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Erschienen in: Journal of General Internal Medicine 9/2021

14.06.2021 | Bottom Line Summary

Dapagliflozin Improves the Clinical Outcomes of Patients with Chronic Kidney Disease and Albuminuria

verfasst von: Stephanie A. Patrick, DO, Tracey D. Dabal, MD, Christopher D. Jackson, MD

Erschienen in: Journal of General Internal Medicine | Ausgabe 9/2021

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Excerpt

Among adult patients with chronic kidney disease (CKD) and albuminuria, with or without type 2 diabetes (T2D), already on stable doses of ACE inhibitor or ARB, dapagliflozin significantly lowered the risk of the composite endpoint of a sustained decline in the estimated glomerular filtration rate (eGFR) of at least 50%, end-stage kidney disease, and death from renal or cardiovascular causes. …
Literatur
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Zurück zum Zitat Dekkers CCJ, Wheeler DC, Sjöström CD, Stefansson BV, Cain V, Heerspink HJL. Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and Stages 3b-4 chronic kidney disease [published correction appears in Nephrol Dial Transplant. 2018;33(7):1280]. Nephrol Dial Transplant. 2018;33(11):2005-2011. doi:https://doi.org/10.1093/ndt/gfx350 Dekkers CCJ, Wheeler DC, Sjöström CD, Stefansson BV, Cain V, Heerspink HJL. Effects of the sodium-glucose co-transporter 2 inhibitor dapagliflozin in patients with type 2 diabetes and Stages 3b-4 chronic kidney disease [published correction appears in Nephrol Dial Transplant. 2018;33(7):1280]. Nephrol Dial Transplant. 2018;33(11):2005-2011. doi:https://​doi.​org/​10.​1093/​ndt/​gfx350
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Zurück zum Zitat Fioretto P, Del Prato S, Buse JB, et al. Efficacy and safety of dapagliflozin in patients with type 2 diabetes and moderate renal impairment (chronic kidney disease stage 3A): The DERIVE Study [published correction appears in Diabetes Obes Metab. 2019;21(1):203]. Diabetes Obes Metab. 2018;20(11):2532-2540. doi:https://doi.org/10.1111/dom.13413 Fioretto P, Del Prato S, Buse JB, et al. Efficacy and safety of dapagliflozin in patients with type 2 diabetes and moderate renal impairment (chronic kidney disease stage 3A): The DERIVE Study [published correction appears in Diabetes Obes Metab. 2019;21(1):203]. Diabetes Obes Metab. 2018;20(11):2532-2540. doi:https://​doi.​org/​10.​1111/​dom.​13413
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Zurück zum Zitat Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjöström CD, Toto RD, Langkilde AM, Wheeler DC; DAPA-CKD Trial Committees and Investigators. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi: https://doi.org/10.1056/NEJMoa2024816.CrossRefPubMed Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjöström CD, Toto RD, Langkilde AM, Wheeler DC; DAPA-CKD Trial Committees and Investigators. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi: https://​doi.​org/​10.​1056/​NEJMoa2024816.CrossRefPubMed
Metadaten
Titel
Dapagliflozin Improves the Clinical Outcomes of Patients with Chronic Kidney Disease and Albuminuria
verfasst von
Stephanie A. Patrick, DO
Tracey D. Dabal, MD
Christopher D. Jackson, MD
Publikationsdatum
14.06.2021
Verlag
Springer International Publishing
Erschienen in
Journal of General Internal Medicine / Ausgabe 9/2021
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-021-06871-w

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