Background
Methods
Patient population
Study end-points
Within 30 since PCI | Within 1 year since PCI | After 1 year since PCI | |
---|---|---|---|
Causes of deaths (n = 80) | |||
Sudden death (n = 22) | 2 | 10 | 10 |
Pulmonary oedema (n = 12) | - | 4 | 8 |
Refractory acute HF (n = 10) | - | 4 | 6 |
Myocardial infarction (n = 7) | 1 | 1 | 5 |
Pneumonia (n = 2) | - | 2 | - |
Ascites (n = 1) | - | 1 | - |
Sepsis (n = 3) | - | 1 | 2 |
Abdominal aneurysm rupture (n = 1) | - | - | 1 |
Hepatic dysfunction (n = 1) | - | - | 1 |
Renal dysfunction (n = 2) | - | - | 2 |
Cerebrovascular accident (n = 2) | - | - | 2 |
Femur fracture (n = 1) | - | - | 1 |
Intestinal occlusion (n = 1) | - | - | 1 |
Gastric perforation (n = 1) | - | - | 1 |
Cancer (n = 5) | - | 2 | 3 |
Unknown (n = 9) | 1 | 1 | 7 |
Statistical analysis
Results
Characteristics of the patient population
Baseline Characteristics | Total Population |
---|---|
N° | 385 |
Age - mean (±SD) | 66 (±9) |
Male sex – n (%) | 333 (86) |
LVEF – mean (±SD) | 34 (±6) |
Risk factors – n (%) | |
Family history – n (%) | 149/357 (42) |
Hypertension - n (%) | 263/366 (72) |
Current Smoker – n (%) | 74/361 (21) |
Ex Smoker – n (%) | 189/361 (52) |
Diabetes – n (%) | 229/385 (59) |
IDDM – n (%) | 52/229 (23) |
Hypercholesterolemia – n (%) | 265/362 (73) |
Clinical history – n (%) | |
Previous MI – n (%) | 286/384 (74) |
Previous CABG – n (%) | 129/376 (34) |
Previous PCI – n (%) | 174/370 (47) |
Symptoms – n (%) | |
Asymptomatic –n (%) | 132/359 (37) |
Typical and Atypical Angina – n (%) | 227/359 (63) |
N° of diseased vessels – n (%) | |
One – n (%) | 254/385 (70) |
Diseased Left main stem or LAD | 109/254 (43) |
Diseased LAD | |
Two or more – n (%) | 125/385 (23) |
Symptoms of HF – n (%) (yes vs no) | 86/385 (22) |
Determinants of mortality and of composite outcome of death plus hospitalization for ADHF
Death | Death + ADHF | |||||
---|---|---|---|---|---|---|
HR | IC 95 % |
P
| HR | IC 95 % |
P
| |
Age | 1.03 | 1.01–1.06 | 0.008 | 1.02 | 1.00–1.04 | 0.04 |
Female sex | 0.56 | 0.26–1.21 | 0.14 | 0.85 | 0,47–1.51 | 0.57 |
IDDM | 2.32 | 1.35–4.00 | 0.002 | 1.93 | 1.18–3.16 | 0.009 |
HF symptoms | 1.65 | 1.03–2.62 | 0.036 | 1.94 | 1.31–2.88 | 0.001 |
Angina symptoms | 1.41 | 0.85–2.34 | 0.18 | 1.35 | 0.87–2.08 | 0.18 |
LVEF < 35 | 2.04 | 1.32–3.23 | 0.001 | 1.96 | 1.35–2.86 | <0.001 |
Stress testing | 0.66 | 0.40–1.08 | 0.10 | 0.53 | 0.34–0.83 | 0.005 |
Multivessel disease | 1.63 | 1.04–2.55 | 0.032 | 1.60 | 1.09–2.35 | 0.017 |
Previous MI | 0.91 | 0.55–1.51 | 0.71 | 0.89 | 0.58–1.37 | 0.59 |
Previous CABG | 1.02 | 0.63–1.66 | 0.93 | 0.96 | 0.64–1.45 | 0.85 |
Previous PCI | 0.77 | 0.49–1.24 | 0.29 | 0.69 | 0.46–1.04 | 0.074 |
Death | Death + ADHF | |||||
---|---|---|---|---|---|---|
HR | IC 95 % |
P
| HR | IC 95 % |
P
| |
Age | 1.03 | 1.00–1.06 | 0.03 | - | - | - |
IDDM | 2.64 | 1.50–4.67 | 0.001 | 2.22 | 1.33–3.70 | 0.002 |
HF symptoms | 1.67 | 1.02–2.73 | 0.042 | 1.94 | 1.27–2.95 | 0.002 |
LVEF < 35 | 1.84 | 1.20–2.94 | 0.006 | 1.79 | 1.22–2.63 | 0.003 |
Multivessel disease | 1.92 | 1.20–3.07 | 0.007 | 1.92 | 1.28–2.89 | 0.002 |
Stress testing | - | - | - | 0.60 | 0.38–0.94 | 0.025 |