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Supportive Care in Cancer

Erschienen in:

10.05.2016 | Original Article

Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir

verfasst von: Joel B. Epstein, Sara Gharapetian, Ali R. Rejali, Rachel Zabner, Michael Lill, Dimitrios Tzachanis

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2016

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Abstract

Purpose

Herpes simplex virus (HSV) infection commonly occurs during the immunosuppression associated with hematopoietic stem cell transplantation (HSCT). Prophylaxis of recurrent infection and management of clinical infection have relied upon acyclovir and congeners. More recently, resistant HSV infection is seen in HSCT and presents new challenges in management. We present a case of HSV following HSCT that provided effective symptomatic management.

Results

Oral symptoms and lesions were repeatedly reduced when topical cidofovir was used, strongly supporting the effect of cidofovir used in a host who could not tolerate systemic antiviral medications.

Conclusions

Topical cidofovir can provide effective management of symptomatic oropharyngeal HSV while reducing risk of systemic toxicity and drug interaction and represents an additional approach to management for management in medically compromised patients.

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Titel: Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir
verfasst von: Joel B. Epstein
Sara Gharapetian
Ali R. Rejali
Rachel Zabner
Michael Lill
Dimitrios Tzachanis
Publikationsdatum: 10.05.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 8/2016
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-016-3264-5

Springer Medizin

Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir