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01.03.2016 | Original Article

CyberKnife stereotactic radiotherapy for isolated recurrence in the prostatic bed

verfasst von: B. Detti, P. Bonomo, L. Masi, R. Doro, S. Cipressi, C. Iermano, I. Bonucci, D. Franceschini, L. Di Brina, M. Baki, G. Simontacchi, I. Meattini, M. Carini, S. Serni, G. Nicita, L. Livi

Erschienen in: World Journal of Urology | Ausgabe 3/2016

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Abstract

Purpose

To report a clinical experience of stereotactic body radiation therapy (SBRT) for isolated recurrence in the prostatic bed from prostate cancer.

Materials and methods

Between November 2011 and November 2013, 16 patients were treated with SBRT for a macroscopic isolated recurrence of prostate cancer in the prostatic bed. All patients were initially treated with radical prostatectomy, and half of them also received radiotherapy. Two schedules of SBRT were used: 30 Gy in 5 fractions in previously irradiated patients, 35 Gy in five fractions in radiotherapy-naïve patients.

Results

At a median follow-up of 10 months (range 2–21 months), a significant biochemical response was found in all but one patient. At imaging evaluation, no local progression was noted: 10 patients showed partial response while four stable disease. At the moment of analysis, all 16 patients were alive. Seven of them experienced distant relapse, while nine maintained biochemical control, with no further therapy. Median time to relapse was 9.3 months (range 3–15.2 months). The treatment was well tolerated: One patient experienced G2 acute genitourinary and gastrointestinal toxicity.

Conclusions

Our experience shows that SBRT with CyberKnife for isolated nodal relapse is a safe and well-tolerated treatment.

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Titel: CyberKnife stereotactic radiotherapy for isolated recurrence in the prostatic bed
verfasst von: B. Detti
P. Bonomo
L. Masi
R. Doro
S. Cipressi
C. Iermano
I. Bonucci
D. Franceschini
L. Di Brina
M. Baki
G. Simontacchi
I. Meattini
M. Carini
S. Serni
G. Nicita
L. Livi
Publikationsdatum: 01.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 3/2016
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-015-1613-5

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