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Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 11/2013

01.11.2013 | Neurotrauma (J Levine, Section Editor)

Coagulopathy Associated with Traumatic Brain Injury

verfasst von: Monisha A. Kumar

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 11/2013

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Abstract

Coagulopathy is often observed after traumatic brain injury (TBI), but the pathogenic mechanisms of this phenomenon remain elusive. Brain injury is the leading cause of trauma deaths, and the development of coagulopathy after TBI is associated with increased morbidity and mortality in these patients. The coagulopathy after TBI comprises a hypocoagulable and a hypercoagulable state with hemorrhagic and thrombotic phenotypes that are both associated with worse outcome. Some theories of its pathogenesis include massive release of tissue factor, altered protein C homeostasis, microparticle upregulation, and platelet hyperactivity. This article aims to examine the coagulopathy associated with blunt head injury, to review its effect on progression of hemorrhagic injury, and to discuss the possible relevant pathophysiological mechanisms.
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Metadaten
Titel
Coagulopathy Associated with Traumatic Brain Injury
verfasst von
Monisha A. Kumar
Publikationsdatum
01.11.2013
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 11/2013
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-013-0391-y

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