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Erschienen in: Journal of General Internal Medicine 1/2022

18.06.2021 | Original Research

Computerized Relational Agent to Deliver Alcohol Brief Intervention and Referral to Treatment in Primary Care: a Randomized Clinical Trial

verfasst von: Amy Rubin, Ph.D., Nicholas A. Livingston, Ph.D., Julianne Brady, M.A., Elise Hocking, Ph.D., Timothy Bickmore, Ph.D., Molly Sawdy, B.A., Nancy Kressin, Ph.D., Richard Saitz, M.D., M.P.H., Steven Simon, M.D., M.P.H.

Erschienen in: Journal of General Internal Medicine | Ausgabe 1/2022

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Abstract

Background

Alcohol screening and brief intervention have demonstrated efficacy but limited effectiveness and implementation in real-world primary care settings.

Objective

To evaluate the effectiveness of a computerized Relational Agent programmed to provide alcohol screening, brief intervention, and referral to treatment. We hypothesized that participants in the experimental condition would report greater reductions in their drinking and higher rates of brief intervention and referrals to specialty care compared to those in treatment as usual (TAU).

Design

This was a Hybrid I implementation design and stratified RCT. Participants were randomized to TAU or Relational Agent + TAU and assessed at baseline and 3-month follow-up.

Participants

A total of 178 veteran participants were recruited by referral from primary care staff after a positive alcohol screen, or via letter sent do patients screening positive during recent visit.

Intervention(s)

TAU involved yearly reminders to screen alcohol use and provide brief intervention and treatment referrals, as needed. The Relational Agent added an automated brief intervention, a 1-month follow-up Relational Agent visit, and referral to treatment if needed.

Main Measures

We measured average drinks per day, drinking days per week, number of brief interventions, and number of referrals over 3 months.

Key Results

Participants decreased their drinking in both study conditions, with no significant between-group differences on primary alcohol measures. However, Relational Agent + TAU participants evidenced greater improvements regarding negative alcohol-related consequences over 3 months, and were significantly more likely to receive a brief intervention and referral to specialty care.

Conclusions

The Relational Agent successfully provided brief intervention and referred many more patients to specialty care and was able to intervene with patients with less severe drinking without increasing primary care burden.
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Literatur
1.
Zurück zum Zitat Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: results from the 2018 National Survey on Drug Use and Health (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality. Substance Abuse and Mental Health Services Administration, Retrieved from https://www samhsa gov/data. 2020. Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: results from the 2018 National Survey on Drug Use and Health (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality. Substance Abuse and Mental Health Services Administration, Retrieved from https://www samhsa gov/data. 2020.
2.
Zurück zum Zitat Grant BF, Goldstein RB, Saha TD, et al. Epidemiology of DSM-5 alcohol use disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA psychiatry. 2015;72(8):757-766.CrossRef Grant BF, Goldstein RB, Saha TD, et al. Epidemiology of DSM-5 alcohol use disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA psychiatry. 2015;72(8):757-766.CrossRef
4.
Zurück zum Zitat Thompson A, Ashcroft DM, Owens L, van Staa TP, Pirmohamed M. Drug therapy for alcohol dependence in primary care in the UK: a Clinical Practice Research Datalink study. PloS one. 2017;12(3) Thompson A, Ashcroft DM, Owens L, van Staa TP, Pirmohamed M. Drug therapy for alcohol dependence in primary care in the UK: a Clinical Practice Research Datalink study. PloS one. 2017;12(3)
5.
Zurück zum Zitat Lan CW, Fiellin DA, Barry DT, et al. The epidemiology of substance use disorders in US veterans: a systematic review and analysis of assessment methods. The American Journal on Addictions. 2016;25(1):7-24.CrossRef Lan CW, Fiellin DA, Barry DT, et al. The epidemiology of substance use disorders in US veterans: a systematic review and analysis of assessment methods. The American Journal on Addictions. 2016;25(1):7-24.CrossRef
6.
Zurück zum Zitat Golub A, Vazan P, Bennett AS, Liberty HJ. Unmet need for treatment of substance use disorders and serious psychological distress among veterans: a nationwide analysis using the NSDUH. Military medicine. 2013;178(1):107-114.CrossRef Golub A, Vazan P, Bennett AS, Liberty HJ. Unmet need for treatment of substance use disorders and serious psychological distress among veterans: a nationwide analysis using the NSDUH. Military medicine. 2013;178(1):107-114.CrossRef
7.
Zurück zum Zitat Hoge C, Messer S, Castro C. Combat duty in Iraq and Afghanistan mental health problems. New England Journal of Medicine. 2004;351(17):1798-1800.CrossRef Hoge C, Messer S, Castro C. Combat duty in Iraq and Afghanistan mental health problems. New England Journal of Medicine. 2004;351(17):1798-1800.CrossRef
13.
Zurück zum Zitat Williams EC, Lapham G, Achtmeyer CE, Volpp B, Kivlahan DR, Bradley KA. Use of an electronic clinical reminder for brief alcohol counseling is associated with resolution of unhealthy alcohol use at follow-up screening. Journal of General Internal Medicine. 2010;25(1):11-17.CrossRef Williams EC, Lapham G, Achtmeyer CE, Volpp B, Kivlahan DR, Bradley KA. Use of an electronic clinical reminder for brief alcohol counseling is associated with resolution of unhealthy alcohol use at follow-up screening. Journal of General Internal Medicine. 2010;25(1):11-17.CrossRef
16.
Zurück zum Zitat Williams EC, Rubinsky AD, Chavez LJ, et al. An early evaluation of implementation of brief intervention for unhealthy alcohol use in the US Veterans Health Administration. Addiction. 2014;109(9):1472-1481.CrossRef Williams EC, Rubinsky AD, Chavez LJ, et al. An early evaluation of implementation of brief intervention for unhealthy alcohol use in the US Veterans Health Administration. Addiction. 2014;109(9):1472-1481.CrossRef
17.
Zurück zum Zitat Osborn R, Moulds D, Schneider EC, Doty MM, Squires D, Sarnak DO. Primary care physicians in ten countries report challenges caring for patients with complex health needs. Health Affairs. 2015;34(12):2104-2112.CrossRef Osborn R, Moulds D, Schneider EC, Doty MM, Squires D, Sarnak DO. Primary care physicians in ten countries report challenges caring for patients with complex health needs. Health Affairs. 2015;34(12):2104-2112.CrossRef
18.
Zurück zum Zitat Mertens JR, Chi FW, Weisner CM, et al. Physician versus non-physician delivery of alcohol screening, brief intervention and referral to treatment in adult primary care: the ADVISe cluster randomized controlled implementation trial. Addiction Science & Clinical Practice. 2015;10(1):26.CrossRef Mertens JR, Chi FW, Weisner CM, et al. Physician versus non-physician delivery of alcohol screening, brief intervention and referral to treatment in adult primary care: the ADVISe cluster randomized controlled implementation trial. Addiction Science & Clinical Practice. 2015;10(1):26.CrossRef
20.
Zurück zum Zitat McNeely J, Kumar PC, Rieckmann T, et al. Barriers and facilitators affecting the implementation of substance use screening in primary care clinics: a qualitative study of patients, providers, and staff. Addiction Science & Clinical Practice. 2018;13(1):8.CrossRef McNeely J, Kumar PC, Rieckmann T, et al. Barriers and facilitators affecting the implementation of substance use screening in primary care clinics: a qualitative study of patients, providers, and staff. Addiction Science & Clinical Practice. 2018;13(1):8.CrossRef
21.
Zurück zum Zitat Probst C, Manthey J, Martinez A, Rehm J. Alcohol use disorder severity and reported reasons not to seek treatment: a cross-sectional study in European primary care practices. Substance Abuse Treatment, Prevention, and Policy. 2015;10(1):32.CrossRef Probst C, Manthey J, Martinez A, Rehm J. Alcohol use disorder severity and reported reasons not to seek treatment: a cross-sectional study in European primary care practices. Substance Abuse Treatment, Prevention, and Policy. 2015;10(1):32.CrossRef
22.
Zurück zum Zitat Livingston NA, Mahoney CT, Ameral V, et al. Changes in alcohol use, PTSD hyperarousal symptoms, and intervention dropout following veterans’ use of VetChange. Addictive behaviors. 2020:106401. Livingston NA, Mahoney CT, Ameral V, et al. Changes in alcohol use, PTSD hyperarousal symptoms, and intervention dropout following veterans’ use of VetChange. Addictive behaviors. 2020:106401.
23.
Zurück zum Zitat Livingston NA, Shingleton R, Heilman ME, Brief D. Self-help smartphone applications for alcohol use, PTSD, anxiety, and depression: addressing the new research-practice gap. Journal of Technology in Behavioral Science. 2019;4(2):139-151.CrossRef Livingston NA, Shingleton R, Heilman ME, Brief D. Self-help smartphone applications for alcohol use, PTSD, anxiety, and depression: addressing the new research-practice gap. Journal of Technology in Behavioral Science. 2019;4(2):139-151.CrossRef
24.
Zurück zum Zitat Ashford RD, Bergman BG, Kelly JF, Curtis B. Systematic review: digital recovery support services used to support substance use disorder recovery. Human Behavior and Emerging Technologies. 2020;2(1):18-32.CrossRef Ashford RD, Bergman BG, Kelly JF, Curtis B. Systematic review: digital recovery support services used to support substance use disorder recovery. Human Behavior and Emerging Technologies. 2020;2(1):18-32.CrossRef
25.
Zurück zum Zitat Bickmore TW, Caruso L, Clough-Gorr K, Heeren T. ‘It’s Just Like You Talk to a Friend’ Relational Agents for Older Adults. Interact Comput. 12// 2005;17(6):711-735. doi:10.1016/j.intcom.2005.09.002 Bickmore TW, Caruso L, Clough-Gorr K, Heeren T. ‘It’s Just Like You Talk to a Friend’ Relational Agents for Older Adults. Interact Comput. 12// 2005;17(6):711-735. doi:10.1016/j.intcom.2005.09.002
26.
Zurück zum Zitat Bickmore TW, Silliman RA, Nelson K, et al. A randomized controlled trial of an automated exercise coach for older adults. Journal of the American Geriatrics Society. 2013;61(10):1676-1683.CrossRef Bickmore TW, Silliman RA, Nelson K, et al. A randomized controlled trial of an automated exercise coach for older adults. Journal of the American Geriatrics Society. 2013;61(10):1676-1683.CrossRef
28.
Zurück zum Zitat Bickmore T, Rubin A, Simon SR. Substance use screening using virtual agents: towards automated Screening, Brief Intervention, and Referral to Treatment (SBIRT). ACM International Conference on Intelligent Virtual Agents (IVA). 2020; Bickmore T, Rubin A, Simon SR. Substance use screening using virtual agents: towards automated Screening, Brief Intervention, and Referral to Treatment (SBIRT). ACM International Conference on Intelligent Virtual Agents (IVA). 2020;
29.
Zurück zum Zitat Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical care. 2012;50(3):217.CrossRef Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical care. 2012;50(3):217.CrossRef
31.
Zurück zum Zitat Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry. 1998. Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry. 1998.
32.
Zurück zum Zitat Sobell LC, Agrawal S, Sobell MB, et al. Comparison of a quick drinking screen with the timeline followback for individuals with alcohol problems. J Stud Alcohol. Nov 2003;64(6):858-61.CrossRef Sobell LC, Agrawal S, Sobell MB, et al. Comparison of a quick drinking screen with the timeline followback for individuals with alcohol problems. J Stud Alcohol. Nov 2003;64(6):858-61.CrossRef
33.
Zurück zum Zitat Roy M, Dum M, Sobell LC, et al. Comparison of the quick drinking screen and the alcohol timeline followback with outpatient alcohol abusers. Substance Use & Misuse. Dec 2008;43(14):2116-23. doi:90318344110.1080/10826080802347586 Roy M, Dum M, Sobell LC, et al. Comparison of the quick drinking screen and the alcohol timeline followback with outpatient alcohol abusers. Substance Use & Misuse. Dec 2008;43(14):2116-23. doi:90318344110.1080/10826080802347586
34.
Zurück zum Zitat Miller WR, Tonigan JS, Longabaugh R. The Drinker Inventory of Consequences (DrInC): an instrument for assessing adverse consequences of alcohol abuse. Vol. 4. 1995. Project MATCH Monograph Series. Miller WR, Tonigan JS, Longabaugh R. The Drinker Inventory of Consequences (DrInC): an instrument for assessing adverse consequences of alcohol abuse. Vol. 4. 1995. Project MATCH Monograph Series.
35.
Zurück zum Zitat Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption--II. Addiction. Jun 1993;88(6):791-804.CrossRef Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption--II. Addiction. Jun 1993;88(6):791-804.CrossRef
36.
Zurück zum Zitat Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Archives of Internal Medicine. Sep 14 1998;158(16):1789-95.CrossRef Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Archives of Internal Medicine. Sep 14 1998;158(16):1789-95.CrossRef
37.
Zurück zum Zitat Miller WR, Rollnick S. Motivational Interviewing: Preparing People for Change. 2nd ed. Guilford Publications; 2002:428. Miller WR, Rollnick S. Motivational Interviewing: Preparing People for Change. 2nd ed. Guilford Publications; 2002:428.
38.
Zurück zum Zitat Team RC. R: A language and environment for statistical computing. Vienna, Austria; 2013. Team RC. R: A language and environment for statistical computing. Vienna, Austria; 2013.
39.
Zurück zum Zitat Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. arXiv preprint arXiv:14065823. 2014; Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. arXiv preprint arXiv:14065823. 2014;
40.
Zurück zum Zitat Pinheiro J, Bates D, DebRoy S, Sarkar D. R Core Team (2019). nlme: linear and nonlinear mixed effects models. R package version 3.1-148. 2020. Pinheiro J, Bates D, DebRoy S, Sarkar D. R Core Team (2019). nlme: linear and nonlinear mixed effects models. R package version 3.1-148. 2020.
41.
Zurück zum Zitat Witkiewitz K, Heather N, Falk DE, et al. World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom. Addiction. 2020. Witkiewitz K, Heather N, Falk DE, et al. World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom. Addiction. 2020.
Metadaten
Titel
Computerized Relational Agent to Deliver Alcohol Brief Intervention and Referral to Treatment in Primary Care: a Randomized Clinical Trial
verfasst von
Amy Rubin, Ph.D.
Nicholas A. Livingston, Ph.D.
Julianne Brady, M.A.
Elise Hocking, Ph.D.
Timothy Bickmore, Ph.D.
Molly Sawdy, B.A.
Nancy Kressin, Ph.D.
Richard Saitz, M.D., M.P.H.
Steven Simon, M.D., M.P.H.
Publikationsdatum
18.06.2021
Verlag
Springer International Publishing
Erschienen in
Journal of General Internal Medicine / Ausgabe 1/2022
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-021-06945-9

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