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01.01.2005 | Clinical Review

Current and Future Concepts of Abdominal Sepsis

verfasst von: Klaus Emmanuel, M.D., Heike Weighardt, Ph.D., Holger Bartels, M.D., Jorg-Rudiger Siewert, M.D., Bernhard Holzmann, M.D.

Erschienen in: World Journal of Surgery | Ausgabe 1/2005

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Severe sepsis is still a major cause of postoperative morbidity and mortality after abdominal surgery. Despite recent progress in understanding the immune conditions of abdominal sepsis, there is a high postoperative incidence (9-12%) and lethality (42-80%) caused by septic complications after major visceral surgery. Therefore, many aspects of the pathophysiology and immunology of sepsis need further elucidation. In particular, a number of studies have of investigated clinical and immunologic parameters to determine the risk of the development and lethal outcome of postoperative abdominal infection. …

Goris, RA, te Boekhorst, TP, Nuytinck, JK, et al. 1985Multiple-organ failure: generalized autodestructive inflammation? ArchSurg.12011091985

Marshall, JC, Sweeney, D 1990Microbial infection and the septic response in critical illnessArch. Surg.12517

Wittmanm, DH 1990Symposium of intra-abdominal infections: introductionWorld J. Surg.14145

Wittmann, DH, Schein, M, Condon, RE 1996Management of secondary peritonitisAnn. Surg.22410

Witmann, DH, Walker, AP 1993Peritonitis, intra-abdominal infection, and intra-abdominal abscessSchwartz, SIShies, GTSpencer, FC eds. Principles of SurgeryMcGraw-HillNew York14491484

Rotstein, OD, Meakinsi, JL 1990Diagnostic and therapeutic challenges of intraabdominal infectionsWorld J. Surg.14159

Rotstein, OD, Simmonsy, RL 1994Peritonitis and intraabdominal abscessBarie, PSShires, GT eds. Surgical Intensive CareLittle BrownBoston10431063

Eichacker, PQ, Parent, C, Kalil, A, et al. 2002Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsisAm. J. Respir. Crit. Care Med.1661197

Marshall, JC, Innes, M 2003Intensive care unit management of intra-abdominal infectionCrit. Care Med.312228

10.

Hotchkiss, RS, Karl, IE 2003The pathophysiology and treatment of sepsisN. Engl. J. Med.348138

11.

Lamme, B, Boermeestey, MA, Reitsma, JB, et al. 2002Meta-analysis of relaparotomy for secondary peritonitisBr. J. Surg.891516CrossRef

12.

Hutchins, RR, Gunning, MP, Lucas, DN, et al. 2004Relaparotomy for suspected intraperitoneal sepsis after abdominal surgeryWorld J. Surg.28137

13.

Adkins, AL, Robbins, J, Villalba, M, et al. 2004Open abdomen management of intra-abdominal sepsisAm. Surg.70137

14.

Bohnen, J, Boulanger, M, Meakins, JL, et al. 1983Prognosis in generalized peritonitis: relation to cause and risk factorsArch. Surg.118285

15.

Meakins, L, Solomkin, JS, Allo, MD 1984Proposed classification of intra-abdominal infectionsArch. Surg.1191372

16.

Dellinger, EP, Wertz, MJ, Meakins, JL 1985Surgical infection stratification system for intra-abdominal infectionArch. Surg.12021

17.

Knaus, WA, Draper, EA, Wagner, DP, et al. 1985APACHE II: a severity of disease classification systemCrit. Care Med.13818

18.

Nystrom, PO, Bax, R, Dellinger, EP 1990Proposed definitions for diagnosis, severity scoring, stratifications, and outcome for trials on intra-abdominal infectionWorld J. Surg.14148

19.

Emmanuilidis, K, Weighardt, H, Matevossian, E, et al. 2002Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: high serum IL-18 as an early predictive indicator of lethal outcomeShock18301

20.

Bartels, H 2002Akutes Abdomen aus intensivmedizinischer SichtChir. Gastroenterol.18260

21.

Bartels, H, Bathlen, W, Stadler, J 1995Therapieaspekte bei septischen AbdominalerkrankungenChir. Gastroenterol.119

22.

Heagy, W, Hansen, C, Niemann, K 2000Impaired ex vivo lipopolysaccharide-stimulated whole blood tumor necrosis factor production may identify “septic” intensive care unit patientsShock14271PubMed

23.

Schein, M 1992Management of severe intra-abdominal infectionSurg. Ann.2447

24.

Schein, M, Saadia, R 1988Intraoperative peritoneal lavageSurg. Gynecol. Obstet.166187

25.

Schein, M, Cecelter, G, Freinkel, W, et al. 1990Peritonel lavage in abdominal sepsis: a controlled clinical studyArch. Surg.1251132

26.

Farthmann, EH, Schoffel, U 1990Principles and limitations of operative management of intra-abdominal infectionsWorld J. Surg.14210

27.

Heidecke, CD, Hensler, T, Weighardt, H, et al. 1999Selective defects of T lymphocyte function in patients with lethal intraabdominal infectionAm. J. Surg.178288

28.

Schein, M, Wittmann, DH, Aprahamian, C, et al. 1995Abdominal compartment syndrome: the physiological and clinical consequences of elevated intra-abdominal pressureJ. Am. Coll. Surg.180745

29.

Steinberg, D 1979On leaving the peritoneal cavity open in acute generalized suppurative peritonitisAm. J. Surg.137216CrossRef

30.

Schein, M, Saadia, R, Decker, GG 1986The open management of the septic abdomenSurg. Gynecol. Obstet.163587

31.

Wittmann, KDH, Aprahamian, C, Bergstein, JM 1990Etappenlavage, advanced diffuse peritonitis managed by planned multiple laparotomies utilizing zippers, slide fastener, and Velcro analogue for temporary abdominal closureWorld J. Surg.14218

32.

Ivatury, R, Nallathambi, M, Prakaschanda, R 1989Open management of the septic abdomen: therapeutic and prognostic consideration based on APACHE IICrit. Care Med.17511

33.

Levy, E, Palmer, D, Frileux, P 1988Septic necrosis of the midline wound in postoperative peritonitisAnn. Surg.207470

34.

Wittmann, DH, Bansal, N, Bergstein, JM 1994Staged abdominal repair compares favorably with conventional operative therapy for intra-abdominal infections when adjusting for prognostic factors with a logistic modelTheor. Surg.9201

35.

Garcia-Sabrido, JL, Tellado, JM, Christou, NW 1988Treatment of severe intra-abdominal sepsis and/or necrotic foci by an “open abdomen” approachArch. Surg.123152

36.

Kinney, EV, Polk, HC 1987Open treatment of peritonitis: an argument againstAdv. Surg.2119

37.

Christou, NV, Barie, PS, Dellinger, EP 1993Surgical Infection Society intra-abdominal infection study: prospective evaluation of management techniques and outcomeArch. Surg.128193

38.

Bosscha, K, Vroonhoven, TJ, Werken, C 1999Surgical management of severe secondary peritonitisBr. J. Surg.861371

39.

Goor, H 1997Surgical treatment of severe intra-abdominal infectionHepatogastroenterology44975

40.

Mulier, S, Penninckx, F, Verwaest, C, et al. 2003Factors affecting mortality in generalized postoperative peritonitis: multivariate analysis in 96 patientsWorld J. Surg.27379

41.

Sauter, T, Gotzinger, P, Redl-Wenzl, E-M, et al. 1997Does reoperation for abdominal sepsis enhance the inflammatory host response?Arch. J. Surg.132250

42.

Weighardt, H, Heidecke, CD, Westerholt, A, et al. 2002Impaired monocyte IL-12 production before surgery as a predictive factor for the lethal outcome of postoperative sepsisAnn. Surg.4560

43.

Majetschak, M, Flohe, S, Obertacke, U, et al. 1999Relation of a TNF gene polymorphism to severe sepsis in trauma patientsAnn. Surg.230207

44.

Kahlke, V, Schafmayer, C, Schniewind, B, et al. 2004Are postoperative complications genetically determined by TNF-? Ncol gene polymorphism?Surgery135365

45.

Riese, J, Woerner, K, Zimmermann, P, et al. 2003Association of a TNFbeta gene polymorphism with complications after major abdominal operationsShock191

46.

Fang, XM, Schroder, S, Hoeft, A, et al. 1999Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsisCrit. Care Med.271330

47.

Arnalich, F, Garcia-Palomero, E, Lopez, J, et al. 2000Predictive value of nuclear factor kappaB activity and plasma cytokine levels in patients with sepsisInfect. Immun.681942

48.

Hensler, T, Heidecke, CD, Hecker, H, et al. 1998Increased susceptibility to postoperative sepsis in patients with impaired monocyte IL-12 productionJ. Immunol.1612655

49.

Mira, JP, Cariou, A, Grall, F, et al. 1999Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter studyJAMA282561

50.

Stuber, F, Petersen, M, Bokelmann, F, et al. 1996A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsisCrit. Care Med.24381

51.

Guillou, PJ 1993Biological variation in the development of sepsis after surgery or traumaSurgery342217

52.

Faist, E 1996The mechanisms of host defense dysfunction following shock and traumaRietschel, ETWagner, H eds. Pathology of Septic ShockSpringer-VerlagHeidelberg259274

53.

Windsor, AC, Klava, A, Somers, SS, et al. 1995Manipulation of local and systemic host defense in the prevention of perioperative sepsisBr. J. Surg.821460

54.

Hensler, T, Hecker, H, Heeg, K, et al. 1997Distinct mechanisms of immunosuppression as a consequence of major surgeryInt. Immunol.652283

55.

Brune, IB, Wilke, W, Hensler, T, et al. 1999Down-regulation of Th1 immune response and altered pro- and anti-inflammatory T cell cytokine balance following conventional, but not laparoscopic, surgeryAm. J. Surg.17755

56.

Carlei, F, Schietroma, M, Cianca, G, et al. 1999Effects of laparoscopic and conventional (open) cholejystectomy on human leukocyte antigen-DR expression peripheral blood monocytes: correlations with immunologic statusWorld J. Surg.2318

57.

Decker, D, Schondorf, M, Bidlingmaier, F, et al. 1996Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the traumaSurgery.119316

58.

Hershman, MJ, Cheadle, WG, Wellhausen, SR, et al. 1990Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patientBr. J. Surg.77204

59.

Akira, S 2000The role of IL-18 in innate immunityCurr. Opin. Immunol.1259

60.

Wakefield, CH, Carey, PD, Foulds, S, et al. 1993Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgeryBr. J. Surg.80205

61.

Steinhausen, ML, Hogaboam, CM, Lukacs, N, et al. 1999Multiple roles for IL-12 in a model of acute septic peritonitisJ Immunol.162543

62.

Zisman, DA, Kunkel, SL, Strieter, RM, et al. 1997Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs clearance in murine Escherichia coli peritoneal sepsisShock8349

63.

Fiedler, VB, Loof, I, Sander, E, et al. 1992Monoclonal antibody to tumor necrosis factor-alpha prevents lethal endotoxin sepsis in adult rhesus monkeysJ. Lab. Clin. Med.120574

64.

Ikuta, S, Ono, S, Kinoshita, M, et al. 2003Interleukin-18 concentration in the peritoneal fluid correlates severity of peritonitisAm. J. Surg.185550

65.

Wunder, C, Eichelbronner, O, Roewer, N 2004Are IL-6, IL-10 and PCT plasma concentrations reliable for prediction in severe sepsis? A comparison with APACHE II SAPS IIInflamm. Res.53158

66.

Seidelin, JB, Nielsen, CH, Strom, J 2002Soluble L-selectin levels predict survival in sepsisIntensive Care Med.281613

67.

Beer, S, Weighardt, H, Emmanuilidis, K, et al. 2002Systemic neuropeptide levels as predictive indicators for lethal outcome in patients with postoperative sepsisCrit. Care Med.301794

68.

Resch, B, Gusenleitner, W, Muller, WD 2003Procalcitonin and interleukin-6 in the diagnosis of early-onset sepsis of the neonateActa. Paediatr.92243

69.

Calandra, T, Bernhagen, J, Mitchell, RA, et al. 1994The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factorJ. Exp. Med.791895

70.

Bernhagen, J, Calandra, T, Mitchell, RA, et al. 1993MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemiaNature.65756

71.

Riedemann, NC, Guo, RF, Ward, PA 2003Novel strategies for the treatment of sepsisNat. Med.9517

72.

Calandra, T, Echtenacher, B, Roy, DL, et al. 2000Protection from septic shock by neutralization of macrophage migration inhibitory factor, NatMed.6164

73.

Calandra, T, Spiegel, L, Metz, CN, et al. 1998Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of gram-positive bacteriaProc. Natl. Acad. Sci. J. U.S.A.9511383

74.

Buijk, SE, Bruining, HA 2004Futire directions in the management of tertiary peritonitisIntensive Care Med.281024

75.

Ulloa, L, Ochani, M, Yang, H, et al. 2002Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammationProc. Natl. Acad. Sci. U.S.A.9912351

76.

Fiuza, C, Bustin, M, Talwar, S, et al. 2003Inflammation-promoting activity of HMGB1 on human microvascular endothelial cellsBlood1012652

77.

Shin, HS, Snyderman, R, Friedman, E, et al. 1968Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complementScience162361

78.

Goldstein, M, Weissmann, G 1974Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leukocyte lysosomesJ. Immunol.1131583

79.

Schumacher, WA, Fantone, JC, Kunkel, SE, et al. 1991The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivoAgents Actions34345

80.

Quo, RF, Huber-Lang, M, Wang, X, et al. 2000Protective effects of anti-C5a in sepsis-induced thymocyte apoptosisJ. Clin. Invest.1061271

81.

Riedemann, NC, Guo, RF, Laudes, IJ, et al. 2002C5a receptor and thymocyte apoptosis in sepsisF.A.S.E.B. J.16887

82.

Huber-Lang, M, Sarma, VJ, Lu, KT, et al. 2001Role of C5a in multiorgan failure during sepsisJ. Immunol.661193

83.

Czermak, BJ, Sarma, V, Pierson, CL, et al. 1999Protective effects of C5a blockade in sepsis, NatMed.5788

84.

Riedemann, NC, Guo, RF, Neff, TA, et al. 2002Increased C5a receptor expression in sepsisJ. Clin. Invest.110101

85.

Riedemann, NC, Neff, TA, Guo, RF, et al. 2003Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expressionJ. Immunol.170503

86.

Hotchkiss, RS, Tinsley, KW, Swanson, PE, et al. 2001Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humansJ. Immunol.666952

87.

Wang, H, Bloom, O, Zhang, M, et al. 1999HMG-1 as a late mediator of endotoxin lethality in miceScience285248

88.

Hotchkiss, RS, Swanson, PE, Knudson, CM, et al. 1999Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsisJ. Immunol.1624148

89.

Beutler, B 2002Toll-like receptors: how they work and what they doCurr. Opin. Hematol.92

90.

Takeda, K, Kaisho, T, Akira, S 2003Toll-like receptorsAnnu. Rev. Immunol.21335

91.

Janeway, CA, Medzhitov, R 2002Innate immune recognition, AnnuRev. Immunol.20197

92.

Akira, S 2003Toll-like receptor signalingJ. Biol. Chem.7838105

93.

Weighardt, H, Kaiser-Moore, S, Vabulas, RM, et al. 2002Myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infectionJ. Immunol.692823

Titel: Current and Future Concepts of Abdominal Sepsis
verfasst von: Klaus Emmanuel, M.D.
Heike Weighardt, Ph.D.
Holger Bartels, M.D.
Jorg-Rudiger Siewert, M.D.
Bernhard Holzmann, M.D.
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: World Journal of Surgery / Ausgabe 1/2005
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-004-7769-6

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