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Erschienen in: Indian Journal of Hematology and Blood Transfusion 1/2016

01.03.2016 | Review Article

Current Role of Genetics in Hematologic Malignancies

verfasst von: Gaurav Prakash, Anupriya Kaur, Pankaj Malhotra, Alka Khadwal, Prashant Sharma, Vikas Suri, Neelam Varma, Subhash Varma

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Ausgabe 1/2016

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Abstract

Rapidly changing field of genetic technology and its application in the management of hematological malignancies has brought significant improvement in treatment and outcome of these disorders. Today, genetics plays pivotal role in diagnosis and prognostication of most hematologic neoplasms. The utilization of genetic tests in deciding specific treatment of various hematologic malignancies as well as for evaluation of depth of treatment response is rapidly advancing. Therefore, it is imperative for practitioners working in the field of hemato-oncology to have sufficient understanding of the basic concepts of genetics in order to comprehend upcoming molecular research in this area and to translate the same for patient care.
Literatur
1.
Zurück zum Zitat Siegel R, Ward E, Brawley O, Jemal A (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61(4):212–236CrossRefPubMed Siegel R, Ward E, Brawley O, Jemal A (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61(4):212–236CrossRefPubMed
2.
Zurück zum Zitat Harper PS (2006) The discovery of the human chromosome number in Lund, 1955–1956. Hum Genet 119(1–2):226–232CrossRefPubMed Harper PS (2006) The discovery of the human chromosome number in Lund, 1955–1956. Hum Genet 119(1–2):226–232CrossRefPubMed
3.
Zurück zum Zitat Rowley JD (1998) The critical role of chromosome translocations in human leukemias. Annu Rev Genet 32:495–519CrossRefPubMed Rowley JD (1998) The critical role of chromosome translocations in human leukemias. Annu Rev Genet 32:495–519CrossRefPubMed
4.
Zurück zum Zitat Nowell PC, Hungerford DA (1960) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25:85–109PubMed Nowell PC, Hungerford DA (1960) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25:85–109PubMed
5.
Zurück zum Zitat Trask BJ (1991) Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. Trends Genet TIG 7(5):149–154CrossRefPubMed Trask BJ (1991) Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. Trends Genet TIG 7(5):149–154CrossRefPubMed
6.
Zurück zum Zitat Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F et al (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258(5083):818–821CrossRefPubMed Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F et al (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258(5083):818–821CrossRefPubMed
7.
Zurück zum Zitat Schröck E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA et al (1996) Multicolor spectral karyotyping of human chromosomes. Science 273(5274):494–497CrossRefPubMed Schröck E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA et al (1996) Multicolor spectral karyotyping of human chromosomes. Science 273(5274):494–497CrossRefPubMed
9.
Zurück zum Zitat Logan J, Edwards K, Saunders N (eds) (2009) Real-time PCR: current technology and applications. Caister Academic Press, Norfolk, p 284 Logan J, Edwards K, Saunders N (eds) (2009) Real-time PCR: current technology and applications. Caister Academic Press, Norfolk, p 284
10.
Zurück zum Zitat Watson JD (ed) (2004) Molecular biology of the gene. San Francisco, Pearson/Benjamin Cummings [u.a.], p 732 Watson JD (ed) (2004) Molecular biology of the gene. San Francisco, Pearson/Benjamin Cummings [u.a.], p 732
11.
Zurück zum Zitat Little S (2001) Amplification-refractory mutation system (ARMS) analysis of point mutations. In: Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR (eds). Current protocols in human genetics [Internet]. Wiley & Sons, Inc., Hoboken [cited 2015 Aug 8]. Available from http://doi.wiley.com/10.1002/0471142905.hg0908s07 Little S (2001) Amplification-refractory mutation system (ARMS) analysis of point mutations. In: Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR (eds). Current protocols in human genetics [Internet]. Wiley & Sons, Inc., Hoboken [cited 2015 Aug 8]. Available from http://​doi.​wiley.​com/​10.​1002/​0471142905.​hg0908s07
12.
13.
Zurück zum Zitat Bench AJ (2012) The role of molecular genetic analysis within the diagnostic haemato-oncology laboratory. Int J Lab Hematol 34(1):21–34CrossRefPubMed Bench AJ (2012) The role of molecular genetic analysis within the diagnostic haemato-oncology laboratory. Int J Lab Hematol 34(1):21–34CrossRefPubMed
14.
Zurück zum Zitat Khan F, Agarwal A, Agrawal S (2004) Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme. Bone Marrow Transplant 34(1):1–12CrossRefPubMed Khan F, Agarwal A, Agrawal S (2004) Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme. Bone Marrow Transplant 34(1):1–12CrossRefPubMed
15.
Zurück zum Zitat Lichter P, Joos S, Bentz M, Lampel S (2000) Comparative genomic hybridization: uses and limitations. Semin Hematol 37(4):348–357CrossRefPubMed Lichter P, Joos S, Bentz M, Lampel S (2000) Comparative genomic hybridization: uses and limitations. Semin Hematol 37(4):348–357CrossRefPubMed
16.
Zurück zum Zitat Read JA, Koff JL, Nastoupil LJ, Williams JN, Cohen JB, Flowers CR (2014) Evaluating cell-of-origin subtype methods for predicting diffuse large B-cell lymphoma survival: a meta-analysis of gene expression profiling and immunohistochemistry algorithms. Clin Lymphoma Myeloma Leuk 14(6):460PubMedCentralCrossRefPubMed Read JA, Koff JL, Nastoupil LJ, Williams JN, Cohen JB, Flowers CR (2014) Evaluating cell-of-origin subtype methods for predicting diffuse large B-cell lymphoma survival: a meta-analysis of gene expression profiling and immunohistochemistry algorithms. Clin Lymphoma Myeloma Leuk 14(6):460PubMedCentralCrossRefPubMed
17.
Zurück zum Zitat Braggio E, Egan JB, Fonseca R, Stewart AK (2013) Lessons from next-generation sequencing analysis in hematological malignancies. Blood Cancer J 3(7):e127PubMedCentralCrossRefPubMed Braggio E, Egan JB, Fonseca R, Stewart AK (2013) Lessons from next-generation sequencing analysis in hematological malignancies. Blood Cancer J 3(7):e127PubMedCentralCrossRefPubMed
18.
Zurück zum Zitat Mrózek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP et al (2012) Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol Off J Am Soc Clin Oncol 30(36):4515–4523CrossRef Mrózek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP et al (2012) Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol Off J Am Soc Clin Oncol 30(36):4515–4523CrossRef
19.
Zurück zum Zitat Renneville A, Boissel N, Zurawski V, Llopis L, Biggio V, Nibourel O et al (2009) Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association. Cancer 115(16):3719–3727CrossRefPubMed Renneville A, Boissel N, Zurawski V, Llopis L, Biggio V, Nibourel O et al (2009) Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association. Cancer 115(16):3719–3727CrossRefPubMed
20.
Zurück zum Zitat Paschka P, Marcucci G, Ruppert AS, Mrózek K, Chen H, Kittles RA et al (2006) Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv (16) and t(8, 21): a Cancer and Leukemia Group B Study. J Clin Oncol Off J Am Soc Clin Oncol 24(24):3904–3911CrossRef Paschka P, Marcucci G, Ruppert AS, Mrózek K, Chen H, Kittles RA et al (2006) Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv (16) and t(8, 21): a Cancer and Leukemia Group B Study. J Clin Oncol Off J Am Soc Clin Oncol 24(24):3904–3911CrossRef
21.
Zurück zum Zitat Schlenk RF, Döhner K, Krauter J, Fröhling S, Corbacioglu A, Bullinger L et al (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 358(18):1909–1918CrossRefPubMed Schlenk RF, Döhner K, Krauter J, Fröhling S, Corbacioglu A, Bullinger L et al (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 358(18):1909–1918CrossRefPubMed
22.
Zurück zum Zitat Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, Konopleva MY et al (2010) Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol Off J Am Soc Clin Oncol 28(11):1856–1862CrossRef Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, Konopleva MY et al (2010) Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol Off J Am Soc Clin Oncol 28(11):1856–1862CrossRef
23.
Zurück zum Zitat Zelent A, Greaves M, Enver T (2004) Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene 23(24):4275–4283CrossRefPubMed Zelent A, Greaves M, Enver T (2004) Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene 23(24):4275–4283CrossRefPubMed
24.
Zurück zum Zitat Stams WAG, den Boer ML, Beverloo HB, Meijerink JPP, van Wering ER, Janka-Schaub GE et al (2005) Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12, 21)—positive pediatric acute lymphoblastic leukemia. Clin Cancer Res Off J Am Assoc Cancer Res 11(8):2974–2980CrossRef Stams WAG, den Boer ML, Beverloo HB, Meijerink JPP, van Wering ER, Janka-Schaub GE et al (2005) Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12, 21)—positive pediatric acute lymphoblastic leukemia. Clin Cancer Res Off J Am Assoc Cancer Res 11(8):2974–2980CrossRef
25.
Zurück zum Zitat Garg R, Kantarjian H, Thomas D, Faderl S, Ravandi F, Lovshe D et al (2009) Adults with acute lymphoblastic leukemia and translocation (1, 19) abnormality have a favorable outcome with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine chemotherapy. Cancer 115(10):2147–2154PubMedCentralCrossRefPubMed Garg R, Kantarjian H, Thomas D, Faderl S, Ravandi F, Lovshe D et al (2009) Adults with acute lymphoblastic leukemia and translocation (1, 19) abnormality have a favorable outcome with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine chemotherapy. Cancer 115(10):2147–2154PubMedCentralCrossRefPubMed
26.
Zurück zum Zitat Campana D (2003) Determination of minimal residual disease in leukaemia patients. Br J Haematol 121(6):823–838CrossRefPubMed Campana D (2003) Determination of minimal residual disease in leukaemia patients. Br J Haematol 121(6):823–838CrossRefPubMed
27.
Zurück zum Zitat Faham M, Zheng J, Moorhead M, Carlton VEH, Stow P, Coustan-Smith E et al (2012) Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia. Blood 120(26):5173–5180PubMedCentralCrossRefPubMed Faham M, Zheng J, Moorhead M, Carlton VEH, Stow P, Coustan-Smith E et al (2012) Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia. Blood 120(26):5173–5180PubMedCentralCrossRefPubMed
28.
Zurück zum Zitat van Dongen JJ, Szczepański T, de Bruijn MA, van den Beemd MW, de Bruin-Versteeg S, Wijkhuijs JM et al (1996) Detection of minimal residual disease in acute leukemia patients. Cytokines Mol Ther 2(2):121–133PubMed van Dongen JJ, Szczepański T, de Bruijn MA, van den Beemd MW, de Bruin-Versteeg S, Wijkhuijs JM et al (1996) Detection of minimal residual disease in acute leukemia patients. Cytokines Mol Ther 2(2):121–133PubMed
29.
Zurück zum Zitat Campana D (2010) Minimal residual disease in acute lymphoblastic leukemia. Hematology 2010(1):7–12CrossRefPubMed Campana D (2010) Minimal residual disease in acute lymphoblastic leukemia. Hematology 2010(1):7–12CrossRefPubMed
30.
Zurück zum Zitat Gabert J, Beillard E, van der Velden VHJ, Bi W, Grimwade D, Pallisgaard N et al (2003) Standardization and quality control studies of “real-time” quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia—a Europe Against Cancer program. Leukemia 17(12):2318–2357CrossRefPubMed Gabert J, Beillard E, van der Velden VHJ, Bi W, Grimwade D, Pallisgaard N et al (2003) Standardization and quality control studies of “real-time” quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia—a Europe Against Cancer program. Leukemia 17(12):2318–2357CrossRefPubMed
31.
Zurück zum Zitat Cross NCP, White HE, Müller MC, Saglio G, Hochhaus A (2012) Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 26(10):2172–2175CrossRefPubMed Cross NCP, White HE, Müller MC, Saglio G, Hochhaus A (2012) Standardized definitions of molecular response in chronic myeloid leukemia. Leukemia 26(10):2172–2175CrossRefPubMed
32.
Zurück zum Zitat Marin D, Milojkovic D, Olavarria E, Khorashad JS, de Lavallade H, Reid AG et al (2008) European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 112(12):4437–4444CrossRefPubMed Marin D, Milojkovic D, Olavarria E, Khorashad JS, de Lavallade H, Reid AG et al (2008) European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 112(12):4437–4444CrossRefPubMed
33.
Zurück zum Zitat Alvarado Y, Kantarjian H, O’Brien S, Faderl S, Borthakur G, Burger J et al (2009) Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase. Cancer 115(16):3709–3718PubMedCentralCrossRefPubMed Alvarado Y, Kantarjian H, O’Brien S, Faderl S, Borthakur G, Burger J et al (2009) Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase. Cancer 115(16):3709–3718PubMedCentralCrossRefPubMed
34.
Zurück zum Zitat Hehlmann R, Müller MC, Lauseker M, Hanfstein B, Fabarius A, Schreiber A et al (2014) Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV. J Clin Oncol Off J Am Soc Clin Oncol 32(5):415–423CrossRef Hehlmann R, Müller MC, Lauseker M, Hanfstein B, Fabarius A, Schreiber A et al (2014) Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV. J Clin Oncol Off J Am Soc Clin Oncol 32(5):415–423CrossRef
35.
Zurück zum Zitat Soverini S, Hochhaus A, Nicolini FE, Gruber F, Lange T, Saglio G et al (2011) BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 118(5):1208–1215CrossRefPubMed Soverini S, Hochhaus A, Nicolini FE, Gruber F, Lange T, Saglio G et al (2011) BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 118(5):1208–1215CrossRefPubMed
36.
Zurück zum Zitat O’Hare T, Eide CA, Deininger MWN (2007) Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 110(7):2242–2249CrossRefPubMed O’Hare T, Eide CA, Deininger MWN (2007) Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 110(7):2242–2249CrossRefPubMed
37.
Zurück zum Zitat Hallek M (2015) Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. Am J Hematol 90(5):446–460CrossRefPubMed Hallek M (2015) Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. Am J Hematol 90(5):446–460CrossRefPubMed
38.
Zurück zum Zitat Lin TS, Ruppert AS, Johnson AJ, Fischer B, Heerema NA, Andritsos LA et al (2009) Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol Off J Am Soc Clin Oncol 27(35):6012–6018CrossRef Lin TS, Ruppert AS, Johnson AJ, Fischer B, Heerema NA, Andritsos LA et al (2009) Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol Off J Am Soc Clin Oncol 27(35):6012–6018CrossRef
39.
Zurück zum Zitat Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N et al (2013) Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood 122(11):1891–1899PubMedCentralCrossRefPubMed Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N et al (2013) Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood 122(11):1891–1899PubMedCentralCrossRefPubMed
40.
Zurück zum Zitat Fonseca R, Debes-Marun CS, Picken EB, Dewald GW, Bryant SC, Winkler JM et al (2003) The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood 102(7):2562–2567CrossRefPubMed Fonseca R, Debes-Marun CS, Picken EB, Dewald GW, Bryant SC, Winkler JM et al (2003) The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood 102(7):2562–2567CrossRefPubMed
41.
Zurück zum Zitat Broyl A, Hose D, Lokhorst H, de Knegt Y, Peeters J, Jauch A et al (2010) Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Blood 116(14):2543–2553CrossRefPubMed Broyl A, Hose D, Lokhorst H, de Knegt Y, Peeters J, Jauch A et al (2010) Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Blood 116(14):2543–2553CrossRefPubMed
42.
Zurück zum Zitat van Laar R, Flinchum R, Brown N, Ramsey J, Riccitelli S, Heuck C et al (2014) Translating a gene expression signature for multiple myeloma prognosis into a robust high-throughput assay for clinical use. BMC Med Genom 7:25CrossRef van Laar R, Flinchum R, Brown N, Ramsey J, Riccitelli S, Heuck C et al (2014) Translating a gene expression signature for multiple myeloma prognosis into a robust high-throughput assay for clinical use. BMC Med Genom 7:25CrossRef
43.
Zurück zum Zitat Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89(6):2079–2088PubMed Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89(6):2079–2088PubMed
44.
Zurück zum Zitat Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F et al (2012) Revised international prognostic scoring system for myelodysplastic syndromes. Blood 120(12):2454–2465PubMedCentralCrossRefPubMed Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F et al (2012) Revised international prognostic scoring system for myelodysplastic syndromes. Blood 120(12):2454–2465PubMedCentralCrossRefPubMed
45.
46.
Zurück zum Zitat Giagounidis A, Mufti GJ, Fenaux P, Germing U, List A, MacBeth KJ (2014) Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes. Ann Hematol 93(1):1–11PubMedCentralCrossRefPubMed Giagounidis A, Mufti GJ, Fenaux P, Germing U, List A, MacBeth KJ (2014) Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes. Ann Hematol 93(1):1–11PubMedCentralCrossRefPubMed
49.
Zurück zum Zitat Kumar S, Fonseca R, Ketterling RP, Dispenzieri A, Lacy MQ, Gertz MA et al (2012) Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics. Blood 119(9):2100–2105PubMedCentralCrossRefPubMed Kumar S, Fonseca R, Ketterling RP, Dispenzieri A, Lacy MQ, Gertz MA et al (2012) Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics. Blood 119(9):2100–2105PubMedCentralCrossRefPubMed
Metadaten
Titel
Current Role of Genetics in Hematologic Malignancies
verfasst von
Gaurav Prakash
Anupriya Kaur
Pankaj Malhotra
Alka Khadwal
Prashant Sharma
Vikas Suri
Neelam Varma
Subhash Varma
Publikationsdatum
01.03.2016
Verlag
Springer India
Erschienen in
Indian Journal of Hematology and Blood Transfusion / Ausgabe 1/2016
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-015-0584-4

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