Erschienen in:
16.02.2016 | CORR Insights
CORR Insights®: Cathodic Voltage-controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model
verfasst von:
Charalampos G. Zalavras, MD, PhD
Erschienen in:
Clinical Orthopaedics and Related Research®
|
Ausgabe 7/2016
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Excerpt
Periprosthetic infections present a major challenge to patients and treating physicians. Antibiotic therapy and limited débridement with implant retention fail to eradicate chronic infections and have limited efficacy in acute infections, especially when duration of symptoms exceeds 5 days, infection is caused by methicillin-resistant
Staphylococci, or a sinus tract is present [
7,
10]. The key pathogenetic mechanism for failure of management in these cases is formation of biofilm on the surface of retained implants. This community of bacterial cells, embedded in a matrix of extracellular polymeric substance and attached to the foreign body surface, is characterized by high resistance to antibiotics and host defense mechanisms [
1,
11]. …