Background
Methods
Study design
Step 1: Transcultural adaptation and qualitative validation (face validity)
Step2: Quantitative validation of the psychometric properties of the questionnaire
-
In the Cured group, patients had to be considered cured of prostate cancer (≥3 years after diagnosis), regardless of initial treatment, and attending a follow-up consultation. Patients with recurrence were excluded.
-
In the Treatment group, patients were prospectively included before curative treatment for localized prostate cancer. Patients were eligible to participate if they had a histologically confirmed diagnosis of localized prostate cancer, and if they had no previous treatment for their prostate cancer. Patients were excluded if the curative treatment had already been performed, or in case of metastasis.
-
In the Cured group, patients completed the questionnaires at baseline (T1) and again 2 weeks later (T2) to assess test-retest reliability;
-
In the Treatment group, patients completed the questionnaires immediately before the initiation of treatment (T1) and then again at the end of treatment (6 to 8 weeks after the first assessment, T2) to assess sensitivity to change.
Sample size calculation
Statistical analysis
Results
Step1: Face validity
Step2: Quantitative validation of psychometric properties
Study population
All patients | Cured group | Treatment group | ||||
---|---|---|---|---|---|---|
N = 215 |
N = 90 |
N = 125 | ||||
N
| % |
N
| % |
N
| % | |
Age. mean (SD) | 187 | 68.1 (6.6) | 76 | 70.0 (6.5) | 111 | 66.9 (6.3) |
Marital status | ||||||
Living maritally | 162 | 75.3 | 70 | 77.8 | 92 | 73.6 |
Divorced | 17 | 7.9 | 6 | 6.7 | 11 | 8.8 |
Widower | 6 | 2.8 | 3 | 3.3 | 3 | 2.4 |
Single | 6 | 2.8 | 1 | 1.1 | 5 | 4.0 |
Missing data | 24 | 11.1 | 10 | 11.1 | 14 | 11.2 |
Profession | ||||||
Retired | 158 | 73.5 | 75 | 83.3 | 83 | 66.4 |
Professionally active | 29 | 13.5 | 5 | 5.6 | 24 | 19.2 |
Unemployed | 2 | 0.9 | 0 | 0 | 2 | 1.6 |
Missing data | 26 | 12.1 | 10 | 11.1 | 16 | 12.8 |
Performance Status at baseline | ||||||
0 | 192 | 89.3 | 81 | 90 | 111 | 88.8 |
1 | 13 | 6.0 | 4 | 4.4 | 9 | 7.2 |
2 | 2 | 0.9 | 1 | 1.1 | 1 | 0.8 |
3 | 0 | 0 | 0 | 0 | 0 | 0 |
4 | 0 | 0 | 0 | 0 | 0 | 0 |
Missing data | 8 | 3.7 | 4 | 4.4 | 4 | 3.2 |
Cancer stage at diagnosis | ||||||
Local | 205 | 95.3 | 84 | 93.3 | 121 | 96.8 |
Locoregional | 6 | 2.8 | 2 | 2.2 | 4 | 3.2 |
Metastatic | 0 | 0 | 0 | 0 | 0 | 0 |
Missing data | 4 | 1.9 | 4 | 4.4 | 0 | 0 |
Disease treatment | ||||||
Chemotherapy | ||||||
Yes | 0 | 0 | 0 | 0 | 0 | |
No | 208 | 96.7 | 86 | 95.6 | 122 | 97.6 |
Missing data | 7 | 3.3 | 4 | 4.4 | 3 | 2.4 |
Radiotherapy | ||||||
Yes | 112 | 52.1 | 58 | 64.4 | 54 | 43.2 |
No | 97 | 45.1 | 27 | 21.4 | 70 | 56 |
Missing data | 6 | 2.8 | 5 | 5.6 | 1 | 0.8 |
Hormone therapy | ||||||
Yes | 45 | 20.9 | 22 | 17.5 | 23 | 18.4 |
No | 162 | 75.3 | 64 | 71.1 | 98 | 78.4 |
Missing data | 8 | 3.7 | 4 | 4.4 | 4 | 3.2 |
Surgery | ||||||
Yes | 103 | 47.9 | 44 | 48.9 | 59 | 47.2 |
No | 103 | 47.9 | 41 | 45.5 | 62 | 49.6 |
Missing data | 9 | 4.2 | 5 | 5.6 | 4 | 3.2 |
Brachytherapy | ||||||
Yes | 17 | 7.9 | 13 | 14.4 | 4 | 3.2 |
No | 187 | 87.0 | 73 | 81.1 | 114 | 91.2 |
Missing data | 11 | 5.1 | 4 | 4.4 | 7 | 5.6 |
Validation of the psychometric properties
HRQoL domain | Number of Items |
N
| mean score (SD) | range (min-max) | Floor effects (%) | Ceiling effects (%) | Cronbach’s α | Cronbach’s α in the original version (Wei et al. 2000) |
---|---|---|---|---|---|---|---|---|
HRQoL Domain Summary Scores | ||||||||
Urinary | 12 | 167 | 86.74 (13.61) | 33.33–100 | 0 | 9.30 | 0.88 | 0.88 |
Bowel | 14 | 165 | 91.70 (9.93) | 30.36–100 | 0 | 15.35 | 0.61 | 0.92 |
Sexual | 13 | 177 | 43.88 (21.98) | 0.0–94.23 | 0.93 | 0 | 0.89 | 0.93 |
Hormonal | 11 | 162 | 87.67 (12.49) | 47.50–100 | 0 | 20.93 | 0.77 | 0.82 |
Domain-Specific HRQoL Subscales | ||||||||
Urinary subscales
| ||||||||
Function | 5 | 192 | 94.39 (11.02) | 40.00–100 | 0 | 60.47 | 0.63 | 0.69 |
Bother | 7 | 162 | 82.03 (17.33) | 17.86–100 | 0 | 10.70 | 0.85 | 0.85 |
Irritation/obstruction | 7 | 163 | 85.42 (14.42) | 17.86–100 | 0 | 11.16 | 0.79 | 0.81 |
Incontinence | 4 | 167 | 91.44 (17.22) | 22.75–100 | 0 | 53.93 | 0.91 | 0.89 |
Bowel subscales
| ||||||||
Function | 7 | 190 | 92.46 (9.07) | 39.29–100 | 0 | 23.72 | 0.53 | 0.75 |
Bother | 7 | 165 | 90.72 (13.36) | 21.43–100 | 0 | 30.70 | 0.83 | 0.90 |
Sexual subscales
| ||||||||
Function | 9 | 174 | 40.76 (28.96) | 0.00–91.67 | 8.84 | 0 | 0.96 | 0.92 |
Bother | 4 | 166 | 53.61 (34.14) | 0.00–100 | 7.91 | 14.88 | 0.94 | 0.84 |
Hormonal subscales
| ||||||||
Function | 5 | 186 | 86.99 (13.18) | 25.00–100 | 0 | 26.51 | 0.76 | 0.51 |
Bother | 6 | 163 | 88.32 (13.59) | 45.83–100 | 0 | 25.58 | 0.63 | 0.73 |
Time 1: baseline | Time 2: two weeks later | ||||
---|---|---|---|---|---|
HRQoL domain |
N
| mean (SD) |
N
| mean (SD) | ICC for test-retest (ICC of Original version) |
HRQoL domain summary scores | |||||
Urinary | 71 | 84.31 (15.01) | 64 | 86.19 (14.18) | 0.90 (0.88) |
Bowel | 70 | 89.34 (11.79) | 67 | 89.54 (12.64) | 0.86 (0.84) |
Sexual | 72 | 33.18 (20.84) | 73 | 33.67 (20.18) | 0.94 (0.91) |
Hormonal | 70 | 86.70 (13.15) | 67 | 88.53 (13.34) | 0.89 (0.80) |
Domain-specific HRQoL subscales | |||||
Urinary subscales
| |||||
Function | 80 | 90.73 (14.37) | 76 | 91.80 (13.29) | 0.84 (0.83) |
Bother | 68 | 80.42 (17.11) | 63 | 82.36 (18.39) | 0.90 (0.87) |
Irritation/obstruction | 68 | 85.31 (13.28) | 63 | 86.43 (13.48) | 0.82 (0.85) |
Incontinence | 72 | 85.10 (22.09) | 65 | 87.88 (19.28) | 0.94 (0.87) |
Bowel subscales
| |||||
Function | 80 | 90.76 (10.46) | 77 | 91.79 (9.94) | 0.68 (0.78) |
Bother | 70 | 88.10 (15.14) | 66 | 88.49 (16.26) | 0.88 (0.85) |
Sexual subscales
| |||||
Function | 71 | 26.06 (26.82) | 74 | 25.07 (25.80) | 0.98 (0.90) |
Bother | 68 | 53.03 (36.36) | 69 | 51.90 (33.23) | 0.78 (0.78) |
Hormonal subscales
| |||||
Function | 78 | 85.40 (15.07) | 76 | 88.49 (13.63) | 0.76 (0.79) |
Bother | 70 | 87.50 (13.63) | 65 | 89.91 (13.44) | 0.84 (0.73) |
Domain | Subscale | Items | Urinary domain | Urinary Function | Urinary Bother | Bowel domain | Bowel Function | Bowel Bother | Sexual domain | Sexual Function | Sexual Bother | Hormonal domain | Hormonal Function | Hormonal Bother |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Urinary | Function |
q23
|
0.48
|
0.59
| 0.56 | 0.38 | 0.27 | 0.36 | 0.29 | 0.28 | 0.06 | 0.32 | 0.30 | 0.29 |
q24
| 0.15 | −0.04 | 0.21 | 0.16 | 0.06 | 0.19 | 0.03 | 0.03 | 0.02 | 0.03 | −0.03 | 0.08 | ||
q25
|
0.43
| 0.21 | 0.40 | 0.42 | 0.41 | 0.32 | 0.11 | 0.11 | 0.01 | 0.22 | 0.20 | 0.16 | ||
q26
|
0.58
|
0.63
| 0.50 | 0.43 | 0.32 | 0.39 | 0.32 | 0.33 | 0.02 | 0.27 | 0.31 | 0.21 | ||
q27
|
−0.50
|
−0.63
| −0.40 | −0.31 | −0.30 | −0.24 | −0.26 | −0.25 | −0.07 | −0.37 | −0.40 | −0.30 | ||
Bother |
q28
|
−0.60
|
−0.72
|
−0.45
| −0.34 | −0.30 | −0.30 | −0.29 | −0.26 | −0.10 | −0.33 | −0.33 | −0.29 | |
q29
|
−0.54
| −0.46 |
−0.50
| −0.48 | −0.36 | −0.46 | −0.13 | −0.08 | −0.11 | −0.32 | −0.25 | −0.30 | ||
q30
| −0.28 | −0.19 | −0.28 | −0.19 | −0.01 | −0.25 | −0.03 | −0.03 | −0.03 | −0.23 | −0.14 | −0.27 | ||
q31
|
−0.58
| −0.35 |
−0.62
| −0.46 | −0.35 | −0.45 | −0.17 | −0.12 | −0.14 | −0.32 | −0.26 | −0.32 | ||
q32
|
−0.59
| −0.32 |
−0.65
| −0.42 | −0.32 | −0.37 | −0.25 | −0.26 | −0.07 | −0.37 | −0.32 | −0.36 | ||
q33
|
0.56
| −0.32 |
−0.60
| −0.33 | −0.27 | −0.27 | −0.26 | −0.23 | −0.13 | −0.29 | −0.21 | −0.28 | ||
q34
|
−0.75
| −0.52 |
−0.74
| −0.43 | 0.31 | −0.42 | −0.27 | −0.24 | −0.11 | −0.39 | −0.36 | −0.36 | ||
Bowel | Function |
q42
| 0.23 | 0.23 | 0.22 | 0.28 | 0.24 | 0.27 | 0.16 | 0.16 | 0.02 | 0.13 | 0.20 | 0.12 |
q43
| 0.31 | 0.40 | 0.25 |
0.50
| 0.34 |
0.51
| 0.10 | 0.06 | 0.05 | 0.33 | 0.29 | 0.30 | ||
q44
| −0.25 | −0.14 | −0.25 | −0.32 | −0.23 | −0.32 | −0.08 | −0.10 | 0.03 | −0.28 | −0.20 | −0.30 | ||
q45
| −0.15 | −0.13 | −0.14 | −0.17 | −0.17 |
−0.18
| −0.17 |
−0.19
| 0.02 | −0.10 | −0.11 | −0.10 | ||
q46
| −0.36 | −0.34 | −0.33 |
−0.48
|
−0.40
|
−0.45
| −0.23 | −0.20 | −0.08 | −0.30 | −0.26 | −0.29 | ||
q47
| −0.11 | −0.12 | −0.11 | −0.19 | −0.17 |
−0.19
| −0.09 | −0.10 | 0.02 | −0.06 | −0.12 | −0.02 | ||
q48
| 0.38 | 0.30 | 0.33 |
0.49
|
0.42
|
0.44
| 0.10 | 0.05 | 0.07 | 0.13 | 0.23 | 0.07 | ||
Bother |
q49
| −0.42 | −0.35 | −0.39 |
−0.69
| −0.51 |
−0.62
| −0.27 | −0.24 | −0.08 | −0.3 | −0.22 | −0.34 | |
q50
| −0.49 | −0.44 | −0.48 |
−0.67
| −0.52 |
−0.64
| −0.29 | −0.24 | −0.14 | −0.36 | −0.28 | −0.37 | ||
q51
| −0.30 | −0.18 | −0.34 |
−0.53
| −0.36 |
−0.55
| −0.16 | −0.19 | −0.15 | −0.24 | −0.15 | −0.30 | ||
q52
| −0.39 | −0.39 | −0.35 |
−0.56
| −0.38 |
−0.60
| −0.06 | 0.01 | −0.09 | −0.27 | −0.19 | −0.30 | ||
q53
| −0.35 | −0.27 | −0.36 | −0.31 |
−0.40
| −0.38 | −0.09 | −0.02 | −0.12 | −0.24 | −0.17 | −0.28 | ||
q54
| −0.35 | −0.27 | −0.36 |
−0.57
| −0.40 |
−0.55
| −0.09 | −0.02 | −0.12 | −0.24 | −0.17 | −0.28 | ||
q55
| −0.37 | −0.32 | −0.33 |
−0.61
| −0.50 |
−0.58
| −0.21 | −0.13 | −0.18 | −0.36 | −0.26 | −0.37 | ||
Sexual | Function |
q56
| 0.28 | 0.30 | 0.22 | 0.23 | 0.24 | 0.15 |
0.56
|
0.76
| −0.23 | 0.14 | 0.22 | 0.10 |
q57
| 0.28 | 0.32 | 0.23 | 0.25 | 0.22 | 0.20 |
0.83
|
0.89
| 0.09 | 0.12 | 0.18 | 0.10 | ||
q58
| 0.30 | 0.29 | 0.26 | 0.22 | 0.22 | 0.17 |
0.72
|
0.86
| −0.04 | 0.15 | 0.20 | 0.13 | ||
q59
| 0.33 | 0.37 | 0.27 | 0.25 | 0.22 | 0.20 |
0.71
|
0.83
| −0.06 | 0.14 | 0.17 | 0.14 | ||
q60
| 0.29 | 0.32 | 0.24 | 0.24 | 0.19 | 0.17 |
0.76
|
0.85
| 0.02 | 0.09 | 0.11 | 0.08 | ||
q61
| 0.33 | 0.29 | 0.31 | 0.25 | 0.27 | 0.18 |
0.52
|
0.60
| −0.05 | 0.14 | 0.19 | 0.14 | ||
q62
| 0.27 | 0.28 | 0.22 | 0.22 | 0.20 | 0.17 |
0.69
|
0.80
| −0.04 | 0.11 | 0.16 | 0.09 | ||
q63
| 0.22 | 0.27 | 0.17 | 0.19 | 0.18 | 0.14 |
0.69
|
0.83
| −0.07 | 0.06 | 0.11 | 0.05 | ||
q64
| 0.23 | 0.26 | 0.20 | 0.24 | 0.20 | 0.17 |
0.79
|
0.91
| −0.02 | 0.07 | 0.11 | 0.05 | ||
Bother |
q65
| −0.11 | <0.01 | −0.14 | −0.12 | −0.04 | −0.16 | −0.22 | 0.09 |
−0.90
| −0.23 | −0.09 | −0.24 | |
q66
| −0.13 | −0.04 | −0.16 | −0.13 | −0.05 | −0.16 | −0.27 | 0.06 |
−0.91
| −0.25 | −0.14 | −0.26 | ||
q67
| −0.09 | −0.05 | −0.08 | −0.08 | <0.01 | −0.14 | −0.25 | 0.07 |
−0.88
| −0.27 | −0.13 | −0.29 | ||
q68
| −0.19 | −0.07 | −0.22 | −0.16 | −0.07 | −0.18 | −0.30 | −0.04 |
−0.75
| −0.23 | −0.18 | −0.20 | ||
Hormonal | Function |
q69
|
0.16
|
0.16
|
0.16
|
0.13
|
0.20
| 0.05 | 0.22 | 0.28 | −0.05 | 0.31 | 0.11 | 0.36 |
q70
|
0.23
| 0.12 | 0.22 | 0.01 | 0.19 | 0.01 | −0.10 | 0.01 | −0.05 | 0.15 | 0.22 | 0.09 | ||
q71
| 0.20 | 0.21 | 0.22 |
0.26
| 0.20 |
0.25
| 0.10 | −0.02 |
0.24
|
0.46
| 0.23 |
0.53
| ||
q72
| 0.40 | 0.29 | 0.37 | 0.31 | 0.23 | 0.28 | 0.17 | 0.07 | 0.21 |
0.51
| 0.34 |
0.54
| ||
q73
| −0.08 | −0.04 | −0.05 | 0.08 | 0.08 | 0.06 | 0.04 | 0.06 | −0.06 | 0.03 | 0.08 | −0.02 | ||
Bother |
q74
| −0.19 | −0.11 | −0.19 | −0.09 | −0.12 | −0.03 | −0.20 | −0.16 | −0.15 |
−0.43
| −0.48 | −0.27 | |
q75
|
−0.25
| −0.09 | −0.30 | −0.10 | −0.16 | −0.09 | 0.03 | 0.05 | <0.01 |
−0.11
| −0.21 | −0.05 | ||
q76
| −0.17 | −0.07 | −0.20 | −0.12 | −0.08 | −0.15 | 0.05 | 0.10 | 0.01 |
−0.17
| −0.05 | −0.25 | ||
q77
| −0.30 | −0.23 | −0.28 | −0.40 | −0.26 | −0.45 | −0.10 | 0.02 | −0.26 |
−0.58
| −0.54 |
−0.54
| ||
q78
| −0.40 | −0.32 | −0.37 | −0.41 | −0.30 | −0.42 | −0.21 | −0.08 | −0.31 |
−0.64
| −0.58 |
−0.60
| ||
q79
| −0.24 | −0.16 |
−0.28
| −0.23 | −0.15 | −0.23 | −0.17 | −0.10 | −0.18 | −0.33 | −0.40 | −0.23 |
Domain | Subscale | Item | Factor 1 | Factor 2 | Factor 3 | Factor 4 |
---|---|---|---|---|---|---|
Urinary | Function |
q23
| 0.164 | −0.141 |
−0.676
| −0.058 |
q24
| −0.017 | −0.036 | 0.097 |
−0.294
| ||
q25
| 0.022 | 0.075 | −0.117 | −0.583 | ||
q26
| 0.180 | −0.024 |
−0.709
| −0.159 | ||
q27
| −0.172 | 0.065 |
0.700
| 0.022 | ||
Bother |
q28
| −0.128 | 0.048 |
0.836
| −0.004 | |
q29
| 0.013 | 0.051 | 0.129 |
0.690
| ||
q30
| 0.142 | 0.098 | 0.129 |
0.245
| ||
q31
| −0.009 | 0.135 |
0.502
| 0.323 | ||
q32
| −0.091 | 0.237 |
0.467
| 0.351 | ||
q33
| −0.182 | 0.149 |
0.505
| 0.176 | ||
q34
| −0.121 | 0.206 |
0.617
| 0.304 | ||
Bowel | Function |
q42
| 0.167 | 0.059 | 0.001 |
−0.304
|
q43
| −0.064 | −0.232 |
−0.410
| −0.064 | ||
q44
| −0.114 | 0.114 | 0.151 |
0.265
| ||
q45
| −0.144 | 0.005 |
0.240
| −0.055 | ||
q46
| −0.191 | 0.096 | −0.038 |
0.398
| ||
q47
| −0.149 | −0.025 | −0.041 |
0.277
| ||
q48
| −0.063 | 0.056 | −0.185 |
−0.586
| ||
Bother |
q49
| −0.175 | 0.164 | 0.148 |
0.579
| |
q50
| −0.129 | 0.107 | 0.264 |
0.557
| ||
q51
| 0.008 | 0.216 | −0.017 |
0.504
| ||
q52
| 0.145 | 0.192 | 0.234 |
0.483
| ||
q53
| 0.021 | 0.184 | 0.076 |
0.384
| ||
q54
| 0.098 | 0.066 | −0.028 |
0.765
| ||
q55
| −0.078 | 0.326 | 0.058 |
0.384
| ||
Sexual | Function |
q56
|
0.820
| 0.097 | −0.056 | 0.007 |
q57
|
0.909
| −0.101 | −0.056 | 0.024 | ||
q58
|
0.885
| 0.002 | −0.077 | 0.005 | ||
q59
|
0.846
| 0.008 | −0.127 | 0.012 | ||
q60
|
0.884
| −0.093 | −0.060 | 0.005 | ||
q61
|
0.604
| 0.037 | −0.143 | −0.065 | ||
q62
|
0.791
| 0.092 | −0.099 | −0.027 | ||
q63
|
0.838
| 0.134 | −0.053 | −0.005 | ||
q64
|
0.923
| −0.041 | 0.037 | −0.074 | ||
Bother |
q65
| 0.022 |
0.831
| 0.099 | −0.013 | |
q66
| −0.013 |
0.838
| 0.045 | 0.029 | ||
q67
| 0.017 |
0.841
| 0.058 | 0.007 | ||
q68
| −0.047 |
0.735
| 0.067 | 0.041 | ||
Hormonal | Function |
q69
|
0.260
| −0.087 | −0.239 | 0.032 |
q70
| −0.104 | 0.056 |
−0.412
| 0.151 | ||
q71
| −0.052 |
−0.646
| 0.024 | −0.074 | ||
q72
| 0.071 |
−0.564
| −0.179 | −0.065 | ||
q73
| 0.074 | −0.034 |
0.249
| 0.060 | ||
Bother |
q74
| −0.157 | 0.279 | 0.270 | −0.101 | |
q75
| 0.131 | −0.046 |
0.443
| −0.119 | ||
q76
|
0.212
| 0.057 | 0.054 | 0.141 | ||
q77
| 0.112 |
0.662
| 0.020 | 0.256 | ||
q78
| −0.018 |
0.636
| 0.161 | 0.137 | ||
q79
| −0.019 | 0.159 | 0.266 | 0.133 |
EPIC | Urinary | Bowel | Sexual | Hormonal | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Domain | Function | Bother | Irritation Obstruction | Incontinence | Domain | Function | Bother | Domain | Function | Bother | Domain | Function | Bother | |
QLQ-PR25 | ||||||||||||||
Sexual activity | −0.13 | −0.13 | −0.12 | −0.12 | −0.10 | −0.09 | −0.15 | −0.07 |
−0.48
|
−0.65
|
0.17
| −0.08 | −0.15 | −0.05 |
Sexual functioning | −0.21 | −0.20 | −0.20 | −0.16 | −0.23 | −0.25 | −0.16 | −0.25 |
−0.62
|
−0.62
|
−0.20
| −0.15 | −0.23 | −0.14 |
Urinary symptoms |
−0.83
|
−0.62
|
−0.81
|
−0.76
|
−0.59
| −0.58 | −0.51 | −0.48 | −0.32 | −0.31 | −0.06 | −0.38 | −0.40 | −0.34 |
Bowel symptoms | −0.44 | −0.45 | −0.39 | −0.34 | −0.41 |
−0.65
|
−0.54
|
−0.62
| −0.28 | −0.23 | −0.12 | −0.36 | −0.28 | −0.35 |
Hormonal treatment-related symptoms | −0.33 | −0.23 | −0.37 | −0.30 | −0.24 | −0.33 | −0.34 | −0.27 | −0.40 | −0.36 | −0.17 |
−0.52
|
−0.45
|
−0.50
|
Incontinence aid | −0.66 | −0.61 | −0.60 | −0.30 |
−0.65
| −0.27 | −0.38 | −0.10 | −0.55 | −0.43 | −0.53 | −0.57 | −0.58 | −0.40 |
Patients without toxicities (N = 70) | Patients experienced toxicities (N = 55) | ||||||
---|---|---|---|---|---|---|---|
Dimensions |
N
| mean difference (SD) | SRM |
N
| mean difference (SD) | SRM |
P-value |
HRQoL domain summary scores | |||||||
Urinary | 41 | −18.49 (22.80) | −0.81 | 43 | −27.64 (19.44) | −1.42 | 0.051 |
Bowel | 40 | −11.30 (17.15) | −0.66 | 39 | −9.16 (12.16) | −0.75 | 0.522 |
Sexual | 48 | −13.61 (17.72) | −0.77 | 44 | −30.59 (24.42) | −1.25 | <0.001 |
Hormonal | 36 | −6.48 (13.67) | −0.47 | 41 | −5.29 (10.24) | −0.52 | 0.664 |
Domain-specific HRQoL subscales | |||||||
Urinary subscales
| |||||||
Function | 52 | −18.48 (22.57) | −0.82 | 47 | −31.57 (21.21) | −1.49 | 0.004 |
Bother | 39 | −20.25 (24.54) | −0.83 | 41 | −24.03 (24.01) | −1.00 | 0.489 |
Irritation/obstruction | 40 | −16.96 (23.39) | −0.73 | 41 | −15.90 (21.00) | −0.76 | 0.830 |
Incontinence | 41 | −18.13 (29.86) | −0.61 | 43 | −45.67 (31.66) | −1.44 | <0.001 |
Bowel subscales
| |||||||
Function | 51 | −11.03 (17.15) | −0.64 | 48 | −10.79 (15.21) | −0.71 | 0.941 |
Bother | 39 | −9.20 (17.01) | −0.54 | 39 | −6.01 (15.49) | −0.39 | 0.389 |
Sexual subscales
| |||||||
Function | 47 | −21.80 (23.42) | −0.93 | 44 | −38.68 (24.32) | −1.59 | 0.001 |
Bother | 41 | 1.83 (24.34) | 0.07 | 43 | −14.10 (37.05) | −0.38 | 0.022 |
Hormonal subscales
| |||||||
Function | 49 | −5.13 (14.10) | −0.36 | 46 | −7.42 (15.61) | −0.47 | 0.454 |
Bother | 38 | −6.64 (14.89) | −0.45 | 41 | −4.27 (10.75) | −0.40 | 0.422 |