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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 1/2012

01.02.2012 | Original Article

Comparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs

verfasst von: S. Burcak Simsek, Gonca Cayir Keles, Sancar Barıs, Burcu Ozkan Cetinkaya

Erschienen in: Clinical Oral Investigations | Ausgabe 1/2012

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Abstract

The purpose of this study was to compare the effectiveness of mesenchymal stem cells (MSCs) with platelet-rich plasma (PRP) as scaffold and autogenous cortical bone (ACB) graft with and without PRP in the regenerative treatment of class II furcation defects in dogs. The mandibular second, third, and fourth premolars (P2, P3, P4) and maxillary P3 and P4 of both sides in three dogs were selected for experimentation. Class II furcation defects (5 mm in height and 2 mm in depth) were surgically created. Five weeks after the first operation, scaling + root planning (group 1), PRP (group 2), ACB (group 3), combination of ACB/PRP (group 4), and combination of MSCs/PRP (group 5) treatments were performed during open flap debridement. The percentage of cementum and alveolar bone formation was evaluated by histomorphometric analysis after a healing period of 8 weeks. There was new cementum along with periodontal ligament and coronal growth of alveolar bone in all groups. Cementum formation was significantly higher in groups 3, 4, and 5 compared to the control group (P < 0.05) with no significant difference between groups 2, 3, 4, and 5. Alveolar bone formation was similar in all groups (P > 0.05). It can be concluded that periodontal regeneration with complete filling of class II furcation defects with cementum, alveolar bone, and periodontal ligament is obtained 8 weeks after ACB, ACB/PRP, and MSCs/PRP treatments; however, efficacy of none is higher than another.
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Metadaten
Titel
Comparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs
verfasst von
S. Burcak Simsek
Gonca Cayir Keles
Sancar Barıs
Burcu Ozkan Cetinkaya
Publikationsdatum
01.02.2012
Verlag
Springer-Verlag
Erschienen in
Clinical Oral Investigations / Ausgabe 1/2012
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-010-0486-7

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