Background
Methods
Patients and controls
HC (n= 59) | All MS (n= 62) | RRMS (n= 23) | SPMS (n= 25) | PPMS (n= 14) | |
---|---|---|---|---|---|
Age (years) | 40.4 ± 10.8 | 45.5 ± 12.1 | 38.0 ± 9.7 | 50.8 ± 10.1 | 48.2 ± 13.3 |
Sex (% female) | 67.8 | 69.3 | 73.9 | 68.0 | 64.3 |
Age of onset of MS (years) | 33.5 ± 9.6 | 31.4 ± 10.6 | 33.4 ± 8.3 | 36.9 ± 9.7 | |
Duration of MS (years) | 12.8 ± 8.4 | 7.6 ± 6.5 | 18.0 ± 7.7 | 11.9 ± 7.1 | |
EDSS score | 5.1 ± 2.3 | 3.1 ± 1.8 | 6.3 ± 1.9 | 6.1 ± 1.6 | |
MSSS | 6.2 ± 2.6 | 4.9 ± 2.8 | 6.9 ± 2.4 | 7.4 ± 1.9 |
Flow cytometry
Data analysis and statistics
Results
HC (n= 59) | All MS (n= 62) | RRMS (n= 23) | SPMS (n= 25) | PPMS (n= 14) | |
---|---|---|---|---|---|
% CD3+ T cells | 72.8 ± 0.8 | 74.4 ± 1.0 | 74.2 ± 1.5 | 72.2 ± 1.7 | 78.9 ± 1.5 |
p value | 0.216* | < 0.05 | |||
% CD4+CD3+ T cells | 46.2 ± 1.1 | 52.2 ± 1.2 | 49.7 ± 1.9 | 51.1 ± 1.8 | 58.1 ± 1.9 |
p value | < 0.001* | < 0.05 | < 0.001 | ||
% CD8+CD3+ T cells | 23.1 ± 0.8 | 19.8 ± 0.7 | 21.7 ± 1.1 | 18.8 ± 1.0 | 18.3 ± 1.6 |
p value | 0.007† | < 0.01 | < 0.05 | ||
CD4:CD8 ratio | 2.2 ± 0.1 | 3.0 ± 0.2 | 2.5 ± 0.2 | 3.0 ± 0.3 | 3.7 ± 0.5 |
p value | < 0.001† | < 0.01 | < 0.001 | ||
% NK cells | 8.1 ± 0.6 | 8.1 ± 0.6 | 9.1 ± 1.1 | 8.0 ± 1.1 | 6.5 ± 1.0 |
p value | 0.553† | ||||
% B cells | 13.1 ± 0.6 | 11.7 ± 0.7 | 11.1 ± 1.1 | 13.0 ± 1.1 | 10.5 ± 1.1 |
p value | 0.143* | ||||
% monocytes | 7.7 ± 0.6 | 7.6 ± 0.6 | 8.2 ± 1.1 | 8.1 ± 1.0 | 5.4 ± 1.0 |
p value | 0.752† | ||||
T cell HLA class I MFI | 2015 ± 60 | 2072 ± 46 | 1964 ± 61 | 2082 ± 73 | 2223 ± 107 |
p value | 0.445* | ||||
T cell HLA class II MFI | 14.0 ± 0.5 | 13.7 ± 0.6 | 13.3 ± 0.8 | 13.3 ± 0.7 | 15.0 ± 1.7 |
p value | 0.406† | ||||
B cell HLA class I MFI | 3838 ± 132 | 4063 ± 123 | 4037 ± 231 | 3919 ± 164 | 4362 ± 261 |
p value | 0.214* | ||||
B cell HLA class II MFI | 4384 ± 146 | 4273 ± 153 | 4313 ± 210 | 3951 ± 265 | 4784 ± 315 |
p value | 0.605* | ||||
Monocyte HLA class I MFI | 4948 ± 221 | 4941 ± 189 | 4823 ± 282 | 4837 ± 355 | 5322 ± 297 |
p value | 0.982* | ||||
Monocyte HLA class II MFI | 2587 ± 218 | 2907 ± 236 | 3053 ± 418 | 2578 ± 317 | 3254 ± 561 |
p value | 0.474† |
HC (n= 30) | All MS (n= 33) | RRMS (n= 10) | SPMS (n= 15) | PPMS (n= 8) | |
---|---|---|---|---|---|
B cell HLA-DR MFI | 4745 ± 127 | 4729 ± 147 | 4894 ± 209 | 4489 ± 279 | 4974 ± 135 |
p value | 0.940 | > 0.05 | > 0.05 | > 0.05 | |
Monocyte HLA-DR MFI | 4122 ± 337 | 4321 ± 314 | 4657 ± 683 | 4122 ± 384 | 4273 ± 729 |
p value | 0.655 | > 0.05 | > 0.05 | > 0.05 |