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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.09.2012 | Original Article

Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy

verfasst von: Jan Kalbitzer, Lorenz Deserno, Florian Schlagenhauf, Anne Beck, Thomas Mell, Gerd Bahr, Hans-Georg Buchholz, Michail Plotkin, Ralph Buchert, Yoshitaka Kumakura, Paul Cumming, Andreas Heinz, Michael A. Rapp

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 9/2012

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Abstract

Purpose

Age-related decline in cognitive speed has been associated with prefrontal dopamine D1 receptor availability, but the contribution of presynaptic dopamine and noradrenaline innervation to age-related changes in cognition is unknown.

Methods

In a group of 16 healthy participants aged 22–61 years, we used PET and the radioligand FDOPA to measure catecholamine synthesis capacity (K _in ^app; millilitres per gram per minute) and the digit symbol substitution test to measure cognitive speed, a component of fluid IQ.

Results

Cognitive speed was associated with the magnitude of K _in ^app in the prefrontal cortex (p < 0.0005). Both cognitive speed (p = 0.003) and FDOPA K _in ^app (p < 0.0005) declined with age, both in a standard voxel-wise analysis and in a volume-of-interest analysis with partial volume correction, and the correlation between cognitive speed and K _in ^app remained significant beyond the effects of age (p = 0.047). MR-based segmentation revealed that these age-related declines were not attributable to age-related alterations in grey matter density.

Conclusion

Our findings indicate that age-related changes in the capacity of the prefrontal cortex to synthesize catecholamines, irrespective of cortical atrophy, may underlie age-related decline in cognitive speed.

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Titel: Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy
verfasst von: Jan Kalbitzer
Lorenz Deserno
Florian Schlagenhauf
Anne Beck
Thomas Mell
Gerd Bahr
Hans-Georg Buchholz
Michail Plotkin
Ralph Buchert
Yoshitaka Kumakura
Paul Cumming
Andreas Heinz
Michael A. Rapp
Publikationsdatum: 01.09.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 9/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2162-4

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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