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11.10.2017 | Original Article

Clinical utility of bioelectrical impedance analysis in patients with locoregional muscle invasive or metastatic urothelial carcinoma: a subanalysis of changes in body composition during neoadjuvant systemic chemotherapy

verfasst von: Makito Miyake, Takuya Owari, Takashi Iwamoto, Yosuke Morizawa, Shunta Hori, Nagaaki Marugami, Keiji Shimada, Kota Iida, Kenta Ohnishi, Daisuke Gotoh, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Tatsuo Yoneda, Nobumichi Tanaka, Kiyohide Fujimoto

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2018

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Abstract

Purpose

The aim of this study was to determine the clinical utility of bioelectrical impedance analysis (BIA) in a cohort of patients with advanced urothelial carcinoma (UC).

Methods

We prospectively evaluated body composition in 35 patients with locoregional muscle invasive (≥ T2 and N0–2M0) or metastatic UC. Body composition was evaluated using multifrequency BIA at baseline (n = 35) and during chemotherapy in patients receiving neoadjuvant chemotherapy (n = 14). The BIA-predicted body composition index was compared with the computed tomography-measured muscle index and the prognostic nutrition index. Changes in body composition during neoadjuvant chemotherapy were recorded and compared with the incidence of hematological adverse events.

Results

There was a significant correlation between the BIA-predicted skeletal muscle index and the computed tomography-measured skeletal muscle index (P = 0.004), while there was no significant correlation between the prognostic nutrition index and the BIA-predicted nutrition index. After the completion of 3 cycles of neoadjuvant chemotherapy, the skeletal muscle index showed a significant decrease (P = 0.016), while the total body fat mass (P = 0.025), body fat percentage (P = 0.013), and body mass index (P = 0.004) showed a significant increase (a tendency toward “sarcopenic obesity”). Patients who experienced grade 2–3 anemia during neoadjuvant chemotherapy showed a significantly lower increase in body mass index compared with patients who did not experience high-grade toxicities (P = 0.032).

Conclusions

BIA could contribute to other methods of nutrition and muscle assessment for pretreatment risk stratification in patients with UC. Further study of a larger cohort is required to elucidate the clinical impact of changes in body composition during chemotherapy.

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Thoresen L, Frykholm G, Lydersen S, Ulveland H, Baracos V, Birdsell L et al (2012) The association of nutritional assessment criteria with health-related quality of life in patients with advanced colorectal carcinoma. Eur J Cancer Care (Engl) 21:505–516CrossRef

Rolland Y, Abellan van Kan G, Gillette-Guyonnet S, Vellas B (2011) Cachexia versus sarcopenia. Curr Opin Clin Nutr Metab Care 14:15–21CrossRefPubMed

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 39:412–423CrossRefPubMedPubMedCentral

Blauwhoff-Buskermolen S, Langius JAE, Becker A, Verheul HMW, de van der Schueren MAE (2017) The influence of different muscle mass measurements on the diagnosis of cancer cachexia. J Cachexia Sarcopenia Muscle 8:615–622CrossRefPubMedPubMedCentral

Kyle UG, Pirlich M, Lochs H, Schuetz T, Pichard C (2005) Increased length of hospital stay in underweight and overweight patients at hospital admission: a controlled population study. Clin Nutr 24:133–142CrossRefPubMed

Sun L, Quan XQ, Yu S (2015) An epidemiological survey of cachexia in advanced cancer patients and analysis on its diagnostic and treatment status. Nutr Cancer 67:1056–1062CrossRefPubMed

Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489–495CrossRefPubMed

Jaffrin MY, Morel H (2008) Body fluid volumes measurements by impedance: a review of bioimpedance spectroscopy (BIS) and bioimpedance analysis (BIA) methods. Med Eng Phys 30:1257–1269CrossRefPubMed

Paiva SI, Borges LR, Halpern-Silveira D, Assunção MC, Barros AJ, Gonzalez MC (2010) Standardized phase angle from bioelectrical impedance analysis as prognostic factor for survival in patients with cancer. Support Care Cancer 19(2):187–192CrossRefPubMed

10.

Ida S, Watanabe M, Karashima R, Imamura Y, Ishimoto T, Baba Y et al (2014) Changes in body composition secondary to neoadjuvant chemotherapy for advanced esophageal cancer are related to the occurrence of postoperative complications after esophagectomy. Ann Surg Oncol 21(11):3675–3679CrossRefPubMed

11.

Miyake M, Morizawa Y, Hori S, Marugami N, Shimada K, Gotoh D et al (2017) Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder. BMC Cancer 17(1):237CrossRefPubMedPubMedCentral

12.

Fukushima H, Yokoyama M, Nakanishi Y, Tobisu K, Koga F (2015) Sarcopenia as a prognostic biomarker of advanced urothelial carcinoma. PLoS One 10(1):e0115895CrossRefPubMedPubMedCentral

13.

Miyake M, Morizawa Y, Hori S, Marugami N, Iida K, Ohnishi K et al (2017) Integrative assessment of pre-treatment inflammation-, nutrition-, and muscle-based prognostic markers in patients with muscle invasive bladder cancer undergoing radical cystectomy. Oncology 93(4):259–269

14.

Miyake M, Tatsumi Y, Fujimoto K, Nagao K, Sakano S, Matsuyama H et al (2016) Changes in oncological outcomes after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma treated in the last two decades: a retrospective analysis based on a multicenter collaborative study. Jpn J Clin Oncol 46(12):1148–1155PubMed

15.

Martin L, Birdsell L, Macdonald N, Reiman T, Clandinin MT, McCargar LJ et al (2013) Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 31:1539–1547CrossRefPubMed

16.

Gonzalez MC, Heymsfield SB (2017) Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: what are we really estimating? J Cachexia Sarcopenia Muscle 8(2):187–189CrossRefPubMedPubMedCentral

17.

Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS et al (2014) Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15:95–101CrossRefPubMed

18.

Stanisavljevic NS, Marisavljevic DZ (2010) Weight and body composition changes during R-CHOP chemotherapy in patients with non-Hodgkin’s lymphoma and their impact on dose intensity and toxicity. J BUON 15(2):290–296PubMed

19.

Torimoto K, Samma S, Kagebayashi Y, Chihara Y, Tanaka N, Hirayama A et al (2011) The effects of androgen deprivation therapy on lipid metabolism and body composition in Japanese patients with prostate cancer. Jpn J Clin Oncol 41(4):577–581CrossRefPubMed

20.

Hara N, Ishizaki F, Saito T, Nishiyama T, Kawasaki T, Takahashi K (2013) Decrease in lean body mass in men with prostate cancer receiving androgen deprivation therapy: mechanism and biomarkers. Urology 81(2):376–380CrossRefPubMed

21.

Sánchez-Lara K, Turcott JG, Juárez E, Guevara P, Núñez-Valencia C, Oñate-Ocaña LF et al (2012) Association of nutrition parameters including bioelectrical impedance and systemic inflammatory response with quality of life and prognosis in patients with advanced non-small-cell lung cancer: a prospective study. Nutr Cancer 64(4):526–534CrossRefPubMed

22.

Miyata H, Sugimura K, Motoori M, Fujiwara Y, Omori T, Yanagimoto Y et al (2017) Clinical assessment of sarcopenia and changes in body composition during neoadjuvant chemotherapy for esophageal cancer. Anticancer Res 37(6):3053–3059PubMed

23.

Palle SS, Møllehave LT, Taheri-Kadkhoda Z, Johansen S, Larsen L, Hansen JW et al (2016) Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy. Clin Nutr ESPEN 16:8–15CrossRefPubMed

24.

Mikamori M, Miyamoto A, Asaoka T, Maeda S, Hama N, Yamamoto K et al (2016) Postoperative changes in body composition after Pancreaticoduodenectomy using multifrequency bioelectrical impedance analysis. J Gastrointest Surg 20(3):611–618CrossRefPubMed

25.

Gonzalez MC, Pastore CA, Orlandi SP, Heymsfield SB (2014) Obesity paradox in cancer: new insights provided by body composition. Am J Clin Nutr 99(5):999–1005CrossRefPubMed

26.

Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Gómez JM et al (2004) Bioelectrical impedance analysis—part I: review of principles and methods. Clin Nutr 23:1226–1243CrossRefPubMed

27.

Faisy C, Rabbat A, Kouchakji B, Laaban JP (2000) Bioelectrical impedance analysis in estimating nutritional status and outcome of patients with chronic obstructive pulmonary disease and acute respiratory failure. Intensive Care Med 26(5):518–525CrossRefPubMed

28.

Oliveira CM, Kubrusly M, Mota RS, Silva CA, Choukroun G, Oliveira VN (2010) The phase angle and mass body cell as markers of nutritional status in hemodialysis patients. J Ren Nutr 20(5):314–320CrossRefPubMed

29.

Halpern-Silveira D, Susin LR, Borges LR, Paiva SI, Assunção MC, Gonzalez MC (2010) Body weight and fat-free mass changes in a cohort of patients receiving chemotherapy. Support Care Cancer 18(5):617–625CrossRefPubMed

30.

Grossman HB, Natale RB, Tangen CM, Speights VO, Vogelzang NJ, Trump DL et al (2003) Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med 349(9):859–866CrossRefPubMed

31.

Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L (2008) Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care 11(6):693–700CrossRefPubMedPubMedCentral

32.

Mei KL, Batsis JA, Mills JB, Holubar SD (2016) Sarcopenia and sarcopenic obesity: do they predict inferior oncologic outcomes after gastrointestinal cancer surgery? Perioper Med (Lond) 5:30CrossRef

33.

Rolland Y, Lauwers-Cances V, Cristini C, Abellan van Kan G, Janssen I, Morley JE, Vellas B (2009) Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l’OSteoporose) study. Am J Clin Nutr 89:1895–1900CrossRefPubMed

34.

Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L et al (2008) Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population based study. Lancet Oncol 9:629–635CrossRefPubMed

Titel: Clinical utility of bioelectrical impedance analysis in patients with locoregional muscle invasive or metastatic urothelial carcinoma: a subanalysis of changes in body composition during neoadjuvant systemic chemotherapy
verfasst von: Makito Miyake
Takuya Owari
Takashi Iwamoto
Yosuke Morizawa
Shunta Hori
Nagaaki Marugami
Keiji Shimada
Kota Iida
Kenta Ohnishi
Daisuke Gotoh
Yoshihiro Tatsumi
Yasushi Nakai
Takeshi Inoue
Satoshi Anai
Kazumasa Torimoto
Katsuya Aoki
Tatsuo Yoneda
Nobumichi Tanaka
Kiyohide Fujimoto
Publikationsdatum: 11.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 4/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-017-3924-0

Springer Medizin

Clinical utility of bioelectrical impedance analysis in patients with locoregional muscle invasive or metastatic urothelial carcinoma: a subanalysis of changes in body composition during neoadjuvant systemic chemotherapy