Background
Methods
PET data acquisition and image analyses
Invasive coronary angiography
Dual-energy CT scan protocol
Dual-energy CT post-processing
Dual-energy CT image analyses
Statistical analysis
Results
Characteristics | Value |
---|---|
Age (years) [mean ± SD; range] | 60 ± 10 [39,76] |
Sex [male/female] | 32/22 |
BMI [kg/m2; mean ± SD; range] | 25 ± 4 [21,30] |
Mean heart rate during DECT (bpm) [mean ± SD; range] | 59 ± 9 [45,78] |
Hypertension (%) | 18(33%) |
Hypercholesterolemia (%) | 12(22%) |
Diabetes mellitus (%) | 12(22%) |
Current or prior cigarette smoking (%) | 14(26%) |
Myocardial dual-energy CT perfusion in detecting myocardial perfusion defects
Per segment (n = 918) | Per territory (n = 162) | Per patient (n = 54) | |
---|---|---|---|
Accuracy | 89.43 (821/918) [87.26–91.35] | 91.98 (149/162) [86.67–95.66] | 94.44 (51/54) [84.61–98.84] |
Sensitivity | 95.52 (320/335) [92.72–97.47] | 97.56 (80/82) [91.47–99.70] | 100.00 (37/37) [90.51–100.00] |
Specificity | 85.93 (501/583) [82.84–88.65] | 86.25 (69/80) [76.73–92.93] | 82.35 (14/17) [56.57–96.20] |
PPV | 79.60 (320/402) [75.32–83.44] | 87.91 (80/91) [79.40–93.81] | 92.50 (37/40) [79.61–98.43] |
NPV | 97.09 (501/516) [95.25–98.36] | 97.18 (69/71) [90.19–99.66] | 100 (14/14) [76.80–100] |
AUC | 0.907 [0.887–0.925] | 0.919 [0.866–0.956] | 0.912 [0.803–0.972] |
Cardiac dual-energy CT in detecting flow-limiting coronary artery disease
CCTA | CCTA plus resting DE-CTP | |
---|---|---|
Accuracy | 83.33 (45/54) [70.71–92.08] | 96.30 (52/54) [87.25–99.55] |
Sensitivity | 100.00 (37/37) [90.51–100.00] | 97.30 (36/37) [85.84–99.93] |
Specificity | 47.06 (8/17) [22.98–72.19] | 94.12 (16/17) [71.31–99.85] |
PPV | 80.43 (37/46) [66.09–90.64] | 97.30 (36/37) [85.84–99.93] |
NPV | 100 .00 (8/8) [63.06–100.00] | 94.12 (16/17) [70.28–99.88] |
AUC | 0.735 [0.598–0.846] | 0.957 [0.864–0.939] |
CCTA | CCTA plus resting DE-CTP | |
---|---|---|
Accuracy | 76.16 (125/162) [69.92–83.38] | 95.68 (155/162) [89.72–97.43] |
Sensitivity | 100.00 (77/77) [95.32–100.00] | 96.10 (74/77) [89.03–99.19] |
Specificity | 56.47 (48/85) [45.28–67.20] | 95.29 (81/85) [88.39–98.70] |
PPV | 67.54 (77/114) [58.14–76.01] | 94.87 (74/78) [87.39–98.59] |
NPV | 100.00 (48/48) [92.60–100.00] | 96.43 (81/84) [89.92–99.26] |
AUC | 0.777 [0.705–0.839] | 0.956 [0.912–0.982] |