Review
Bone marrow, umbilical cord blood, placental and mesenchymal stem cells
Cardiac repair
Neurological applications
Immunological applications
Genetic blood diseases
Adipose stem cells
Endothelial stem cells
Pancreatic β islet cells
Neural stem cells
NSC CLINICAL TRIALS | ||
---|---|---|
Regenerative, Cell Replacement
| ||
StemCells Inc., CA
|
HuCNS-SC
®
(fetal derived human NSCs)
| |
Phase I - completed | Batten's Disease (NCL) | USA |
Phase Ib | Discontinued for lack of enrollment | |
Phase I | Pelizaeus-Merzbacher Disease (PMD) | USA |
Phase I/II | Chronic Spinal Cord Injury | Switzerland |
NeuroGeneration, CA
|
Autologous NSC-derived Neurons
| |
Phase I - completed | Advanced Parkinson's Disease | USA |
Phase II - clinical hold | ||
Neuralstem Inc., MD
|
Fetal derived hu spinal cord SCs
| |
Phase I
| ALS (Lou Gehrig's Disease) | USA |
ReNeuron, UK
|
ReN001 Immortalized huNSCs
| |
Phase I | Stroke | UK |
Targeted Delivery of Therapeutics
| ||
City of Hope, CA
|
HB1.F3.CD Immortalized hu NSCS
| |
Phase I | Recurrent High Grade Glioma | USA |
Limbal stem cells
Myoblasts
Hepatocytes
Pluripotent stem cells
Trial sponsor | Disease target | Cell therapy |
---|---|---|
Geron Inc. Phase I: 10 patients enrolled 2010-12 | Complete subacute thoracic spinal cord injuries. T3 to T10 segments between seven and 14 days after injury | Human embryonic stem cell derived Oligodendrocyte progenitor cells (GRNOPC1) |
Advanced Cell Technologies (ACT)
Phase I/II: 12 patients Enrolled 2011 | Stargardt's Macular Dystrophy (juvenile macular degeneration) | Retinal Pigment Epithelium derived from human embryonic stem cells |
Advanced Cell Technologies (ACT)
Phase I/II: 12 patients Enrolled 2011-12 | Age-related Macular Degeneration | Retinal Pigment Epithelium derived from human embryonic stem cells |
California Stem Cell (CSC)
Phase I Currently on hold 2011 | Spinal muscular atrophy (SMA) Type 1 | Human motor neuron progenitor cells derived from human embryonic stem cells |