Skip to main content
Erschienen in: Breast Cancer Research 4/2010

01.12.2010 | Short communication

Deciding priorities in Pharma

verfasst von: Maria Koehler

Erschienen in: Breast Cancer Research | Sonderheft 4/2010

Einloggen, um Zugang zu erhalten

Excerpt

It is commonly assumed that the primary objective of Pharma is to generate and maximize profit to share-holders rather than to serve humanity by the prevention and cure of disease and furthering science. Pharma is also felt to lack an incentive to fund and deliver personalized medicines, so it is up to the scientific community to do that (AT Fojo, Head of the Experimental Therapeutics Section, NCI at AACR 2010). Meanwhile, there are doubts within Pharma itself: 'increasing regulatory requirements, related escalating costs of development, and well publicized product withdrawals are leading those in the industry and its investors to wonder where future value can be realized,' (Ken Fyvie, expert in commercial strategy). …
Literatur
1.
Zurück zum Zitat Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, Nambu MD, Los G, Bender SL, Mroczkowski B, Christensen JG: An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007, 67: 4408-4417. 10.1158/0008-5472.CAN-06-4443.CrossRefPubMed Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, Nambu MD, Los G, Bender SL, Mroczkowski B, Christensen JG: An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007, 67: 4408-4417. 10.1158/0008-5472.CAN-06-4443.CrossRefPubMed
2.
Zurück zum Zitat Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007, 448: 561-566. 10.1038/nature05945.CrossRefPubMed Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007, 448: 561-566. 10.1038/nature05945.CrossRefPubMed
3.
Zurück zum Zitat Rodig SJ, Mino-Kenudson M, Dacic S, Yeap BY, Shaw A, Barletta JA, Stubbs H, Law K, Lindeman N, Mark E, Janne PA, Lynch T, Johnson BE, Lafrate J, Chirieac LR: Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009, 15: 5216-5223. 10.1158/1078-0432.CCR-09-0802.CrossRefPubMedPubMedCentral Rodig SJ, Mino-Kenudson M, Dacic S, Yeap BY, Shaw A, Barletta JA, Stubbs H, Law K, Lindeman N, Mark E, Janne PA, Lynch T, Johnson BE, Lafrate J, Chirieac LR: Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009, 15: 5216-5223. 10.1158/1078-0432.CCR-09-0802.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Bang Y, Kwak EL, Shaw AT, Camidge DR, Iafrate AJ, Maki RG, Solomon BJ, Ou SI, Salgia R, Clark JW: Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2010, 28: 18S-(suppl; abstr 3) Bang Y, Kwak EL, Shaw AT, Camidge DR, Iafrate AJ, Maki RG, Solomon BJ, Ou SI, Salgia R, Clark JW: Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2010, 28: 18S-(suppl; abstr 3)
Metadaten
Titel
Deciding priorities in Pharma
verfasst von
Maria Koehler
Publikationsdatum
01.12.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 4/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2750

Weitere Artikel der Sonderheft 4/2010

Breast Cancer Research 4/2010 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.