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Supportive Care in Cancer

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01.01.2016 | Commentary

Defining cancer-related fatigue for biomarker discovery

verfasst von: Kristin Filler, Leorey N. Saligan

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2016

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Cancer-related fatigue (CRF) is a prominent and distressing symptom for cancer patients that can impair their overall health-related quality of life [1]. CRF is often described as a complex and multidimensional concept consisting of physical, cognitive, affective, spiritual, psychosocial, and environmental factors [1, 2]. Assessment of CRF is obtained from responses on various valid, self-report questionnaires established from several theoretical models of CRF. The complexity of CRF as a concept and the variability in the method of CRF assessment pose a challenge to investigators attempting to understand the etiology of CRF. Establishing a clear definition of a phenomenon, such as CRF, is an essential starting point for phenotypic characterization and biomarker discovery [3]. Therefore, this commentary aims to increase our awareness of the need for better definition and clearer phenotypic characterization of CRF. …

Bower JE (2007) Cancer-related fatigue: links with inflammation in cancer patients and survivors. Brain Behav Immun 21:863–871. doi:10.1016/j.bbi.2007.03.013 PubMedCentralCrossRefPubMed

Kwak SM, Choi YS, Yoon HM, et al (2012) The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients. Palliat Med 26:275–282. doi:10.1177/0269216311406991 CrossRefPubMed

Mischak H, Allmaier G, Apweiler R, et al (2010) Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med 2:46 ps42. doi:10.1126/scitranslmed.3001249 CrossRef

Bower JE, Bak K, Berger A, et al (2014) Screening, assessment, and management of fatigue in adult survivors of cancer: an American society of clinical oncology clinical practice guideline adaptation. J Clin Oncol 32:1840–1850. doi:10.1200/JCO.2013.53.4495 PubMedCentralCrossRefPubMed

Howell D, Keshavarz H, Broadfield L, et al. A pan canadian practice guideline for screening, assessment, and management of cancer-related fatigue in adults: Version 2–2015. Toronto: Canadian Partnership Against Cancer (Cancer Journey Advisory Group) and the Canadian Association of Psychosocial Oncology, April 2015. Retrieved from http://www.capo.ca/pdf/CRF_Guideline.pdf

Saligan LN, Olson K, Filler K, et al (2015) The biology of cancer-related fatigue: a review of the literature. Support Care Cancer 23:2461–2478. doi:10.1007/s00520-015-2763-0 CrossRefPubMed

Alexander S, Minton O, Andrews P, Stone P (2009) A comparison of the characteristics of disease-free breast cancer survivors with or without cancer-related fatigue syndrome. Eur J Cancer 45:384–392. doi:10.1016/j.ejca.2008.09.010 PubMedCentralCrossRefPubMed

Massacesi C, Terrazzino S, Marcucci F, et al (2006) Uridine diphosphate glucuronosyltransferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. Cancer 106:1007–1016. doi:10.1002/cncr.21722 CrossRefPubMed

Cashion A, Grady P (2015) The national institutes of health/national institutes of nursing research intramural research program and the development of the national institutes of health symptom science model. Nurs Outlook 63:484–487. doi:10.1016/j.outlook.2015.03.001 CrossRefPubMed

10.

Wratten C, Kilmurray J, Nash S, Seldon M, Hamilton CS, O’Brien PC, Denham JW (2004) Fatigue during breast radiotherapy and its relationship to biological factors. Int J Radiat Oncol Biol Phys 59:160–167. doi:10.1016/j.ijrobp.2003.10.008 CrossRefPubMed

11.

Courtier N, Gambling T, Enright S, Barrett-Lee P, Abraham J, Mason MD (2013) Psychological and immunological characteristics of fatigued women undergoing radiotherapy for early-stage breast cancer. Support Care Cancer 21:173–181. doi:10.1007/s00520-012-1508-6 CrossRefPubMed

12.

Cheville A (2009) Cancer-related fatigue. Phys Med Rehabil Clin N Am 20:405–416. doi:10.1016/j.pmr.2008.12.005 CrossRefPubMed

13.

Wood LJ, Nail LM, Perrin NA, Elsea CR, Fischer A, Druker BJ (2006) The cancer chemotherapy drug etoposide (VP-16) induces proinflammatory cytokine production and sickness behavior-like symptoms in a mouse model of cancer chemotherapy-related symptoms. Biol Res Nurs 8:57–169. doi:10.1177/1099800406290932 CrossRef

14.

Tezal M, Scannapieco FA, Wactawski-Wende J, Hyland A, Marshall JR, Rigual NR, Stoler DL (2012) Local inflammation and human papillomavirus status of head and neck cancers. Arch Otolaryngol Head Neck Surg 138:669–675. doi:10.1001/archoto.2012.873 PubMedCentralCrossRefPubMed

15.

Marquette C, Linard C, Galonnier M, Van Uye A, Mathieu J, Gourmelon P, Clarençon D (2003) IL-1beta, TNFalpha and IL-6 induction in the rat brain after partial-body irradiation: role of vagal afferents. Int J Radiat Biol 79:777–785. doi:10.1080/09553000310001610998 CrossRefPubMed

16.

Seigers R, Schagen SB, Van Tellingen O, Dietrich J (2013) Chemotherapy-related cognitive dysfunction: current animal studies and future directions. Brain Imaging Behav 7:453–459. doi:10.1007/s11682-013-9250-3 CrossRefPubMed

17.

Bower JE, Lamkin DM (2013) Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications. Brain Behav Immun 30:S48–S57. doi:10.1016/j.bbi.2012.06.011 PubMedCentralCrossRefPubMed

18.

Ganz PA, Bower JE (2007) Cancer related fatigue: a focus on breast cancer and Hodgkin’s disease survivors. Acta Oncol 46:474–479. doi:10.1080/02841860701367845 CrossRefPubMed

19.

Lutgendorf SK, Weinrib AZ, Penedo F, et al (2008) Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients. J Clin Oncol 26:4820–4827. doi:10.1200/JCO.2007.14.1978 PubMedCentralCrossRefPubMed

20.

Raison CL, Capuron L, Miller AH (2006) Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 27:24–31. doi:10.1016/j.it.2005.11.006 PubMedCentralCrossRefPubMed

Titel: Defining cancer-related fatigue for biomarker discovery
verfasst von: Kristin Filler
Leorey N. Saligan
Publikationsdatum: 01.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 1/2016
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-015-2965-5

Springer Medizin

Defining cancer-related fatigue for biomarker discovery

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