Erschienen in:
20.06.2017 | Cochrane in CORR
Cochrane in CORR
®: Industry Sponsorship and Research Outcome
verfasst von:
Tahira Devji, BSc, Jason W. Busse, DC, PhD
Erschienen in:
Clinical Orthopaedics and Related Research®
|
Ausgabe 9/2017
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Excerpt
In the past decade, the number of clinical trials funded by industry has substantially increased in the United States [
9]. The drug and device industry now funds six times more clinical trials than the federal government [
3]. This may be cause for concern, as publication agreements in which industry sponsors constrain academic authors’ independence are common [
5] and several research articles suggest industry sponsorship is more likely to result in pro-industry findings, pro-industry conclusions, and suppression of negative results [
1,
2,
6,
8,
11]. A recent example of industry manipulation involved a randomized trial on low-intensity pulsed ultrasound for tibial shaft fractures. The industry sponsor conducted an unplanned interim analysis and, on the grounds of no difference in effect between treatment and control, discontinued the trial early [
4,
13]. …