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Clinical Oral Investigations

Erschienen in:

22.09.2023 | Research

Clinical data, survival, and prognosis of 426 cases of oropharyngeal cancer: a retrospective analysis

verfasst von: Jiancheng Li, Feng Zhuo, Xuji Wang, Yun Guo, Lina Jiang

Erschienen in: Clinical Oral Investigations | Ausgabe 11/2023

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Abstract

Objective

To determine factors influencing survival and prognosis of HPV-related and non-related oropharyngeal cancer.

Methods

Subjects were determined from the three hospitals in Anhui province of China between 2015 and 2020. Paraffin-embedded specimens from participants’ tissues were analyzed, and the subjects were classified as P16 + and P16 − cases using immunohistochemical staining for P16 protein.

Results

A total of 426 patients with oropharyngeal cancer were recruited in this study; 108 cases were found to be P16 + . The subjects were treated with the three regimens: surgery/radiotherapy/chemotherapy (SRCT), radiotherapy/chemotherapy (RCT), and surgery/chemotherapy (SCT). There were no statistically significant differences in the survival rates within the P16 + or P16 − groups between the three treatment regimens (P > 0.05). The 1-, 3-, and 5-year survival rates for P16 + and P16 − groups were statistically different (P < 0.05). Multivariate analysis showed that age, physical health status, smoking, and alcohol abuse were independent risk factors affecting the prognosis of P16 + cases, while pathological grading and TNM staging were independent risk factors affecting the P16 − cases.

Conclusion

The etiology, pathogenesis, survival status, and prognostic factors of HPV-related oropharyngeal cancer are very different from those of traditional oropharyngeal cancer. Thus, HPV-related oropharyngeal cancer could be classified as a separate type of disease. This distinction could be of great significance for treatment, prevention, and prognostication of oropharyngeal cancer.

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Titel: Clinical data, survival, and prognosis of 426 cases of oropharyngeal cancer: a retrospective analysis
verfasst von: Jiancheng Li
Feng Zhuo
Xuji Wang
Yun Guo
Lina Jiang
Publikationsdatum: 22.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 11/2023
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05265-y

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Clinical data, survival, and prognosis of 426 cases of oropharyngeal cancer: a retrospective analysis

Abstract

Objective

Methods

Results

Conclusion

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