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Erschienen in: Current Allergy and Asthma Reports 2/2024

31.01.2024

Cognitive Impairment and Depression in Mastocytosis: A Synthesis of the Literature

verfasst von: Jennifer Nicoloro-SantaBarbara, Marzieh Majd, Katherine E. Burdick, Victoria Dixon, Matthew P. Giannetti

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 2/2024

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Abstract

Purpose of Review

Symptoms of depression and cognitive dysfunction are commonly reported in mastocytosis. The aims of this review paper are to summarize the current literature on cognitive dysfunction and depressive symptoms, elucidate some of the mechanistic pathways underlying depressive symptoms in mastocytosis, identify gaps in the literature, and offer guidance for future research in this area.

Recent Findings

The study of cognition and depression in mastocytosis is in its infancy and the methodological flaws of the current literature limit interpretability. There is preliminary evidence that some individuals with mastocytosis might experience mild deficits in memory. On average, depression symptom scores fell within the mild to moderate or sub-syndromal range. Regrettably, only one study utilized a standardized diagnostic instrument to assess major depressive disorder. The authors’ tendency to inaccurately equate depressive symptoms with a diagnosis of major depressive disorder presents a notable issue.

Summary

The prevalence of cognitive deficits and depression appears to be similar to other chronic illnesses. Future work needs to better characterize cognition and characterize “depression” in this population.
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Metadaten
Titel
Cognitive Impairment and Depression in Mastocytosis: A Synthesis of the Literature
verfasst von
Jennifer Nicoloro-SantaBarbara
Marzieh Majd
Katherine E. Burdick
Victoria Dixon
Matthew P. Giannetti
Publikationsdatum
31.01.2024
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 2/2024
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-024-01127-z

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