nach oben

European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.04.2009 | Original Article

Constant ambient temperature of 24°C significantly reduces FDG uptake by brown adipose tissue in children scanned during the winter

verfasst von: Katherine A. Zukotynski, Frederic H. Fahey, Stephen Laffin, Royal Davis, S. Ted Treves, Frederick D. Grant, Laura A. Drubach

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2009

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The aim of this study was to determine if warming patients prior to and during ¹⁸F-FDG uptake by controlling the room temperature could decrease uptake by brown adipose tissue (BAT).

Methods

A group of 40 children underwent ¹⁸F-FDG PET after being kept in the injection room at a constant temperature of 24°C for half an hour before and 1 hour after intravenous tracer administration. The rate of uptake by BAT in this group was compared to the uptake in a control group of 45 patients who underwent PET when the injection room temperature was 21°C.

Results

Uptake by BAT occurred in 5% of studies in the temperature-controlled room compared to 31% of studies performed when the injection room temperature was 21°C (p<0.002).

Conclusion

Maintaining room temperature at a constant 24°C, half an hour prior to and during the period of FDG uptake significantly decreases accumulation of FDG in BAT in children.

Clarke JR, Brglevska S, Lau EW, Ramdave S, Hicks RJ. Atypical brown fat distribution in young males demonstrated on PET/CT. Clin Nucl Med 2007;32:679–82.PubMedCrossRef

Yeung HW, Grewal RK, Gonen M, Schöder H, Larson SM. Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET. J Nucl Med 2003;44:1789–96.PubMed

Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 2002;29:1393–98.PubMedCrossRef

Cohade C, Osman M, Pannu HK, Wahl RL. Uptake in supraclavicular area fat (“USA-Fat”): description on 18F-FDG PET/CT. J Nucl Med 2003;44:170–76.PubMed

Wehrli NE, Bural G, Houseni M, Alkhawaldeh K, Alavi A, Torigian DA. Determination of age-related changes in structure and function of skin, adipose tissue, and skeletal muscle with computed tomography, magnetic resonance imaging, and positron emission tomography. Semin Nucl Med 2007;37:195–205.PubMedCrossRef

Cohade C, Mourtzikos K, Wahl R. “USA-Fat”: prevalence is related to ambient outdoor temperature – evaluation with 18F-FDG PET/CT. J Nucl Med 2003;44:1267–70.PubMed

Kim S, Krynyckyi BR, Machac J, Kim CK. Temporal relation between temperature change and FDG uptake in brown adipose tissue. Eur J Nucl Med Mol Imaging 2008;35:984–89.PubMedCrossRef

Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277–359.PubMedCrossRef

Gelfand MJ, O’Hara SM, Curtwright LA, Maclean JR. Pre-medication to block [(18)F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients. Pediatr Radiol 2005;35:984–90.PubMedCrossRef

10.

Parysow O, Mollerach AM, Jager V, Racioppi S, San Roman J, Gerbaudo VH. Low-dose oral propranolol could reduce brown adipose tissue F-18 FDG uptake in patients undergoing PET scans. Clin Nucl Med 2007;32:351–57.PubMedCrossRef

11.

Söderlund V, Larsson SA, Jacobsson H. Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging 2007;34:1018–22.PubMedCrossRef

12.

Tatsumi M, Engles JM, Ishimori T, Nicely O, Cohade C, Wahl RL. Intense (18)F-FDG uptake in brown adipose fat can be reduced pharmacologically. J Nucl Med 2004;45:1189–93.PubMed

13.

Garcia CA, Van Nostrand D, Atkins F, Acio E, Butler C, Esposito G, et al. Reduction of brown fat 2-deoxy-2-[F-18]fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan. Mol Imaging Biol 2006;8:24–9.PubMedCrossRef

14.

Christensen CR, Clark PB, Morton KA. Reversal of hypermetabolic brown adipose tissue in F-18 FDG PET imaging. Clin Nucl Med 2006;31:193–96.PubMedCrossRef

15.

Garcia CA, Van Nostrand D, Majd M, Atkins F, Acio E, Sheikh A, et al. Benzodiazepine-resistant "brown fat" pattern in positron emission tomography: two case reports of resolution with temperature control. Mol Imaging Biol 2004;6:368–72.PubMedCrossRef

16.

Gessner K. Conradi Gesneri medici Tigurini Historiae Animalium: Lib 1 - De Quadrupedibus Viviparis (1551).

17.

Cannon B, Nedergaard J. Developmental biology: Neither fat nor flesh. Nature 2008;454:947–48.PubMedCrossRef

Titel: Constant ambient temperature of 24°C significantly reduces FDG uptake by brown adipose tissue in children scanned during the winter
verfasst von: Katherine A. Zukotynski
Frederic H. Fahey
Stephen Laffin
Royal Davis
S. Ted Treves
Frederick D. Grant
Laura A. Drubach
Publikationsdatum: 01.04.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2009
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0983-y

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2009

Determinants of 131I radiation dose to thyroid follicular cells

Standardization of the heart-to-mediastinum ratio of 123I-labelled-metaiodobenzylguanidine uptake using the dual energy window method: feasibility of correction with different camera–collimator combinations

Agreement and disagreement between contrast-enhanced magnetic resonance imaging and nuclear imaging for assessment of myocardial viability

Cancer-associated stroma affects FDG uptake in experimental carcinomas. Implications for FDG-PET delineation of radiotherapy target

Helmut Madjar, Ellen Mendelson: The practice of breast ultrasound. Techniques – findings – differential diagnosis, 2nd edition

Respiration-averaged CT for attenuation correction in non-small-cell lung cancer