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01.11.2015

Complex coevolution of depression and health-related quality of life in old age

verfasst von: André Hajek, Christian Brettschneider, Annette Ernst, Carolin Lange, Birgitt Wiese, Jana Prokein, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Janine Stein, Horst Bickel, Edelgard Mösch, Kathrin Heser, Frank Jessen, Wolfgang Maier, Martin Scherer, Steffi G. Riedel-Heller, Hans-Helmut König

Erschienen in: Quality of Life Research | Ausgabe 11/2015

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Abstract

Purpose

To investigate the coevolution of depression and health-related quality of life (HRQoL) in old age.

Methods

In a representative survey of the German general population aged 75 years and older, the course of HRQoL and depression was observed over 4.5 years (3 waves). HRQoL was assessed by the Visual Analogue Scale (EQ VAS) of the EQ-5D instrument, while the Geriatric Depression Scale was used to measure depression. A panel vector autoregressive model was used to account for the complex coevolution of depression and HRQoL. Unobserved heterogeneity was taken into account by taking the first differences.

Results

We revealed a robust negative association between an initial change in HRQoL and a subsequent change in depression score, with substantial sex differences: In women there was a robust association, while in men the significance of this association depended on the model specification. Surprisingly, in the total sample and in both sexes, no robust association between an initial increase in depression and a subsequent change in HRQoL was found.

Conclusion

Findings indicate that the direction of evolution from HRQoL to depression deserves more attention. Furthermore, treatment of depression in late life should aim at improving HRQoL in which remission of depressive symptoms is necessary but not sufficient.

Nur mit Berechtigung zugänglich

In contrast to exogenous variables, endogenous variables are related to the error term.

First differences were generated by the Time series operator “D.” in Stata 13.1.

However, Allison [63] recently proposed structural equation models with fixed effects. This might be a fruitful approach in future research.

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Titel: Complex coevolution of depression and health-related quality of life in old age
verfasst von: André Hajek
Christian Brettschneider
Annette Ernst
Carolin Lange
Birgitt Wiese
Jana Prokein
Siegfried Weyerer
Jochen Werle
Michael Pentzek
Angela Fuchs
Janine Stein
Horst Bickel
Edelgard Mösch
Kathrin Heser
Frank Jessen
Wolfgang Maier
Martin Scherer
Steffi G. Riedel-Heller
Hans-Helmut König
Publikationsdatum: 01.11.2015
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 11/2015
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-1005-8

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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