure of children to organophosphate pesticides: Implications for a longitudinal study of children’s environmental health. Environ Health Perspect 111:1939–1946PubMed

Whittaker M (1984) Cholinesterase. In: Bergmeye HU, Bergmeyer J, Grabi M (eds) Methods of enzymatic analysis, vol IV. Verlag Chemie, Weinheim

WHO World, Organization Health (1986) World Health Organization: Metabolism and mode of action. Organophosphate insecticides: a general introduction. WHO, Geneva

Worek F, Koller M, Thiermann H, Szinicz L (2005) Diagnostic aspects of organophosphate poisoning. Toxicology 214:182–189. doi:10.1016/j.tox.2005.06.012 PubMedCrossRef

Yassin MM, Amr SS, Al-Najar HM (2006) Assessment of microbiological water quality and its relation to human health in Gaza Governorate, Gaza Strip. Public Health 120:1177–1187. doi:10.1016/j.puhe.2006.07.026 PubMedCrossRef

Titel: Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates
verfasst von: Sirivarasai Jintana
Kaojarern Sming
Yoovathaworn Krongtong
Sura Thanyachai
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 7/2009
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-009-0422-9

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2009

Sedentary lifestyle as a risk factor for low back pain: a systematic review

Metrics of whole-body vibration and exposure–response relationship for low back pain in professional drivers: a prospective cohort study

Chronic fatigue of the small enterprise workers participating in an occupational health checkup center in southern Taiwan

Metabolic syndrome in carbon disulfide-poisoned subjects in Korea: does chemical poisoning induce metabolic syndrome?

Working at night and work ability among nursing personnel: when precarious employment makes the difference

Psychosocial factors at work and perceived health among agricultural meat industry workers in France