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BMC Cancer

Ausgabe 1/2018

Inhalt (1299 Artikel)

Open Access Research article

Feasibility and acceptability of combining cognitive behavioural therapy techniques with swallowing therapy in head and neck cancer dysphagia

J. M. Patterson, M. Fay, C. Exley, E. McColl, M. Breckons, V. Deary

Open Access Research article

Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance

Katerina Pestova, Adam J. Koch, Charles P. Quesenberry, Jun Shan, Ying Zhang, Amethyst D. Leimpeter, Beth Blondin, Svetlana Sitailo, Lela Buckingham, Jing Du, Huixin Fei, Stephen K. Van Den Eeden

Open Access Research article

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool

Pablo Cabezas-Sainz, Jorge Guerra-Varela, María J. Carreira, Javier Mariscal, María Roel, Juan A. Rubiolo, Andrés A. Sciara, Miguel Abal, Luis M. Botana, Rafael López, Laura Sánchez

Open Access Research article

Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer

Ming Li, Anqi Li, Shuling Zhou, Yan Xu, Yaoxing Xiao, Rui Bi, Wentao Yang

Open Access Research article

An inflammation-based cumulative prognostic score system in patients with diffuse large B cell lymphoma in rituximab era

Feifei Sun, Jia Zhu, Suying Lu, Zijun Zhen, Juan Wang, Junting Huang, Zonghui Ding, Musheng Zeng, Xiaofei Sun

Open Access Research article

Differential efficacy of cisplatin plus pemetrexed between L858R and Del-19 in advanced EGFR-mutant non-squamous non-small cell lung cancer

Toshihiko Kaneda, Hiroshige Yoshioka, Motohiro Tamiya, Akihiro Tamiya, Akito Hata, Asukaka Okada, Takashi Niwa, Takayuki Shiroyama, Masaki Kanazu, Tadashi Ishida, Nobuyuki Katakami

Open Access Case report

Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature

Anna Myriam Perrone, Giulia Girolimetti, Simona Cima, Ivana Kurelac, Alessandra Livi, Giacomo Caprara, Donatella Santini, Paolo Castellucci, Alessio Giuseppe Morganti, Giuseppe Gasparre, Pierandrea De Iaco

Open Access Research article

Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations

René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster, Geert J. L. H. van Leenders

Open Access Research article

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population

Min-jie Mao, Ning Xue, Xue-ping Wang, Pei-dong Chi, Yi-jun Liu, Qi Huang, Shu-qin Dai, Wan-li Liu

Open Access Research article

Crizotinib in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer versus chemotherapy as a first-line treatment

Jianya Zhou, Jing Zheng, Xiaochen Zhang, Jing Zhao, Yanping Zhu, Qian Shen, Yuehong Wang, Ke Sun, Zeying Zhang, Zhijie Pan, Yihong Shen, Jianying Zhou

Open Access Research article

Sidedness and TP53 mutations impact OS in anti-EGFR but not anti-VEGF treated mCRC - an analysis of the KRAS registry of the AGMT (Arbeitsgemeinschaft Medikamentöse Tumortherapie)

Florian Huemer, Josef Thaler, Gudrun Piringer, Hubert Hackl, Lisa Pleyer, Clemens Hufnagl, Lukas Weiss, Richard Greil

Open Access Research article

Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma

Fang-Hui Ren, Hong Yang, Rong-quan He, Jing-ning Lu, Xing-gu Lin, Hai-Wei Liang, Yi-Wu Dang, Zhen-Bo Feng, Gang Chen, Dian-Zhong Luo

Open Access Research article

IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production

Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Milena Benítez-Londoño, Moises Armides Franco-Molina, Cristina Rodríguez-Padilla

Open Access Study protocol

Adjuvant stereotactic fractionated radiotherapy to the resection cavity in recurrent glioblastoma – the GlioCave study (NOA 17 – ARO 2016/3 – DKTK ROG trial)

Christoph Straube, Hagen Scherb, Jens Gempt, Jan Kirschke, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer, Stephanie E. Combs

Open Access Research article

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations

Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Melanie Mackean, Fiona Nussey, Mark J. Arends, Andrew H. Sims, Colin A. Semple, C. Simon Herrington, Charlie Gourley

Open Access Research article

Preoperative serum immunoglobulin G and A antibodies to Porphyromonas gingivalis are potential serum biomarkers for the diagnosis and prognosis of esophageal squamous cell carcinoma

She-Gan Gao, Jun-Qiang Yang, Zhi-Kun Ma, Xiang Yuan, Chen Zhao, Guang-Chao Wang, Hua Wei, Xiao-Shan Feng, Yi-Jun Qi

Open Access Study protocol

The Brainfit study: efficacy of cognitive training and exergaming in pediatric cancer survivors – a randomized controlled trial

Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts, Kurt Leibundgut

Open Access Research article

Development of the body image self-rating questionnaire for breast cancer (BISQ-BC) for Chinese mainland patients

Kaina Zhou, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang, Xiaomei Li

Open Access Research article

Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

Ildar V. Gainetdinov, Yulia V. Skvortsova, Sofia A. Kondratieva, Alexey Klimov, Alexey A. Tryakin, Tatyana L. Azhikina

Open Access Research article

Testicular self examination among Bahir Dar University students: application of integrated behavioral model

Hordofa Gutema, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Habtamu Wondiye

Open Access Research article

The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC)

Shavira Narrandes, Shujun Huang, Leigh Murphy, Wayne Xu

Open Access Research article

Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers

Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski, Tomasz Wilanowski

Open Access Case report

Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report

Keiichi Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Masafumi Yoshida, Hiroshi Fukuhara, Mitsuhiro Fujishiro, Teppei Morikawa, Tatsuya Yamasoba, Kazuhiko Koike, Masashi Fukayama, Toshiaki Watanabe

Open Access Research article

A quantitative multimodal metabolomic assay for colorectal cancer

Farshad Farshidfar, Karen A. Kopciuk, Robert Hilsden, S. Elizabeth McGregor, Vera C. Mazurak, W. Donald Buie, Anthony MacLean, Hans J. Vogel, Oliver F. Bathe

Open Access Research article

PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells

Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen, Ye Zhang

Open Access Research article

Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery

Rasha Swadi, Grace Mather, Barry L. Pizer, Paul D. Losty, Violaine See, Diana Moss

Open Access Research article

Using Resistin, glucose, age and BMI to predict the presence of breast cancer

Miguel Patrício, José Pereira, Joana Crisóstomo, Paulo Matafome, Manuel Gomes, Raquel Seiça, Francisco Caramelo

Open Access Research article

Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells

Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li, Yang-Sook Chun

Open Access Research article

Evaluation of Endoglin (CD105) expression in pediatric rhabdomyosarcoma

Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano, Angela Di Giannatale

Open Access Research article

Evolutionary aspects of non-metastatic breast cancer after primary treatment in a sub-Saharan African setting: a 16-year retrospective review at the Douala general hospital, Cameroon

Bibiana Ateh Nzeangung, Martin Essomba Biwole, Benjamin Momo Kadia, Ndemazie Nkafu Bechem, Christian Akem Dimala, Albert Mouelle Sone

Open Access Research article

MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall

Open Access Research article

Regulation of pancreatic stellate cell activation by Notch3

Haiyan Song, Yuxiang Zhang

Open Access Research article

High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer

Asmus Heumann, Nina Heinemann, Claudia Hube-Magg, Dagmar S. Lang, Katharina Grupp, Martina Kluth, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Waldemar Wilczak, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Guido Sauter, Stefan Steurer, Patrick Lebok, Andrea Hinsch

Open Access Research article

Attributable causes of colorectal cancer in China

Meng-Jia Gu, Qiu-Chi Huang, Cheng-Zhen Bao, Ying-Jun Li, Xiao-Qin Li, Ding Ye, Zhen-Hua Ye, Kun Chen, Jian-Bing Wang

Open Access Research article

A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma

Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, Siqi Bao, Jie Sun

Open Access Research article

A systematic review of clinic and community intervention to increase fecal testing for colorectal cancer in rural and low-income populations in the United States – How, what and when?

Melinda M. Davis, Michele Freeman, Jackilen Shannon, Gloria D. Coronado, Kurt C. Stange, Jeanne-Marie Guise, Stephanie B. Wheeler, David I. Buckley

Open Access Research article

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery

Open Access Research article

Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up

Gulisa Turashvili, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y. Wen

Open Access Research article

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest, Deborah Bell-Pedersen

Open Access Research article

Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States

Rohini K. Hernandez, Sally W. Wade, Adam Reich, Melissa Pirolli, Alexander Liede, Gary H. Lyman

Open Access Research article

A train the trainer program for healthcare professionals tasked with providing psychosocial support to breast cancer survivors

Eunyoung Park, Junghee Yoon, Eun-kyung Choi, Im Ryung Kim, Danbee Kang, Se-Kyung Lee, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Adriaan Visser, Juhee Cho

Open Access Research article

Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer

Akhileshwar Namani, Md. Matiur Rahaman, Ming Chen, Xiuwen Tang

Open Access Research article

Mechanism of recipient cell-dependent differences in exosome uptake

Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Yoshiki Murakami, Yoshiyuki Rikitake

Open Access Research article

Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype

Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi, Mounir Trimeche

Open Access Research article

A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database

Kong Xiangxing, Li Jun, Cai Yibo, Tian Yu, Chi Shengqiang, Tong Danyang, Hu Yeting, Yang Qi, Li Jingsong, Graeme Poston, Yuan Ying, Ding Kefeng

Open Access Research article

Trastuzumab without chemotherapy in the adjuvant treatment of breast cancer: subgroup results from a large observational study

Peter Dall, Thorsten Koch, Thomas Göhler, Johannes Selbach, Andreas Ammon, Jochen Eggert, Nidal Gazawi, Daniela Rezek, Arthur Wischnik, Carsten Hielscher, Nicolas Schleif, Ursula Cirrincione, Axel Hinke, Gabriele Feisel-Schwickardi

Open Access Research article

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram, Gopal C. Kundu

Open Access Research article

Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski, Denise Tostes Oliveira

Open Access Study protocol

Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study

Susana García-Gutierrez, Miren Orive, Cristina Sarasqueta, Maria Jose Legarreta, Nerea Gonzalez, Maximino Redondo, Amado Rivero, Pedro Serrano-Aguilar, Xavier Castells, Jose Maria Quintana, Maria Sala, Xavier Castells, Mercè Comas, Laia Domingo, Francesc Macià, Marta Roman, Anabel Romero, María Sala, Teresa Barata, Isabel Diez de la Lastra, Mariola de la Vega, Marisa Bare, Núria Torà, Joana Ferrer, Francesc Castanyer, Carmen Carmona, Susana García, Maximina Martín, Nerea Gonzalez, Miren Orive, Maria Amparo Valverde, Alberto Saez, Inma Barredo, Manuel de Toro, Josefa Ferreiro, Jose María Quintana, Jeanette Pérez, Amado Rivero, Cristina Valcárcel, María del Carmen Padilla, Maximino Redondo, Teresa Téllez, Irene Zarcos, Cristina Churruca, Amaia Perales, Javier Recio, Irune Ruiz, Cristina Sarasqueta, Jose María Urraca, Ma Jesús Michelena, Julio Moreno, Gaizka Mallabiabarrena, Patricia Cobos, Borja Otero, Javier Gorostiaga, Itsaso Troya

Open Access Study protocol

A randomized controlled trial of a skills training for oncologists and a communication aid for patients to stimulate shared decision making about palliative systemic treatment (CHOICE): study protocol

I. Henselmans, E. M. A. Smets, J. C. J. M. de Haes, M. G. W. Dijkgraaf, F. Y. de Vos, H. W. M. van Laarhoven

Open Access Research article

Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D’Incalci, Massimo Ghiani, Vincenzo Marras, Daniela Onnis, Maria Cristina Santona, Giuseppina Sarobba, Enrichetta Valle, Luisa Canu, Sergio Cossu, Alessandro Bulfone, Paolo Cossu Rocca, Maria Rosaria De Miglio, Sandra Orrù

Open Access Study protocol

Study protocol of a phase II clinical trial (KSCC1501A) examining oxaliplatin + S-1 for treatment of HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy

Hiroshi Saeki, Yasunori Emi, Eiji Oki, Shoji Tokunaga, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Eishi Baba, Yoshihiko Maehara

Open Access Research article

Ethnic disparities in breast cancer survival in New Zealand: which factors contribute?

Sandar Tin Tin, J. Mark Elwood, Charis Brown, Diana Sarfati, Ian Campbell, Nina Scott, Reena Ramsaroop, Sanjeewa Seneviratne, Vernon Harvey, Ross Lawrenson

Open Access Research article

Efficacy of a telephone outcall program to reduce caregiver burden among caregivers of cancer patients [PROTECT]: a randomised controlled trial

Leila Heckel, Kate M. Fennell, John Reynolds, Anna Boltong, Mari Botti, Richard H. Osborne, Cathrine Mihalopoulos, Jacquie Chirgwin, Melinda Williams, Cadeyrn J. Gaskin, David M. Ashley, Patricia M. Livingston

Open Access Research article

MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway

Izzet Akiva, Necla Birgül Iyison

Open Access Research article

Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms

Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu, Qing H. Meng

Open Access Study protocol

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP

Fiona Streckmann, Maryam Balke, Helmar C. Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T. Baumann, Wilhelm Bloch

Open Access Study protocol

Staging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study

Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji

Open Access Study protocol

Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial

Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet

Open Access Research article

Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis

Christopher B. Chen, Maxim Eskin, Dean T. Eurich, Sumit R. Majumdar, Jeffrey A. Johnson

Open Access Research article

The quality of working life questionnaire for cancer survivors (QWLQ-CS): factorial structure, internal consistency, construct validity and reproducibility

Merel de Jong, Sietske J. Tamminga, Robert J. J. van Es, Monique H. W. Frings-Dresen, Angela G. E. M. de Boer

Open Access Research article

RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin, Sheng Xiao

Open Access Research article

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M. Hoff, A. Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I. Skotheim, Paula Soares

Open Access Research article

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation

Jeffrey J. Heard, Ivy Phung, Mark I. Potes, Fuyuhiko Tamanoi

Open Access Correction

Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang, Zhihai Peng

Open Access Research article

Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis

Eileen Shaw, Megan S. Farris, Chelsea R. Stone, Jeroen W. G. Derksen, Rhys Johnson, Robert J. Hilsden, Christine M. Friedenreich, Darren R. Brenner

Open Access Research article

Adjuvant treatment of resectable biliary tract cancer with cisplatin plus gemcitabine: A prospective single center phase II study

Alexander R. Siebenhüner, Heike Seifert, Helga Bachmann, Burkhardt Seifert, Thomas Winder, Jonas Feilchenfeldt, Stefan Breitenstein, Pierre-Alain Clavien, Roger Stupp, Alexander Knuth, Bernhard Pestalozzi, Panagiotis Samaras

Open Access Research article

Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center

Shiela S. Macalindong, Kwang Hee Kim, Byung-Ho Nam, Keun Won Ryu, Norihito Kubo, Ja Yeon Kim, Bang Wool Eom, Hong Man Yoon, Myeong-Cherl Kook, Il Ju Choi, Young Woo Kim

Open Access Research article

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer

San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di, Zhi-Ming Shao

Open Access Research article

Obesity and breast cancer outcomes in chemotherapy patients in New Zealand – a population-based cohort study

J. Mark Elwood, Sandar Tin Tin, Marion Kuper-Hommel, Ross Lawrenson, Ian Campbell

Open Access Research article

Colorectal cancer liver metastases – a population-based study on incidence, management and survival

Jennie Engstrand, Henrik Nilsson, Cecilia Strömberg, Eduard Jonas, Jacob Freedman

Open Access Research article

Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making

S. Mokhles, J. J. M. E. Nuyttens, M. de Mol, J. G. J. V. Aerts, A. P. W. M. Maat, Ö. Birim, A. J. J. C. Bogers, J. J. M. Takkenberg

Open Access Correction

Correction to: A systematic comparison of copy number alterations in four types of female cancer

Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen, Hiroko K. Solvang

Open Access Research article

Additional dexamethasone in chemotherapies with carboplatin and paclitaxel could reduce the impaired glycometabolism in rat models

Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang, Heng Cui

Open Access Technical advance

Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors

Evan L. Busch, Prabhani Kuruppumullage Don, Haitao Chu, David B. Richardson, Temitope O. Keku, David A. Eberhard, Christy L. Avery, Robert S. Sandler

Open Access Research article

Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer

Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim, Hyung Seok Park

Open Access Research article

Cost-effectiveness of prostate cancer screening: a systematic review of decision-analytical models

Sabina Sanghera, Joanna Coast, Richard M. Martin, Jenny L. Donovan, Syed Mohiuddin

Open Access Research article

Somatic evolutionary timings of driver mutations

Karen Gomez, Sayaka Miura, Louise A. Huuki, Brianna S. Spell, Jeffrey P. Townsend, Sudhir Kumar

Open Access Research article

What is it about a cancer diagnosis that would worry people? A population-based survey of adults in England

Philippa J. Murphy, Laura A. V. Marlow, Jo Waller, Charlotte Vrinten

Open Access Research article

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder, Jeff Hammerbacher

Open Access Research article

Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

Guang-hua Xu, Ning Lou, Hang-chuan Shi, Yu-chen Xu, Hai-long Ruan, Wen Xiao, Lei Liu, Xiang Li, Hai-bing Xiao, Bin Qiu, Lin Bao, Chang-fei Yuan, Ya-li Zhou, Wen-jun Hu, Ke Chen, Hong-mei Yang, Xiao-ping Zhang

Open Access Research article

AZGP1 inhibits soft tissue sarcoma cells invasion and migration

Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li, Jiafu Ji

Open Access Research article

FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-XL cell survival genes

Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário, Humberto Miguel Garay-Malpartida

Open Access Sarkome in der Gynäkologie Case report

A remarkable response to pazopanib, despite recurrent liver toxicity, in a patient with a high grade endometrial stromal sarcoma, a case report

Arie J. Verschoor, Fabiënne A. R. M. Warmerdam, Tjalling Bosse, Judith V. M. G. Bovée, Hans Gelderblom

Open Access Research article

Assessment of cancers’ diagnostic stage in a Deaf community - survey about 4363 Deaf patients recorded in French units

Vladimir Druel, Hélène Hayet, Laetitia Esman, Marie Clavel, Marie-Eve Rougé Bugat

Open Access Research article

Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer

Qing-Hua Cao, Fang Liu, Chang-Zhao Li, Ni Liu, Man Shu, Yuan Lin, Li Ding, Ling Xue

Open Access Case report

Neuromyelitis optica spectrum disorder secondary to treatment with anti-PD-1 antibody nivolumab: the first report

Yoshitsugu Narumi, Ryohei Yoshida, Yoshinori Minami, Yasushi Yamamoto, Shiori Takeguchi, Kohei Kano, Kae Takahashi, Tsukasa Saito, Jun Sawada, Hiroya Terui, Takayuki Katayama, Takaaki Sasaki, Yoshinobu Ohsaki

Open Access Research article

Shifting breast cancer surveillance from current hospital setting to a community based setting: a cost-effectiveness study

Kelly M. de Ligt, Annemieke Witteveen, Sabine Siesling, Lotte M. G. Steuten

Open Access Case report

Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review

Giuseppina Rosaria Rita Ricciardi, Alessandro Russo, Tindara Franchina, Silvia Schifano, Giampiero Mastroeni, Anna Santacaterina, Vincenzo Adamo

Open Access Study protocol

The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and BRAF wild-type elderly metastatic colorectal cancer patients

Francesca Battaglin, Marta Schirripa, Federica Buggin, Filippo Pietrantonio, Federica Morano, Giorgia Boscolo, Giuseppe Tonini, Eufemia Stefania Lutrino, Jessica Lucchetti, Lisa Salvatore, Alessandro Passardi, Chiara Cremolini, Ermenegildo Arnoldi, Mario Scartozzi, Nicoletta Pella, Luca Boni, Francesca Bergamo, Vittorina Zagonel, Fotios Loupakis, Sara Lonardi

Open Access Research article

Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati, Sushanta K. Banerjee

Open Access Research article

Intra-arterial ethanol embolization augments response to TACE for treatment of HCC with portal venous tumor thrombus

Biao Yang, Chun-Lin Li, Wen-hao Guo, Tian-qiang Qin, He Jiao, Ze-jun Fei, Xuan Zhou, Lin-jia Duan, Zheng-yin Liao

Open Access Research article

Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients

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Open Access Study protocol

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma

A. Arjona-Sánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo-Campos, J. M. Sánchez-Hidalgo, A. Casado-Adam, Ruben García-Martin, Manuel Medina, T. Caro, C. Villar, Enrique Aranda, M. T. Cano-Osuna, C. Díaz-López, E. Torres-Tordera, F. J. Briceño-Delgado, S. Rufián-Peña

Open Access Research article

Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

Masanori Nojima, Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida, Shoichiro Tsugane

Open Access Research article

Impact of PKCε downregulation on autophagy in glioblastoma cells

Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski, Maria Rybczynska

Open Access Study protocol

Treatment using oxaliplatin and S-1 adjuvant chemotherapy for pathological stage III gastric cancer: a multicenter phase II study (TOSA trial) protocol

Tsutomu Namikawa, Hiromichi Maeda, Hiroyuki Kitagawa, Koji Oba, Akihito Tsuji, Takaki Yoshikawa, Michiya Kobayashi, Kazuhiro Hanazaki

Open Access Study protocol

Phase I study of an active immunotherapy for asymptomatic phase Lymphoplasmacytic lymphoma with DNA vaccines encoding antigen-chemokine fusion: study protocol

Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu, Larry W. Kwak

Open Access Research article

Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for hepatocellular carcinoma: comparative study

Tatjana Gruber-Rouh, Cornelia Schmitt, Nagy N. N. Naguib, N. A. Nour-Eldin, Katrin Eichler, Martin Beeres, Thomas J. Vogl

Open Access Research article

Physical activity and risk of testicular cancer: a systematic review

Stephanie Huang, Virginia Signal, Diana Sarfati, Caroline Shaw, James Stanley, Katherine McGlynn, Jason Gurney

Open Access Research article

Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres

Yufeng Chen, Yifei Xu, Weilin Zhao, Xue Xiao, Xiaoying Zhou, Longde Lin, Tingting Huang, Jian Liao, Yancheng Li, Xiaoyun Zeng, Guangwu Huang, Weimin Ye, Zhe Zhang

Open Access Research article

The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment

Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard, Boe Sandahl Sorensen

Open Access Review

Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?

Kathleen Melan, Frederic Amant, Jacqueline Veronique-Baudin, Clarisse Joachim, Eustase Janky

Open Access Research article

In vitro and in silico validation of CA3 and FHL1 downregulation in oral cancer

Cláudia Maria Pereira, Ana Carolina de Carvalho, Felipe Rodrigues da Silva, Matias Eliseo Melendez, Roberta Cardim Lessa, Valéria Cristina C. Andrade, Luiz Paulo Kowalski, André L. Vettore, André Lopes Carvalho

Open Access Research article

Safety and efficacy of temsirolimus as second line treatment for patients with recurrent bladder cancer

Marina Pulido, Guilhem Roubaud, Anne-Laure Cazeau, Hakim Mahammedi, Lionel Vedrine, Florence Joly, Loic Mourey, Christian Pfister, Alejandro Goberna, Barbara Lortal, Carine Bellera, Philippe Pourquier, Nadine Houédé

Open Access Research article

RECORD-4 multicenter phase 2 trial of second-line everolimus in patients with metastatic renal cell carcinoma: Asian versus non-Asian population subanalysis

Lin Yang, Anna Alyasova, Dingwei Ye, Antonia Ridolfi, Luca Dezzani, Robert J. Motzer

Open Access Study protocol

Radiotherapy related skin toxicity (RAREST-01): Mepitel® film versus standard care in patients with locally advanced head-and-neck cancer

Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl, Dirk Rades

Open Access Research article

Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1

Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira, Fabio Dall’Olio

Open Access Research article

A prospective study to investigate the role of serial serum mesothelin in monitoring mesothelioma

Duneesha de Fonseka, David T. Arnold, Louise Stadon, Anna Morley, Emma Keenan, Michael Darby, Lynne Armstrong, Paul Virgo, Nick A. Maskell

Open Access Research article

MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

Zhikun Liu, Jie Li, Jun Chen, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng

Open Access Research article

Association of differential miRNA expression with hepatic vs. peritoneal metastatic spread in colorectal cancer

Sabine Heublein, Markus Albertsmeier, David Pfeifer, Lisa Loehrs, Alexandr V. Bazhin, Thomas Kirchner, Jens Werner, Jens Neumann, Martin Kurt Angele

Open Access Research article

Metastatic cardiac tumors: from clinical presentation through diagnosis to treatment

Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack, Yehuda Adler

Open Access Research article

Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A.L. Brown, M. J. Kerin

Open Access Research article

Filtration based assessment of CTCs and CellSearch® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients

Hanna Huebner, Peter A. Fasching, Walter Gumbrecht, Sebastian Jud, Claudia Rauh, Mark Matzas, Peter Paulicka, Katja Friedrich, Michael P. Lux, Bernhard Volz, Paul Gass, Lothar Häberle, Franziska Meier-Stiegen, Andreas Hartkopf, Hans Neubauer, Katrin Almstedt, Matthias W. Beckmann, Tanja N. Fehm, Matthias Ruebner

Open Access Research article

Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours: a prospective study in the Swedish AMORIS cohort

Cecilia Bosco, Hans Garmo, Niklas Hammar, Göran Walldius, Ingmar Jungner, Håkan Malmström, Lars Holmberg, Mieke Van Hemelrijck

Open Access Research article

Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer

Teng Wang, Kuan Ning, Xu Sun, Chun Zhang, Lin-fang Jin, Dong Hua

Open Access Research article

Determinants of cancer screening awareness and participation among Indonesian women

Sumadi L. Anwar, Gindo Tampubolon, Mieke Van Hemelrijck, Susanna H. Hutajulu, Johnathan Watkins, Wahyu Wulaningsih

Open Access Research article

Evaluating different breast tumor progression models using screening data

Åsbjørn Schumacher Westvik, Harald Weedon-Fekjær, Jan Mæhlen, Knut Liestøl

Open Access Research article

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy

Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab, Malgorzata Firczuk

Open Access Research article

Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma

David J. Pinato, Madhava Pai, Isabella Reccia, Markand Patel, Alexandros Giakoustidis, Georgios Karamanakos, Azelea Rushd, Shiraz Jamshaid, Alberto Oldani, Glenda Grossi, Mario Pirisi, Paul Tait, Rohini Sharma

Open Access Case report

Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report

Yu Qiao, Jihong Yang, Lili Liu, Yixin Zeng, Jie Ma, Jing Jia, Li Zhang, Xiaoguang Li, Peihong Wu, Wenchao Wang, Dongge Liu, Huan Chen, Yunbo Zhao, Huan Xi, Yao Wang

Open Access Research article

Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients

Marek Kowalczyk, Marcin Orłowski, Piotr Siermontowski, Dariusz Mucha, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Ewa Zieliński, Iwona Kowalczyk, Agnieszka Pedrycz

Open Access Research article

Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional data

Rana Maroun, Laura Mitrofan, Laure Benjamin, Gaelle Nachbaur, Franck Maunoury, Philippe Le Jeunne, Isabelle Durand-Zaleski

Open Access Research article

Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

Yu Han, Lin-Feng Yan, Xi-Bin Wang, Ying-Zhi Sun, Xin Zhang, Zhi-Cheng Liu, Hai-Yan Nan, Yu-Chuan Hu, Yang Yang, Jin Zhang, Ying Yu, Qian Sun, Qiang Tian, Bo Hu, Gang Xiao, Wen Wang, Guang-Bin Cui

Open Access Research article

A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization

Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang, Ming-qing Xu

Open Access Research article

The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells

Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters, Janet M. Shipley

Open Access Study protocol

A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B

Wietske C. M. Schimmel, Eline Verhaak, Patrick E. J. Hanssens, Karin Gehring, Margriet M. Sitskoorn

Open Access Research article

LGR5 overexpression confers poor relapse-free survival in breast cancer patients

Ming-Feng Hou, Po-Ming Chen, Pei-Yi Chu

Open Access Research article

Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies

Harinakshi Sanikini, Jian-Min Yuan, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Annika Steffen, Mattias Johansson, Paolo Vineis, Gary E. Goodman, Matt J. Barnett, Rayjean J. Hung, Chu Chen, Isabelle Stücker

Open Access Research article

Gap junctions contribute to anchorage-independent clustering of breast cancer cells

Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun, Valérie Lobjois

Open Access Research article

Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines

Egle Strainiene, Mindaugas Binkis, Silvija Urnikyte, Vaidotas Stankevicius, Ausra Sasnauskiene, Gabrielis Kundrotas, Andrius Kazlauskas, Kestutis Suziedelis

Open Access Research article

High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer

Anniina Jääskeläinen, Ylermi Soini, Arja Jukkola-Vuorinen, Päivi Auvinen, Kirsi-Maria Haapasaari, Peeter Karihtala

Open Access Research article

The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

Heleen K. Bronsveld, Marie L. De Bruin, Jelle Wesseling, Joyce Sanders, Ingrid Hofland, Vibeke Jensen, Marloes T. Bazelier, Bas ter Braak, Anthonius de Boer, Peter Vestergaard, Marjanka K. Schmidt

Open Access Research article

Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi, Shireen Vali

Open Access Research article

Centralising specialist cancer surgery services in England: survey of factors that matter to patients and carers and health professionals

Mariya Melnychuk, Cecilia Vindrola-Padros, Michael Aitchison, Caroline S. Clarke, Naomi J. Fulop, Claire Levermore, Satish B. Maddineni, Caroline M. Moore, Muntzer M. Mughal, Catherine Perry, Kathy Pritchard-Jones, Angus I. G. Ramsay, David Shackley, Jonathan Vickers, Stephen Morris

Open Access Research article

Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma

Ming-Chun Ma, Yi-Ju Chen, Tai-Jan Chiu, Jui Lan, Chien-Ting Liu, Yi-Ching Chen, Hsin-Ho Tien, Yen-Yang Chen

Open Access Research article

Low-dose aspirin use and survival in colorectal cancer: results from a population-based cohort study

Ronan T. Gray, Helen G. Coleman, Carmel Hughes, Liam J. Murray, Chris R. Cardwell

Open Access Research article

Development and evaluation of a risk assessment tool to improve clinical triage accuracy for colonoscopic investigations

Anton R. Lord, Lisa A. Simms, Allison Brown, Katherine Hanigan, Krupa Krishnaprasad, Belinda Schouten, Anthony R. Croft, Mark N. Appleyard, Graham L. Radford-Smith

Open Access Research article

Stellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer – an observational study

Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström, Håkan Olsson

Open Access Research article

Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8

Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee, Chanitra Thuwajit

Open Access Research article

Dairy products and colorectal cancer in middle eastern and north African countries: a systematic review

K. El kinany, M. Deoula, Z. Hatime, B. Bennani, K. El Rhazi

Open Access Research article

Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study

Peng Gao, Xuan-zhang Huang, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Yu Sun, Yu-meng Jiang, Zhen-ning Wang

Open Access Research article

Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer

Tadej Dovšak, Alojz Ihan, Vojko Didanovič, Andrej Kansky, Miha Verdenik, Nataša Ihan Hren

Open Access Research article

Comparative oesophageal cancer risk assessment of hot beverage consumption (coffee, mate and tea): the margin of exposure of PAH vs very hot temperatures

Alex O. Okaru, Anke Rullmann, Adriana Farah, Elvira Gonzalez de Mejia, Mariana C. Stern, Dirk W. Lachenmeier

Open Access Research article

A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies

Marilia Takada, Maciej Parys, Emmalena Gregory-Bryson, Paulo Vilar Saavedra, Matti Kiupel, Vilma Yuzbasiyan-Gurkan

Open Access Research article

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2

Hamid Maadi, Babak Nami, Junfeng Tong, Gina Li, Zhixiang Wang

Open Access Case report

Clinical decision making in the era of immunotherapy for high grade-glioma: report of four cases

Surabhi Ranjan, Martha Quezado, Nancy Garren, Lisa Boris, Christine Siegel, Osorio Lopes Abath Neto, Brett J. Theeler, Deric M. Park, Edjah Nduom, Kareem A. Zaghloul, Mark R. Gilbert, Jing Wu

Open Access Correction

Correction to: Oncology practitioners’ perspectives and practice patterns of post-treatment cancer survivorship care in the Asia-Pacific region: results from the STEP study

Raymond Javan Chan, Patsy Yates, Qiuping Li, Hiroko Komatsu, Violeta Lopez, Myat Thandar, Selva Titus Chacko, Winnie Kwok Wei So, Kanaungnit Pongthavornkamol, Myungsun Yi, Pongpak Pittayapan, Jesson Butcon, David Wyld, Alex Molassiotis

Open Access Research article

Phase II study of bevacizumab, cisplatin, and docetaxel plus maintenance bevacizumab as first-line treatment for patients with advanced non-squamous non-small-cell lung cancer combined with exploratory analysis of circulating endothelial cells: Thoracic Oncology Research Group (TORG)1016

Satoshi Ikeda, Terufumi Kato, Takashi Ogura, Akimasa Sekine, Tsuneyuki Oda, Noriyuki Masuda, Satoshi Igawa, Ken Katono, Sakiko Otani, Kouzo Yamada, Haruhiro Saito, Tetsuro Kondo, Yukio Hosomi, Yoshiro Nakahara, Masanori Nishikawa, Keiko Utumi, Yuki Misumi, Takeharu Yamanaka, Kentaro Sakamaki, Hiroaki Okamoto

Open Access Research article

Patients’ experiences of diagnosis and management of papillary thyroid microcarcinoma: a qualitative study

Brooke Nickel, Juan P. Brito, Ray Moynihan, Alexandra Barratt, Susan Jordan, Kirsten McCaffery

Open Access Research article

High CD8+ and absence of Foxp3+ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival

Paula Fluxá, Daniel Rojas-Sepúlveda, María Alejandra Gleisner, Andrés Tittarelli, Pablo Villegas, Loreto Tapia, María Teresa Rivera, Mercedes Natalia López, Felipe Catán, Mario Uribe, Flavio Salazar-Onfray

Open Access Research article

Feasibility, useability and acceptability of technology-based interventions for informal cancer carers: a systematic review

Natalie Heynsbergh, Leila Heckel, Mari Botti, Patricia M. Livingston

Open Access Research article

New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance

Ayumi Sakuramoto, Yoko Hasegawa, Kazuma Sugahara, Yoshiyuki Komoda, Kana Hasegawa, Shinichi Hikasa, Mai Kurashita, Junya Sakai, Masahiro Arita, Kazuhiro Yasukawa, Hiromitsu Kishimoto

Open Access Review

Systematic reviews and cancer research: a suggested stepwise approach

George A. Kelley, Kristi S. Kelley

Open Access Research article

Safety assessment of sorafenib in Chinese patients with unresectable hepatocellular carcinoma: subgroup analysis of the GIDEON study

Sheng-Long Ye, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan, Zhiren Fu, Keiko Nakajima, Zhengguang Lv

Open Access Research article

Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing

Ye Tao, Neil Gross, Xiaojiao Fan, Jianming Yang, Maikun Teng, Xu Li, Guojun Li, Yang Zhang, Zhigang Huang

Open Access Research article

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès, Vincent Picco

Open Access Research article

Threat of biographical disruption: the gendered construction and experience of infertility following cancer for women and men

Jane M. Ussher, Janette Perz, Annie Miller, Pandora Patterson, Gerard Wain, Kim Hobbs, Catherine Mason, Laura Kirsten, Edith Weisberg, Alison Butt, Joanne Cummings, Kathryn Nattress, Chloe Parton

Open Access Research article

Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma

Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao, Weimin Mao

Open Access Research article

A phase II trial of S-1 and oxaliplatin in patients with advanced hepatocellular carcinoma

Dae-Won Lee, Kyung-Hun Lee, Hee-Jun Kim, Tae-Yong Kim, Jin-Soo Kim, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Tae-You Kim

Open Access Case report

Mixed response on regorafenib treatment for GIST (gastro-intestinal stromal tumor) according to 18F–FDG-PET/CT

Donatienne Van Weehaeghe, Olivier Gheysens, Vincent Vandecaveye, Patrick Schöffski, Koen Van Laere, Christophe M. Deroose

Open Access Research article

A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention

Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks, Gillian Mitchell

Open Access Research article

ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer

Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei

Open Access Research article

Detection and interval cancer rates during the transition from screen-film to digital mammography in population-based screening

Valérie D. V. Sankatsing, Jacques Fracheboud, Linda de Munck, Mireille J. M. Broeders, Nicolien T. van Ravesteyn, Eveline A. M. Heijnsdijk, André L. M. Verbeek, Johannes D. M. Otten, Ruud M. Pijnappel, Sabine Siesling, Harry J. de Koning

Open Access Research article

Temporal and geographic variation in the systemic treatment of advanced prostate cancer

Megan E. V. Caram, Jason P. Estes, Jennifer J. Griggs, Paul Lin, Bhramar Mukherjee

Open Access Research article

Signaling protein signature predicts clinical outcome of non-small-cell lung cancer

Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu, Shuai Chen, Sai-Sai Guo, Yu-Cheng Zhang, Jing Chen, Dan-Hua Shen, Kun-Kun Sun, Lu Chen, Wei-Hua Li, Ai-Ling Li, Na Wang, Qing Xia, Jun Wang, Tao Zhou

Open Access Research article

TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location

Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang, Qun Wang

Open Access Research article

Quality assurance target for community-based breast cancer screening in China: a model simulation

Lan Yang, Jing Wang, Juan Cheng, Yuan Wang, Wenli Lu

Open Access Research article

Burden of early, advanced and metastatic breast cancer in The Netherlands

G. T. Vondeling, G. L. Menezes, E. P. Dvortsin, F. G. A. Jansman, I. R. Konings, M. J. Postma, M. H. Rozenbaum

Open Access Research article

GABAB receptor regulates proliferation in the high-grade chondrosarcoma cell line OUMS-27 via apoptotic pathways

Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi, Masashi Neo

Open Access Research article

Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history

Christoph Engel, Kerstin Rhiem, Eric Hahnen, Sibylle Loibl, Karsten E. Weber, Sabine Seiler, Silke Zachariae, Jan Hauke, Barbara Wappenschmidt, Anke Waha, Britta Blümcke, Marion Kiechle, Alfons Meindl, Dieter Niederacher, Claus R. Bartram, Dorothee Speiser, Brigitte Schlegelberger, Norbert Arnold, Peter Wieacker, Elena Leinert, Andrea Gehrig, Susanne Briest, Karin Kast, Olaf Riess, Günter Emons, Bernhard H. F. Weber, Jutta Engel, Rita K. Schmutzler

Open Access Case report

Scar site metastasis of renal cell carcinoma diagnosed on-site cytology: a case report

Santosh Tummidi, Pragati Sathe, Prachi Gholap, Manoj Patil, Kanchan Kothari

Open Access Research article

Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers

Tao Jiang, Xiaofeng Xu, Meng Qiao, Xuefei Li, Chao Zhao, Fei Zhou, Guanghui Gao, Fengying Wu, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Changyun Zhai, Caicun Zhou

Open Access Correction

Correction to: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti

Open Access Research article

NSCLC molecular testing in Central and Eastern European countries

Ales Ryska, Peter Berzinec, Luka Brcic, Tanja Cufer, Rafal Dziadziuszko, Maya Gottfried, Ilona Kovalszky, Włodzimierz Olszewski, Buge Oz, Lukas Plank, Jozsef Timar

Open Access Research article

Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen, Bjarne W. Kristensen

Open Access Research article

Androgen deprivation therapy during and after post-prostatectomy radiotherapy in patients with prostate cancer: a case control study

Myong Kim, Cheryn Song, In Gab Jeong, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Young Seok Kim, Dalsan You, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn

Open Access Research article

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

Anke Schlüter, Patrick Weller, Oliver Kanaan, Ivonne Nel, Lukas Heusgen, Benedikt Höing, Pia Haßkamp, Sebastian Zander, Magis Mandapathil, Nina Dominas, Judith Arnolds, Boris A. Stuck, Stephan Lang, Agnes Bankfalvi, Sven Brandau

Open Access Research article

Preventing cervical cancer using HPV self-sampling: direct mailing of test-kits increases screening participation more than timely opt-in procedures - a randomized controlled trial

Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm, Berit Andersen

Open Access Research article

MYC amplification in subtypes of breast cancers in African American women

Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. DeWitty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi, Jan K. Blancato

Open Access Research article

Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers

James M. Dolezal, Arie P. Dash, Edward V. Prochownik

Open Access Research article

Time to diagnosis and associated costs of an outpatient vs inpatient setting in the diagnosis of lymphoma: a retrospective study of a large cohort of major lymphoma subtypes in Spain

Xavier Bosch, Carmen Sanclemente-Ansó, Ona Escoda, Esther Monclús, Jonathan Franco-Vanegas, Pedro Moreno, Mar Guerra-García, Neus Guasch, Alfons López-Soto

Open Access Research article

Sepsis increases perioperative metastases in a murine model

Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy, Rebecca C. Auer

Open Access Research article

The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis

Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang, Changli Lu

Open Access Research article

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Trinidad Dierssen-Sotos, Camilo Palazuelos-Calderón, José-Juan Jiménez-Moleón, Nuria Aragonés, Jone M. Altzibar, Gemma Castaño-Vinyals, Vicente Martín-Sanchez, Inés Gómez-Acebo, Marcela Guevara, Adonina Tardón, Beatriz Pérez-Gómez, Pilar Amiano, Victor Moreno, Antonio J. Molina, Jéssica Alonso-Molero, Conchi Moreno-Iribas, Manolis Kogevinas, Marina Pollán, Javier Llorca

Open Access Research article

Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study

D. Yao, L. Zhang, P. L. Wu, X. L. Gu, Y. F. Chen, L. X. Wang, X. Y. Huang

Open Access Correction

Correction to: Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A. L. Brown, M. J. Kerin

Open Access Research article

The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases

N. Andratschke, H. Alheid, M. Allgäuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, S. Gerum, M. Guckenberger, G. Hildebrandt, R. J. Klement, V. Lewitzki, C. Ostheimer, A. Papachristofilou, C. Petersen, T. Schneider, R. Semrau, S. Wachter, D. Habermehl

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Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression

Diana David, Arun Surendran, Jissa V. Thulaseedharan, Asha S. Nair

Open Access Research article

Prognostic nutritional index as a predictor of survival in resectable gastric cancer patients with normal preoperative serum carcinoembryonic antigen levels: a propensity score matching analysis

Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura, Yasunari Kawabata

Open Access Case report

A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report

Ying Pang, Garima Gupta, Chunzhang Yang, Herui Wang, Thanh-Truc Huynh, Ziedulla Abdullaev, Svetlana D. Pack, Melanie J. Percy, Terence R. J. Lappin, Zhengping Zhuang, Karel Pacak

Open Access Research article

Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma

Peng Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Yang, Shu-Peng Wang, Song Wu

Open Access Research article

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong, Zuxun Lu

Open Access Research article

Using nomogram of the Barcelona Clinic Liver Cancer system for treatment selection in patients with stage C hepatocellular carcinoma

Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Cheng-Yuan Hsia, Praneeth Kudaravalli, Yun-Hsuan Lee, Yi-You Chiou, Ya-Ju Tsai, Yi-Hsiang Huang, Teh-Ia Huo

Open Access Research article

A comparison of nephrotoxicity between patients with a solitary-functioning kidney and those with bilateral-functioning kidneys in cisplatin-based chemotherapy for advanced urothelial carcinoma: a Japanese retrospective multi-institutional study

Takamitsu Inoue, Jun Miyazaki, Daishi Ichioka, Shintaro Narita, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Yoshiyuki Matsui, Keiko Fujie, Tomonori Habuchi, Hiroyuki Nishiyama

Open Access Research article

Thyroid cancer: trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China

Lingbin Du, Youqing Wang, Xiaohui Sun, Huizhang Li, Xinwei Geng, Minghua Ge, Yimin Zhu

Open Access Research article

Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

Hanaa Hardi, Rahma Melki, Zouhour Boughaleb, Tijani El Harroudi, Souria Aissaoui, Noureddine Boukhatem

Open Access Debate

The curious case of Gαs gain-of-function in neoplasia

Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi, Claudio Bassi

Open Access Research article

Long-term trastuzumab (Herceptin®) treatment in a continuation study of patients with HER2-positive breast cancer or HER2-positive gastric cancer

Volkmar Müller, Michael Clemens, Jacek Jassem, Nedal Al-Sakaff, Petra Auclair, Eveline Nüesch, Debbie Holloway, Mona Shing, Yung-Jue Bang

Open Access Research article

Dose escalation can maximize therapeutic potential of sunitinib in patients with metastatic renal cell carcinoma

Anikó Maráz, Adrienn Cserháti, Gabriella Uhercsák, Éva Szilágyi, Zoltán Varga, János Révész, Renáta Kószó, Linda Varga, Zsuzsanna Kahán

Open Access Research article

Cancer awareness among community pharmacist: a systematic review

Kofi Boamah Mensah, Frasia Oosthuizen, Adwoa Bemah Bonsu

Open Access Case report

Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report

Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito

Open Access Gastrointestinale Tumoren Case report

Unusual bilateral ovarian metastases from ileal gastrointestinal stromal tumor (GIST): a case report

Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone, Maria Abbondanza Pantaleo

Open Access Research article

CircRNAs as biomarkers of cancer: a meta-analysis

Miao Wang, Yuxi Yang, Jian Xu, Wen Bai, Xueli Ren, Huijian Wu

Open Access Research article

Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients

Hans Roland Dürr, Jessica Rauh, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson, Alexander Klein

Open Access Research article

Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer

Jing-Jie Zhang, Hang Shu, Shuai-Shuai Hu, Yang Yu, Yi Sun, Yin Lv

Open Access Research article

Underutilization and disparities in access to EGFR testing among Medicare patients with lung cancer from 2010 – 2013

Julie A. Lynch, Brygida Berse, Merry Rabb, Paul Mosquin, Rob Chew, Suzanne L. West, Nicole Coomer, Daniel Becker, John Kautter

Open Access Research article

Novel biomarker-based model for the prediction of sorafenib response and overall survival in advanced hepatocellular carcinoma: a prospective cohort study

Hwi Young Kim, Dong Hyeon Lee, Jeong-Hoon Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon

Open Access Review article

Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations

Toshinori Ozaki, Meng Yu, Danjing Yin, Dan Sun, Yuyan Zhu, Youquan Bu, Meixiang Sang

Open Access Research article

The serum-based VeriStrat® test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients

Mary Jo Fidler, Cristina L. Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi, Jeffrey A. Borgia

Open Access Research article

From symptom discovery to treatment - women's pathways to breast cancer care: a cross-sectional study

Jennifer Moodley, Lydia Cairncross, Thurandrie Naiker, Deborah Constant

Open Access Research article

Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu, Jiejie Xu

Open Access Research article

Germline breast cancer susceptibility gene mutations and breast cancer outcomes

Yong Alison Wang, Jhih-Wei Jian, Chen-Fang Hung, Hung-Pin Peng, Chi-Fan Yang, Hung-Chun Skye Cheng, An-Suei Yang

Open Access Research article

Age greater than 60 years portends a worse prognosis in patients with papillary thyroid cancer: should there be three age categories for staging?

Rondi M. Kauffmann, J. Blair Hamner, Philip H. G. Ituarte, John H. Yim

Open Access Research article

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata, Keiko Nohara

Open Access Research article

Punch biopsies shorten time to clearance of high-risk human papillomavirus infections of the uterine cervix

K. U. Petry, J. Horn, A. Luyten, R. T. Mikolajczyk

Open Access Research article

The characteristics of ctDNA reveal the high complexity in matching the corresponding tumor tissues

Nong Yang, Yi Li, Zhidong Liu, Hao Qin, Duanming Du, Xinkai Cao, Xiaoqing Cao, Jun Li, Dongge Li, Bo Jiang, Lincan Duan, Haiyan Yang, Zhenghua Zhang, Hao Lin, Jianying Li, Zhenhua Yang, Lei Xiong, Hua Shen, Lizhu Lin, Fugen Li

Open Access Research article

Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer

Sung Gwe Ahn, Yoon Jin Cha, Soon June Bae, Chanik Yoon, Hak Woo Lee, Joon Jeong

Open Access Research article

Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages

Eng-Yen Huang, Jen-Chieh Chang, Hong-Hwa Chen, Chieh-Ying Hsu, Hsuan-Chih Hsu, Keng-Liang Wu

Open Access Research article

Mental disorders around cancer diagnosis and increased hospital admission rate - a nationwide cohort study of Swedish cancer patients

Jianwei Zhu, Arvid Sjölander, Katja Fall, Unnur Valdimarsdottir, Fang Fang

Open Access Research article

Anti-EGFR targeted therapy delivered before versus during radiotherapy in locoregionally advanced nasopharyngeal carcinoma: a big-data, intelligence platform-based analysis

Hao Peng, Ling-Long Tang, Xu Liu, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Yuan Zhang, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma

Open Access Research article

Frequency of HPV in oral cavity squamous cell carcinoma

Priscila Marinho de Abreu, Anna Clara Gregório Có, Pedro Leite Azevedo, Isabella Bittencourt do Valle, Karine Gadioli de Oliveira, Sônia Alves Gouvea, Melissa Freitas Cordeiro-Silva, Iúri Drummond Louro, José Roberto Vasconcelos de Podestá, Jeferson Lenzi, Agenor Sena, Elismauro Francisco Mendonça, Sandra Lúcia Ventorin von Zeidler

Open Access Research article

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi

Open Access Research article

Outcomes of Pemetrexed-based chemotherapies in HER2-mutant lung cancers

Yan Wang, Shijia Zhang, Fengying Wu, Jing Zhao, Xuefei Li, Chao Zhao, Shengxiang Ren, Caicun Zhou

Open Access Research article

Nomograms predict long-term survival for patients with periampullary adenocarcinoma after pancreatoduodenectomy

Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin, Shengping Li

Open Access Research article

The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer

Xin An, Fei Xu, Rongzhen Luo, Qiufan Zheng, Jiabin Lu, Yanhua Yang, Tao Qin, Zhongyu Yuan, Yanxia Shi, Wenqi Jiang, Shusen Wang

Open Access Research article

A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer

Raghav Sundar, Sun Young Rha, Hiroki Yamaue, Masahiro Katsuda, Koji Kono, Hyo Song Kim, Chan Kim, Kousaku Mimura, Ley-Fang Kua, Wei Peng Yong

Open Access Research article

Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan

Dai Shida, Yuka Ahiko, Taro Tanabe, Takefumi Yoshida, Shunsuke Tsukamoto, Hiroki Ochiai, Atsuo Takashima, Narikazu Boku, Yukihide Kanemitsu

Open Access Research article

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

Susan Tsai, Laura McOlash, Katie Palen, Bryon Johnson, Christine Duris, Qiuhui Yang, Michael B. Dwinell, Bryan Hunt, Douglas B. Evans, Jill Gershan, Michael A. James

Open Access Case report

Detection of circulating tumor cells in patients with pituitary tumors

Gao Hua, He Yanjiao, Liu Qian, Wang Jichao, Zhang Yazhuo

Open Access Debate

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Riccardo Caccialanza, Emanuele Cereda, Francesco De Lorenzo, Gabriella Farina, Paolo Pedrazzoli

Open Access Case report

Effective treatment of apatinib in desmoplastic small round cell tumor: a case report and literature review

Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan, Lu Pan

Open Access Research article

Patterns of follow up and survivorship care for people with colorectal cancer in new South Wales, Australia: a population-based survey

Jane M. Young, Ivana Durcinoska, Katie DeLoyde, Michael J. Solomon

Open Access Study protocol

Randomized clinical trial testing the efficacy and safety of 0.5% colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of skin field cancerization: study protocol

Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt, Helio Amante Miot

Open Access Research article

Activated innate lymphoid cell populations accumulate in human tumour tissues

Maryam Salimi, Ruozheng Wang, Xuan Yao, Xi Li, Xiyan Wang, Yuhui Hu, Xumei Chang, Peiwen Fan, Tao Dong, Graham Ogg

Open Access Research article

Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells

Jingyao Chen, Yanfeng Zhu, Weiwei Zhang, Xiaoli Peng, Jie Zhou, Fei Li, Bin Han, Xin Liu, Yu Ou, Xiaoping Yu

Open Access Research article

Expression of Reg IV and SOX9 and their correlation in human gastric cancer

Na Zhang, Dandan Chai, Huifen Du, Kesheng Li, Wenguang Xie, Xingwen Li, Rong Yang, Xiaowen Lian, Yang Xu

Open Access Research article

A national cross-sectional study of adherence to timely mammography use in Malta

Danika Marmarà, Vincent Marmarà, Gill Hubbard

Open Access Research article

Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers

Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N. Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H. Nelson, Marcus Q. Bernardini, John M. S. Bartlett, Dimcho Bachvarov, Walter H. Gotlieb, Blake Gilks, Jessica N. McAlpine, Mark W. Nachtigal, Alain Piché, Peter H. Watson, Barbara Vanderhyden, David G. Huntsman, Diane M. Provencher, Anne-Marie Mes-Masson

Open Access Research article

Androgen receptor in advanced breast cancer: is it useful to predict the efficacy of anti-estrogen therapy?

Giuseppe Bronte, Andrea Rocca, Sara Ravaioli, Maurizio Puccetti, Maria Maddalena Tumedei, Emanuela Scarpi, Daniele Andreis, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Anna Fedeli, Elisabetta Pietri, Valeria De Simone, Silvia Asioli, Dino Amadori, Sara Bravaccini

Open Access Research article

Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer

Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López, Miguel A. Mendoza-Catalán

Open Access Research article

Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study

Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto, Nobukazu Fujimoto

Open Access Research article

Impact of a behaviorally-based weight loss intervention on parameters of insulin resistance in breast cancer survivors

Kim L. Dittus, Jean R. Harvey, Janice Y. Bunn, Nathan D. Kokinda, Karen M. Wilson, Jeff Priest, Richard E. Pratley

Open Access Research article

Validation of the Taiwan Chinese version of the EORTC QLQ-CR29 to assess quality of life in colorectal cancer patients

Ming-Hung Shen, Ling-Ping Chen, Thien-Fiew Ho, Ying-Yih Shih, Ching-Shui Huang, Wei-Chu Chie, Chi-Cheng Huang

Open Access Study protocol

Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial

Lorenzo Tosco, Annouschka Laenen, Thomas Gevaert, Isabelle Salmon, Christine Decaestecker, Elai Davicioni, Christine Buerki, Frank Claessens, Johan Swinnen, Karolien Goffin, Raymond Oyen, Wouter Everaerts, Lisa Moris, Gert De Meerleer, Karin Haustermans, Steven Joniau

Open Access Research article

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery

Open Access Research article

The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma

Xin Min Li, Xin Song, Xue Ke Zhao, Shou Jia Hu, Rang Cheng, Shuang Lv, Dan Feng Du, Xiang Yang Zhang, Jian Liang Lu, Jian Wei Ku, Dong Yun Zhang, Yao Zhang, Zong Min Fan, Li Dong Wang

Open Access Research article

Significance of CD133 positive cells in four novel HPV-16 positive cervical cancer-derived cell lines and biopsies of invasive cervical cancer

Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal, Radhika Srinivasan

Open Access Research article

The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito, Fernando Gianfrancesco

Open Access Study protocol

Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia

Ehab Atallah, Charles A. Schiffer, Kevin P. Weinfurt, Mei-Jie Zhang, Jerald P. Radich, Vivian G. Oehler, Javier Pinilla-Ibarz, Michael W. N. Deininger, Li Lin, Richard A. Larson, Michael J. Mauro, Joseph O. Moore, Ellen K. Ritchie, Neil P. Shah, Richard T. Silver, Martha Wadleigh, Jorge Cortes, James Thompson, Jessica Guhl, Mary M. Horowitz, Kathryn E. Flynn

Open Access Research article

The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells

Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui, Wencong Tian

Open Access Research article

Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Chengsheng Wu, Nidhi Gupta, Yung-Hsing Huang, Hai-Feng Zhang, Abdulraheem Alshareef, Alexandra Chow, Raymond Lai

Open Access Research article

A study on volatile organic compounds emitted by in-vitro lung cancer cultured cells using gas sensor array and SPME-GCMS

Reena Thriumani, Ammar Zakaria, Yumi Zuhanis Has-Yun Hashim, Amanina Iymia Jeffree, Khaled Mohamed Helmy, Latifah Munirah Kamarudin, Mohammad Iqbal Omar, Ali Yeon Md Shakaff, Abdul Hamid Adom, Krishna C. Persaud

Open Access Research article

Negative cancer beliefs, recognition of cancer symptoms and anticipated time to help-seeking: an international cancer benchmarking partnership (ICBP) study

Anette Fischer Pedersen, Lindsay Forbes, Kate Brain, Line Hvidberg, Christian Nielsen Wulff, Magdalena Lagerlund, Senada Hajdarevic, Samantha L. Quaife, Peter Vedsted

Open Access Study protocol

Internet-based self-help smoking cessation and alcohol moderation interventions for cancer survivors: a study protocol of two RCTs

Ajla Mujcic, Matthijs Blankers, Brigitte Boon, Rutger Engels, Margriet van Laar

Open Access Research article

Higher satisfaction with an alternative collection device for stool sampling in colorectal cancer screening with fecal immunochemical test: a cross-sectional study

Hye Young Shin, Mina Suh, Kui Son Choi, Sang-Hyun Hwang, Jae Kwan Jun, Dong Soo Han, You Kyoung Lee, Jae Hwan Oh, Chan Wha Lee, Do-Hoon Lee

Open Access Research article

Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer

Chih-Hsing Hung, Fang-Ming Chen, Yi-Ching Lin, Mei-Lan Tsai, Shih-Ling Wang, Yen-Chun Chen, Yi-Ting Chen, Ming-Feng Hou

Open Access Research article

Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer

Yun Liu, Yaying Du, Xiaopeng Hu, Lu Zhao, Wenfei Xia

Open Access Research article

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial

Jacqueline K. Dawson, Tanya B. Dorff, E. Todd Schroeder, Christianne J. Lane, Mitchell E. Gross, Christina M. Dieli-Conwright

Open Access Research article

Laparoscopy-assisted colectomy as an Oncologically safe alternative for patients with stage T4 Colon Cancer: a propensity-matched cohort study

Hao Wang, Xiaoyu Chen, Hao Liu, Tingyu Mou, Haijun Deng, Liying Zhao, Guoxin Li

Open Access Research article

A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira

Open Access Research article

Compared characteristics of current vs. past smokers at the time of diagnosis of a first-time lung or head and neck cancer: a cross-sectional study

Corinne Vannimenus, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Florence Richard, Benjamin Rolland, Corinne Vannimenus, Françoise Weingertner, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Stéphanie Clisant, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Dienabou Sylla, Florence RICHARD, Benjamin Rolland

Open Access Case report

Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report

Zihang Chen, Limin Gao, Mi Wang, Yuan Tang, Sha Zhao, Weiping Liu

Open Access Research article

Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial

Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu

Open Access Research article

Gynecologic cancer survivor preferences for long-term surveillance

Matthew Schlumbrecht, Charlotte Sun, Marilyn Huang, Andrea Milbourne, Diane Bodurka

Open Access Research article

Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation

Marvin A. Böttcher, Janka Held-Feindt, Michael Synowitz, Ralph Lucius, Arne Traulsen, Kirsten Hattermann

Open Access Research article

Chemoradiotherapy versus chemotherapy as adjuvant treatment for localized gastric cancer: a propensity score-matched analysis

Daniel M. Girardi, Mariana A. de Lima, Gabriel C. B. Pereira, Marcelo V. Negrão, Rossana V. M. López, Fernanda C. Capareli, Jorge Sabbaga, Paulo Marcelo G. Hoff

Open Access Research article

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen

Open Access Research article

Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis

Xuan-Anh Phi, Alberto Tagliafico, Nehmat Houssami, Marcel J. W. Greuter, Geertruida H. de Bock

Open Access Research article

Cancer patients’ knowledge about their disease and treatment before, during and after treatment: a prospective, longitudinal study

Ola Berger, Bjørn Henning Grønberg, Jon Håvard Loge, Stein Kaasa, Kari Sand

Open Access Research article

The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model

Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Linh Nguyen, Marcos Perini, Christopher Christophi

Open Access Research article

Pretreatment neutrophil to lymphocyte ratio in determining the prognosis of head and neck cancer: a meta-analysis

Yalian Yu, Hongbo Wang, Aihui Yan, Hailong Wang, Xinyao Li, Jiangtao Liu, Wei Li

Open Access Research article

Sequential tests for monitoring methods to detect elevated incidence – a simulation study

Tammo Konstantin Reinders, Joachim Kieschke, Antje Timmer, Verena Jürgens

Open Access Research article

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

Frank K. Leusink, Eleftherios Koudounarakis, Michael H. Frank, Ronald Koole, Paul J. van Diest, Stefan M. Willems

Open Access Research article

Breast density and breast cancer-specific survival by detection mode

Daniëlle van der Waal, André L. M. Verbeek, Mireille J. M. Broeders

Open Access Research article

Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases

Augustin Balekouzou, Ping Yin, Cavin Epi Bekolo, Christian Maucler Pamatika, Marceline Djeintote, Sylvain Wilfrid Nambei, Bertrand Ba-Mpoutou, Dieubeni Rawago Mandjiza, Chang Shu, Minghui Yin, Tingting Qing, Boniface Koffi

Open Access Research article

Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

Christine Barul, Matthieu Carton, Loredana Radoï, Gwenn Menvielle, Corinne Pilorget, Simona Bara, Isabelle Stücker, Danièle Luce, Anne-Valérie Guizard, Arlette Danzon, Anne-Sophie Woronoff, Michel Velten, Antoine Buemi, Émilie Marrer, Brigitte Trétarre, Marc Colonna, Patricia Delafosse, Paolo Bercelli, Florence Molinié, Simona Bara, Bénédicte Lapotre-Ledoux, Nicole Raverdy, Sylvie Cénée, Oumar Gaye, Florence Guida, Farida Lamkarkach, Loredana Radoï, Marie Sanchez, Isabelle Stücker, Matthieu Carton, Diane Cyr, Annie Schmaus, Joëlle Févotte, Corinne Pilorget, Gwenn Menvielle, Danièle Luce

Open Access Study protocol

The PiGeOn project: protocol for a longitudinal study examining psychosocial, behavioural and ethical issues and outcomes in cancer tumour genomic profiling

Megan Best, Ainsley J. Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L. Ballinger, Dominique Hess, Timothy E. Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs, Phyllis Butow

Open Access Research article

Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma

Lei Jianyong, Li Zhihui, Gong Rixiang, Zhu Jingqiang

Open Access Research article

Adjuvant trastuzumab duration trials in HER2 positive breast cancer – what results would be practice-changing? Persephone investigator questionnaire prior to primary endpoint results

Louise Hiller, Janet A. Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L. Howe, David A. Cameron, David Miles, Andrew M. Wardley, Helena M. Earl

Open Access Research article

Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis

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Open Access Case report

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Debate

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Open Access Research article

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Open Access Research article

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Open Access Correction

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Open Access Technical advance

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Jingbo Yu, Shreekant Parasuraman, Dilan Paranagama, Andrew Bai, Ahmad Naim, David Dubinski, Ruben Mesa

Open Access Research article

Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells

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Open Access Research article

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Open Access Research article

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

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Open Access Debate

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

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Open Access Research article

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Open Access Correction

Correction to: Sepsis increases perioperative metastases in a murine model

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Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis

Danxia Chu, Jie Wu, Kaili Wang, Mengling Zhao, Chunfang Wang, Liuxia Li, Ruixia Guo

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Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma

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Open Access Research article

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Open Access Research article

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Open Access Study protocol

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Fei He, Ren-dong Xiao, Tao Lin, Wei-min Xiong, Qiu-ping Xu, Xu Li, Zhi-qiang Liu, Bao-chang He, Zhi-jian Hu, Lin Cai

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Jia Jin, Yu Gao, Jian Zhang, Leiping Wang, Biyun Wang, Jun Cao, Zhimin Shao, Zhonghua Wang

Open Access Research article

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Veronika Seebacher, Stephan Polterauer, Alexander Reinthaller, Heinz Koelbl, Regina Achleitner, Astrid Berger, Nicole Concin

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Open Access Study protocol

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Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population

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Retrospective analysis of the impact of anthracycline dose reduction and chemotherapy delays on the outcomes of early breast cancer molecular subtypes

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Open Access Study protocol

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Open Access Research article

Chemotherapy for metastatic colon cancer: No effect on survival when the dose is reduced due to side effects

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Open Access Study protocol

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Open Access Research article

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Open Access Case report

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Open Access Study protocol

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Irene Teo, Ratna Singh, Chetna Malhotra, Semra Ozdemir, Rebecca A. Dent, Nesaretnam Barr Kumarakulasinghe, Wee Lee Yeo, Yin Bun Cheung, Rahul Malhotra, Ravindran Kanesvaran, Alethea Chung Pheng Yee, Noreen Chan, Huei Yaw Wu, Soh Mun Chin, Hum Yin Mei Allyn, Grace Meijuan Yang, Patricia Soek Hui Neo, Nivedita V. Nadkarni, Richard Harding, Eric A. Finkelstein

Open Access Research article

Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection

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Open Access Research article

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Open Access Research article

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Open Access Case report

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A. Rezniczek, Clemens B. Tempfer

Open Access Research article

Cost-effectiveness and budget impact analyses of a colorectal cancer screening programme in a high adenoma prevalence scenario using MISCAN-Colon microsimulation model

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Open Access Research article

Impact of differences in adenoma and proximal serrated polyp detection rate on the long-term effectiveness of FIT-based colorectal cancer screening

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Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

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Open Access Research article

Amphotericin B suppresses M2 phenotypes and B7-H1 expression in macrophages to prevent Raji cell proliferation

Jing Zhang, Dongqing Cao, Shuangquan Yu, Lingchao Chen, Daolin Wei, Chang Shen, Lin Zhuang, Qian Wang, Xiaoping Xu, Yin Tong

Open Access Research article

Impact of clinical trial participation on survival in patients with castration-resistant prostate cancer: a multi-center analysis

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Brian J. Morrison, Jason C. Steel, John C. Morris

Open Access Kolorektales Karzinom Case report

FOLFOX activity in a rare case of metastatic colonic adenocarcinoma of the tongue: a case report

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Open Access Research article

Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma

Licun Wu, Walter Blum, Chang-Qi Zhu, Zhihong Yun, Laszlo Pecze, Mikihiro Kohno, Mei-Lin Chan, Yidan Zhao, Emanuela Felley-Bosco, Beat Schwaller, Marc de Perrot

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Shujun Huang, Leigh Murphy, Wayne Xu

Open Access Case report

Computerized tomography findings in calcified signet-ring gastric cancer receiving chemotherapy: a case report

Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang, Long Huang

Open Access Research article

Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter

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Open Access Research article

The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

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Open Access Research article

Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized

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Open Access Research article

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

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Open Access Research article

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Mark A. Healy, Arden M. Morris, Paul Abrahamse, Kevin C. Ward, Ikuko Kato, Christine M. Veenstra

Open Access Research article

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Ashan Fernando, Umesh Jayarajah, Saumyakala Prabashani, Eshani A. Fernando, Sanjeewa A. Seneviratne

Open Access Research article

Extra-capsular growth of lymph node metastasis correlates with poor prognosis and high SOX9 expression in gastric cancer

Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner, Jens Neumann

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Microsatellite instability testing in colorectal cancer using the QiaXcel advanced platform

Isabel Förster, Michael Brockmann, Oliver Schildgen, Verena Schildgen

Open Access Research article

HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner

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Open Access Research article

Distribution of human papilloma virus genotype prevalence in invasive cervical carcinomas and precancerous lesions in the Yangtze River Delta area, China

Hongyun WANG, Xiaodong CHENG, Jing YE, Xiuyun XU, Ying HONG, Long SUI, Zhixue YOU, Xing XIE

Open Access Research article

Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities

Alexander L. Lazarides, Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer III, Brian E. Brigman, William C. Eward

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Validation of the SNACOR clinical scoring system after transarterial chemoembolisation in patients with hepatocellular carcinoma

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Anton S. Prasanth, Umesh Jayarajah, Ranganathan Mohanappirian, Sanjeewa A. Seneviratne

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Aziz Aiderus, Michael A. Black, Anita K. Dunbier

Open Access Astrozytom Case report

An elderly patient presenting with a primary spinal multifocal intradural extramedullary pilocytic astrocytoma: a case report and review of the literature

Devin McBride, Zaid Aljuboori, Eyas M. Hattab, Richard Downs, Shiao Woo, Brian Williams, Joseph Neimat, Eric Burton

Open Access Research article

Comparison of local tumor control in patients with HCC treated with SBRT or TACE: a propensity score analysis

Dominik Bettinger, Eleni Gkika, Michael Schultheiss, Nicolas Glaser, Sophie Lange, Lars Maruschke, Nico Buettner, Simon Kirste, Ursula Nestle, Anca-Ligia Grosu, Robert Thimme, Thomas B. Brunner

Open Access Research article

Irinotecan-platinum combination therapy for previously untreated extensive-stage small cell lung cancer patients: a meta-analysis

Fei Xu, Xiaoli Ren, Yuan Chen, Qianxia Li, Ruichao Li, Yu Chen, Shu Xia

Open Access Research article

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

Lan Lan, Hao Liu, Amber R. Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Xiaoqing Wu, Frank Y. Liu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aubé, Kristi L. Neufeld, Liang Xu

Open Access Research article

Comparison of cervical cancer screening among women with and without hysterectomies: a nationwide population-based study in Korea

Ji-Yeon Shin, Kui Son Choi, Mina Suh, Boyoung Park, Jae Kwan Jun

Open Access Research article

MRI in predicting the response of gastrointestinal stromal tumor to targeted therapy: a patient-based multi-parameter study

Lei Tang, Jian Li, Zi-Yu Li, Xiao-Ting Li, Ji-Fang Gong, Jia-Fu Ji, Ying-Shi Sun, Lin Shen

Open Access Research article

Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

Diego Tosi, Esther Pérez-Gracia, Salima Atis, Nadia Vié, Eve Combès, Mélissa Gabanou, Christel Larbouret, Marta Jarlier, Caroline Mollevi, Adeline Torro, Maguy Del Rio, Pierre Martineau, Céline Gongora

Open Access Research article

Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer

Sarah Ruderman, Adam Eshein, Vesta Valuckaite, Urszula Dougherty, Anas Almoghrabi, Andrew Gomes, Ajaypal Singh, Baldeep Pabla, Hemant K. Roy, John Hart, Marc Bissonnette, Vani Konda, Vadim Backman

Open Access Research article

Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma

Linyan Chen, Hao Zeng, Jiapeng Yang, Yuqing Lu, Dan Zhang, Jinggan Wang, Chienyun Kuang, Sha Zhu, Manni Wang, Xuelei Ma

Open Access Research article

Hornerin promotes tumor progression and is associated with poor prognosis in hepatocellular carcinoma

Shun-Jun Fu, Shun-Li Shen, Shao-Qiang Li, Yun-Peng Hua, Wen-Jie Hu, BeiChu Guo, Bao-Gang Peng

Open Access Research article

A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells

Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E. Lykkesfeldt, Olga Kovalchuk

Open Access Research article

Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma

Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang, Yongbaek Kim

Open Access Research article

Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients

Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz, Asta Försti

Open Access Study protocol

Colorectal liver metastases: surgery versus thermal ablation (COLLISION) – a phase III single-blind prospective randomized controlled trial

Robbert S. Puijk, Alette H. Ruarus, Laurien G. P. H. Vroomen, Aukje A. J. M. van Tilborg, Hester J. Scheffer, Karin Nielsen, Marcus C. de Jong, Jan J. J. de Vries, Babs M. Zonderhuis, Hasan H. Eker, Geert Kazemier, Henk Verheul, Bram B. van der Meijs, Laura van Dam, Natasha Sorgedrager, Veerle M. H. Coupé, Petrousjka M. P. van den Tol, Martijn R. Meijerink, Warner Prevoo, Niels Kok, Arjen L. Diederik, Gert Jan Spaargaren, Colin Sietses, Tjarda N. van Heek, Gian Piero Serafino, Jurgen J. Futterer, Peter B. van den Boezem, Martijn Stommel, Hans de Wilt, Mark Arntz, Sjoerd Jenniskens, Mark Besselink, Otto M. van Delden, Thomas M. van Gulik, Pieter J. Tanis, Krijn P. van Lienden, Mark C. Burgmans, Rutger-Jan Swijnenburg, Arian R. van Erkel, Henk H. Hartgrink, Jan Peringa, Hendrik Marsman, Peter C. A. Jacobs, Michael F. Gerhards, Christiaan van der Leij, Rutger Brans, Marielle M. E. Coolsen, Kees C. H. C. Dejong, Ronald van Dam, Abbas Millad Solouki, Johan A. Dol, Ted W. F. Vink, Eric R. Manusama, Gijs A. Patijn, Vincent B. Nieuwenhuijs, Mark A. J. Meijer, Hans Torrenga, Eric D. J. A. Sonneveld, Jan-Willem W. D. de Waard, Joris J. A. Joosten, Cees Verhoef, Adriaan Moelker, Dirk Jan Grunhagen, Bas Groot Koerkamp, Jeroen Hagendoorn, I.Q Molenaar, Rutger C. G. Bruijnen, Karin C. M. J. van Nieuwkerk, Peter van de Ven, Astrid de Wind, Han Anema, Jacob de Bakker, Martijn W. H. Leenders, Tessa Hellingman, Nicole van Grieken, Sanne Nieuwenhuizen, Bart Geboers, David J. Breen, Luca Aldrighetti, Francesco De Cobelli, Francesca Ratti, Paolo Marra, Thomas Albrecht, P. D. Muller, Cornelis van Kuijk

Open Access Research article

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes

Mona M. Saber, Abdulaziz M. Al-mahallawi, Noha N. Nassar, Björn Stork, Samia A. Shouman

Open Access Research article

Galectin 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas

Falk Wehrhan, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam, Marco Kesting, Manuel Weber

Open Access Research article

Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling

Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han, Guo-Hui Fu

Open Access Lungenkarzinome Case report

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis

Hironori Uruga, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Kazuma Kishi

Open Access Research article

PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue

Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa, Yasuhiro Koh

Open Access Research article

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

Xiaodong Sun, Tongzhong Ju, Richard D. Cummings

Open Access Technical advance

Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study

Cecily P. Vaughn, José Luis Costa, Harriet E. Feilotter, Rosella Petraroli, Varun Bagai, Anna Maria Rachiglio, Federica Zito Marino, Bastiaan Tops, Henriette M. Kurth, Kazuko Sakai, Andrea Mafficini, Roy R. L. Bastien, Anne Reiman, Delphine Le Corre, Alexander Boag, Susan Crocker, Michel Bihl, Astrid Hirschmann, Aldo Scarpa, José Carlos Machado, Hélène Blons, Orla Sheils, Kelli Bramlett, Marjolijn J. L. Ligtenberg, Ian A. Cree, Nicola Normanno, Kazuto Nishio, Pierre Laurent-Puig

Open Access Research article

Lesions of “uncertain malignant potential” in the breast (B3) identified with mammography screening

Christiane Richter-Ehrenstein, Katharina Maak, Sonja Röger, Tilman Ehrenstein

Open Access Research article

Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networks

Eric J. Fish, Kristopher J. Irizarry, Patricia DeInnocentes, Connor J. Ellis, Nripesh Prasad, Anthony G. Moss, R. Curt Bird

Open Access Research article

A novel approach to monitoring the efficacy of anti-tumor treatments in animal models: combining functional MRI and texture analysis

Ming Meng, Huadan Xue, Jing Lei, Qin Wang, Jingjuan Liu, Yuan Li, Ting Sun, Haiyan Xu, Zhengyu Jin

Open Access Debate

Circular RNA: new star, new hope in cancer

Zikang Zhang, Qing Xie, Dongmei He, Yuan Ling, Yuchao Li, Jiangbin Li, Hua Zhang

Open Access Research article

Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma

Jing-jing Yu, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-xiang Zhang, Zhi-yong Huang, Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen, Xiao-ping Chen

Open Access Research article

Expression of oxidized protein tyrosine phosphatase and γH2AX predicts poor survival of gastric carcinoma patients

Usama Khamis Hussein, Ho Sung Park, Jun Sang Bae, Kyoung Min Kim, Yun Jo Chong, Chan Young Kim, Keun Sang Kwon, Myoung Ja Chung, Ho Lee, Myoung Jae Kang, Woo Sung Moon, Kyu Yun Jang

Open Access Research article

The crucial role of blood VEGF kinetics in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Chang-Chun Hsiao, Chao-Cheng Huang, Li-Hsueh Shih, Su-Wei Chen, Shau-Hsuan Li

Open Access Research article

Poor prognosis of nucleophosmin overexpression in solid tumors: a meta-analysis

Siying Chen, Hairong He, Yan Wang, Leichao Liu, Yang Liu, Haisheng You, Yalin Dong, Jun Lyu

Open Access Mammakarzinom Case report

Successfully treatment by eribulin in visceral crisis: a case of lymphangitic carcinomatosis from metastatic breast cancer

Jean-David Fumet, Mark Wickre, Jean-Philippe Jacquot, Marie-Helene Bizollon, Adrien Melis, André Vanoli, Erika Viel

Open Access Research article

Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model

Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber, Robert M. Hoffman

Open Access Research article

Early detection of colorectal adenocarcinoma: a clinical decision support tool based on plasma porphyrin accumulation and risk factors

Manuela Lualdi, Adalberto Cavalleri, Luigi Battaglia, Ambrogio Colombo, Giulia Garrone, Daniele Morelli, Emanuele Pignoli, Elisa Sottotetti, Ermanno Leo

Open Access Research article

Impact of viral presence in tumor on gene expression in non-small cell lung cancer

Youngchul Kim, Christine M. Pierce, Lary A. Robinson

Open Access Study protocol

Evaluation of postoperative ascites after somatostatin infusion following hepatectomy for hepatocellular carcinoma by laparotomy: a multicenter randomized double-blind controlled trial (SOMAPROTECT)

Kayvan Mohkam, Michel Rayar, Jean-Philippe Adam, Fabrice Muscari, Agnès Rode, Philippe Merle, Pierre Pradat, Stéphanie Bauler, Isabelle Delfour, Laurence Chiche, Christian Ducerf, Karim Boudjema, Mickaël Lesurtel, Christophe Laurent, Jean-Yves Mabrut

Open Access Study protocol

Study protocol for a controlled trial of an eHealth system utilising patient reported outcome measures for personalised treatment and care: PROMPT-Care 2.0

Afaf Girgis, Ivana Durcinoska, Martha Gerges, Nasreen Kaadan, Anthony Arnold, Joseph Descallar, Geoff P. Delaney, Sandra Avery, Martin Carolan, Stephen Della-Fiorentina, Kenneth Masters, Andrew Miller, Weng Ng, Tiffany Sandell, Thomas T. Tran, Janelle V. Levesque

Open Access Research article

Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study

Supannee Promthet, Nopparat Songserm, Somkiattiyos Woradet, Chamsai Pientong, Tipaya Ekalaksananan, Surapon Wiangnon, Akhtar Ali

Open Access Research article

Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysis

Qiuping Li, Chao Ma, Zhihui Zhang, Suhua Chen, Weiguo Zhi, Lei Zhang, Guoyao Zhang, Lei Shi, Fei Cao, Tianjiang Ma

Open Access Research article

ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells

Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova, Miroslava Matuskova

Open Access Research article

Survival and prognostic factors in conventional central chondrosarcoma

Julian Fromm, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Christof Birkenmaier, Falk Roeder, Volkmar Jansson, Hans Roland Dürr

Open Access Research article

Association of tamoxifen resistance and lipid reprogramming in breast cancer

Susanne Hultsch, Matti Kankainen, Lassi Paavolainen, Ruusu-Maaria Kovanen, Elina Ikonen, Sara Kangaspeska, Vilja Pietiäinen, Olli Kallioniemi

Open Access Study protocol

RESPONDER – diagnosis of pathological complete response by vacuum-assisted biopsy after neoadjuvant chemotherapy in breast Cancer - a multicenter, confirmative, one-armed, intra-individually-controlled, open, diagnostic trial

Joerg Heil, Peter Sinn, Hannah Richter, André Pfob, Benedikt Schaefgen, André Hennigs, Fabian Riedel, Bettina Thomas, Marc Thill, Markus Hahn, Jens-Uwe Blohmer, Sherko Kuemmel, Maria Margarete Karsten, Mattea Reinisch, John Hackmann, Toralf Reimer, Geraldine Rauch, Michael Golatta

Open Access Research article

Contribution of KCTD12 to esophageal squamous cell carcinoma

Mohammad Reza Abbaszadegan, Negin Taghehchian, Liping Li, Azadeh Aarabi, Meysam Moghbeli

Open Access Study protocol

Protocol for the P3BEP trial (ANZUP 1302): an international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours

Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis, Peter Grimison

Open Access Research article

An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines

Radhika S. Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael Bittner

Open Access Research article

Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo

Myra O. Villareal, Yuki Sato, Kyoko Matsuyama, Hiroko Isoda

Open Access Research article

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells

Wenming Liu, Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang, Wei Huang, Dongyan Shen, Zhongquan Qi

Open Access Research article

Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival

David Roder, Margaret Davy, Sid Selva-Nayagam, Sellvakumaram Paramasivam, Jacqui Adams, Dorothy Keefe, Ian Olver, Caroline Miller, Elizabeth Buckley, Kate Powell, Kellie Fusco, Dianne Buranyi-Trevarton, Martin K. Oehler

Open Access Research article

Local response and pathologic fractures following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for spinal metastases - a randomized controlled trial

Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus, Harald Rief

Open Access Research article

The impact of mammography screening programmes on incidence of advanced breast cancer in Europe: a literature review

M. J. M. Broeders, P. Allgood, S. W. Duffy, S. Hofvind, I. D. Nagtegaal, E. Paci, S. M. Moss, L. Bucchi

Open Access Study protocol

Robot assisted radical cystectomy versus open radical cystectomy in bladder cancer (RACE): study protocol of a non-randomized comparative effectiveness study

C. J. Wijburg, C. T. J. Michels, J. R. Oddens, J. P. C. Grutters, J. A. Witjes, M. M. Rovers

Open Access Research article

Angiogenesis and radiological tumor growth in patients with glioblastoma

Vilde Elisabeth Mikkelsen, Anne Line Stensjøen, Unn Sophie Granli, Erik Magnus Berntsen, Øyvind Salvesen, Ole Solheim, Sverre Helge Torp

Open Access Research article

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder, John Kevin Olynyk

Open Access Study protocol

Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John M. Mackey, Kerry S. Courneya, Edith Pituskin, Richard B. Thompson

Open Access Research article

Prognostic value of differentiation status in gastric cancer

Fan Feng, Jinqiang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian, Hongwei Zhang

Open Access Study protocol

Impact of breast cancer on prospective memory functioning assessed by virtual reality and influence of sleep quality and hormonal therapy: PROSOM-K study

Mylène Duivon, Joy Perrier, Florence Joly, Idlir Licaj, Jean-Michel Grellard, Bénédicte Clarisse, Christelle Lévy, Philippe Fleury, Sophie Madeleine, Nicolas Lefèvre, Géraldine Rauchs, Grégory Lecouvey, Florence Fraisse, Fausto Viader, Francis Eustache, Béatrice Desgranges, Bénédicte Giffard

Open Access Research article

Relationship between the Ki67 index and its area based approximation in breast cancer

Muhammad Khalid Khan Niazi, Caglar Senaras, Michael Pennell, Vidya Arole, Gary Tozbikian, Metin N. Gurcan

Open Access Research article

The plasma glutamate concentration as a complementary tool to differentiate benign PET-positive lung lesions from lung cancer

K. Vanhove, P. Giesen, O. E. Owokotomo, L. Mesotten, E. Louis, Z. Shkedy, M. Thomeer, P. Adriaensens

Open Access Research article

Tumor necrosis as a prognostic variable for the clinical outcome in patients with renal cell carcinoma: a systematic review and meta-analysis

Lijin Zhang, Zhenlei Zha, Wei Qu, Hu Zhao, Jun Yuan, Yejun Feng, Bin Wu

Open Access Research article

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Askar Abubakar, Stephanie H. Lim, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin, Cheok Soon Lee

Open Access Research article

Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas

Xue Song, Xiao-Hong Shu, Mo-Li Wu, Xu Zheng, Bin Jia, Qing-You Kong, Jia Liu, Hong Li

Open Access Research article

Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells

Roberta Fajka-Boja, Annamária Marton, Anna Tóth, Péter Blazsó, Vilmos Tubak, Balázs Bálint, István Nagy, Zoltán Hegedűs, Csaba Vizler, Robert L. Katona

Open Access Study protocol

Topical steroid versus placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving chemoradiotherapy: the study protocol of J-SUPPORT 1602 (TOPICS study), a randomized double-blinded phase 3 trial

Sadamoto Zenda, Takuhiro Yamaguchi, Tomoya Yokota, Tempei Miyaji, Tomoe Mashiko, Mari Tanaka, Masahito Yonemura, Misaki Takeno, Tomoka Okano, Toshikatsu Kawasaki, Yuko Nakamori, Shinobu Ishii, Sanae Shimada, Miyuki Kanamaru, Yosuke Uchitomi

Open Access Research article

Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

Lenka Kalinkova, Iveta Zmetakova, Bozena Smolkova, Gabriel Minarik, Tatiana Sedlackova, Viera Horvathova Kajabova, Zuzana Cierna, Michal Mego, Ivana Fridrichova

Open Access Correction

Correction to: Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients

Elisabetta Venturelli, Annalisa Orenti, Aline S. C. Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini, Elia Biganzoli

Open Access Study protocol

CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer

Astrid E. Slagter, Edwin P. M. Jansen, Hanneke W. M. van Laarhoven, Johanna W. van Sandick, Nicole C. T. van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C. C. M. Hulshof, Henk Boot, Maartje Los, Laurens V. Beerepoot, Frank P. J. Peters, Geke A. P. Hospers, Boudewijn van Etten, Henk H. Hartgrink, Mark I. van Berge Henegouwen, Grard A. P. Nieuwenhuijzen, Richard van Hillegersberg, Donald L. van der Peet, Heike I. Grabsch, Marcel Verheij

Open Access Research article

Nomograms for predicting risk of locoregional recurrence and distant metastases for esophageal cancer patients after radical esophagectomy

Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang, Chang-Lin Zou

Open Access Study protocol

Light therapy as a treatment of cancer-related fatigue in (non-)Hodgkin lymphoma survivors (SPARKLE trial): study protocol of a multicenter randomized controlled trial

Daniëlle E. J. Starreveld, Laurien A. Daniels, Heiddis B. Valdimarsdottir, William H. Redd, Jessie L. de Geus, Sonia Ancoli-Israel, Susan Lutgendorf, Catharina M. Korse, Jacobien M. Kieffer, Flora E. van Leeuwen, Eveline M. A. Bleiker

Open Access Study protocol

The ‘Be Cancer Alert Campaign’: protocol to evaluate a mass media campaign to raise awareness about breast and colorectal cancer in Malaysia

Désirée Schliemann, Michael Donnelly, Maznah Dahlui, Siew Yim Loh, Nor Saleha Binti Tamin Ibrahim, Saunthari Somasundaram, Conan Donnelly, Tin Tin Su

Open Access Research article

Local ablation or radioembolization of colorectal cancer metastases: comorbidities or older age do not affect overall survival

Ricarda Seidensticker, Robert Damm, Julia Enge, Max Seidensticker, Konrad Mohnike, Maciej Pech, Peter Hass, Holger Amthauer, Jens Ricke

Open Access Research article

The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer

Zheng Feng, Hao Wen, Xingzhu Ju, Rui Bi, Xiaojun Chen, Wentao Yang, Xiaohua Wu

Open Access Case report

Synchronous anal canal carcinoma in a heterosexual couple

Lucas C. Mendez, Eugene Hsieh, Craig C. Earle, Shun Wong

Open Access Research article

Could local surgery improve survival in de novo stage IV breast cancer?

Zhenchong Xiong, Guangzheng Deng, Jin Wang, Xing Li, Xinhua Xie, Zeyu Shuang, Xi Wang

Open Access Research article

Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial

Kristin Schink, Hans J. Herrmann, Raphaela Schwappacher, Julia Meyer, Till Orlemann, Elisabeth Waldmann, Bernd Wullich, Andreas Kahlmeyer, Rainer Fietkau, Dorota Lubgan, Matthias W. Beckmann, Carolin Hack, Wolfgang Kemmler, Jürgen Siebler, Markus F. Neurath, Yurdagül Zopf

Open Access Case report

Clinical benefit and radiological response with BRAF inhibitor in a patient with recurrent ameloblastoma harboring V600E mutation

Gustavo S. Fernandes, Daniel M. Girardi, João Paulo G. Bernardes, Felipe P. Fonseca, Eduardo R. Fregnani

Open Access Ösophaguskarzinom Case report

Genomic profiles of primary and metastatic esophageal adenocarcinoma identified via digital sorting of pure cell populations: results from a case report

Federica Isidori, Deborah Malvi, Silvia Fittipaldi, Claudio Forcato, Isotta Bozzarelli, Claudia Sala, Giovanni Raulli, Antonia D’Errico, Michelangelo Fiorentino, Marco Seri, Kausilia K. Krishnadath, Elena Bonora, Sandro Mattioli, Sandro Mattioli, Maria Luisa Lugaresi, Elena Bonora, Federica Isidori, Isotta Bozzarelli, Antonietta D’Errico, Deborah Malvi, Gastone Castellani, Claudia Sala, Kausilia K. Krishnadath, Roberto Fiocca, Luca Mastracci, Jari Räsänen, Henna Söderström

Open Access Study protocol

Study protocol: HepaT1ca – an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies

Damian J. Mole, Jonathan A. Fallowfield, Timothy J. Kendall, Fenella Welsh, Scott I. Semple, Velicia Bachtiar, Matt Kelly, Stephen J. Wigmore, O. James Garden, Henry R. Wilman, Rajarshi Banerjee, Myrddin Rees, Michael Brady

Open Access Research article

Validation of a frailty index in older cancer patients with solid tumours

A. L. McCarthy, N. M. Peel, K. M. Gillespie, R. Berry, E. Walpole, P. Yates, R. E. Hubbard

Open Access Research article

Polymorphisms in the H19 gene and the risk of lung Cancer among female never smokers in Shenyang, China

Zhihua Yin, Zhigang Cui, Hang Li, Juan Li, Baosen Zhou

Open Access Research article

Early cost-effectiveness of tumor infiltrating lymphocytes (TIL) for second line treatment in advanced melanoma: a model-based economic evaluation

Valesca P. Retèl, Lotte M. G. Steuten, Marnix H. Geukes Foppen, Janne C. Mewes, Melanie A. Lindenberg, John B. A. G. Haanen, Wim H. van Harten

Open Access Research article

MiR-126 in intestinal-type sinonasal adenocarcinomas: exosomal transfer of MiR-126 promotes anti-tumour responses

Marco Tomasetti, Massimo Re, Federica Monaco, Simona Gaetani, Corrado Rubini, Andrea Bertini, Ernesto Pasquini, Cristiana Bersaglieri, Massimo Bracci, Sara Staffolani, Mariastella Colomba, Armando Gregorini, Matteo Valentino, Adriano Tagliabracci, Massimo Bovenzi, Jiri Neuzil, Monica Amati, Lory Santarelli

Open Access Research article

Development and validation of a new predictive model for breast cancer survival in New Zealand and comparison to the Nottingham prognostic index

J. Mark Elwood, Essa Tawfiq, Sandar TinTin, Roger J. Marshall, Tung M. Phung, Ian Campbell, Vernon Harvey, Ross Lawrenson

Open Access Study protocol

EXclusion of non-Involved uterus from the Target Volume (EXIT-trial): an individualized treatment for locally advanced cervical cancer using modern radiotherapy and imaging techniques

Katrien Vandecasteele, Philippe Tummers, Mieke Van Bockstal, Pieter De Visschere, Tom Vercauteren, Werner De Gersem, Hannelore Denys, Eline Naert, Amin Makar, Wilfried De Neve

Open Access Research article

Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer

Francesca Andriani, Elena Landoni, Mavis Mensah, Federica Facchinetti, Rosalba Miceli, Elda Tagliabue, Marta Giussani, Maurizio Callari, Loris De Cecco, Mario Paolo Colombo, Luca Roz, Ugo Pastorino, Gabriella Sozzi

Open Access Research article

Detection of PIK3/AKT pathway in Moroccan population with triple negative breast cancer

Farah Jouali, Nabila Marchoudi, Salwa Talbi, Basma Bilal, Mohamed El Khasmi, Houria Rhaissi, Jamal Fekkak

Open Access Research article

Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatment

Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen

Open Access Correction

Correction to: Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo

Myra O. Villareal, Yuki Sato, Kyoko Matsuyama, Hiroko Isoda

Open Access Study protocol

Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matching ‘liquid biopsy’ and quantitative tumor modeling

Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E. Cardenas, Anthony Lucci, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Ying Yuan, Diana L. Urbauer, Yao Ding, Shane Ikner, Vi Dinh, Baher A. Elgohari, Jason M. Johnson, Heath D. Skinner, G. Brandon Gunn, Adam S. Garden, Jack Phan, David I. Rosenthal, William H. Morrison, Steven J. Frank, Katherine A. Hutcheson, Abdallah S. R. Mohamed, Stephen Y. Lai, Renata Ferrarotto, Michael P. MacManus, Clifton D. Fuller

Open Access Research article

A new promising way of maintenance therapy in advanced ovarian cancer: a comparative clinical study

Vsevolod I. Kiselev, Levon A. Ashrafyan, Ekaterina L. Muyzhnek, Evgeniya V. Gerfanova, Irina B. Antonova, Olga I. Aleshikova, Fazlul H. Sarkar

Open Access Case report

Endometriosis-associated recto-sigmoid cancer: a case report

Ningning Li, Weixun Zhou, Lin Zhao, Jiaolin Zhou

Open Access Research article

A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK

Alan White, Lucy Ironmonger, Robert J. C. Steele, Nick Ormiston-Smith, Carina Crawford, Amanda Seims

Open Access Research article

A trend towards a more intense adjuvant treatment of low-grade-gliomas in tertiary centers in Germany after RTOG 9802 – results from a multi-center survey

Christoph Straube, Kerstin A. Kessel, Friederike Schmidt-Graf, Sandro M. Krieg, Bernhard Meyer, Jens Gempt, Stephanie E. Combs

Open Access Research article

Prediction of perioperative complications after robotic-assisted radical hysterectomy for cervical cancer using the modified surgical Apgar score

Seon Hee Park, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim

Open Access Research article

PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity

Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song, Jun Zhu

Open Access Review

Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma

Liang Zhong, Yutong Liu, Kai Wang, Zhijing He, Zhaojian Gong, Zhili Zhao, Yaocheng Yang, Xiaofei Gao, Fangjie Li, Hanjiang Wu, Sheng Zhang, Lin Chen

Open Access Research article

The supportive care needs of women experiencing gynaecological cancer: a Western Australian cross-sectional study

Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray, Yvonne L. Hauck

Open Access Study protocol

Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma

Emily Z. Keung, Alexander J. Lazar, Keila E. Torres, Wei-Lien Wang, Janice N. Cormier, B. Ashleigh Guadagnolo, Andrew J. Bishop, Heather Lin, Kelly K. Hunt, Justin Bird, Valerae O. Lewis, Shreyaskumar R. Patel, Jennifer A. Wargo, Neeta Somaiah, Christina L. Roland

Open Access Study protocol

Noncontrast magnetic resonance imaging versus ultrasonography for hepatocellular carcinoma surveillance (MIRACLE-HCC): study protocol for a prospective randomized trial

Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh, Myeong-Jin Kim

Open Access Study protocol

Preventing adverse events of chemotherapy by educating patients about the nocebo effect (RENNO study) – study protocol of a randomized controlled trial with gastrointestinal cancer patients

Julia Quidde, Yiqi Pan, Melanie Salm, Armin Hendi, Sven Nilsson, Karin Oechsle, Alexander Stein, Yvonne Nestoriuc

Open Access Research article

A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study

Hongwei Liu, Zhaojun Liu, Xue-wei Liu, Si Xu, Lei Wang, Yang Liu, Jing Zhou, Liankun Gu, Yan Gao, Xiao-yong Liu, Huidong Shi, Zheng Sun, Dajun Deng

Open Access Research article

RETRACTED ARTICLE: Knockdown long non-coding RNA ANRIL inhibits proliferation, migration and invasion of HepG2 cells by down-regulation of miR-191

Deyu Huang, Chunhua Bi, Qingxi Zhao, Xueli Ding, Cheng Bian, Hui Wang, Ting Wang, Hua Liu

Open Access Research article

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study

Antonia Pahl, Anja Wehrle, Sarah Kneis, Albert Gollhofer, Hartmut Bertz

Open Access Onkologische Therapie Case report

Rare perianal extramammary Paget disease successfully treated using topical Imiquimod therapy

Jéssica Silva dos Santos, Gabriel Alves Bonafé, José Aires Pereira, Danilo Toshio Kanno, Carlos Augusto Real Martinez, Manoela Marques Ortega

Open Access Research article

Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma

Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli, Jürgen Grünberg

Open Access Research article

Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer

Minbin Chen, Baohu Jiang, Bangshun He, Min Tang, Ping Wang, Li Chen, Jianwei Lu, Peihua Lu

Open Access Research article

Greater family size is associated with less cancer risk: an ecological analysis of 178 countries

Wenpeng You, Frank J Rühli, Renata J Henneberg, Maciej Henneberg

Open Access Research article

Serum Se, Ni, and As are associated with HPV infection and CIN2+ among Uyghur women in rural China

Guzhalinuer Abulizi, Yuan-Yuan Zhang, Patiman Mijiti, Hua Li, Guzhalinuer Abuduxikuer, Jing Cai, Zhi-Hong Dong, Gulimire Naizhaer, Xiu-Wei Yang, Miherinisha Maimaiti, Ling-Lu, Guligeina Abudurexiti, Gulixian Tuerxun, Kailibinuer Aierken, Yu-Jie Jiang, Li-Li, Ming-Yue Zhu, Lu Zhang, Tangnuer Abulimiti

Open Access Research article

Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria

Juliane Hoyer, Georgia Vasileiou, Steffen Uebe, Marius Wunderle, Cornelia Kraus, Peter A. Fasching, Christian T. Thiel, Arndt Hartmann, Matthias W. Beckmann, Michael P. Lux, André Reis

Open Access Study protocol

The BETTER WISE protocol: building on existing tools to improve cancer and chronic disease prevention and screening in primary care for wellness of cancer survivors and patients – a cluster randomized controlled trial embedded in a mixed methods design

Donna Patricia Manca, Carolina Fernandes, Eva Grunfeld, Kris Aubrey-Bassler, Melissa Shea-Budgell, Aisha Lofters, Denise Campbell-Scherer, Nicolette Sopcak, Mary Ann O’Brien, Christopher Meaney, Rahim Moineddin, Kerry McBrien, Ginetta Salvalaggio, Paul Krueger

Open Access Research article

Molecular iodine inhibits the expression of stemness markers on cancer stem-like cells of established cell lines derived from cervical cancer

Gabriele Davide Bigoni-Ordóñez, Elizabeth Ortiz-Sánchez, Pedro Rosendo-Chalma, Heriberto A Valencia-González, Carmen Aceves, Alejandro García-Carrancá

Open Access Research article

The efficacy and safety of anti-CD19/CD20 chimeric antigen receptor- T cells immunotherapy in relapsed or refractory B-cell malignancies:a meta-analysis

Hui Zhou, Yuling Luo, Sha Zhu, Xi Wang, Yunuo Zhao, Xuejin Ou, Tao Zhang, Xuelei Ma

Open Access Study protocol

Genetic variation in gonadal impairment in female survivors of childhood cancer: a PanCareLIFE study protocol

Anne-Lotte L. F. van der Kooi, Eva Clemens, Linda Broer, Oliver Zolk, Julianne Byrne, Helen Campbell, Marleen van den Berg, Claire Berger, Gabriele Calaminus, Uta Dirksen, Jeanette Falck Winther, Sophie D Fosså, Desiree Grabow, Riccardo Haupt, Melanie Kaiser, Tomas Kepak, Leontien Kremer, Jarmila Kruseova, Dalit Modan-Moses, Andreas Ranft, Claudia Spix, Peter Kaatsch, Joop S. E. Laven, Eline van Dulmen-den Broeder, André G. Uitterlinden, Marry M. van den Heuvel-Eibrink, Kylie O’Brien, Thorsten Langer, Anja Borgmann-Staudt, Antoinette am Zehnhoff-Dinnesen, Claudia Kuehni, Katja Baust, Floor van Leeuwen, Gabriele Strauss, R Haupt, M L Garré, Alison Leiper, H Lackner, Anna Panasiuk, Maryna Krawczuk-Rybak, Marina Kunstreich, Holger Cario, Stefan Bielack, Joanna Stefanowicz, Victoria Grandage

Open Access Research article

Second primary colorectal cancer after the initial primary colorectal cancer

Lin Yang, Zhenchong Xiong, Qian Kun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Xiaojun Xia, Liangping Xia

Open Access Research article

An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project

Giacomo Pelizzari, Grazia Arpino, Laura Biganzoli, Saverio Cinieri, Michelino De Laurentiis, Lucia Del Mastro, Angelo Di Leo, Stefania Gori, Valentina Guarneri, Paolo Marchetti, Fabio Puglisi

Open Access Research article

Data mining of digitized health records in a resource-constrained setting reveals that timely immunophenotyping is associated with improved breast cancer outcomes

Arturo López-Pineda, Mario F Rodríguez-Moran, Cleto Álvarez-Aguilar, Sarah M Fuentes Valle, Román Acosta-Rosales, Ami S Bhatt, Shruti N Sheth, Carlos D Bustamante

Open Access Study protocol

Engaging the older cancer patient; Patient Activation through Counseling, Exercise and Mobilization – Pancreatic, Biliary tract and Lung cancer (PACE-Mobil-PBL) - study protocol of a randomized controlled trial

Marta Kramer Mikkelsen, Cecilia Margareta Lund, Anders Vinther, Anders Tolver, Anne-Mette Ragle, Julia Sidenius Johansen, Inna Chen, Lotte Engell-Noerregaard, Finn Ole Larsen, Bo Zerahn, Dorte Lisbet Nielsen, Mary Jarden

Open Access Research article

Lymphovascular invasion and extranodal tumour extension are risk indicators of breast cancer related lymphoedema: an observational retrospective study with long-term follow-up

Marco Invernizzi, Chiara Corti, Gianluca Lopez, Anna Michelotti, Luca Despini, Donatella Gambini, Daniele Lorenzini, Elena Guerini-Rocco, Stefania Maggi, Marianna Noale, Nicola Fusco

Open Access Research article

Cross-sectional increase of adherence to multidisciplinary tumor board decisions

S. Hollunder, U. Herrlinger, M. Zipfel, J. Schmolders, V. Janzen, T. Thiesler, E. Güresir, A. Schröck, F. Far, T. Pietsch, D. Pantelis, D. Thomas, S. Vornholt, N. Ernstmann, T. Manser, M. Neumann, B. Funke, I. G. H. Schmidt-Wolf

Open Access Research article

Secondary spontaneous pneumothorax in patients with sarcoma treated with Pazopanib, a case control study

Bruce Sabath, Hasan A Muhammad, Amulya Balagani, David E Ost, Erik Vakil, Tahreem Ahmed, Macarena R Vial, Horiana B Grosu

Open Access Research article

The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer

Kwan Ho Lee, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Sung-Im Do, Seoung Wan Chae, Chan Heun Park

Open Access Review

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

Krzysztof Marek Mrozik, Orest William Blaschuk, Chee Man Cheong, Andrew Christopher William Zannettino, Kate Vandyke

Open Access Research article

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines

Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda, De-Chen Lin, Henry Yang, H. Phillip Koeffler

Open Access Research article

Prognostic value of the fibrinogen/albumin ratio (FAR) in patients with operable soft tissue sarcoma

Yao Liang, Wei Wang, Yi Que, Yuanxiang Guan, Wei Xiao, Cheng Fang, Xing Zhang, Zhiwei Zhou

Open Access Research article

Engrailed-2 (EN2) – a novel biomarker in epithelial ovarian cancer

Sophie Elena McGrath, Nicola Annels, Thumuluru K. Madhuri, Anil Tailor, Simon A. Butler-Manuel, Richard Morgan, Hardev Pandha, Agnieszka Michael

Open Access Study protocol

Study on safety of laparoscopic total gastrectomy for clinical stage I gastric cancer: the protocol of the CLASS02–01 multicenter randomized controlled clinical trial

Hongyong He, Haojie Li, Xiangqian Su, Ziyu Li, Peiwu Yu, Hua Huang, Changming Huang, Jianxin Ye, Yong Li, Jian Suo, Jiren Yu, Guoxin Li, Zekuan Xu, Gang Zhao, Hui Cao, Jiankun Hu, Xiaohui Du, Fenglin Liu, Yihong Sun

Open Access Research article

PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?

Ramón Cantero-Cid, José Casas-Martin, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Avendaño-Ortiz, Marta Casarrubios, Karla Montalbán-Hernández, Ignacio Villacañas-Gil, Laura Guerra-Pastrián, Begoña Peinado, Cristóbal Marcano, Luis A Aguirre, Eduardo López-Collazo

Open Access Research article

Efficacy of anti-PD-1/PD-L1 antibodies after discontinuation due to adverse events in non-small cell lung cancer patients (HANSHIN 0316)

Motoko Tachihara, Shunichi Negoro, Takako Inoue, Motohiro Tamiya, Yuki Akazawa, Takeshi Uenami, Yoshiko Urata, Yoshihiro Hattori, Akito Hata, Nobuyuki Katakami, Soichiro Yokota

Open Access Case report

A case report of isolated distal upper extremity weakness due to cerebral metastasis involving the hand knob area

András Folyovich, Viktória Varga, György Várallyay, Lajos Kozák, Mária Bakos, Erika Scheidl, Katalin Anna Béres-Molnár, Zita Kajdácsi, Dániel Bereczki

Open Access Research article

The rs2147578 C > G polymorphism in the Inc-LAMC2–1:1 gene is associated with increased neuroblastoma risk in the Henan children

Tianyou Yang, Zhuorong Zhang, Jiao Zhang, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Jiahao Li, Huimin Xia, Jing He, Yan Zou

Open Access Research article

The improved cure fraction for esophageal cancer in Linzhou city

Shuzheng Liu, Lanwei Guo, Qiong Chen, Liang Yu, Bianyun Li, Xiaoqin Cao, Xibin Sun

Open Access Research article

Health utility scores of family caregivers for leukemia patients measured by EQ-5D-3L: a cross-sectional survey in China

Hongjuan Yu, Huan Zhang, Jinjin Yang, Chaojie Liu, Chengfang Lu, Hongbin Yang, Weidong Huang, Jin Zhou, Wenqi Fu, Linmei Shi, Yan Yan, Guoxiang Liu, Limin Li

Open Access Research article

Patients’ quality of life during active cancer treatment: a qualitative study

Jordan Sibeoni, Camille Picard, Massimiliano Orri, Mathilde Labey, Guilhem Bousquet, Laurence Verneuil, Anne Revah-Levy

Open Access Research article

Uc.416 + A promotes epithelial-to-mesenchymal transition through miR-153 in renal cell carcinoma

Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Thang Pham Quoc, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Fumi Kawakami, Jose A Karam, Kanishka Sircar, Akio Matsubara, Wataru Yasui

Open Access Study protocol

Population-based phase II trial of stereotactic ablative radiotherapy (SABR) for up to 5 oligometastases: SABR-5

Robert Olson, Mitchell Liu, Alanah Bergman, Sonya Lam, Fred Hsu, Benjamin Mou, Tanya Berrang, Ante Mestrovic, Nick Chng, Derek Hyde, Quinn Matthews, Chad Lund, Daniel Glick, Howard Pai, Parminder Basran, Hannah Carolan, Boris Valev, Shilo Lefresene, Scott Tyldesley, Devin Schellenberg

Open Access Research article

Dynapenia could predict chemotherapy-induced dose-limiting neurotoxicity in digestive cancer patients

Damien Botsen, Marie-Amélie Ordan, Coralie Barbe, Camille Mazza, Marine Perrier, Johanna Moreau, Mathilde Brasseur, Yohann Renard, Barbara Taillière, Florian Slimano, Eric Bertin, Olivier Bouché

Open Access Research article

SoLAT (Sorafenib Lenvatinib alternating treatment): a new treatment protocol with alternating Sorafenib and Lenvatinib for refractory thyroid Cancer

Soo Young Kim, Seok-Mo Kim, Ho-Jin Chang, Bup-Woo Kim, Yong Sang Lee, Cheong Soo Park, Ki Cheong Park, Hang-Seok Chang

Open Access Research article

Oral mucositis associated with anti-EGFR therapy in colorectal cancer: single institutional retrospective cohort study

Satoshi Dote, Shoji Itakura, Kohei Kamei, Daiki Hira, Satoshi Noda, Yuka Kobayashi, Tomohiro Terada

Open Access Research article

Risk factors for paclitaxel-induced peripheral neuropathy in patients with breast cancer

Zohreh Ghoreishi, Seyedali Keshavarz, Mohammad Asghari Jafarabadi, Zahra Fathifar, Karyn A Goodman, Ali Esfahani

Open Access Research article

Impact of the epidermal growth factor receptor mutation status on the prognosis of recurrent adenocarcinoma of the lung after curative surgery

Tetsuya Isaka, Haruhiko Nakayama, Hiroyuki Ito, Tomoyuki Yokose, Kouzo Yamada, Munetaka Masuda

Open Access Research article

Genomic analysis of DNA repair genes and androgen signaling in prostate cancer

Kasey Jividen, Katarzyna Z Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan, Bryce M Paschal

Open Access Case report

Treatment of colon cancer in a patient with systemic lupus erythematosus: a case report

Junfeng Shi, Jianquan Fei, Qingqing Yi, Lijuan Shen, Boshun Wan, Yueyu Chen, Qing Chang

Open Access Research article

Prognostic and predictive factors for angiosarcoma patients receiving paclitaxel once weekly plus or minus bevacizumab: an ancillary study derived from a randomized clinical trial

Loïc Lebellec, François Bertucci, Emmanuelle Tresch-Bruneel, Isabelle Ray-Coquard, Axel Le Cesne, Emmanuelle Bompas, Jean-Yves Blay, Antoine Italiano, Olivier Mir, Thomas Ryckewaert, Yves Toiron, Luc Camoin, Anthony Goncalves, Nicolas Penel, Marie-Cécile Le Deley

Open Access Case report

Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma

Lea Loriguet, Mony Chenda Morisse, Julie Dremaux, Louison Collet, Christophe Attencourt, Alexandre Coutte, Mathieu Boone, Henri Sevestre, Antoine Galmiche, Brigitte Gubler, Bruno Chauffert, Stephanie Trudel

Open Access Research article

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown

Open Access Research article

A molecular and staging model predicts survival in patients with resected non-small cell lung cancer

Lei Liu, Minxin Shi, Zhiwei Wang, Haimin Lu, Chang Li, Yu Tao, Xiaoyan Chen, Jun Zhao

Open Access Research article

Enhanced antitumor and anti-angiogenic effects of metronomic Vinorelbine combined with Endostar on Lewis lung carcinoma

Rong-Sheng Qin, Zhen-Hua Zhang, Neng-Ping Zhu, Fei Chen, Qian Guo, Hao-Wen Hu, Shao-Zhi Fu, Shan-Shan Liu, Yue Chen, Juan Fan, Yun-Wei Han

Open Access Case report

Coexistence of gastric gastrointestinal stromal tumor, intro-abdominal and retroperitoneal liposarcomas –a case report

Yong Zhou, Xu-Dong Wu, Quan Shi, Chuan-hai Xu, Jing Jia

Open Access Research article

Optimal cutoff of pretreatment neutrophil-to-lymphocyte ratio in head and neck cancer patients: a meta-analysis and validation study

Jae-Keun Cho, Myoung Woo Kim, Ick Soo Choi, Uk Yeol Moon, Min-Ji Kim, Insuk Sohn, Seonwoo Kim, Han-Sin Jeong

Open Access Research article

Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study

Laurie L. Brunette, Paulette Y. Mhawech-Fauceglia, Lingyun Ji, Joseph G. Skeate, Heike E. Brand, Kate Lawrenson, Saloni Walia, Maurizio Chiriva-Internati, Susan Groshen, Lynda D. Roman, W. Martin Kast, Diane M. Da Silva

Open Access Research article

Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells

Xiao Song, Chengli Guo, Yutian Zheng, Ying Wang, Zhongtian Jin, Yanhui Yin

Open Access Research article

Osteoporosis development and vertebral fractures after abdominal irradiation in patients with gastric cancer

Gokhan Yaprak, Cengiz Gemici, Sule Temizkan, Sevim Ozdemir, Berfu Cinkit Dogan, Ozgur Ozan Seseogullari

Open Access Research article

Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment

Yukio Suzuki, Aya Tokinaga-Uchiyama, Taichi Mizushima, Yasuyo Maruyama, Tae Mogami, Nahoko Shikata, Atsuko Ikeda, Hiroshi Yamamoto, Etsuko Miyagi

Open Access Research article

Prognostic influence of endoscopic ultrasound-guided fine needle aspiration in IPMN-derived invasive adenocarcinoma

Rei Suzuki, Hiroki Irie, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Ko Watanabe, Jun Nakamura, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohira

Open Access Research article

Efficacy and safety of concurrent anti-Cancer and anti-tuberculosis chemotherapy in Cancer patients with active Mycobacterium tuberculosis: a retrospective study

Tomonori Hirashima, Yoshitaka Tamura, Yuki Han, Shoji Hashimoto, Ayako Tanaka, Takayuki Shiroyama, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Shinobu Akada, Makoto Fujishima, Yoshihisa Kadota, Kazuya Sakata, Akiko Nishitani, Satoru Miyazaki, Takayuki Nagai

Open Access Research article

Expression of fibronectin in esophageal squamous cell carcinoma and its role in migration

Jiefei Xiao, Weilin Yang, Bo Xu, Haoshuai Zhu, Jianyong Zou, Chunhua Su, Jian Rong, Tao Wang, Zhenguang Chen

Open Access Research article

Clinical outcomes comparison of 10 years versus 5 years of adjuvant endocrine therapy in patients with early breast cancer

Li Li, Bingmei Chang, Xiaoyue Jiang, Xueke Fan, Yingrui Li, Teng Li, Shanshan Wu, Jun Zhang, Seyed Kariminia, Qin Li

Open Access Case report

A rare case of primary breast angiosarcoma in a male: a case report

Benedito Borges da Silva, Walberto Monteiro Neiva Eulálio Filho, Pedro Vitor Lopes Costa, Rozirene Araújo Silva, Ariton Mendes Conde Junior, Diego Cipriano Chagas, Mariella de Almeida Melo, Fidelis Manes Neto, Cleciton Braga Tavares, Edilson Carvalho de Sousa Júnior, Eid Gonçalves Coelho, Viriato Campelo, Luis Henrique Gebrim, Raimundo Gerônimo da Silva Junior

Open Access Research article

The bone microenvironment promotes tumor growth and tissue perfusion compared with striated muscle in a preclinical model of prostate cancer in vivo

Haider Mussawy, Lennart Viezens, Malte Schroeder, Svenja Hettenhausen, Jördis Sündermann, Jasmin Wellbrock, Kai Kossow, Christian Schaefer

Open Access Research article

Impact of CDX2 expression status on the survival of patients after curative resection for colorectal cancer liver metastasis

Yasuyuki Shigematsu, Kentaro Inamura, Noriko Yamamoto, Yoshihiro Mise, Akio Saiura, Yuichi Ishikawa, Shunji Takahashi, Hiroaki Kanda

Open Access Research article

Estrogen receptor β is associated with expression of cancer associated genes and survival in ovarian cancer

Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck

Open Access Research article

Predictive impact of absolute lymphocyte counts for progression-free survival in human epidermal growth factor receptor 2-positive advanced breast cancer treated with pertuzumab and trastuzumab plus eribulin or nab-paclitaxel

Kazuhiro Araki, Yoshinori Ito, Ippei Fukada, Kokoro Kobayashi, Yoshimasa Miyagawa, Michiko Imamura, Ayako Kira, Yuichi Takatsuka, Chiyomi Egawa, Hirofumi Suwa, Shinji Ohno, Yasuo Miyoshi

Open Access Research article

Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients

Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli, Roberto Luksch

Open Access Research article

Co-culture of dendritic cells and cytokine-induced killer cells effectively suppresses liver cancer stem cell growth by inhibiting pathways in the immune system

Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang, Yingyu Nan

Open Access Study protocol

A prospective clinical and biological database for pancreatic adenocarcinoma: the BACAP cohort

Cindy Canivet, Sophie Gourgou-Bourgade, Bertrand Napoléon, Laurent Palazzo, Nicolas Flori, Pierre Guibert, Guillaume Piessen, Dominique Farges-Bancel, Jean-François Seitz, Eric Assenat, Véronique Vendrely, Stéphanie Truant, Geoffroy Vanbiervliet, Philippe Berthelémy, Stéphane Garcia, Anne Gomez-Brouchet, Louis Buscail, Barbara Bournet, Barbara Bournet, Cindy Canivet, Louis Buscail, Nicolas Carrère, Fabrice Muscari, Bertrand Suc, Rosine Guimbaud, Corinne Couteau, Marion Deslandres, Pascale Rivera, Anne-Pascale Laurenty, Nadim Fares, Karl Barange, Janick Selves, Anne Gomez-Brouchet, Bertrand Napoléon, Bertrand Pujol, Fabien Fumex, Jérôme Desrame, Christine Lefort, Vincent Lepilliez, Rodica Gincul, Pascal Artru, Léa Clavel, Anne-Isabelle Lemaistre, Laurent Palazzo, Jérôme Cros, Sarah Tubiana, Nicolas Flori, Pierre Senesse, Pierre-Emmanuel Colombo, Emmanuelle Samail-Scalzi, Fabienne Portales, Sophie Gourgou, Claire Honfo-Ga, Carine Plassot, Julien Fraisse, Frédéric Bibeau, Marc Ychou, Pierre Guibert, Christelle de la Fouchardière, Matthieu Sarabi, Patrice Peyrat, Séverine Tabone-Eglinger, Caroline Renard, Guillaume Piessen, Stéphanie Truant, Alain Saudemont, Guillaume Millet, Florence Renaud, Emmanuelle Leteurtre, Patrick Gele, Eric Assenat, Jean-Michel Fabre, François-Régis Souche, Marie Dupuy, Anne-Marie Gorce-Dupuy, Jeanne Ramos, Jean-François Seitz, Jean Hardwigsen, Emmanuelle Norguet-Monnereau, Philippe Grandval, Muriel Duluc, Dominique Figarella-Branger, Véronique Vendrely, Clément Subtil, Eric Terrebonne, Jean-Frédéric Blanc, Etienne Buscail, Jean-Philippe Merlio, Dominique Farges-Bancel, Jean-Marc Gornet, Daniela Geromin, Geoffroy Vanbiervliet, Anne-Claire Frin, Delphine Ouvrier, Marie-Christine Saint-Paul, Philippe Berthelémy, Chelbabi Fouad, Stéphane Garcia, Nathalie Lesavre, Mohamed Gasmi, Marc Barthet, Vanessa Cottet, Cyrille Delpierre

Open Access Research article

Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study

Min Kyoung Kim, Jeong Yee, Yoon Sook Cho, Hong Won Jang, Ji Min Han, Hye Sun Gwak

Open Access Research article

Decelerated DNA methylation age predicts poor prognosis of breast cancer

Jun-Ting Ren, Mei-Xia Wang, Yi Su, Lu-Ying Tang, Ze-Fang Ren

Open Access Research article

Bioelectrical impedance analysis for monitoring cancer patients receiving chemotherapy and home parenteral nutrition

Paolo Cotogni, Taira Monge, Maurizio Fadda, Antonella De Francesco

Open Access Research article

Age-related sarcoma patient experience: results from a national survey in England

Eugenie Younger, Olga Husson, Lindsey Bennister, Jeremy Whelan, Roger Wilson, Andy Roast, Robin L Jones, Winette TA van der Graaf

Open Access Research article

miR-618: possible control over TIMP-1 and its expression in localized prostate cancer

Renato F. Ivanovic, Nayara I. Viana, Denis R. Morais, Caio Moura, Iran A. Silva, Katia R. Leite, José Pontes-Junior, William C. Nahas, Miguel Srougi, Sabrina T. Reis

Open Access Research article

Clinical characteristics of Japanese patients with epithelioid hemangioendothelioma: a multicenter retrospective study

Satoshi Shiba, Hiroshi Imaoka, Kazuhiko Shioji, Eiichiro Suzuki, Shigeru Horiguchi, Takeshi Terashima, Yasushi Kojima, Tatsuya Okuno, Yasutaka Sukawa, Kunihiko Tsuji, Kumiko Umemoto, Akinori Asagi, Akiko Todaka, Makoto Ueno, Masafumi Ikeda, Chigusa Morizane, Junji Furuse

Open Access Research article

Oncological safety of autologous breast reconstruction after mastectomy for invasive breast cancer

Joachim Geers, Hans Wildiers, Katrien Van Calster, Annouschka Laenen, Giuseppe Floris, Marc Vandevoort, Gerd Fabre, Ines Nevelsteen, Ann Smeets

Open Access Case report

Possible involvement of interleukin-18 in the pathology of hepatobiliary adverse effects related to treatment with ceritinib

Taizou Hirano, Akira koarai, Tomohiro Ichikawa, Teruyuki Sato, Takashi Ohe, Masakazu Ichinose

Open Access Research article

Untargeted lipidomic features associated with colorectal cancer in a prospective cohort

Kelsi Perttula, Courtney Schiffman, William M B Edmands, Lauren Petrick, Hasmik Grigoryan, Xiaoming Cai, Marc J Gunter, Alessio Naccarati, Silvia Polidoro, Sandrine Dudoit, Paolo Vineis, Stephen M Rappaport

Open Access Research article

Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma

Shuang Wu, Ye Zhou, Hai-Ying Hua, Yan Zhang, Wen-Yan Zhu, Zhi-Qing Wang, Jin Li, Hua-Qiang Gao, Xiao-Hong Wu, Ting-Xun Lu, Dong Hua

Open Access Research article

Genetic and immunological biomarkers predict metastatic disease recurrence in stage III colon cancer

Andreas Sperlich, Alexander Balmert, Dietrich Doll, Sabine Bauer, Fabian Franke, Gisela Keller, Dirk Wilhelm, Anna Mur, Michael Respondek, Helmut Friess, Ulrich Nitsche, Klaus-Peter Janssen

Open Access Research article

Human mesenchymal stem cells in the tumour microenvironment promote ovarian cancer progression: the role of platelet-activating factor

Tong Gao, Yi Yu, Qing Cong, Yisheng Wang, Mingming Sun, Liangqing Yao, Congjian Xu, Wei Jiang

Open Access Research article

Low-dose trofosfamide plus rituximab is an effective and safe treatment for diffuse large B-cell lymphoma of the elderly: a single center experience

Roland Christian Schelker, Wolfgang Herr, Albrecht Reichle, Martin Vogelhuber

Open Access Case report

Latissimus dorsi rotational flap combined with a custom-made scapular prosthesis after oncological surgical resection: a report of two patients

Giovanni Beltrami, Gabriele Ristori, Guido Scoccianti, Angela Tamburini, Rodolfo Capanna, Domenico Campanacci, Marco Innocenti

Open Access Research article

Human papillomavirus infection in patients with laryngeal carcinoma

Ozlem Onerci Celebi, Ebru Sener, Sefik Hosal, Mustafa Cengiz, Ibrahim Gullu, Gaye Guler Tezel

Open Access Study protocol

Preoperative image-guided identification of response to neoadjuvant chemoradiotherapy in esophageal cancer (PRIDE): a multicenter observational study

A. S. Borggreve, S. Mook, M. Verheij, V. E. M. Mul, J. J. Bergman, A. Bartels-Rutten, L. C. ter Beek, R. G. H. Beets-Tan, R. J. Bennink, M. I. van Berge Henegouwen, L. A. A. Brosens, I. L. Defize, J. M. van Dieren, H. Dijkstra, R. van Hillegersberg, M. C. Hulshof, H. W. M. van Laarhoven, M. G. E. H. Lam, A. L. H. M. W. van Lier, C. T. Muijs, W. B. Nagengast, A. J. Nederveen, W. Noordzij, J. T. M. Plukker, P. S. N. van Rossum, J. P. Ruurda, J. W. van Sandick, B. L. A. M. Weusten, F. E. M. Voncken, D. Yakar, G. J. Meijer, B M P Aleman, R J H Borra, B van Etten, S S Gisbertz, L Goense, N Haj Mohammad, K J Hartemink, P Kappert, G Kats-Ugurlu, L L Kodach, T Korteweg, K K Krishnadath, J A Langendijk, W W J de Leng, S L Meijer, J H Potze, J Stoker, E Vegt, H M Verkooijen, S E Vollenbrock, F Wessels

Open Access Research article

Rigor prophylaxis in stage IV melanoma and renal cell carcinoma patients treated with high dose IL-2

Brian Khong, Benjamin O. Lawson, Junjie Ma, Cheryl McGovern, Joan K. Van Atta, Abhijit Ray, Hung T. Khong

Open Access Research article

Impact of renal impairment on outcomes after autologous stem cell transplantation in multiple myeloma: a multi-center, retrospective cohort study

Marlies Antlanger, Tobias Dust, Thomas Reiter, Alexandra Böhm, Wolfgang W. Lamm, Max Gornicec, Ella Willenbacher, David Nachbaur, Roman Weger, Werner Rabitsch, Susanne Rasoul-Rockenschaub, Nina Worel, Daniel Lechner, Hildegard Greinix, Felix Keil, Heinz Gisslinger, Hermine Agis, Maria-Theresa Krauth

Open Access Research article

NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia

Yu-Qiong Yang, Tian Tian, Hua-Yuan Zhu, Jin-Hua Liang, Wei Wu, Jia-Zhu Wu, Yi Xia, Li Wang, Lei Fan, Jian-Yong Li, Wei Xu

Open Access Research article

Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort

Danja Sarink, Helena Schock, Theron Johnson, Jenny Chang-Claude, Kim Overvad, Anja Olsen, Anne Tjønneland, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Heiner Boeing, Anna Karakatsani, Antonia Trichopoulou, Carlo La Vecchia, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Carla H. van Gils, Petra H. M. Peeters, Elisabete Weiderpass, Antonio Agudo, Miguel Rodríguez-Barranco, José María Huerta, Eva Ardanaz, Leire Gil, Kay Tee Kaw, Julie A. Schmidt, Laure Dossus, Mathilde His, Dagfinn Aune, Elio Riboli, Rudolf Kaaks, Renée T. Fortner

Open Access Research article

High postoperative monocyte indicates inferior Clinicopathological characteristics and worse prognosis in lung adenocarcinoma or squamous cell carcinoma after lobectomy

Yang Hai, Nan Chen, Wenwen Wu, Zihuai Wang, Feng Lin, Chenglin Guo, Chengwu Liu, Weimin Li, Lunxu Liu

Open Access Research article

Comparison of the efficacies of first-generation epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in patients with advanced non-small-cell lung cancer harboring EGFR mutations

Naoto Aiko, Tsuneo Shimokawa, Kazuhito Miyazaki, Yuki Misumi, Yoko Agemi, Mari Ishii, Yukiko Nakamura, Takeharu Yamanaka, Hiroaki Okamoto

Open Access Research article

Access to innovative drugs for metastatic lung cancer treatment in a French nationwide cohort: the TERRITOIRE study

Arnaud Scherpereel, Isabelle Durand-Zaleski, François-Emery Cotté, Jérôme Fernandes, Didier Debieuvre, Cécile Blein, Anne-Françoise Gaudin, Charlène Tournier, Alexandre Vainchtock, Pierre Chauvin, Pierre-Jean Souquet, Virginie Westeel, Christos Chouaïd

Open Access Research article

Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

Bruna Dalmasso, Sigrid Hatse, Barbara Brouwers, Annouschka Laenen, Lieze Berben, Cindy Kenis, Ann Smeets, Patrick Neven, Patrick Schöffski, Hans Wildiers

Open Access Research article

The effects of shared decision-making compared to usual care for prostate cancer screening decisions: a systematic review and meta-analysis

Nahara Anani Martínez-González, Stefan Neuner-Jehle, Andreas Plate, Thomas Rosemann, Oliver Senn

Open Access Research article

Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer

Y. E. Smith, S. Toomey, S. Napoletano, G. Kirwan, C. Schadow, A. J. Chubb, J. H. Mikkelsen, C. Oxvig, J. H. Harmey

Open Access Research article

Gut disruption impairs rehabilitation in patients curatively operated for pancreaticoduodenal cancer - a qualitative study

Kristine Elberg Dengsø, Tine Tjørnhøj-Thomsen, Susanne Oksbjerg Dalton, Bo Marcel Christensen, Jens Hillingsø, Thordis Thomsen

Open Access Research article

Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink

Kendal Chidwick, Helen Strongman, Anthony Matthews, Susannah Stanway, Alexander R. Lyon, Liam Smeeth, Krishnan Bhaskaran

Open Access Research article

Caveolin-1 expression predicts efficacy of weekly nab-paclitaxel plus gemcitabine for metastatic breast cancer in the phase II clinical trial

Yannan Zhao, Fangfang Lv, She Chen, Zhonghua Wang, Jian Zhang, Sheng Zhang, Jun Cao, Leiping Wang, Enying Cao, Biyun Wang, Xichun Hu

Open Access Research article

Prognostic factors for survival after curative resection of gastric mixed adenoneuroendocrine carcinoma: a series of 80 patients

Jian-Wei Xie, Jun Lu, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chao-Hui Zheng, Ping Li, Chang-Ming Huang

Open Access Research article

Colorectal cancer survivors: an investigation of symptom burden and influencing factors

Claire O’Gorman, Jim Stack, Alan O’Ceilleachair, Suzanne Denieffe, Martina Gooney, Martina McKnight, Linda Sharp

Open Access Research article

The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

Xiaoxia Ye, Mingming Mo, Simin Xu, Qingjin Yang, Minhua Wu, Junjie Zhang, Bin Chen, Jian Li, Yu Zhong, Qionglin Huang, Chun Cai

Open Access Case report

A case report of eyelid Merkel cell carcinoma occurring under treatment with nivolumab for a lung adenocarcinoma

Daniele Lavacchi, Stefania Nobili, Marco Brugia, Agnese Paderi, Sara Fancelli, Enrico Caliman, Federica Vergoni, Enrico Mini

Open Access Research article

Krüppel-like factor 9 and histone deacetylase inhibitors synergistically induce cell death in glioblastoma stem-like cells

Brian Tung, Ding Ma, Shuyan Wang, Olutobi Oyinlade, John Laterra, Mingyao Ying, Sheng-Qing Lv, Shuang Wei, Shuli Xia

Open Access Research article

Feasibility of concomitant cisplatin with hypofractionated radiotherapy for locally advanced head and neck squamous cell carcinoma

Alexandre Arthur Jacinto, Eronides Salustiano Batalha Filho, Luciano de Souza Viana, Pedro De Marchi, Renato de Castro Capuzzo, Ricardo Ribeiro Gama, Domingos Boldrini Junior, Carlos Roberto Santos, Gustavo Dix Junqueira Pinto, Josiane Mourão Dias, Heloisa Pelisser Canton, Raiany Carvalho, Lucas Augusto Radicchi, Soren Bentzen, Eduardo Zubizarreta, Andre Lopes Carvalho

Open Access Research article

Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

Simon J. Johnston, Dena Ahmad, Mohammed A. Aleskandarany, Sasagu Kurozumi, Chris C. Nolan, Maria Diez-Rodriguez, Andrew R. Green, Emad A. Rakha

Open Access Research article

Generation and characterization of MEK and ERK inhibitors- resistant non-small-cells-lung-cancer (NSCLC) cells

Alice Iezzi, Elisa Caiola, Arianna Scagliotti, Massimo Broggini

Open Access Research article

Expression of calcium pumps is differentially regulated by histone deacetylase inhibitors and estrogen receptor alpha in breast cancer cells

Karolina Varga, Anna Hollósi, Katalin Pászty, Luca Hegedűs, Gergely Szakács, József Tímár, Béla Papp, Ágnes Enyedi, Rita Padányi

Open Access Study protocol

TROG 15.03 phase II clinical trial of Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney - FASTRACK II

Shankar Siva, Brent Chesson, Mathias Bressel, David Pryor, Braden Higgs, Hayley M. Reynolds, Nicholas Hardcastle, Rebecca Montgomery, Ben Vanneste, Vincent Khoo, Jeremy Ruben, Eddie Lau, Michael S. Hofman, Richard De Abreu Lourenco, Swetha Sridharan, Nicholas R. Brook, Jarad Martin, Nathan Lawrentschuk, Tomas Kron, Farshad Foroudi

Open Access Study protocol

Protocol for a phase III RCT and economic analysis of two exercise delivery methods in men with PC on ADT

Shabbir M. H. Alibhai, Paul Ritvo, Daniel Santa Mina, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Himu Lukka, Padraig Warde, Sara Durbano, Meagan O’Neill, S. Nicole Culos-Reed

Open Access Research article

Thick-wall cavity predicts worse progression-free survival in lung adenocarcinoma treated with first-line EGFR-TKIs

Fei Zhou, Wanrong Ma, Wei Li, Huijuan Ni, Guanghui Gao, Xiaoxia Chen, Jie Zhang, Jingyun Shi

Open Access Research article

Meta-analysis on resected pancreatic cancer: a comparison between adjuvant treatments and gemcitabine alone

Hua Chen, Ruizhi He, Xiuhui Shi, Min Zhou, Chunle Zhao, Hang Zhang, Renyi Qin

Open Access Research article

Preadmission antidepressant use and bladder cancer: a population-based cohort study of stage at diagnosis, time to surgery, and surgical outcomes

Ellen Hollands Steffensen, Clint Cary, Jørgen Bjerggaard Jensen, Heidi Larsson, Michael Weiner, Mette Nørgaard

Open Access Case report

The usefulness of wide excision assisted by a computer navigation system and reconstruction using a frozen bone autograft for malignant acetabular bone tumors: a report of two cases

Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Hiroyuki Inatani, Yu Aoki, Takashi Higuchi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki, Hiroyuki Tsuchiya

Open Access Research article

Two-dimensional speckle tracking echocardiography predicts early subclinical cardiotoxicity associated with anthracycline-trastuzumab chemotherapy in patients with breast cancer

Maria C. Arciniegas Calle, Nicole P. Sandhu, Hongmei Xia, Stephen S. Cha, Patricia A. Pellikka, Zi Ye, Joerg Herrmann, Hector R. Villarraga

Open Access Research article

Effects of FGFR gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-docetaxel-based chemotherapy in breast cancer patients

Lu Chen, Huijie Qi, Liudi Zhang, Haixia Li, Jie Shao, Haifei Chen, Mingkang Zhong, Xiaojin Shi, Ting Ye, Qunyi Li

Open Access Research article

Long-term mortality among women with epithelial ovarian cancer: a population-based study in British Columbia, Canada

Nimisha Arora, Aline Talhouk, Jessica N. McAlpine, Michael R. Law, Gillian E. Hanley

Open Access Research article

Long-term outcomes of the 2-week schedule of hypofractionated radiotherapy for recurrent hepatocellular carcinoma

Jongmoo Park, Jinhong Jung, Daegeun Kim, In-Hye Jung, Jin-hong Park, Jong Hoon Kim, Sang-wook Lee, Sang Min Yoon

Open Access Research article

Neoadjuvant chemotherapy is associated with a high rate of perioperative blood transfusion at the time of interval cytoreductive surgery

Kevin W McCool, Emmanuel Sampene, Brock Polnaszek, Joseph Connor, Erin E Medlin, Lisa Barroilhet

Open Access Research article

Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1

Yang Jiao, Tanya Watts, Jing Xue, Bethany Hannafon, Wei-Qun Ding

Open Access Research article

Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ β -catenin signaling pathway

Suhail Razak, Tayyaba Afsar, Asad Ullah, Ali Almajwal, Musaed Alkholief, Aws Alshamsan, Sarwat Jahan

Open Access Research article

Doctor, are you healthy? A cross-sectional investigation of oncologist burnout, depression, and anxiety and an investigation of their associated factors

Carlos Eduardo Paiva, Beatriz Parreira Martins, Bianca Sakamoto Ribeiro Paiva

Open Access Research article

Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4–1 and NRDP1, in primary breast cancer

Satu Luhtala, Synnöve Staff, Anne Kallioniemi, Minna Tanner, Jorma Isola

Open Access Case report

Synchronous cancers of gallbladder carcinoma and combined hepatocellular cholangiocarcinoma: an unusual case and literature review

Zhan-Guo Zhang, Yan Chen, Ran Ji, Ya-Jie Zhao, Jian Wang, Lily Robinson, Xiao-Ping Chen, Lei Zhang

Open Access Correction

Correction to: Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer–testis (CT-X) antigens

Uwe Schirmer, Heidi Fiegl, Marco Pfeifer, Alain G. Zeimet, Elisabeth Müller-Holzner, Peter K. Bode, Verena Tischler, Peter Altevogt

Open Access Research article

microRNAs expression profile related with response to preoperative radiochemotherapy in patients with locally advanced gastric cancer

Xiaowen Liu, Hong Cai, Weiqi Sheng, Hua Huang, Ziwen Long, Yanong Wang

Open Access Research article

Expression of estrogen receptor beta correlates with adverse prognosis in resected pancreatic adenocarcinoma

Hendrik Seeliger, Ioannis Pozios, Gerald Assmann, Yue Zhao, Mario H. Müller, Thomas Knösel, Martin E. Kreis, Christiane J. Bruns

Open Access Research article

Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study

Linda Kaerlev, Maria Iachina, Oleg Trosko, Niels Qvist, Pernille Møller Ljungdalh, Bente Mertz Nørgård

Open Access Research article

Prediction of pathological complete response and prognosis in patients with neoadjuvant treatment for triple-negative breast cancer

Paul Gass, Michael P. Lux, Claudia Rauh, Alexander Hein, Mayada R. Bani, Cornelia Fiessler, Arndt Hartmann, Lothar Häberle, Jutta Pretscher, Ramona Erber, David L. Wachter, Rüdiger Schulz-Wendtland, Matthias W. Beckmann, Peter A. Fasching, Marius Wunderle

Open Access Research article

Effect of COPD on symptoms, quality of life and prognosis in patients with advanced non-small cell lung cancer

Young-Soo Yi, Woo Ho Ban, Kyeong-Yae Sohng

Open Access Research article

Feasibility, validity and reliability of objective smartphone measurements of physical activity and fitness in patients with cancer

Joeri A. J. Douma, Henk M. W. Verheul, Laurien M. Buffart

Open Access Research article

Predominance of triple wild-type and IGF2R mutations in mucosal melanomas

Yuuki Iida, Matthew P. Salomon, Keisuke Hata, Kevin Tran, Shuichi Ohe, Chester F. Griffiths, Sandy C. Hsu, Nellie Nelson, Dave S. B. Hoon

Open Access Research article

APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes

Leandro Magalhães, Luciana Gonçalves Quintana, Dielly Catrina Favacho Lopes, Amanda Ferreira Vidal, Adenilson Leão Pereira, Lara Carolina D’Araujo Pinto, João de Jesus Viana Pinheiro, André Salim Khayat, Luiz Ricardo Goulart, Rommel Burbano, Paulo Pimentel de Assumpção, Ândrea Ribeiro-dos-Santos

Open Access Research article

The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo

Pedro Cruz-Nova, Michael Schnoor, José Correa-Basurto, Martiniano Bello, Paola Briseño-Diaz, Arturo Rojo-Domínguez, Carlos M. Ortiz-Mendoza, Jorge Guerrero-Aguirre, Francisco J. García-Vázquez, Rosaura Hernández-Rivas, María del Rocío Thompson-Bonilla, Miguel Vargas

Open Access Research article

Clinical significance and predictors of oncologic outcome after radical prostatectomy for invisible prostate cancer on multiparametric MRI

Doo Yong Chung, Dong Hoon Koh, Hyeok Jun Goh, Min Seok Kim, Jong Soo Lee, Won Sik Jang, Young Deuk Choi

Open Access Research article

Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles

Chan-Hyeong Lee, Eun-Ju Im, Pyong-Gon Moon, Moon-Chang Baek

Open Access Research article

Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls

Yulu Gu, Jikang Shi, Shuang Qiu, Yichun Qiao, Xin Zhang, Yi Cheng, Yawen Liu

Open Access Research article

Performance of prostate cancer recurrence nomograms by obesity status: a retrospective analysis of a radical prostatectomy cohort

Charnita Zeigler-Johnson, Aaron Hudson, Karen Glanz, Elaine Spangler, Knashawn H. Morales

Open Access Research article

βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors

Michal Chovanec, Zuzana Cierna, Viera Miskovska, Katarina Machalekova, Katarina Kalavska, Katarina Rejlekova, Daniela Svetlovska, Dusan Macak, Stanislav Spanik, Karol Kajo, Pavel Babal, Michal Mego, Jozef Mardiak

Open Access Research article

Domain-specific physical activity and the risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

Shahid Mahmood, Dallas R. English, Robert J. MacInnis, Amalia Karahalios, Neville Owen, Roger L. Milne, Graham G. Giles, Brigid M. Lynch

Open Access Research article

Are the indications for postoperative radiotherapy in the NCCN guidelines for patients with gastric adenocarcinoma too broad? A study based on the SEER database

Ze-Ning Huang, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Hua-long Zheng, Chang-Ming Huang

Open Access Research article

Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells

Akihiko Yoshimura, Kenjiro Sawada, Koji Nakamura, Yasuto Kinose, Erika Nakatsuka, Masaki Kobayashi, Mayuko Miyamoto, Kyoso Ishida, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi, Tadashi Kimura

Open Access Research article

Increased risk of non-AIDS-defining cancers in Asian HIV-infected patients: a long-term cohort study

Naoyoshi Nagata, Takeshi Nishijima, Ryota Niikura, Tetsuji Yokoyama, Yumi Matsushita, Koji Watanabe, Katsuji Teruya, Yoshimi Kikuchi, Junichi Akiyama, Mikio Yanase, Naomi Uemura, Shinichi Oka, Hiroyuki Gatanaga

Open Access Research article

GPNMB methylation: a new marker of potentially carcinogenic colon lesions

Hassan Ashktorab, Hamed Rahi, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haydari, Adeyinka O. Laiyemo, Peter Siegel, Hassan Brim

Open Access Research article

The impact of introducing tyrosine kinase inhibitors on chronic myeloid leukemia survival: a population-based study

Enza Di Felice, Francesca Roncaglia, Francesco Venturelli, Lucia Mangone, Stefano Luminari, Claudia Cirilli, Giuliano Carrozzi, Paolo Giorgi Rossi

Open Access Case report

Case report: primary resistance to osimertinib in erlotinib-pretreated lung adenocarcinoma with EGFR T790 M mutation

Lin-Peng Zheng, Li-Ying Chen, Xing-Yun Liao, Zi-Han Xu, Zheng-Tang Chen, Jian-Guo Sun

Open Access Research article

Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study

Eunjung Lee, Jianning Luo, Fredrick R. Schumacher, David Van Den Berg, Anna H. Wu, Daniel O. Stram, Leslie Bernstein, Giske Ursin

Open Access Study protocol

(Cost-)effectiveness of an internet-based physical activity support program (with and without physiotherapy counselling) on physical activity levels of breast and prostate cancer survivors: design of the PABLO trial

H. J. van de Wiel, M. M. Stuiver, A. M. May, S. van Grinsven, N. K. Aaronson, V. P. Retèl, H. S. A. Oldenburg, H. G. van der Poel, S. Horenblas, W. H. van Harten, W. G. Groen

Open Access Study protocol

Ixazomib in combination with carboplatin in pretreated women with advanced triple-negative breast cancer, a phase I/II trial of the AGMT (AGMT MBC-10 trial)

Gabriel Rinnerthaler, Simon Peter Gampenrieder, Andreas Petzer, Sonja Burgstaller, David Fuchs, Dieter Rossmann, Marija Balic, Daniel Egle, Holger Rumpold, Christian F. Singer, Rupert Bartsch, Edgar Petru, Thomas Melchardt, Hanno Ulmer, Brigitte Mlineritsch, Richard Greil

Open Access Research article

Trends in cervical cancer incidence and survival in Estonia from 1995 to 2014

Kristiina Ojamaa, Kaire Innos, Aleksei Baburin, Hele Everaus, Piret Veerus

Open Access Research article

The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients

Ping Yu, Mingyi Zhou, Jinglei Qu, Lingyu Fu, Xuedan Li, Ruimei Cai, Bo Jin, Yuee Teng, Jing Liu, Jing Shi, Jingdong Zhang

Open Access Study protocol

Comparison of implementation strategies to influence adherence to the clinical pathway for screening, assessment and management of anxiety and depression in adult cancer patients (ADAPT CP): study protocol of a cluster randomised controlled trial

Phyllis Butow, Joanne Shaw, Heather L. Shepherd, Melanie Price, Lindy Masya, Brian Kelly, Nicole M. Rankin, Afaf Girgis, Thomas F. Hack, Philip Beale, Rosalie Viney, Haryana M. Dhillon, Joseph Coll, Patrick Kelly, Melanie Lovell, Peter Grimison, Tim Shaw, Tim Luckett, Jessica Cuddy, Fiona White, Phyllis Butow, Joanne Shaw, Melanie Price, Heather Shepherd, Lindy Masya, Nicole Rankin, Afaf Girgis, Brian Kelly, Thomas Hack, Rosalie Viney, Josephine Clayton, Philip Beale, Laura Kirsten, Haryana Dhillon, Peter Grimison, Michael Murphy, Jill Newby, John Stubbs, Frances Orr, Toni Lindsay, Gavin Andrews, Tim Shaw, Joseph Coll, Karen Allison, Jessica Cuddy, Fiona White, Liesbeth Geerligs, Melanie Lovell, Tim Luckett, Kate Baychek, Don Piro, Alison Pearce, Jackie Yim

Open Access Research article

MiR-155, a potential serum marker of extramammary Paget’s disease

Hao Guo, Rui-Qun Qi, Jie Sheng, Chang Liu, Hang Ma, He-Xiao Wang, Jiu-Hong Li, Xing-Hua Gao, Yin-Sheng Wan, Hong-Duo Chen

Open Access Research article

Overall survival and time trends in breast and cervical cancer incidence and mortality in the Regional Health District (RHD) of Barretos, São Paulo, Brazil

Allini Mafra da Costa, Dana Hashim, José Humberto Tavares Guerreiro Fregnani, Elisabete Weiderpass

Open Access Case report

Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma

Seong Eun Kim, Younggon Jung, Tae Hoon Oh, Uh Jin Kim, Seung-Ji Kang, Hee-Chang Jang, Kyung-Hwa Park, Kyung-Hwa Lee, Sook In Jung

Open Access Research article

Disease severity-based evaluation of utility weights for lung cancer-related health states in Korea

Eun-Jung Kim, Minsu Ock, Kyu-pyo Kim, Nuri Hyun Jung, Hyeon-Jeong Lee, Seon-Ha Kim, Min-Woo Jo

Open Access Case report

Pancreatic acinar cell carcinoma—case report and literature review

Zhang Xing-mao, Zhang Hong-juan, Li Qing, He Qiang

Open Access Research article

Spatially varying effects of predictors for the survival prediction of nonmetastatic colorectal Cancer

Yu Tian, Jun Li, Tianshu Zhou, Danyang Tong, Shengqiang Chi, Xiangxing Kong, Kefeng Ding, Jingsong Li

Open Access Research article

Anti-colorectal cancer effects of anti-p21Ras scFv delivered by the recombinant adenovirus KGHV500 and cytokine-induced killer cells

Fang-Rui Liu, Shuang Bai, Qiang Feng, Xin-Yan Pan, Shu-Ling Song, Hong Fang, Jing Cui, Ju-Lun Yang

Open Access Research article

Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility

Tianbiao Zhou, Hong-Yan Li, Wei-Ji Xie, Zhiqing Zhong, Hongzhen Zhong, Zhi-Jun Lin

Open Access Research article

Preoperative diagnosis and prediction of hepatocellular carcinoma: Radiomics analysis based on multi-modal ultrasound images

Zhao Yao, Yi Dong, Guoqing Wu, Qi Zhang, Daohui Yang, Jin-Hua Yu, Wen-Ping Wang

Open Access Research article

Porphyrins are increased in the faeces of patients with prostate cancer: a case-control study

Daniel Riani Gotardelo, Lilia Coronato Courrol, Maria Helena Bellini, Flávia Rodrigues de Oliveira Silva, Carlos Roberto Jorge Soares

Open Access Research article

Are comorbidities associated with long-term survival of lung cancer? A population-based cohort study from French cancer registries

A. Seigneurin, P. Delafosse, B. Trétarre, A. S. Woronoff, M. Velten, P. Grosclaude, A. V. Guizard, B. Lapôtre-Ledoux, S. Bara, F. Molinié, M. Colonna

Open Access Research article

Epithelial cell adhesion molecule (EpCAM) is involved in prostate cancer chemotherapy/radiotherapy response in vivo

Jie Ni, Paul Cozzi, Julia Beretov, Wei Duan, Joseph Bucci, Peter Graham, Yong Li

Open Access Research article

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice

Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi, Xin Chen

Open Access Research article

Elevated platelet count is a negative predictive and prognostic marker in locally advanced rectal cancer undergoing neoadjuvant chemoradiation: a retrospective multi-institutional study on 965 patients

Claudio Belluco, Marco Forlin, Paolo Delrio, Daniela Rega, Maurizio Degiuli, Silvia Sofia, Matteo Olivieri, Salvatore Pucciarelli, Matteo Zuin, Giovanni De Manzoni, Alberto Di Leo, Stefano Scabini, Luigi Zorcolo, Angelo Restivo

Open Access Research article

Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC

Kevin Lee Min Chua, Eugenia Li Ling Yeo, Waseem Ahamed Shihabudeen, Sze Huey Tan, Than Than Shwe, Enya Hui Wen Ong, Paula Yeng Po Lam, Khee Chee Soo, Yoke Lim Soong, Kam Weng Fong, Terence Wee Kiat Tan, Joseph Tien Seng Wee, Melvin Lee Kiang Chua

Open Access Research article

Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma

Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Monika Bauden, Yi Jiang, Roland Andersson

Open Access Research article

MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms

Pierre-Yves Dumas, Olivier Mansier, Valerie Prouzet-Mauleon, Junji Koya, Arnaud Villacreces, Philippe Brunet de la Grange, Damien Luque Paz, Audrey Bidet, Jean-Max Pasquet, Vincent Praloran, Franck Salin, Mineo Kurokawa, François-Xavier Mahon, Bruno Cardinaud, Eric Lippert

Open Access Research article

Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway

Jiuyang Liu, Chaoqun Huang, Chunwei Peng, Fei Xu, Yan Li, Yonemura Yutaka, Bin Xiong, Xiaojun Yang

Open Access Research article

Testing for minimal residual disease in adults with acute lymphoblastic leukemia in Europe: a clinician survey

Arnaud Pigneux, Pau Montesinos, Ze Cong, Xinke Zhang, Anja K. Pownell, Heather Wieffer, Jan McKendrick, Monika Brüggemann

Open Access Research article

Neo-adjuvant treatment of adenocarcinoma and squamous cell carcinoma of the cervix results in significantly different pathological complete response rates

Karen Couvreur, Eline Naert, Emiel De Jaeghere, Philippe Tummers, Amin Makar, Pieter De Visschere, Mieke Van Bockstal, Jo Van Dorpe, Wilfried De Neve, Hannelore Denys, Katrien Vandecasteele

Open Access Research article

Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer

Fang Wang, Wenzhuo He, Chang Jiang, Guifang Guo, Bin Ke, Qiangsheng Dai, Jianting Long, Liangping Xia

Open Access Research article

Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line

Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Joon Oh Park

Open Access Research article

International phase IV validation study of an EORTC quality of life questionnaire for testicular cancer patients: the EORTC QLQ-TC26

Monika Sztankay, Neil K. Aaronson, Juan I. Arraras, Umberto Basso, Uros Bumbasirevic, Fabio Efficace, Johannes M. Giesinger, Colin D. Johnson, Marieke van Leeuwen, Anne S. Oberguggenberger, Roman Sosnowski, Teresa Young, Bernhard Holzner

Open Access Case report

Successful response to the combination of immunotherapy and chemotherapy in cholangiocarcinoma with high tumour mutational burden and PD-L1 expression: a case report

Haibo Mou, Lanfang Yu, Qin Liao, Xuehua Hou, Yinfang Wu, Qiang Cui, Na Yan, Ruobing Ma, Lingjian Wang, Ming Yao, Kai Wang

Open Access Research article

Reduced RBM3 expression is associated with aggressive tumor features in esophageal cancer but not significantly linked to patient outcome

Katharina Grupp, Bianca Hofmann, Asad Kutup, Kai Bachmann, Dean Bogoevski, Nathaniel Melling, Faik Guntac Uzunoglu, Alexander Tarek El Gammal, Christina Koop, Ronald Simon, Stefan Steurer, Till Krech, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter, Jakob Izbicki, Waldemar Wilczak

Open Access Research article

Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma

Liyong Zhang, Zhihong Li, Yehai Liu, Shuping Xu, Manuj Tandon, Brittany Appelboom, Courtney R. LaValle, Simion I. Chiosea, Lin Wang, Malabika Sen, Vivian W. Y. Lui, Jennifer R. Grandis, Q. Jane Wang

Open Access Research article

Low-dose Bacillus Calmette-Guerin versus full-dose for intermediate and high-risk of non-muscle invasive bladder cancer: a Markov model

Zongren Wang, Han Xiao, Guangyan Wei, Ning Zhang, Mengchao Wei, Zebin Chen, Zhenwei Peng, Sui Peng, Shaopeng Qiu, Heping Li, Jianting Long

Open Access Case report

Rare case of neglected large sacral Chordoma in a young female treated by wide En bloc resection and Sacrectomy

Zi Hao Phang, Xue Yi Saw, Noreen Fadzlina Binti Mat Nor, Zolqarnain Bin Ahmad, Sa’adon Bin Ibrahim

Open Access Study protocol

Randomized controlled trial of an 8-week intervention combining self-care and hypnosis for post-treatment cancer patients: study protocol

Charlotte Grégoire, Marie-Elisabeth Faymonville, Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Guy Jerusalem, Isabelle Bragard

Open Access Research article

Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma

Kazuhiro Nagao, Nachi Shinohara, Frank Smit, Mirjam de Weijert, Sander Jannink, Yuji Owada, Peter Mulders, Egbert Oosterwijk, Hideyasu Matsuyama

Open Access Case report

Intravascular NK/T-cell lymphoma, Epstein–Barr virus positive with multiorgan involvement: a clinical dilemma

Magda Zanelli, Maria Cecilia Mengoli, Rachele Del Sordo, Angelo Cagini, Loredana De Marco, Edoardo Simonetti, Giovanni Martino, Maurizio Zizzo, Stefano Ascani

Open Access Research article

Multidisciplinary treatment for patients with stage IV gastric cancer: the role of conversion surgery following chemotherapy

Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha, Sung Hoon Noh

Open Access Case report

Inotuzumab ozogamicin is effective in relapsed/refractory extramedullary B acute lymphoblastic leukemia

Luca Bertamini, Jacopo Nanni, Giovanni Marconi, Mariachiara Abbenante, Valentina Robustelli, Francesco Bacci, Antonella Matti, Stefania Paolini, Chiara Sartor, Silvia Lo Monaco, Maria Chiara Fontana, Stefano De Polo, Michele Cavo, Antonio Curti, Giovanni Martinelli, Cristina Papayannidis

Open Access Case report

Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report

Kihwan Hwang, Kyu Sang Lee, Gheeyoung Choe, Byung-Gyu Cho, Chae-Yong Kim

Open Access Research article

Comparative study of dual energy CT iodine imaging and standardized concentrations before and after chemoradiotherapy for esophageal cancer

Xiaomin Ge, Jingping Yu, Zhongling Wang, Yiqun Xu, Changjie Pan, Lu Jiang, Yanling Yang, Kai Yuan, Wei Liu

Open Access Case report

Solitary pancreatic metastasis of extremity myxoid liposarcoma: a case report and literature review

Dingding Wang, Jie Wu, Jian Yu, Hong Zhang, Honggang Liu

Open Access Research article

Delays and routes to diagnosis of neuroendocrine tumours

Ron Basuroy, Catherine Bouvier, John Keith Ramage, Maia Sissons, Raj Srirajaskanthan

Open Access Research article

A tight balance of Karyopherin β1 expression is required in cervical cancer cells

Sarah Carden, Pauline van der Watt, Alicia Chi, Aderonke Ajayi-Smith, Katie Hadley, Virna D. Leaner

Open Access Research article

Safety profile of trifluridine/tipiracil monotherapy in clinical practice: results of the German compassionate-use program for patients with metastatic colorectal cancer

Stefan Kasper, Jens Kisro, Martin Fuchs, Christian Müller, Armin Schulz-Abelius, Meinolf Karthaus, Mohammad-Reza Rafiyan, Alexander Stein

Open Access Research article

Does fibrosis have an impact on survival of patients with hepatocellular carcinoma: evidence from the SEER database?

Hui Liu, Dong Cen, Yunxian Yu, Yanting Wang, Xiao Liang, Hui Lin, Xiujun Cai

Open Access Research article

Risk of febrile neutropenia among patients with multiple myeloma or lymphoma who undergo inpatient versus outpatient autologous stem cell transplantation: a systematic review and meta-analysis

Weerapat Owattanapanich, Kittima Suphadirekkul, Chutima Kunacheewa, Patompong Ungprasert, Kannadit Prayongratana

Open Access Research article

Biosimilar filgrastim treatment patterns and prevention of febrile neutropenia: a prospective multicentre study in France in patients with solid tumours (the ZOHé study)

Henri Roché, Jean-Christophe Eymard, Abderraouf Radji, Alain Prevost, Rafik Diab, Michele Lamuraglia, Ravaka-Fatoma Soumoudronga, Isabelle Gasnereau, Alain Toledano

Open Access Research article

BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway

Fenfen Wang, Qin Chen, Genping Huang, Xuedong Guo, Na Li, Yang Li, Baohua Li

Open Access Research article

Homoharringtonine interacts synergistically with bortezomib in NHL cells through MCL-1 and NOXA-dependent mechanisms

Tri Nguyen, Rebecca Parker, Yu Zhang, Elisa Hawkins, Maciej Kmieciak, William Craun, Steven Grant

Open Access Research article

Pattern of care of prostate cancer patients across the Martinique: results of a population-based study in the Caribbean

Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Jonathan Macni, Thierry Almont, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung, Patrick Escarmant

Open Access Study protocol

Ruxolitinib in GvHD (RIG) study: a multicenter, randomized phase 2 trial to determine the response rate of Ruxolitinib and best available treatment (BAT) versus BAT in steroid-refractory acute graft-versus-host disease (aGvHD) (NCT02396628)

Nikolas von Bubnoff, Gabriele Ihorst, Olga Grishina, Nadine Röthling, Hartmut Bertz, Justus Duyster, Jürgen Finke, Robert Zeiser

Open Access Research article

Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma

Jing Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin, Nianyong Chen

Open Access Case report

NUT carcinoma of the nasal cavity that responded to a chemotherapy regimen for Ewing’s sarcoma family of tumors: a case report

Kohei Arimizu, Gen Hirano, Chinatsu Makiyama, Mioko Matsuo, Takakazu Sasaguri, Akitaka Makiyama

Open Access Research article

Novel risk factors for primary prevention of oesophageal carcinoma: a case-control study from Sri Lanka

Ishanka Ayeshwari Talagala, Metthananda Nawarathne, Carukshi Arambepola

Open Access Research article

Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR

Ryohei Yoshida, Takaaki Sasaki, Yasuhiro Umekage, Sachie Tanno, Yusuke Ono, Munehiko Ogata, Shinichi Chiba, Yusuke Mizukami, Yoshinobu Ohsaki

Open Access Research article

Predictive value of lymphocyte-to-monocyte ratio in the preoperative setting for progression of patients with breast cancer

Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Kosei Hirakawa, Masaichi Ohira

Open Access Case report

Breast cancer and synchronous multiple primary lung adenocarcinomas with heterogeneous mutations: a case report

Bo Jin, Simeng Zhang, Xin Chuang, Ping Yu, Ying Chen, Yuee Teng, Xiaofang Che, Yibo Fan, Chunlei Zheng, Xiaohan Li, Xueshan Qiu, Xiujuan Qu, Yunpeng Liu

Open Access Research article

Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma

Fangfang Kong, Junjun Zhou, Chengrun Du, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying

Open Access Study protocol

Study protocol: a randomized control trial of African American families fighting parental cancer together

Nicole S. McKinney, Shannon Virtue, Frances Marcus Lewis, Alliric I. Willis, Tanisha Pettyjohn, La-Rhonda Harmon, Adam Davey

Open Access Research article

Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer

Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai, Xudong Yao

Open Access Case report

Anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease, successfully treated with modified FOLFOX6: a case report

Masamichi Yamaura, Takeshi Yamada, Rei Watanabe, Hitomi Kawai, Suguru Hirose, Hiroki Tajima, Masashi Sato, Yuichi Uchida, Daisuke Suganuma, Yoshiyuki Yamamoto, Toshikazu Moriwaki, Ichinosuke Hyodo

Open Access Case report

CAR-T bridging to allo-HSCT as a treatment strategy for relapsed adult acute B-lymphoblastic leukemia: a case report

Shupeng Wen, Zhiyun Niu, Lina Xing, Ying Wang, Hang Li, Na Kuang, Jianmin Luo, Xuejun Zhang, Fuxu Wang

Open Access Research article

Achieving Thoracic Oncology data collection in Europe: a precursor study in 35 Countries

Anna Rich, David Baldwin, Inmaculada Alfageme, Paul Beckett, Thierry Berghmans, Stephen Brincat, Otto Burghuber, Alexandru Corlateanu, Tanja Cufer, Ronald Damhuis, Edvardas Danila, Joanna Domagala-Kulawik, Stefano Elia, Mina Gaga, Tuncay Goksel, Bogdan Grigoriu, Gunnar Hillerdal, Rudolf Maria Huber, Erik Jakobsen, Steinn Jonsson, Dragana Jovanovic, Elena Kavcova, Assia Konsoulova, Tanel Laisaar, Riitta Makitaro, Bakir Mehic, Robert Milroy, Judit Moldvay, Ross Morgan, Milda Nanushi, Marianne Paesmans, Paul Martin Putora, Miroslav Samarzija, Arnaud Scherpereel, Marc Schlesser, Jean-Paul Sculier, Jana Skrickova, Renato Sotto-Mayor, Trond-Eirik Strand, Paul Van Schil, Torsten-Gerriet Blum

Open Access Research article

CEA clearance pattern as a predictor of tumor response to neoadjuvant treatment in rectal cancer: a post-hoc analysis of FOWARC trial

Huabin Hu, Jin Huang, Ping Lan, Lei Wang, Meijin Huang, Jianping Wang, Yanhong Deng

Open Access Study protocol

Selecting the optimal position of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer – the SONIA study: study protocol for a randomized controlled trial

A. van Ommen-Nijhof, I. R. Konings, C. J. J. van Zeijl, C. A. Uyl-de Groot, V. van der Noort, A. Jager, G. S. Sonke, Sylvia Luykx-de Bakker, Hiltje de Graaf, Wouter Dercksen, Aafke Honkoop, Alex Imholz, Quirine van Rossum-Schornagel, Ester Siemerink, Inge Baas, Rianne Oosterkamp, Carolien Schröder, Judith Kroep, Annebeth Haringhuizen, Cathrien Tromp-van Driel, Frans Erdkamp, Paul de Jong, Jolien Tol, Yes van de Wouw, Joan Heijns, Anne-Marie van Riel, Caroline Mandigers, Marga Schrieks

Open Access Research article

The impact of clinicopathologic and surgical factors on relapse and pregnancy in young patients (≤40 years old) with borderline ovarian tumors

Chenyan Fang, Lingqin Zhao, Xi Chen, Aijun Yu, Liang Xia, Ping Zhang

Open Access Research article

Radiomics score: a potential prognostic imaging feature for postoperative survival of solitary HCC patients

Bo-Hao Zheng, Long-Zi Liu, Zhi-Zhi Zhang, Jie-Yi Shi, Liang-Qing Dong, Ling-Yu Tian, Zhen-bin Ding, Yuan Ji, Sheng-Xiang Rao, Jian Zhou, Jia Fan, Xiao-Ying Wang, Qiang Gao

Open Access Research article

Sleep duration and the risk of cancer: a systematic review and meta-analysis including dose–response relationship

Yuheng Chen, Fengwei Tan, Luopei Wei, Xin Li, Zhangyan Lyu, Xiaoshuang Feng, Yan Wen, Lanwei Guo, Jie He, Min Dai, Ni Li

Open Access Research article

Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

Wen-Wen Lv, Dahai Liu, Xing-Cun Liu, Tie-Nan Feng, Lei Li, Bi-Yun Qian, Wen-Xing Li

Open Access Research article

The feasibility, acceptability and outcomes of exergaming among individuals with cancer: a systematic review

Daniel Tough, Jonathan Robinson, Steven Gowling, Peter Raby, John Dixon, Samantha L. Harrison

Open Access Research article

Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma

Chunyan Gu, Xuefang Jing, Carol Holman, Ramakrishna Sompallae, Fenghuang Zhan, Guido Tricot, Ye Yang, Siegfried Janz

Open Access Research article

Overview of the pathological results and treatment characteristics in the first 1000 patients randomized in the SERC trial: axillary dissection versus no axillary dissection in patients with involved sentinel node

Gilles Houvenaeghel, Monique Cohen, Pédro Raro, Jérémy De Troyer, Christine Tunon de Lara, Pierre Gimbergues, Tristan Gauthier, Christelle Faure-Virelizier, Véronique Vaini-Cowen, Stéphane Lantheaume, Claudia Regis, Emile Darai, Vivien Ceccato, Gauthier D’Halluin, Francesco Del Piano, Richard Villet, Eva Jouve, Bassoodéo Beedassy, Pierrick Theret, Philippe Gabelle, Cécile Zinzindohoue, Pierre Opinel, Catherine Marsollier-Ferrer, Caroline Dhainaut-Speyer, Pierre-Emmanuel Colombo, Eric Lambaudie, Agnès Tallet, Jean-Marie Boher, Nicolas Sterkers, Jean-Claude Darmon, Julia Pernaut, Xavier Martin, Aubert Agostini, Max Buttarelli, Emile Mereb, Jean-François Le Digabel, Sophie Girard, Sandra Houlard, Ludivine Genre, Jean-Marie Brandone, Théophile Hoyek, Issam Baalbaky, Ludivine Loussert, Brice Gurriet, Renaud Haberstich, Christiane Pourny, Olivier Audrin, Gilles Carrasset, Frédéric Caquant, Jean-Philibert Combier, Frédéric Dedecker

Open Access Research article

A systematic review of non-standard dosing of oral anticancer therapies

Faouzi Djebbari, Nicola Stoner, Verna Teresa Lavender

Open Access Research article

Prevalence of drug-drug interactions in oncology patients enrolled on National Clinical Trials Network oncology clinical trials

Lauren A. Marcath, Taylor D. Coe, Emily K. Hoylman, Bruce G. Redman, Daniel L. Hertz

Open Access Research article

Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study

Ilka Ratjen, Clemens Schafmayer, Janna Enderle, Romina di Giuseppe, Sabina Waniek, Manja Koch, Greta Burmeister, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger, Wolfgang Lieb

Open Access Research article

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells

Srikanth Barkeer, Seema Chugh, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Satyanarayana Rachagani, Surinder K. Batra, Moorthy P. Ponnusamy

Open Access Research article

RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance

Claudia Vollbrecht, Dido Lenze, Michael Hummel, Annika Lehmann, Markus Moebs, Nikolaj Frost, Philipp Jurmeister, Leonille Schweizer, Udo Kellner, Manfred Dietel, Maximilian von Laffert

Open Access Case report

Long-term efficacy of crizotinib in a metastatic papillary renal carcinoma with MET amplification: a case report and literature review

Philippe Rochigneux, Jeanne Thomassin-Piana, Sophy Laibe, Serge Brunelle, Naji Salem, Bernard Escudier, Gilles Vassal, Gwenaelle Gravis

Open Access Research article

Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours

Shuang-zheng Jia, Jun-ji Zhang, Zhi-yong Liang, Jun-jun Yang, Yang Xiang, Cong-wei Jia, Jin-hua Leng

Open Access Research article

Decisional conflict of physicians during the decision-making process for a simulated advanced-stage cancer patient: an international longitudinal study with German and Belgian physicians

Catharina Schoenfeld, Yves Libert, Heribert Sattel, Delphine Canivet, France Delevallez, Andreas Dinkel, Pascal O. Berberat, Alexander Wuensch, Darius Razavi

Open Access Research article

Factors associated with high-risk HPV infection and cervical cancer screening methods among rural Uyghur women aged > 30 years in Xinjiang

Sulaiya Husaiyin, Lili Han, Lin Wang, Chunhua Ma, Zumurelaiti Ainiwaer, Nuermanguli Rouzi, Mireguli Akemujiang, Hatiguli Simayil, Zumulaiti Aniwa, Rouzi Nurimanguli, Mayinuer Niyazi

Open Access Research article

Mindfulness-based interventions and cognitive function among breast cancer survivors: a systematic review

Gabriella Cifu, Melinda C. Power, Sarah Shomstein, Hannah Arem

Open Access Research article

Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats

Norihisa Nishimura, Kosuke Kaji, Mitsuteru Kitade, Yosuke Aihara, Shinya Sato, Kenichiro Seki, Yasuhiko Sawada, Hiroaki Takaya, Yasushi Okura, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Akira Mitoro, Hitoshi Yoshiji

Open Access Research article

Prognostic significance of supradiaphragmatic lymph node metastasis detected by 18F-FDG PET/CT in advanced epithelial ovarian cancer

In Ok Lee, Jung-Yun Lee, Hyun Jeong Kim, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Chang Young Lee, Won Jun Kang, Young Tae Kim

Open Access Research article

Hospital utilization and disposition among patients with malignant bowel obstruction: a population-based comparison of surgical to medical management

Sarah B. Bateni, Alicia A. Gingrich, Susan L. Stewart, Frederick J. Meyers, Richard J. Bold, Robert J. Canter

Open Access Research article

TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90α/uPA/MMP2 signaling pathway

Kai Liu, Shao-Hua Xu, Zhao Chen, Qing-Xin Zeng, Zhi-Jun Li, Zhou-Miao Chen

Open Access Research article

RETRACTED ARTICLE:Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan, D. Velmurugan

Open Access Research article

Can pre-diagnostic serum levels of sodium and potassium predict prostate cancer survival?

Arunangshu Ghoshal, Hans Garmo, Niklas Hammar, Ingmar Jungner, Håkan Malmström, Göran Walldius, Mieke Van Hemelrijck

Open Access Research article

Cetuximab for esophageal cancer: an updated meta-analysis of randomized controlled trials

Ze-Hao Huang, Xiao-Wen Ma, Jing Zhang, Xiao Li, Na-Lin Lai, Sheng-Xiao Zhang

Open Access Research article

Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression

Rui-Lian Chen, Jun Zhao, Xu-Chao Zhang, Na-Na Lou, Hua-Jun Chen, Xue Yang, Jian Su, Zhi Xie, Qing Zhou, Hai-Yan Tu, Wen-Zhao Zhong, Hong-Hong Yan, Wei-Bang Guo, Yi-Long Wu, Jin-Ji Yang

Open Access Research article

Comparison of Germline versus Somatic BAP1 Mutations for Risk of Metastasis in Uveal Melanoma

K. G. Ewens, E. Lalonde, J. Richards-Yutz, C. L. Shields, A. Ganguly

Open Access Research article

Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials

Shailesh M. Advani, Pragati G. Advani, Helena M. VonVille, Syed H. Jafri

Open Access Research article

Differences in prostate tumor characteristics and survival among religious groups in Songkhla, Thailand

Christian S. Alvarez, Eduardo Villamor, Rafael Meza, Laura S. Rozek, Hutcha Sriplung, Alison M. Mondul

Open Access Research article

Microenvironment in neuroblastoma: isolation and characterization of tumor-derived mesenchymal stromal cells

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Application of Ventana immunocytochemical analysis on ThinPrep cytology slides for detection of ALK rearrangement in patients with advanced non–small-cell lung cancer

Hui Qin Guo, Jia Jia, Lin Lin Zhao, Huan Zhao, Cong Wang, Yue Sun, Jian Ming Ying, Lei Guo, Jian Cao, Zhi Hui Zhang

Open Access Research article

CCL1 is a major regulatory T cell attracting factor in human breast cancer

Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke, David Anz

Open Access Research article

Liposomal paclitaxel versus docetaxel in induction chemotherapy using Taxanes, cisplatin and 5-fluorouracil for locally advanced nasopharyngeal carcinoma

Sai-Lan Liu, Xue-Song Sun, Xiao-Yun Li, Qiu-Yan Chen, Huan-Xin Lin, Yue-Feng Wen, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Jin-Jie Yan, Chao Lin, Zhen-Chong Yang, Lin-Quan Tang, Ling Guo, Hai-Qiang Mai

Open Access Research article

Characteristics and impact of the most-cited palliative oncology studies from 1995 to 2016

Corbin Eule, Nizar Bhulani, Elizabeth Paulk, Ramona Rhodes, Muhammad Shaalan Beg

Open Access Case report

Hormone signaling via androgen receptor affects breast cancer and prostate cancer in a male patient: A case report

Haruko Takuwa, Wakako Tsuji, Masayuki Shintaku, Fumiaki Yotsumoto

Open Access Research article

Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells

Sugandha Saxena, Abhilasha Purohit, Michelle L. Varney, Yuri Hayashi, Rakesh K. Singh

Open Access Research article

The interactions of novel mononuclear platinum-based complexes with DNA

Ben W. Johnson, Mark W. Burgess, Vincent Murray, Janice R. Aldrich-Wright, Mark D. Temple

Open Access Research article

Breast diseases histologically diagnosed at a tertiary facility in Uganda (2005–2014)

Salvatore Ssemmanda, Eric Katagirya, Phiona Bukirwa, David Alele, Robert Lukande, Samuel Kalungi

Open Access Research article

RETRACTED ARTICLE: Ras-ERK1/2 signaling contributes to the development of colorectal cancer via regulating H3K9ac

Peng Tian, Yanfei Zhu, Chao Zhang, Xinyu Guo, Peng Zhang, Huanzhou Xue

Open Access Research article

HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions

Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel, Houshang Rafatpanah, Mohammad Mehdi Akbarin, Alireza Bari, Samaneh Ramezani, Seyed Abdolrahim Rezaee

Open Access Correction

Correction to: Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases

Wan-Ling Tan, Quan Sing Ng, Cindy Lim, Eng Huat Tan, Chee Keong Toh, Mei-Kim Ang, Ravindran Kanesvaran, Amit Jain, Daniel S. W. Tan, Darren Wan-Teck Lim

Open Access Research article

Effects of a combined physical and psychosocial training for children with cancer: a randomized controlled trial

Katja I. Braam, Elisabeth M. van Dijk-Lokkart, Gertjan J. L. Kaspers, Tim Takken, Jaap Huisman, Laurien M. Buffart, Marc B. Bierings, Johannes H. M. Merks, Marry M. van den Heuvel-Eibrink, Margreet A. Veening, Eline van Dulmen-den Broeder

Open Access Research article

Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases

Juan Zhao, Chunxiu Hu, Cheng Wang, Wei Yu, Yinglu Guo, Minghan Shi, Yongjie Shui, Qichun Wei

Open Access Research article

Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy

Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini, Charles H. Rochat

Open Access Research article

Randomized phase II study of the PDGFRα antibody olaratumab plus liposomal doxorubicin versus liposomal doxorubicin alone in patients with platinum-refractory or platinum-resistant advanced ovarian cancer

William P. McGuire, Richard T. Penson, Martin Gore, Antonio Casado Herraez, Patrick Peterson, Ashwin Shahir, Robert Ilaria Jr

Open Access Research article

miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas

Pengfei Cao, Meili Zhang, Lujuan Wang, Buqing Sai, Jiuqi Tang, Zhaohui Luo, Cijun Shuai, Liyang Zhang, Zheng Li, Yanjin Wang, Guiyuan Li, Juanjuan Xiang

Open Access Research article

MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway

Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang, Xingsheng Yang

Open Access Research article

A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci

Yosr Hamdi, Mariem Ben Rekaya, Shan Jingxuan, Majdi Nagara, Olfa Messaoud, Amel Benammar Elgaaied, Ridha Mrad, Lotfi Chouchane, Mohamed Samir Boubaker, Sonia Abdelhak, Hamouda Boussen, Lilia Romdhane

Open Access Case report

Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy

Robert Nakayama, Jyothi Priya Jagannathan, Nikhil Ramaiya, Marco L. Ferrone, Chandrajit P. Raut, John E. Ready, Jason L. Hornick, Andrew J. Wagner

Open Access Research article

Symptomatic venous thromboembolism associated with peripherally inserted central catheters predicts a worse survival in nasopharyngeal carcinoma: results of a large cohort, propensity score–matched analysis

Yu-Jing Liang, Lin-Quan Tang, Xue-Song Sun, Yu-Ying Fan, Jin-Jie Yan, Yu-Yun Du, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Sai-Lan Liu, Qing-Nan Tang, Xiao-Yun Li, Hai-Qiang Mai, Qiu-Yan Chen

Open Access Study protocol

Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group

Thomas J. Ettrich, Andreas W. Berger, Lukas Perkhofer, Severin Daum, Alexander König, Andreas Dickhut, Uwe Wittel, Kai Wille, Michael Geissler, Hana Algül, Eike Gallmeier, Jens Atzpodien, Marko Kornmann, Rainer Muche, Nicole Prasnikar, Andrea Tannapfel, Anke Reinacher-Schick, Waldemar Uhl, Thomas Seufferlein

Open Access Research article

KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer

Diana Casique-Aguirre, Paola Briseño-Díaz, Ponciano García-Gutiérrez, Claudia Haydée González-de la Rosa, Reyna Sara Quintero-Barceinas, Arturo Rojo-Domínguez, Irene Vergara, Luis Alberto Medina, José Correa-Basurto, Martiniano Bello, Rosaura Hernández-Rivas, María del RocioThompson-Bonilla, Miguel Vargas

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

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