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International Archives of Occupational and Environmental Health

Erschienen in:

01.12.2011 | Original Article

Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/PCDFs/dioxin-like PCBs in blood from the Japanese population

verfasst von: Atsushi Kitayama, Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Hidenobu Takami, Fusakazu Sawachika, Miwa Yamaguchi, Mariko Nakamoto, Manabu Hasegawa, Masaharu Tanto, Masayuki Shima, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Taka-ichiro Suzuki, Masaki Nagai, Hiroshi Satoh

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 8/2011

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Abstract

Purpose

The purpose of the present study was to investigate the factors associated with blood levels of each congener of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (DL-PCBs) in the Japanese population.

Methods

A cross-sectional study was performed on 1,656 subjects (755 men and 901 women) aged 15–73 years, who were living in 90 different areas of 30 prefectures in Japan. Blood levels of 29 PCDD, PCDF, and DL-PCB congeners were determined by high-resolution gas chromatography/mass spectrometry. In addition, a questionnaire survey on life style, including dietary habit, was carried out.

Results

The median total toxicity equivalent (TEQ) was 17 pgTEQ/g lipid. After adjustment for age, sex, body mass index, smoking habit, and consumption of other food groups, six PCDDs/PCDFs with 4–6 substituted chlorine atoms and 10 DL-PCBs, but not HeptaCDD/F or OctaCDD, showed significant positive correlations with the frequency of intake of fish and shellfish. Furthermore, significant positive relationships were also found between plasma levels of docosahexaenoic acid (DHA), a biomarker of fish intake, and 10 PCDDs/PCDFs with 4–6 chlorine atoms and 10 DL-PCBs. The partial correlation coefficients with plasma DHA were significantly higher for DL-PCBs than for PCDDs/PCDFs, and partial correlation coefficients for PCDDs/PCDFs significantly decreased with increasing number of chlorine atoms (Spearman r = −0.80, P = 0.001).

Conclusions

Blood levels of PCDDs/PCDFs with 4–6 chlorine atoms and DL-PCBs were positively associated with fish intake in the Japanese population. These results may be explained by the higher degree of bioaccumulation of these congeners in fish and shellfish in the ecosystem, and the high consumption of fish among the Japanese population.

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Titel: Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/PCDFs/dioxin-like PCBs in blood from the Japanese population
verfasst von: Atsushi Kitayama
Kokichi Arisawa
Hirokazu Uemura
Mineyoshi Hiyoshi
Hidenobu Takami
Fusakazu Sawachika
Miwa Yamaguchi
Mariko Nakamoto
Manabu Hasegawa
Masaharu Tanto
Masayuki Shima
Yoshio Sumiyoshi
Kenji Morinaga
Kazunori Kodama
Taka-ichiro Suzuki
Masaki Nagai
Hiroshi Satoh
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 8/2011
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-011-0618-7

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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