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Erschienen in: Current Treatment Options in Neurology 9/2014

01.09.2014 | Traumatic Brain Injury (JR Couch, Section Editor)

Current Understanding of Chronic Traumatic Encephalopathy

verfasst von: Christine M. Baugh, MPH, Clifford A. Robbins, BA, Robert A. Stern, PhD, Ann C. McKee, MD

Erschienen in: Current Treatment Options in Neurology | Ausgabe 9/2014

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Opinion statement

Chronic traumatic encephalopathy (CTE) is a unique neurodegenerative disease found in individuals with a history of repetitive head impacts. The neuropathology of CTE is increasingly well defined. Prospective, longitudinal studies with post-mortem neuropathologic validation as well as in vivo diagnostic techniques are needed in order to advance the understanding of CTE clinically. Given the large number of individuals who incur concussions and other forms of brain trauma, this is an important area for scientific and public health inquiry.
Literatur
1.
Zurück zum Zitat Corsellis J, Bruton C, Freeman-Browne D. The aftermath of boxing. Psychol Med. 1973;3(03):270–303.PubMedCrossRef Corsellis J, Bruton C, Freeman-Browne D. The aftermath of boxing. Psychol Med. 1973;3(03):270–303.PubMedCrossRef
2.
Zurück zum Zitat Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery. 2005;57(1):128–34. discussion −34.PubMedCrossRef Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery. 2005;57(1):128–34. discussion −34.PubMedCrossRef
6.
Zurück zum Zitat Omalu BI, Bailes J, Hammers JL, Fitzsimmons RP. Chronic traumatic encephalopathy, suicides and parasuicides in professional American athletes: the role of the forensic pathologist. Am J Forensic Med Pathol. 2010;31(2):130–2. doi:10.1097/PAF.0b013e3181ca7f35.PubMedCrossRef Omalu BI, Bailes J, Hammers JL, Fitzsimmons RP. Chronic traumatic encephalopathy, suicides and parasuicides in professional American athletes: the role of the forensic pathologist. Am J Forensic Med Pathol. 2010;31(2):130–2. doi:10.​1097/​PAF.​0b013e3181ca7f35​.PubMedCrossRef
9.••
Zurück zum Zitat McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013;136(Pt 1):43–64. doi:10.1093/brain/aws307. The largest case series of neuropathologically confirmed cases of CTE; proposes neuropathological staging criteria.PubMedCentralPubMedCrossRef McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013;136(Pt 1):43–64. doi:10.​1093/​brain/​aws307. The largest case series of neuropathologically confirmed cases of CTE; proposes neuropathological staging criteria.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Hof PR, Knabe R, Bovier P, Bouras C. Neuropathological observations in a case of autism presenting with self-injury behavior. Acta Neuropathologica. 1991;82(4):321–6.PubMedCrossRef Hof PR, Knabe R, Bovier P, Bouras C. Neuropathological observations in a case of autism presenting with self-injury behavior. Acta Neuropathologica. 1991;82(4):321–6.PubMedCrossRef
11.
Zurück zum Zitat Geddes JF, Vowles GH, Nicoll JA, Revesz T. Neuronal cytoskeletal changes are an early consequence of repetitive head injury. Acta Neuropathologica. 1999;98(2):171–8.PubMedCrossRef Geddes JF, Vowles GH, Nicoll JA, Revesz T. Neuronal cytoskeletal changes are an early consequence of repetitive head injury. Acta Neuropathologica. 1999;98(2):171–8.PubMedCrossRef
12.•
Zurück zum Zitat Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4(134):134–60. doi:10.1126/scitranslmed.3003716. Novel blast neurotrauma model in mice, led to CTE-type pathology.CrossRef Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012;4(134):134–60. doi:10.​1126/​scitranslmed.​3003716. Novel blast neurotrauma model in mice, led to CTE-type pathology.CrossRef
14.
Zurück zum Zitat Millspaugh JA. Dementia Pugilistica. US Naval Med Bull. 1937;35:297–303. Millspaugh JA. Dementia Pugilistica. US Naval Med Bull. 1937;35:297–303.
15.
16.••
Zurück zum Zitat Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, et al. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013;81(13):1122–9. doi:10.1212/WNL.0b013e3182a55f7f. Case series of neuropathologically-confirmed CTE cases, clinical presentation discussed in detail, two distinct clinical presentations proposed.PubMedCrossRef Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, et al. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013;81(13):1122–9. doi:10.​1212/​WNL.​0b013e3182a55f7f​. Case series of neuropathologically-confirmed CTE cases, clinical presentation discussed in detail, two distinct clinical presentations proposed.PubMedCrossRef
18.
Zurück zum Zitat Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012;6(2):244–54. doi:10.1007/s11682-012-9164-5.PubMedCrossRef Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012;6(2):244–54. doi:10.​1007/​s11682-012-9164-5.PubMedCrossRef
20.•
Zurück zum Zitat Victoroff J. Traumatic encephalopathy: review and provisional research diagnostic criteria. NeuroRehabilitation. 2013;32(2):211–24. doi:10.3233/nre-130839. Proposed clinical research diagnositc criteria for CTE.PubMed Victoroff J. Traumatic encephalopathy: review and provisional research diagnostic criteria. NeuroRehabilitation. 2013;32(2):211–24. doi:10.​3233/​nre-130839. Proposed clinical research diagnositc criteria for CTE.PubMed
21.•
22.
Zurück zum Zitat Mawdsley C, Ferguson F. Neurological disease in boxers. Lancet. 1963;282(7312):795–801.CrossRef Mawdsley C, Ferguson F. Neurological disease in boxers. Lancet. 1963;282(7312):795–801.CrossRef
23.
Zurück zum Zitat Soeder M, Arndt T. Affective disorders and changes in the electroencephalogram of boxers. Deutsche medizinische Wochenschrift (1946). 1954;79(48):1792–5. Soeder M, Arndt T. Affective disorders and changes in the electroencephalogram of boxers. Deutsche medizinische Wochenschrift (1946). 1954;79(48):1792–5.
24.
Zurück zum Zitat Grahmann H, Ule G. Diagnosis of chronic cerebral symptoms in boxers (dementia pugilistica & traumatic encephalopathy of boxers. Psychiatria et Neurologia. 1957;134(3–4):261–83.PubMedCrossRef Grahmann H, Ule G. Diagnosis of chronic cerebral symptoms in boxers (dementia pugilistica & traumatic encephalopathy of boxers. Psychiatria et Neurologia. 1957;134(3–4):261–83.PubMedCrossRef
25.•
27.
Zurück zum Zitat Viano DC, Casson IR, Pellman EJ, Bir CA, Zhang L, Sherman DC, et al. Concussion in professional football: comparison with boxing head impacts–part 10. Neurosurgery. 2005;57(6):1154–72. discussion −72.PubMedCrossRef Viano DC, Casson IR, Pellman EJ, Bir CA, Zhang L, Sherman DC, et al. Concussion in professional football: comparison with boxing head impacts–part 10. Neurosurgery. 2005;57(6):1154–72. discussion −72.PubMedCrossRef
28.
Zurück zum Zitat Beitz JM. Parkinson's disease: a review. Frontiers Biosci (Scholar Ed). 2014;6:65–74.CrossRef Beitz JM. Parkinson's disease: a review. Frontiers Biosci (Scholar Ed). 2014;6:65–74.CrossRef
33.•
Zurück zum Zitat Montenigro PH, Baugh CM, Daneshvar DH, Mez J, Budson AE, Au R, et al. Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome. Alzheimer's Res Ther. (In press). Review: discusses historical examples of CTE, proposes research diagnostic criteria for CTE. Montenigro PH, Baugh CM, Daneshvar DH, Mez J, Budson AE, Au R, et al. Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome. Alzheimer's Res Ther. (In press). Review: discusses historical examples of CTE, proposes research diagnostic criteria for CTE.
34.
Zurück zum Zitat McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack Jr CR, Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dementia. 2011;7(3):263–9. doi:10.1016/j.jalz.2011.03.005.PubMedCentralPubMedCrossRef McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack Jr CR, Kawas CH, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dementia. 2011;7(3):263–9. doi:10.​1016/​j.​jalz.​2011.​03.​005.PubMedCentralPubMedCrossRef
35.•
Zurück zum Zitat Small GW, Kepe V, Siddarth P, Ercoli LM, Merrill DA, Donoghue N, et al. PET scanning of brain tau in retired national football league players: preliminary findings. Am J Geriatr Psychiatry. 2013;21(2):138–44. doi:10.1016/j.jagp.2012.11.019. Pilot study utilizing 18F-FDDNP PET radioligand in 5 former NFL athletes as a possible marker of CTE.PubMedCrossRef Small GW, Kepe V, Siddarth P, Ercoli LM, Merrill DA, Donoghue N, et al. PET scanning of brain tau in retired national football league players: preliminary findings. Am J Geriatr Psychiatry. 2013;21(2):138–44. doi:10.​1016/​j.​jagp.​2012.​11.​019. Pilot study utilizing 18F-FDDNP PET radioligand in 5 former NFL athletes as a possible marker of CTE.PubMedCrossRef
36.
Zurück zum Zitat Riley DO, Robbins CA, Cantu RC, Stern RA. Chronic traumatic encephalopathy: contributions from the Boston University Center for the Study of Traumatic Encephalopathy. Brain Inj. (In press). Riley DO, Robbins CA, Cantu RC, Stern RA. Chronic traumatic encephalopathy: contributions from the Boston University Center for the Study of Traumatic Encephalopathy. Brain Inj. (In press).
37.
Zurück zum Zitat Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nuclr Med Mol Imaging. 2013;40(1):125–32. doi:10.1007/s00259-012-2261-2. Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nuclr Med Mol Imaging. 2013;40(1):125–32. doi:10.​1007/​s00259-012-2261-2.
38.••
Zurück zum Zitat Chien DT, Bahri S, Szardenings AK, Walsh JC, Mu F, Su MY, et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimer's Dis. 2013;34(2):457–68. doi:10.3233/jad-122059. Early study of novel PHF-tau specific PET radioligand. Chien DT, Bahri S, Szardenings AK, Walsh JC, Mu F, Su MY, et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimer's Dis. 2013;34(2):457–68. doi:10.​3233/​jad-122059. Early study of novel PHF-tau specific PET radioligand.
39.•
Zurück zum Zitat Koerte IK, Ertl-Wagner B, Reiser M, Zafonte R, Shenton ME. White matter integrity in the brains of professional soccer players without a symptomatic concussion. JAMA. 2012;308(18):1859–61. doi:10.1001/jama.2012.13735. Study utilizing diffusion tensor imaging to examine professional soccer players, finds white matter disintegrity despite no symptomatic concussion.PubMedCentralPubMedCrossRef Koerte IK, Ertl-Wagner B, Reiser M, Zafonte R, Shenton ME. White matter integrity in the brains of professional soccer players without a symptomatic concussion. JAMA. 2012;308(18):1859–61. doi:10.​1001/​jama.​2012.​13735. Study utilizing diffusion tensor imaging to examine professional soccer players, finds white matter disintegrity despite no symptomatic concussion.PubMedCentralPubMedCrossRef
40.•
Zurück zum Zitat Bazarian JJ, Zhu T, Zhong J, Janigro D, Rozen E, Roberts A, et al. Persistent, long-term cerebral white matter changes after sports-related repetitive head impacts. PloS One. 2014;9(4):e94734. doi:10.1371/journal.pone.0094734. Study utilizing diffusion tensor imaging to examine 10 college football players finds persistent white matter disintegrity, despite no clinically evident concussion.PubMedCentralPubMedCrossRef Bazarian JJ, Zhu T, Zhong J, Janigro D, Rozen E, Roberts A, et al. Persistent, long-term cerebral white matter changes after sports-related repetitive head impacts. PloS One. 2014;9(4):e94734. doi:10.​1371/​journal.​pone.​0094734. Study utilizing diffusion tensor imaging to examine 10 college football players finds persistent white matter disintegrity, despite no clinically evident concussion.PubMedCentralPubMedCrossRef
41.•
Zurück zum Zitat Lin AP, Liao HJ, Merugumala SK, Prabhu SP, Meehan III WP, Ross BD. Metabolic imaging of mild traumatic brain injury. Brain imaging and behavior. 2012;6(2):208–23. doi:10.1007/s11682-012-9181-4. Review of the potential use of magnetic resonance spectroscopy in examining mTBI in acute and chronic stages.PubMedCrossRef Lin AP, Liao HJ, Merugumala SK, Prabhu SP, Meehan III WP, Ross BD. Metabolic imaging of mild traumatic brain injury. Brain imaging and behavior. 2012;6(2):208–23. doi:10.​1007/​s11682-012-9181-4. Review of the potential use of magnetic resonance spectroscopy in examining mTBI in acute and chronic stages.PubMedCrossRef
42.
Zurück zum Zitat Buerger K, Ewers M, Pirttila T, Zinkowski R, Alafuzoff I, Teipel SJ, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain. 2006;129(Pt 11):3035–41. doi:10.1093/brain/awl269.PubMedCrossRef Buerger K, Ewers M, Pirttila T, Zinkowski R, Alafuzoff I, Teipel SJ, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain. 2006;129(Pt 11):3035–41. doi:10.​1093/​brain/​awl269.PubMedCrossRef
43.
Zurück zum Zitat Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN, et al. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology. 2012;38(1):1–17. doi:10.1159/000334607.PubMedCrossRef Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN, et al. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology. 2012;38(1):1–17. doi:10.​1159/​000334607.PubMedCrossRef
44.
Zurück zum Zitat Jordan BD, Relkin NR, Ravdin LD, Jacobs AR, Bennett A, Gandy S. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA. 1997;278(2):136–40.PubMedCrossRef Jordan BD, Relkin NR, Ravdin LD, Jacobs AR, Bennett A, Gandy S. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA. 1997;278(2):136–40.PubMedCrossRef
46.
Zurück zum Zitat Kutner KC, Erlanger DM, Tsai J, Jordan B, Relkin NR. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2000;47(3):651–7. discussion 7–8.PubMed Kutner KC, Erlanger DM, Tsai J, Jordan B, Relkin NR. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2000;47(3):651–7. discussion 7–8.PubMed
47.
Zurück zum Zitat Mayeux R, Ottman R, Maestre G, Ngai C, Tang MX, Ginsberg H, et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology. 1995;45(3 Pt 1):555–7.PubMedCrossRef Mayeux R, Ottman R, Maestre G, Ngai C, Tang MX, Ginsberg H, et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology. 1995;45(3 Pt 1):555–7.PubMedCrossRef
50.
Zurück zum Zitat Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med (Auckland, NZ). 2004;34(8):513–54.CrossRef Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med (Auckland, NZ). 2004;34(8):513–54.CrossRef
52.••
Zurück zum Zitat Lehman EJ, Hein MJ, Baron SL, Gersic CM. Neurodegenerative causes of death among retired National Football League players. Neurology. 2012;79:1970–4. doi:10.1212/WNL.0b013e31826daf50. Study examining mortality associated with neurodegenerative diseases in NFL athletes, finds neurodegenerative mortality to be 3–4 times higher in NFL than general population.PubMedCentralPubMedCrossRef Lehman EJ, Hein MJ, Baron SL, Gersic CM. Neurodegenerative causes of death among retired National Football League players. Neurology. 2012;79:1970–4. doi:10.​1212/​WNL.​0b013e31826daf50​. Study examining mortality associated with neurodegenerative diseases in NFL athletes, finds neurodegenerative mortality to be 3–4 times higher in NFL than general population.PubMedCentralPubMedCrossRef
53.
Zurück zum Zitat Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21(5):375–8.PubMedCrossRef Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21(5):375–8.PubMedCrossRef
Metadaten
Titel
Current Understanding of Chronic Traumatic Encephalopathy
verfasst von
Christine M. Baugh, MPH
Clifford A. Robbins, BA
Robert A. Stern, PhD
Ann C. McKee, MD
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Current Treatment Options in Neurology / Ausgabe 9/2014
Print ISSN: 1092-8480
Elektronische ISSN: 1534-3138
DOI
https://doi.org/10.1007/s11940-014-0306-5

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