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04.08.2022 | COVID-19 | Correspondence

Antibody responses and correlates after two and three doses of BNT162b2 COVID-19 vaccine

verfasst von: Shohei Yamamoto, Akihito Tanaka, Yusuke Oshiro, Natsumi Inamura, Tetsuya Mizoue, Norio Ohmagari, for SARS-CoV-2 Seroepidemiological Study among NCGM staff

Erschienen in: Infection

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Excerpt

While the mRNA COVID-19 vaccines are highly effective in decreasing the risk of infection, hospitalization, and death [ 1], a significant variation in the immune response among vaccine recipients has been identified. Specifically, male sex, older age, and chronic diseases have been associated with lower anti-spike antibody levels after two vaccine doses [ 2, 3]. It remains elusive, however, whether such a difference in humoral immune response persists after the third vaccine dose, which is currently administered in many countries. Here, we report immunogenicity after the third dose of the BNT162b2 vaccine in relation to the correlates of that after the second dose. …
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Literatur
1.
Zurück zum Zitat Chemaitelly H, Tang P, Hasan MR, et al. Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar. N Engl J Med. 2021;385:e83. CrossRef Chemaitelly H, Tang P, Hasan MR, et al. Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar. N Engl J Med. 2021;385:e83. CrossRef
2.
Zurück zum Zitat Levin EG, Lustig Y, Cohen C, et al. Waning immune humoral response to BNT162b2 COVID-19 vaccine over 6 months. N Engl J Med. 2021;385:e84. CrossRef Levin EG, Lustig Y, Cohen C, et al. Waning immune humoral response to BNT162b2 COVID-19 vaccine over 6 months. N Engl J Med. 2021;385:e84. CrossRef
3.
Zurück zum Zitat Kageyama T, Ikeda K, Tanaka S, et al. Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan. Clin Microbiol Infect. 2021;27:1861-e1. CrossRef Kageyama T, Ikeda K, Tanaka S, et al. Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan. Clin Microbiol Infect. 2021;27:1861-e1. CrossRef
Metadaten
Titel
Antibody responses and correlates after two and three doses of BNT162b2 COVID-19 vaccine
verfasst von
Shohei Yamamoto
Akihito Tanaka
Yusuke Oshiro
Natsumi Inamura
Tetsuya Mizoue
Norio Ohmagari
for SARS-CoV-2 Seroepidemiological Study among NCGM staff
Publikationsdatum
04.08.2022
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
Infection
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-022-01898-5

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