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Erschienen in: Rheumatology International 8/2019

22.05.2019 | Review

Conventional radiography of the hands and wrists in rheumatoid arthritis. What a rheumatologist should know and how to interpret the radiological findings

verfasst von: Alexandros A. Drosos, Eleftherios Pelechas, Paraskevi V. Voulgari

Erschienen in: Rheumatology International | Ausgabe 8/2019

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the synovial membrane, leading to joint damage and bone destruction. Conventional radiography (CR) of the hands and wrists has been, for many years, the primary imaging modality used to diagnose and monitor RA. On the other hand, many investigators in clinical trials and observational studies used CR of the hands and wrists to demonstrate drug effectiveness and structural damage progression. The purpose of this review is to discuss the evaluation and interpretation of the hands and wrists by CR in RA patients and the radiographic changes occurring in a specific joint. Thus, the literature was reviewed until January 2019 for studies regarding RA radiological evaluation of the hands and wrists, as well as radiological progression using CR. The assessment of joint pathology in RA patients should begin with CR which is the best imaging modality to evaluate any subtle changes occurring at the bone level. Once high-quality radiographs are obtained in appropriate views/projections, then an accurate evaluation can often be made without any further imaging studies. Therefore, CR is a valuable tool for RA screening. It is an easy-to-perform technique and gives important information assisting in differentiating between RA from other arthritides. In contrary CR does not provide good information when early RA changes start to appear, such as synovial inflammation or other soft-tissue structural changes. Nevertheless, it still remains the most commonly used imaging tool in rheumatology and has a number of advantages: it is easily available in most rheumatologists and readily accessible in most patients. It is inexpensive and relatively safe. It provides immediate information and can be interpreted easily by the requested rheumatologist. Finally, the data are reproducible and can be used for serial evaluation and follow-up.
Literatur
1.
Zurück zum Zitat Alamanos Y, Drosos AA (2005) Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 4:130–136CrossRefPubMed Alamanos Y, Drosos AA (2005) Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 4:130–136CrossRefPubMed
2.
Zurück zum Zitat Drosos AA, Alamanos I, Voulgari PV et al (1997) Epidemiology of adult rheumatoid arthritis in northwest Greece 1987–1995. J Rheumatol 24:2129–2133PubMed Drosos AA, Alamanos I, Voulgari PV et al (1997) Epidemiology of adult rheumatoid arthritis in northwest Greece 1987–1995. J Rheumatol 24:2129–2133PubMed
3.
Zurück zum Zitat Alamanos Y, Voulgari PV, Drosos AA (2006) Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Semin Arthritis Rheum 36:182–188CrossRefPubMed Alamanos Y, Voulgari PV, Drosos AA (2006) Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Semin Arthritis Rheum 36:182–188CrossRefPubMed
4.
Zurück zum Zitat Aletaha D, Neogi T, Silman AJ et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569–2581CrossRefPubMed Aletaha D, Neogi T, Silman AJ et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569–2581CrossRefPubMed
5.
Zurück zum Zitat Llopis E, Kroon HM, Acosta J, Bloem JL (2017) Conventional radiology in rheumatoid arthritis. Radiol Clin N Am 55:917–941CrossRefPubMed Llopis E, Kroon HM, Acosta J, Bloem JL (2017) Conventional radiology in rheumatoid arthritis. Radiol Clin N Am 55:917–941CrossRefPubMed
6.
Zurück zum Zitat Salaffi F, Carotti M, Carlo MD (2016) Conventional radiography in rheumatoid arthritis: new scientific insights and practical application. Int J Clin Exp Med 9:17012–17027 Salaffi F, Carotti M, Carlo MD (2016) Conventional radiography in rheumatoid arthritis: new scientific insights and practical application. Int J Clin Exp Med 9:17012–17027
7.
Zurück zum Zitat Sommer OJ, Kladosek A, Weiler V, Czembirek H, Boeck M, Stiskal M (2005) Rheumatoid arthritis: a practical guide to state-of-the-art imaging, image interpretation, and clinical implications. Radiographics 25:381–398CrossRefPubMed Sommer OJ, Kladosek A, Weiler V, Czembirek H, Boeck M, Stiskal M (2005) Rheumatoid arthritis: a practical guide to state-of-the-art imaging, image interpretation, and clinical implications. Radiographics 25:381–398CrossRefPubMed
8.
Zurück zum Zitat Wakefield RJ, Gibbon WW, Conaghan PG et al (2000) The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis Rheum 43:2762–2770CrossRefPubMed Wakefield RJ, Gibbon WW, Conaghan PG et al (2000) The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis Rheum 43:2762–2770CrossRefPubMed
9.
10.
Zurück zum Zitat Ejbjerg BJ, Vestergaard A, Jacobsen S, Thomsen HS, Ostergaard M (2005) The smallest detectable difference and sensitivity to change of magnetic resonance imaging and radiographic scoring of structural joint damage in rheumatoid arthritis finger, wrist, and toe joints: a comparison of the OMERACT rheumatoid arthritis magnetic resonance imaging score applied to different joint combinations and the Sharp/van der Heijde radiographic score. Arthritis Rheum 52:2300–2306CrossRefPubMed Ejbjerg BJ, Vestergaard A, Jacobsen S, Thomsen HS, Ostergaard M (2005) The smallest detectable difference and sensitivity to change of magnetic resonance imaging and radiographic scoring of structural joint damage in rheumatoid arthritis finger, wrist, and toe joints: a comparison of the OMERACT rheumatoid arthritis magnetic resonance imaging score applied to different joint combinations and the Sharp/van der Heijde radiographic score. Arthritis Rheum 52:2300–2306CrossRefPubMed
11.
Zurück zum Zitat Mcqueen FM, Stewart N, Crabbe J et al (1999) Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. Ann Rheum Dis 58:156–163CrossRefPubMedPubMedCentral Mcqueen FM, Stewart N, Crabbe J et al (1999) Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. Ann Rheum Dis 58:156–163CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Jans L, de Kock I, Herregods N et al (2018) Dual-energy CT: a new imaging modality for bone marrow oedema in rheumatoid arthritis. Ann Rheum Dis 77(6):958–960PubMed Jans L, de Kock I, Herregods N et al (2018) Dual-energy CT: a new imaging modality for bone marrow oedema in rheumatoid arthritis. Ann Rheum Dis 77(6):958–960PubMed
13.
Zurück zum Zitat Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM et al (2015) Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis 18:628–639CrossRefPubMed Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM et al (2015) Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis 18:628–639CrossRefPubMed
14.
Zurück zum Zitat Hartley RM, Liang MH, Weissman BN, Sosman JL, Katz R, Charlton JR (1984) The value of conventional views and radiographic magnification in evaluating early rheumatoid arthritis. Arthritis Rheum 27:744–751CrossRefPubMed Hartley RM, Liang MH, Weissman BN, Sosman JL, Katz R, Charlton JR (1984) The value of conventional views and radiographic magnification in evaluating early rheumatoid arthritis. Arthritis Rheum 27:744–751CrossRefPubMed
15.
Zurück zum Zitat Ostergaard M, Emery P, Conaghan PG et al (2011) Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naïve rheumatoid arthritis patients. Arthritis Rheum 63(12):3712–3722CrossRefPubMed Ostergaard M, Emery P, Conaghan PG et al (2011) Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naïve rheumatoid arthritis patients. Arthritis Rheum 63(12):3712–3722CrossRefPubMed
16.
Zurück zum Zitat Irnbjerg LM, Ostergaard M, Boyesen P et al (2013) Impact of tumour necrosis factor inhibitor treatment on radiographic progression in rheumatoid arthritis patients in clinical practice: results from the nationwide Danish DANBIO registry. Ann Rheum Dis 72:57–63CrossRef Irnbjerg LM, Ostergaard M, Boyesen P et al (2013) Impact of tumour necrosis factor inhibitor treatment on radiographic progression in rheumatoid arthritis patients in clinical practice: results from the nationwide Danish DANBIO registry. Ann Rheum Dis 72:57–63CrossRef
17.
Zurück zum Zitat Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD (2011) Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 31(11):1409–1417CrossRefPubMed Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD (2011) Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 31(11):1409–1417CrossRefPubMed
18.
Zurück zum Zitat Loredo RA, Sorge DG, Garcia G (2005) Radiographic evaluation of the wrist: a vanishing art. Semn Roentgenol 40(3):248–289CrossRef Loredo RA, Sorge DG, Garcia G (2005) Radiographic evaluation of the wrist: a vanishing art. Semn Roentgenol 40(3):248–289CrossRef
19.
20.
Zurück zum Zitat Brower AC (1997) Evaluation of the hand film. In: Brower AC (ed) Arthritis in black and white, 2nd edn. Saunders, Philadelphia, pp 33–67 Brower AC (1997) Evaluation of the hand film. In: Brower AC (ed) Arthritis in black and white, 2nd edn. Saunders, Philadelphia, pp 33–67
21.
Zurück zum Zitat Brower AC (1997) Rheumatoid arthritis. In: Brower AC (ed) Arthritis in black and white, 2nd edn. Saunders, Philadelphia, pp 195–224 Brower AC (1997) Rheumatoid arthritis. In: Brower AC (ed) Arthritis in black and white, 2nd edn. Saunders, Philadelphia, pp 195–224
22.
Zurück zum Zitat Resnick D, Kyriakos M, Greenway GD (2002) Rheumatoid arthritis. Diagnosis of bone and joint disorders, 4th edn. Saunders, Philadelphia, pp 891–974 Resnick D, Kyriakos M, Greenway GD (2002) Rheumatoid arthritis. Diagnosis of bone and joint disorders, 4th edn. Saunders, Philadelphia, pp 891–974
23.
Zurück zum Zitat Jacobson JA, Girish G, Jiang Y et al (2008) Radiographic evaluation of arthritis: inflammatory conditions. Radiology 248(2):378–389CrossRefPubMed Jacobson JA, Girish G, Jiang Y et al (2008) Radiographic evaluation of arthritis: inflammatory conditions. Radiology 248(2):378–389CrossRefPubMed
24.
Zurück zum Zitat Resnick D, Kransdorf M (2004) Rheumatoid arthritis and the seronegative spondyloarthropathies: radiographic and pathologic concepts Bone and joint imaging, 3rd edn. Elsevier, Philadelphia, pp 220–221 Resnick D, Kransdorf M (2004) Rheumatoid arthritis and the seronegative spondyloarthropathies: radiographic and pathologic concepts Bone and joint imaging, 3rd edn. Elsevier, Philadelphia, pp 220–221
25.
Zurück zum Zitat Haugen IK, Cotofana S, Englund M, Kvien TK, Dreher D et al (2012) Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. J Rheumatol 39(1):161–166CrossRefPubMed Haugen IK, Cotofana S, Englund M, Kvien TK, Dreher D et al (2012) Hand joint space narrowing and osteophytes are associated with magnetic resonance imaging-defined knee cartilage thickness and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. J Rheumatol 39(1):161–166CrossRefPubMed
26.
Zurück zum Zitat Bielefeld T, Neumann DA (2005) The unstable metacarpophalangeal joint in rheumatoid arthritis: anatomy, pathomechanics, and physical rehabilitation considerations. J Orthop Sports Phys Ther 35(8):502–520CrossRefPubMed Bielefeld T, Neumann DA (2005) The unstable metacarpophalangeal joint in rheumatoid arthritis: anatomy, pathomechanics, and physical rehabilitation considerations. J Orthop Sports Phys Ther 35(8):502–520CrossRefPubMed
27.
Zurück zum Zitat Swagerty DL, Hellinger D (2001) Radiographic assessment of osteoarthritis. Am Fam Physician 64(2):279–287PubMed Swagerty DL, Hellinger D (2001) Radiographic assessment of osteoarthritis. Am Fam Physician 64(2):279–287PubMed
29.
Zurück zum Zitat Pelechas E, Kaltsonoudis E, Voulgari PV, Drosos AA (2019) Rheumatoid arthritis. In: Pelechas E (ed) Illustrated handbook of rheumatic and musculo-skeletal diseases. Springer, Cham, pp 45–76CrossRef Pelechas E, Kaltsonoudis E, Voulgari PV, Drosos AA (2019) Rheumatoid arthritis. In: Pelechas E (ed) Illustrated handbook of rheumatic and musculo-skeletal diseases. Springer, Cham, pp 45–76CrossRef
30.
Zurück zum Zitat Markatseli TE, Papagoras C, Drosos AA (2010) Prognostic factors for erosive rheumatoid arthritis. Clin Exp Rheumatol 28:114–123PubMed Markatseli TE, Papagoras C, Drosos AA (2010) Prognostic factors for erosive rheumatoid arthritis. Clin Exp Rheumatol 28:114–123PubMed
31.
Zurück zum Zitat Papadopoulos NG, Alamanos Y, Voulgari PV, Epagelis EK, Tsifetaki N, Drosos AA (2005) Does cigarette smoking influence disease expression, activity and severity in early rheumatoid arthritis patients? Clin Exp Rheumatol 23:861–866PubMed Papadopoulos NG, Alamanos Y, Voulgari PV, Epagelis EK, Tsifetaki N, Drosos AA (2005) Does cigarette smoking influence disease expression, activity and severity in early rheumatoid arthritis patients? Clin Exp Rheumatol 23:861–866PubMed
32.
Zurück zum Zitat Klareskog L, Stolt P, Lundberg K et al (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54:38–46CrossRefPubMed Klareskog L, Stolt P, Lundberg K et al (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54:38–46CrossRefPubMed
33.
Zurück zum Zitat Eriksson K, Nise L, Alfredsson L et al (2018) Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis. Ann Rheum Dis 77:1236–1238PubMed Eriksson K, Nise L, Alfredsson L et al (2018) Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis. Ann Rheum Dis 77:1236–1238PubMed
34.
Zurück zum Zitat Hedström AK, Stawiarz L, Klareskog L, Alfredsson L (2018) Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case–control study. Eur J Epidemiol 33:415–423CrossRefPubMedPubMedCentral Hedström AK, Stawiarz L, Klareskog L, Alfredsson L (2018) Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case–control study. Eur J Epidemiol 33:415–423CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Berglin E, Johansson T, Sundin U et al (2006) Radiological outcome in rheumatoid arthritis is predicted by presence of antibodies against cyclic citrullinated peptide before and at disease onset, and by IgA-RF at disease onset. Ann Rheum Dis 65:453–458CrossRefPubMed Berglin E, Johansson T, Sundin U et al (2006) Radiological outcome in rheumatoid arthritis is predicted by presence of antibodies against cyclic citrullinated peptide before and at disease onset, and by IgA-RF at disease onset. Ann Rheum Dis 65:453–458CrossRefPubMed
36.
Zurück zum Zitat Markatseli TE, Voulgari PV, Alamanos Y, Drosos AA (2011) Prognostic factors of radiological damage in rheumatoid arthritis: a 10-year retrospective study. J Rheumatol 38:44–52CrossRefPubMed Markatseli TE, Voulgari PV, Alamanos Y, Drosos AA (2011) Prognostic factors of radiological damage in rheumatoid arthritis: a 10-year retrospective study. J Rheumatol 38:44–52CrossRefPubMed
38.
Zurück zum Zitat Dirven L, Visser K, Klarenbeek NB et al (2012) Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression. Scand J Rheumatol 41:15–19CrossRefPubMed Dirven L, Visser K, Klarenbeek NB et al (2012) Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression. Scand J Rheumatol 41:15–19CrossRefPubMed
39.
Zurück zum Zitat Drosos AA, Karantanas AH, Psychos D, Tsampoulas C, Moutsopoulos HM (1990) Can treatment with methotrexate influence the radiological progression of rheumatoid arthritis? Clin Rheumatol 9:342–345CrossRefPubMed Drosos AA, Karantanas AH, Psychos D, Tsampoulas C, Moutsopoulos HM (1990) Can treatment with methotrexate influence the radiological progression of rheumatoid arthritis? Clin Rheumatol 9:342–345CrossRefPubMed
40.
Zurück zum Zitat Drosos AA, Tsifetaki N, Tsiakou EK et al (1997) Influence of methotrexate on radiographic progression in rheumatoid arthritis: a sixty-month prospective study. Clin Exp Rheumatol 15:263–267PubMed Drosos AA, Tsifetaki N, Tsiakou EK et al (1997) Influence of methotrexate on radiographic progression in rheumatoid arthritis: a sixty-month prospective study. Clin Exp Rheumatol 15:263–267PubMed
41.
Zurück zum Zitat Alarcón GS, López-Méndez A, Walter J et al (1992) Radiographic evidence of disease progression in methotrexate treated and nonmethotrexate disease modifying antirheumatic drug treated rheumatoid arthritis patients: a meta-analysis. J Rheumatol 19:1868–1873PubMed Alarcón GS, López-Méndez A, Walter J et al (1992) Radiographic evidence of disease progression in methotrexate treated and nonmethotrexate disease modifying antirheumatic drug treated rheumatoid arthritis patients: a meta-analysis. J Rheumatol 19:1868–1873PubMed
42.
Zurück zum Zitat Drosos AA, Lanchbury JS, Panayi GS, Moutsopoulos HM (1992) Rheumatoid arthritis in Greek and British patients. A comparative clinical, radiologic, and serologic study. Arthritis Rheum 35:745–748CrossRefPubMed Drosos AA, Lanchbury JS, Panayi GS, Moutsopoulos HM (1992) Rheumatoid arthritis in Greek and British patients. A comparative clinical, radiologic, and serologic study. Arthritis Rheum 35:745–748CrossRefPubMed
43.
Zurück zum Zitat Lerd LR, Visser H, Speyer I, van der Horst-Bruinsma IE, Zwinderman AH, Breedveld FC, Hazes JM (2001) Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. Am J Med 111:446–451CrossRef Lerd LR, Visser H, Speyer I, van der Horst-Bruinsma IE, Zwinderman AH, Breedveld FC, Hazes JM (2001) Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. Am J Med 111:446–451CrossRef
44.
Zurück zum Zitat Van Aken J, Lard LR, Le Cessie S, Hazes JM, Breedveld FC, Huizinga TW (2004) Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis. Ann Rheum Dis 63:274–279CrossRefPubMedPubMedCentral Van Aken J, Lard LR, Le Cessie S, Hazes JM, Breedveld FC, Huizinga TW (2004) Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis. Ann Rheum Dis 63:274–279CrossRefPubMedPubMedCentral
45.
Zurück zum Zitat Van Der Heijde D, Van Der Helm-Van Mil AH, Aletaha D et al (2013) EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria. Ann Rheum Dis 72:479–481CrossRefPubMed Van Der Heijde D, Van Der Helm-Van Mil AH, Aletaha D et al (2013) EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria. Ann Rheum Dis 72:479–481CrossRefPubMed
46.
Zurück zum Zitat Smolen JS, Landewé R, Breedveld FC et al (2014) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 73:492–509CrossRefPubMed Smolen JS, Landewé R, Breedveld FC et al (2014) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 73:492–509CrossRefPubMed
47.
Zurück zum Zitat Boini S, Guillemin F (2001) Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages. Ann Rheum Dis 60:817–827PubMedPubMedCentral Boini S, Guillemin F (2001) Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages. Ann Rheum Dis 60:817–827PubMedPubMedCentral
48.
Zurück zum Zitat Larsen A, Dale K, Eek M (1977) Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 18:481–491CrossRef Larsen A, Dale K, Eek M (1977) Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 18:481–491CrossRef
49.
Zurück zum Zitat Sharp JT, Lidsky MD, Collins LC, Moreland J (1971) Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum 14:706–720CrossRefPubMed Sharp JT, Lidsky MD, Collins LC, Moreland J (1971) Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum 14:706–720CrossRefPubMed
50.
Zurück zum Zitat Sharp JT, Young DY, Bluhm GB et al (1985) How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? Arthritis Rheum 28:1326–1335CrossRefPubMed Sharp JT, Young DY, Bluhm GB et al (1985) How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? Arthritis Rheum 28:1326–1335CrossRefPubMed
51.
Zurück zum Zitat Van Der Heijde D (1999) How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 26:743–745PubMed Van Der Heijde D (1999) How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 26:743–745PubMed
52.
Zurück zum Zitat Van Der Heijde D, Boonen A, Boers M, Kostense P, Van Der Linden S (1999) Reading radiographs in chronological order, in pairs or as single films has important implications for the discriminative power of rheumatoid arthritis clinical trials. Rheumatol (Oxf) 38:1213–1220CrossRef Van Der Heijde D, Boonen A, Boers M, Kostense P, Van Der Linden S (1999) Reading radiographs in chronological order, in pairs or as single films has important implications for the discriminative power of rheumatoid arthritis clinical trials. Rheumatol (Oxf) 38:1213–1220CrossRef
Metadaten
Titel
Conventional radiography of the hands and wrists in rheumatoid arthritis. What a rheumatologist should know and how to interpret the radiological findings
verfasst von
Alexandros A. Drosos
Eleftherios Pelechas
Paraskevi V. Voulgari
Publikationsdatum
22.05.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 8/2019
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-019-04326-4

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