nach oben

PharmacoEconomics

Erschienen in:

01.12.2010 | Review Article

Concordance of Adherence Measurement Using Self-Reported Adherence Questionnaires and Medication Monitoring Devices

verfasst von: Dr Lizheng Shi, Jinan Liu, Yordanka Koleva, Vivian Fonseca, Anupama Kalsekar, Manjiri Pawaskar

Erschienen in: PharmacoEconomics | Ausgabe 12/2010

Einloggen, um Zugang zu erhalten

Abstract

The primary objective of this review was to identify and examine the literature on the association between medication adherence self-reported questionnaires (SRQs) and medication monitoring devices. The primary literature search was performed for 1980–2009 using PubMed, PubMed In Process and Non-Indexed, Ovid MEDLINE, Ovid MEDLINE In-Process, PsycINFO (EBSCO), CINAHL (EBSCO), Ovid HealthStar, EMBASE (Elsevier) and Cochrane Databases and using the following search terms: ‘patient compliance’, ‘medication adherence’, ‘treatment compliance’, ‘drug monitoring’, ‘drug therapy’, ‘electronic’, ‘digital’, ‘computer’, ‘monitor’, ‘monitoring’, ‘drug’, ‘drugs’, ‘pharmaceutical preparations’, ‘compliance’ and ‘medications’. We identified studies that included SRQs and electronic monitoring devices to measure adherence and focused on the SRQs that were found to be moderately to highly correlated with the monitoring devices.

Of the 1679 citations found via the primary search, 41 full-text articles were reviewed for correlation between monitoring devices and SRQs. A majority (68%) of articles reported high (27%), moderate (29%) or significant (12%) correlation between monitoring devices (37 using Medication Event Monitoring System [MEMS®] and four using other devices) and SRQs (11 identified and numerous other unnamed SRQs). The most commonly used SRQs were the Adult/Pediatric AIDS Clinical Trial Group (AACTG/ PACTG; 24.4%, 10/41) followed by the 4-item Morisky (9.8%, 4/41), Brief Medication Questionnaire (9.8%, 4/41) and visual analogue scale (VAS; 7.3%, 3/41). Although study designs differed across the articles, SRQs appeared to report a higher rate of medication adherence (+14.9%) than monitoring devices.

In conclusion, several medication adherence SRQs were validated using electronic monitoring devices. A majority of them showed high or moderate correlation with medication adherence measured using monitoring devices, and could be considered for measuring patient-reported adherence prospectively.

Osterberg L, Blaschke T. Adherence to medication. NEngl J Med 2005; 353 (5): 487–97CrossRef

Hawkshead J, Krousel-Wood MA. Techniques for measuring medication adherence in hypertensive patients in outpatient settings: advantages and limitations. Dis Manage Health Outcomes 2007; 15 (2): 109–18CrossRef

Johnson JA, Bootman JL. Drug-related morbidity and mortality: a cost-of-illness model. Arch Intern Med 1995; 155 (18): 1949–56PubMedCrossRef

Bender BG, Rand C. Medication non-adherence and asthma treatment cost. Curr Opin Allergy Clin Immunol 2004; 4 (3): 191–5PubMedCrossRef

Farmer KC. Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther 1999; 21 (6): 1074–90PubMedCrossRef

Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; 23 (8): 1296–310PubMedCrossRef

Garber MC, Nau DP, Erickson SR, et al. The concordance of self-report with other measures of medication adherence: a summary of the literature. Med Care 2004; 42 (7): 649–52PubMedCrossRef

Cook CL, Wade WE, Martin BC, et al. Concordance among three self-reported measures of medication adherence and pharmacy refill records. J Am Pharm Assoc 2005; 45 (2): 151–9CrossRef

Wang P, Benner JS, Glynn RJ, et al. How well do patients report noncompliance with antihypertensive medications? A comparison of self-report versus filled prescriptions. Pharmacoepidemiol Drug Saf 2004; 13 (1): 11–9PubMedCrossRef

10.

Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Metaanalyses. Lancet 1999; 354 (9193): 1896–900PubMedCrossRef

11.

Fletcher CV, Testa MA, Brundage RC, et al. Four measures of antiretroviral medication adherence and virologic response in AIDS clinical trials group study 359. J Acquir Immune Defic Syndr 2005; 40 (3): 301–6PubMedCrossRef

12.

Holzemer WL, Bakken S, Portillo CJ, et al. Testing a nursetailored HIV medication adherence intervention. Nurs Res 2006; 55 (3): 189–97PubMedCrossRef

13.

Kastrissios H, Suárez JR, Katzenstein D, et al. Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial. AIDS 1998; 12 (17): 2295–303PubMedCrossRef

14.

Levine AJ, Hinkin CH, Marion S, et al. Adherence to antiretroviral medications in HIV: differences in data collected via self-report and electronic monitoring. Health Psychol 2006; 25 (3): 329–35PubMedCrossRef

15.

Llabre MM, Weaver KE, Durán RE, et al. A measurement model of medication adherence to highly active antiretroviral therapy and its relation to viral load in HIV-positive adults. AIDS Patient Care STDs 2006; 20 (10): 701–11PubMedCrossRef

16.

Mathews WC, Mar-Tang M, Ballard C, et al. Prevalence, predictors, and outcomes of early adherence after starting or changing antiretroviral therapy. AIDS Patient Care STDs 2002; 16 (4): 157–72PubMedCrossRef

17.

Oyugi JH, Byakika-Tusiime J, Charlebois ED, et al. Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resourcelimited setting. J Acquir Immune Defic Syndr 2004; 36 (5): 1100–2PubMedCrossRef

18.

Pearson CR, Simoni JM, Hoff P, et al. Assessing antiretroviral adherence via electronic drug monitoring and selfreport: an examination of key methodological issues. AIDS Behav 2007; 11 (2): 161–73PubMedCrossRef

19.

Kilbourne AM, Good CB, Sereika SM, et al. Algorithm for assessing patients’ adherence to oral hypoglycemic medication. Am J Health Syst Pharm 2005; 62 (2): 198–204PubMed

20.

Farley J, Hines S, Musk A, et al. Assessment of adherence to antiviral therapy in HIV-infected children using the Medication Event Monitoring System, pharmacy refill, provider assessment, caregiver self-report, and appointment keeping. J Acquir Immune Defic Syndr 2003; 33 (2): 211–8PubMedCrossRef

21.

Butler JA, Peveler RC, Roderick P, et al. Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring. Transplantation 2004; 77 (5): 786–9PubMedCrossRef

22.

Elixhauser A, Eisen SA, Romeis JC, et al. The effects of monitoring and feedback on compliance. Med Care 1990; 28 (10): 882–93PubMedCrossRef

23.

Hamilton GA. Measuring adherence in a hypertension clinical trial. Eur J Cardiovasc Nurs 2003; 2 (3): 219–28PubMedCrossRef

24.

Choo PW, Rand CS, Inui TS, et al. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care 1999; 37 (9): 846–57PubMedCrossRef

25.

Curtin RB, Svarstad BL, Keller TH. Hemodialysis patients’ noncompliance with oral medications. ANNA J 1999; 26 (3): 307–16; discussion 317, 335PubMed

26.

Rathbun RC, Farmer KC, Stephens JR, et al. Impact of an adherence clinic on behavioral outcomes and virologic response in treatment of HIV infection: a prospective, randomized, controlled pilot study. Clin Ther 2005; 27 (2): 199–209PubMedCrossRef

27.

Svarstad BL, Chewning BA, Sleath BL, et al. The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ Couns 1999; 37 (2): 113–24PubMedCrossRef

28.

Hugen PW, Langebeek N, Burger DM, et al. Assessment of adherence to HIV protease inhibitors: comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring. J Acquir Immune Defic Syndr 2002; 30 (3): 324–34PubMed

29.

Byerly MJ, Nakonezny PA, Rush AJ. The Brief Adherence Rating Scale (BARS) validated against electronic monitoring in assessing the antipsychotic medication adherence of outpatients with schizophrenia and schizoaffective disorder. Schizophr Res 2008; 100 (1-3): 60–9PubMedCrossRef

30.

Denhaerynck K, Abraham I, Gourley G, et al. Validity testing of the Long-Term Medication Behavior Self-Efficacy Scale. J Nurs Meas 2003; 11 (3): 267–82PubMedCrossRef

31.

Walsh JC, Mandalia S, Gazzard BG. Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome. AIDS 2002; 16 (2): 269–77PubMedCrossRef

32.

Zeller A, Schroeder K, Peters TJ. Electronic pillboxes (MEMS) to assess the relationship between medication adherence and blood pressure control in primary care. Scand J Prim Health Care 2007; 25 (4): 202–7PubMedCrossRef

33.

Arnsten JH, Demas PA, Farzadegan H, et al. Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: comparison of self-report and electronic monitoring. Clin Infect Dis 2001; 33 (8): 1417–23PubMedCrossRef

34.

Balkrishnan R, Bond JB, Byerly WG, et al. Medicationrelated predictors of health-related quality of life in glaucoma patients enrolled in a medicare health maintenance organization. Am J Geriatr Pharmacother 2003; 1 (2): 75–81PubMedCrossRef

35.

Bangsberg DR, Hecht FM, Charlebois ED, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS 2000; 14 (4): 357–66PubMedCrossRef

36.

Geletko SM, Segarra M, Ravin DS, et al. Zidovudine compliance as measured by different methods in an HIV ambulatory clinic. J Pharm Technol 1996; 12 (3): 105–8

37.

Halkitis PN, Kutnick AH, Slater S. The social realities of adherence to protease inhibitor regimens: substance use, health care and psychological states. J Health Psychol 2005; 10 (4): 545–58PubMedCrossRef

38.

Hope CJ, Wu J, Tu W, et al. Barriers to adherence in elderly heart failure patients. Drug Inf J 2004; 38 (4): 331–41CrossRef

39.

Jasti S, Siega-Riz AM, Cogswell ME, et al. Correction for errors in measuring adherence to prenatal multivitamin/mineral supplement use among low-income women. J Nutr 2006; 136 (2): 479–83PubMed

40.

Klein A, Kramer I. Medication event monitoring systems (MEMS®) in measuring patient compliance. Krankenhauspharmazie 2006; 27 (10): 439–46

41.

Kozuki Y, Poupore E, Schepp K. Visual feedback therapy to enhance medication adherence in psychosis. Arch Psychiatr Nurs 2005; 19 (2): 70–80PubMedCrossRef

42.

Leopold NA, Polansky M, Hurka MR. Drug adherence in Parkinson’s disease. Mov Disord 2004; 19 (5): 513–7PubMedCrossRef

43.

Lu M, Safren SA, Skolnik PR, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav 2008; 12 (1): 86–94PubMedCrossRef

44.

Melbourne KM, Geletko SM, Brown SL, et al. Medication adherence in patients with HIV infection: a comparison of two measurement methods. AIDS Read 1999; 9 (5): 329–38PubMed

45.

Mooney M, Sayre S, Green C, et al. Comparing measures of medication taking in a pharmacotherapy trial for cocaine dependence. Addict Disord Their Treat 2004; 3 (4): 165–73CrossRef

46.

Paes AHP, Bakker A, Soe-Agnie CJ. Measurement of patient compliance. Pharm World Sci 1998; 20 (2): 73–7PubMedCrossRef

47.

Parker CS, Chen Z, Price M, et al. Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study. J Gen Intern Med 2007; 22 (9): 1254–9PubMedCrossRef

48.

Rand CS, Nides M, Cowles MK, et al. Long-term metereddose inhaler adherence in a clinical trial. The Lung Health Study Research Group. Am J Respir Crit Care Med 1995; 152 (2): 580–8PubMed

49.

Remington G, Kwon J, Collins A, et al. The use of electronic monitoring (MEMSAE) to evaluate antipsychotic compliance in outpatients with schizophrenia. Schizophr Res 2007; 90 (1): 229–37PubMedCrossRef

50.

Rudd P, Ramesh J, Bryant-Kosling C, et al. Gaps in cardiovascular medication taking: the tip of the iceberg. J Gen Intern Med 1993; 8 (12): 659–66PubMedCrossRef

51.

Thompson K, Kulkarni J, Sergejew AA. Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses. Schizophr Res 2000; 42 (3): 241–7PubMedCrossRef

52.

Thompson C, Peveles RC, Stephenson D, et al. Compliance with antidepressant medication in the treatment of major depressive disorder in primary care: a randomized comparison of fluoxetine and a tricyclic antidepressant. Am J Psychiatr 2000; 157 (3): 338–43PubMedCrossRef

53.

Velligan DI, Wang M, Diamond P, et al. Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Psychiatr Serv 2007; 58 (9): 1187–92PubMedCrossRef

54.

WickstrÖm G, Bendix T. The ‘Hawthorne effect’: what did the original Hawthorne studies actually show? Scand J Work Environ Health 2000; 26 (4): 363–7PubMedCrossRef

55.

Cramer JA. Medication compliance in epilepsy. Arch Int Med 1991; 151 (6): 1236–7CrossRef

56.

Kruse W, Weber E. Dynamics of drug regimen compliance: its assessment by microprocessor-based monitoring. Eur J Clin Pharmacol 1990; 38 (6): 561–5PubMedCrossRef

57.

Denhaerynck K, Schäfer-Keller P, Young J, et al. Examining assumptions regarding valid electronic monitoring of medication therapy: development of a validation framework and its application on a European sample of kidney transplant patients. BMC Med Res Methodol 2008; 8: 5PubMedCrossRef

58.

Feinstein AR. On white-coat effects and the electronic monitoring of compliance [comment]. Arch Intern Med 1990; 150 (7): 1377–8PubMedCrossRef

59.

Burnier M, Schneider MP, Chioléro A, et al. Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions. J Hypertension 2001; 19 (2): 335–41CrossRef

60.

Chesney MA, Ickovics JR, Chambers DB, et al. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee and Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care 2000; 12 (3): 255–66PubMedCrossRef

61.

Fang MC, Machtinger EL, Wang F, et al. Health literacy and anticoagulation-related outcomes among patients taking warfarin. J Gen Intern Med 2006; 21 (8): 841–6PubMedCrossRef

62.

Reinhard MJ, Hinkin CH, Barclay TR, et al. Discrepancies between self-report and objective measures for stimulant drug use in HIV: cognitive, medication adherence and psychological correlates. Addict Behav 2007; 32 (12): 2727–36PubMedCrossRef

63.

Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986; 24 (1): 67–74PubMedCrossRef

64.

Joshi AV, Madhavan SS, Ambegaonkar A, et al. Association of medication adherence with workplace productivity and health-related quality of life in patients with asthma. J Asthma 2006; 43 (7): 521–6PubMedCrossRef

65.

Larizza MA, Dooley MJ, Stewart K, et al. Factors influencing adherence to molecular therapies in haematologyoncology outpatients. J Pharmacy Practice Res 2006; 36 (2): 115–8

66.

Guilera M, Fuentes M, Grifols M, et al. Does an educational leaflet improve self-reported adherence to therapy in osteoporosis? The OPTIMA study. Osteoporos Int 2006; 17 (5): 664–71PubMedCrossRef

67.

Morisky DE, Ang A, Krousel-Wood M, et al. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich) 2008; 10 (5): 348–54CrossRef

68.

Brown C, Battista DR, Bruehlman R, et al. Beliefs about antidepressant medications in primary care patients: relationship to self-reported adherence. Med Care 2005; 43 (12): 1203–7PubMedCrossRef

69.

Holzemer WL, Corless IB, Nokes KM, et al. Predictors of self-reported adherence in persons living with HIV disease. AIDS Patient Care STDs 1999; 13 (3): 185–97PubMedCrossRef

70.

Sewitch MJ, Leffondré K, Dobkin PL. Clustering patients according to health perceptions: relationships to psychosocial characteristics and medication nonadherence. J Psychosomatic Res 2004; 56 (3): 323–32CrossRef

71.

Shalansky SJ, Levy AR, Ignaszewski AP. Self-reported Morisky score for identifying nonadherence with cardiovascular medications. Ann Pharmacother 2004; 38 (9): 1363–8PubMedCrossRef

72.

Koneru S, Shishov M, Ware A, et al. Effectively measuring adherence tomedications for systemic lupus erythematosus in a clinical setting. Arthritis Rheum 2007; 57 (6): 1000–6PubMedCrossRef

73.

Fialko L, Garety PA, Kuipers E, et al. A large-scale validation study of the Medication Adherence Rating Scale (MARS). Schizophr Res 2008; 100 (1-3): 53–9PubMedCrossRef

74.

Fogel J, Fauerbach JA, Ziegelstein RC, et al. Quality of life in physical health domains predicts adherence among myocardial infarction patients even after adjusting for depressive symptoms. J Psychosomatic Res 2004; 56 (1): 75–82CrossRef

75.

Horne R. Compliance, adherence, and concordance: implications for asthma treatment. Chest 2006; 130 (1 Suppl.): 65S–72SPubMedCrossRef

76.

Bell JS, Airaksinen MS, Lyles A, et al. Concordance is not synonymous with compliance or adherence. Br J Clin Pharmacol 2007; 64 (5): 710–1PubMedCrossRef

Titel: Concordance of Adherence Measurement Using Self-Reported Adherence Questionnaires and Medication Monitoring Devices
verfasst von: Dr Lizheng Shi
Jinan Liu
Yordanka Koleva
Vivian Fonseca
Anupama Kalsekar
Manjiri Pawaskar
Publikationsdatum: 01.12.2010
Verlag: Springer International Publishing
Erschienen in: PharmacoEconomics / Ausgabe 12/2010
Print ISSN: 1170-7690
Elektronische ISSN: 1179-2027
DOI: https://doi.org/10.2165/11537400-000000000-00000

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2010

Acknowledgement

The Economics of a ‘Liberated’ NHS

The Cost Utility of Autologous Chondrocytes Implantation Using ChondroCelect® in Symptomatic Knee Cartilage Lesions in Belgium

A Review and Critique of Studies Reporting Utility Values for Schizophrenia-Related Health States

Measuring the Externality of Antibacterial Use from Promoting Antimicrobial Resistance

The Analysis of Multinational Cost-Effectiveness Data for Reimbursement Decisions