Skip to main content
Erschienen in: Osteoporosis International 12/2012

01.12.2012 | Original Article

Delay from fracture to hospital admission: a new risk factor for hip fracture mortality?

verfasst von: E. I. O. Vidal, D. C. Moreira-Filho, R. S. Pinheiro, R. C. Souza, L. M. Almeida, K. R. Camargo Jr., P. J. F. Villas Boas, F. B. Fukushima, C. M. Coeli

Erschienen in: Osteoporosis International | Ausgabe 12/2012

Einloggen, um Zugang zu erhalten

Abstract

Summary

The relationship between surgical timing and hip fracture mortality is unknown in the context of developing countries where large delays to surgery are common. We observed that delay from fracture to hospital admission is associated with decreased survival after a hip fracture.

Introduction

To examine the relationship between the time interval from fracture to surgery as well as its subcomponents (time from fracture to hospital admission and time from admission to surgery) and hip fracture survival.

Methods

The medical records of all patients aged 60 years and older admitted to a public university hospital in the city of Rio de Janeiro with a primary diagnosis of hip fracture between 1995 and 2000 were reviewed. Survival to hospital discharge and at 1 year were examined.

Results

Among 343 patients included in the study, there were 18 (5.3%) in-hospital deaths, and 297 (86.6%) patients remained alive 1 year after surgery. Very long delays from the time of fracture to hospital admission (mean 3 days) and from hospital admission to surgery (mean 13 days) were identified. Increased time from fracture to hospital admission was associated with reduced survival to hospital discharge (hazard ratio [HR] 1.09, 95% CI 1.03–1.15, p = 0.005) and reduced survival at 1 year after surgery (HR 1.07, 95% CI 1.03–1.10, p < 0.001). The interval of time from hospital admission to surgery was not associated with reduced survival to hospital discharge (HR 1.03, 95% CI 0.96–1.10, p = 0.379) or at 1 year after surgery (HR 1.03, 95% CI 0.99–1.07, p = 0.185).

Conclusions

If the association estimated in our study is causal, our results provide evidence that some hip fracture-related deaths could be prevented by improved patient access to appropriate and timely hospital care in the context of a developing country.
Literatur
1.
Zurück zum Zitat Johnell O, Kanis JA (2005) Epidemiology of osteoporotic fractures. Osteoporos Int 16(Suppl 2):S3–S7PubMedCrossRef Johnell O, Kanis JA (2005) Epidemiology of osteoporotic fractures. Osteoporos Int 16(Suppl 2):S3–S7PubMedCrossRef
2.
Zurück zum Zitat Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767PubMedCrossRef Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767PubMedCrossRef
3.
Zurück zum Zitat Hiligsmann M, Bruyere O, Ethgen O, Gathon HJ, Reginster JY (2008) Lifetime absolute risk of hip and other osteoporotic fracture in Belgian women. Bone 43(6):991–994PubMedCrossRef Hiligsmann M, Bruyere O, Ethgen O, Gathon HJ, Reginster JY (2008) Lifetime absolute risk of hip and other osteoporotic fracture in Belgian women. Bone 43(6):991–994PubMedCrossRef
4.
Zurück zum Zitat Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152(6):380–390PubMed Haentjens P, Magaziner J, Colon-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152(6):380–390PubMed
5.
Zurück zum Zitat Vidan MT, Sanchez E, Gracia Y, Maranon E, Vaquero J, Serra JA (2011) Causes and effects of surgical delay in patients with hip fracture: a cohort study. Ann Intern Med 155(4):226–233PubMed Vidan MT, Sanchez E, Gracia Y, Maranon E, Vaquero J, Serra JA (2011) Causes and effects of surgical delay in patients with hip fracture: a cohort study. Ann Intern Med 155(4):226–233PubMed
6.
Zurück zum Zitat Majumdar SR, Beaupre LA, Johnston DW, Dick DA, Cinats JG, Jiang HX (2006) Lack of association between mortality and timing of surgical fixation in elderly patients with hip fracture: results of a retrospective population-based cohort study. Med Care 44(6):552–559PubMedCrossRef Majumdar SR, Beaupre LA, Johnston DW, Dick DA, Cinats JG, Jiang HX (2006) Lack of association between mortality and timing of surgical fixation in elderly patients with hip fracture: results of a retrospective population-based cohort study. Med Care 44(6):552–559PubMedCrossRef
7.
Zurück zum Zitat Novack V, Jotkowitz A, Etzion O, Porath A (2007) Does delay in surgery after hip fracture lead to worse outcomes? A multicenter survey. Int J Qual Health Care 19(3):170–176PubMedCrossRef Novack V, Jotkowitz A, Etzion O, Porath A (2007) Does delay in surgery after hip fracture lead to worse outcomes? A multicenter survey. Int J Qual Health Care 19(3):170–176PubMedCrossRef
8.
Zurück zum Zitat Shiga T, Wajima Z, Ohe Y (2008) Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth 55(3):146–154PubMedCrossRef Shiga T, Wajima Z, Ohe Y (2008) Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Can J Anaesth 55(3):146–154PubMedCrossRef
9.
Zurück zum Zitat Kahn SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ (2009) Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury 40(7):692–697CrossRef Kahn SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ (2009) Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury 40(7):692–697CrossRef
10.
Zurück zum Zitat Leung F, Lau TW, Kwan K, Chow SP, Kung AWC (2010) Does timing of surgery matter in fragility hip fractures? Osteoporos Int 21(Suppl 4):S529–S534PubMedCrossRef Leung F, Lau TW, Kwan K, Chow SP, Kung AWC (2010) Does timing of surgery matter in fragility hip fractures? Osteoporos Int 21(Suppl 4):S529–S534PubMedCrossRef
11.
Zurück zum Zitat Vidal EI, Moreira-Filho DC, Coeli CM, Camargo KR, Fukushima FB, Blais R (2009) Hip fracture in the elderly: does counting time from fracture to surgery or from hospital admission to surgery matter when studying in-hospital mortality? Osteoporos Int 20(5):723–729PubMedCrossRef Vidal EI, Moreira-Filho DC, Coeli CM, Camargo KR, Fukushima FB, Blais R (2009) Hip fracture in the elderly: does counting time from fracture to surgery or from hospital admission to surgery matter when studying in-hospital mortality? Osteoporos Int 20(5):723–729PubMedCrossRef
12.
Zurück zum Zitat Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7(5):407–413PubMedCrossRef Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7(5):407–413PubMedCrossRef
13.
Zurück zum Zitat Computerised record linkage: compared with traditional patient follow-up methods in clinical trials and illustrated in a prospective epidemiological study. West of Scotland Coronary Prevention Study Group. J Clin Epidemiol. 1995;48(12):1441–52. Computerised record linkage: compared with traditional patient follow-up methods in clinical trials and illustrated in a prospective epidemiological study. West of Scotland Coronary Prevention Study Group. J Clin Epidemiol. 1995;48(12):1441–52.
14.
Zurück zum Zitat Jaro M (1995) Probabilistic linkage of large public health data files. Stat Med 14(5–7):491–498PubMedCrossRef Jaro M (1995) Probabilistic linkage of large public health data files. Stat Med 14(5–7):491–498PubMedCrossRef
15.
Zurück zum Zitat Vidal EI, Coeli CM, Pinheiro RS, Camargo KR (2006) Mortality within 1 year after hip fracture surgical repair in the elderly according to postoperative period: a probabilistic record linkage study in Brazil. Osteoporos Int 17(10):1569–1576PubMedCrossRef Vidal EI, Coeli CM, Pinheiro RS, Camargo KR (2006) Mortality within 1 year after hip fracture surgical repair in the elderly according to postoperative period: a probabilistic record linkage study in Brazil. Osteoporos Int 17(10):1569–1576PubMedCrossRef
16.
Zurück zum Zitat Shannon HS, Jamieson E, Walsh C, Julian JA, Fair ME, Buffet A (1989) Comparison of individual follow-up and computerized record linkage using the Canadian Mortality Data Base. Can J Public Health 80(1):54–57PubMed Shannon HS, Jamieson E, Walsh C, Julian JA, Fair ME, Buffet A (1989) Comparison of individual follow-up and computerized record linkage using the Canadian Mortality Data Base. Can J Public Health 80(1):54–57PubMed
17.
Zurück zum Zitat Coutinho ES, Coeli CM (2006) Accuracy of the probabilistic record linkage methodology to ascertain deaths in survival studies. Cad Saude Publica 22(10):2249–2252PubMedCrossRef Coutinho ES, Coeli CM (2006) Accuracy of the probabilistic record linkage methodology to ascertain deaths in survival studies. Cad Saude Publica 22(10):2249–2252PubMedCrossRef
18.
Zurück zum Zitat Camargo KR Jr, Coeli CM (2000) Reclink: an application for database linkage implementing the probabilistic record linkage method. Cad Saude Publica 16(2):439–447PubMedCrossRef Camargo KR Jr, Coeli CM (2000) Reclink: an application for database linkage implementing the probabilistic record linkage method. Cad Saude Publica 16(2):439–447PubMedCrossRef
19.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383PubMedCrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383PubMedCrossRef
20.
Zurück zum Zitat Grambsch P, Therneau T (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81(3):515–526CrossRef Grambsch P, Therneau T (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81(3):515–526CrossRef
21.
Zurück zum Zitat R Development Core Team (2009) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria R Development Core Team (2009) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
22.
Zurück zum Zitat Orosz GM, Hannan EL, Magaziner J, Koval K, Gilbert M, Aufses A, Straus E, Vespe E, Siu AL (2002) Hip fracture in the older patient: reasons for delay in hospitalization and timing of surgical repair. J Am Geriatr Soc 50(8):1336–1340PubMedCrossRef Orosz GM, Hannan EL, Magaziner J, Koval K, Gilbert M, Aufses A, Straus E, Vespe E, Siu AL (2002) Hip fracture in the older patient: reasons for delay in hospitalization and timing of surgical repair. J Am Geriatr Soc 50(8):1336–1340PubMedCrossRef
23.
Zurück zum Zitat Hefley FG, Nelson CL, Puskarich-May CL (1996) Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip. J Bone Joint Surg Am 78(4):581–583PubMed Hefley FG, Nelson CL, Puskarich-May CL (1996) Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip. J Bone Joint Surg Am 78(4):581–583PubMed
24.
Zurück zum Zitat Grimes JP, Gregory PM, Noveck H, Butler MS, Carson JL (2002) The effects of time-to-surgery on mortality and morbidity in patients following hip fracture. Am J Med 112(9):702–709PubMedCrossRef Grimes JP, Gregory PM, Noveck H, Butler MS, Carson JL (2002) The effects of time-to-surgery on mortality and morbidity in patients following hip fracture. Am J Med 112(9):702–709PubMedCrossRef
25.
Zurück zum Zitat Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR (2005) Best practices for elderly hip fracture patients. A systematic overview of the evidence. J Gen Intern Med 20(11):1019–1025PubMedCrossRef Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR (2005) Best practices for elderly hip fracture patients. A systematic overview of the evidence. J Gen Intern Med 20(11):1019–1025PubMedCrossRef
26.
Zurück zum Zitat Orosz GM, Magaziner J, Hannan EL et al (2004) Association of timing of surgery for hip fracture and patient outcomes. Jama 291(14):1738–1743PubMedCrossRef Orosz GM, Magaziner J, Hannan EL et al (2004) Association of timing of surgery for hip fracture and patient outcomes. Jama 291(14):1738–1743PubMedCrossRef
27.
Zurück zum Zitat Bhandari M, Tornetta P, Ellis T, Audige L, Sprague S, Kuo JC, Swiontkowski MF (2004) Hierarchy of evidence: differences in results between non-randomized studies and randomized trials in patients with femoral neck fractures. Arch Orthop Trauma Surg 124(1):10–16PubMedCrossRef Bhandari M, Tornetta P, Ellis T, Audige L, Sprague S, Kuo JC, Swiontkowski MF (2004) Hierarchy of evidence: differences in results between non-randomized studies and randomized trials in patients with femoral neck fractures. Arch Orthop Trauma Surg 124(1):10–16PubMedCrossRef
28.
Zurück zum Zitat McGuire K, Bernstein J, Polsky D, Silber J (2004) Delays until surgery after hip fracture increases mortality. Clin Orthop Rel Res 428:294–301CrossRef McGuire K, Bernstein J, Polsky D, Silber J (2004) Delays until surgery after hip fracture increases mortality. Clin Orthop Rel Res 428:294–301CrossRef
29.
Zurück zum Zitat Zuckerman JD, Skovron ML, Koval KJ, Aharonoff G, Frankel VH (1995) Postoperative complications and mortality associated with operative delay in older patients who have a fracture of the hip. J Bone Joint Surg Am 77(10):1551–1556PubMed Zuckerman JD, Skovron ML, Koval KJ, Aharonoff G, Frankel VH (1995) Postoperative complications and mortality associated with operative delay in older patients who have a fracture of the hip. J Bone Joint Surg Am 77(10):1551–1556PubMed
Metadaten
Titel
Delay from fracture to hospital admission: a new risk factor for hip fracture mortality?
verfasst von
E. I. O. Vidal
D. C. Moreira-Filho
R. S. Pinheiro
R. C. Souza
L. M. Almeida
K. R. Camargo Jr.
P. J. F. Villas Boas
F. B. Fukushima
C. M. Coeli
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 12/2012
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-012-1917-x

Weitere Artikel der Ausgabe 12/2012

Osteoporosis International 12/2012 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.