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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

15.11.2019 | Review Article

Diagnostic performance of ¹⁸F-FDG PET/CT in patients with spinal infection: a systematic review and a bivariate meta-analysis

verfasst von: Giorgio Treglia, Mariarosa Pascale, Elena Lazzeri, Wouter van der Bruggen, Roberto C. Delgado Bolton, Andor W. J. M. Glaudemans

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 5/2020

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Abstract

Purpose

Diagnosis of spinal infection (SI) is challenging and usually requires multiple tests. We aimed to perform a systematic review and a bivariate meta-analysis on the diagnostic role of ¹⁸F-FDG PET/CT in patients with SI.

Methods

A comprehensive literature search of studies published through February 2019 in PubMed/MEDLINE and Cochrane library databases was carried out. Studies investigating the diagnostic performance of ¹⁸F-FDG PET/CT in patients with SI were eligible for inclusion in the qualitative analysis. For the quantitative analysis, pooled sensitivity, specificity, positive and negative likelihood ratio (LR+ and LR−) and diagnostic odds ratio (DOR) of ¹⁸F-FDG PET/CT in patients with suspected SI were calculated on a per examination-based analysis. Pooled data were presented with 95% confidence intervals (95% CI).

Results

Twenty-six articles (833 patients) using ¹⁸F-FDG PET/CT were eligible for the qualitative analysis. Twelve studies (396 patients) were selected for the meta-analysis. Overall, ¹⁸F-FDG PET/CT demonstrated a very good diagnostic performance in patients with SI and several studies underlined the value of ¹⁸F-FDG PET/CT in assessing the response to treatment. The bivariate meta-analysis on ¹⁸F-FDG PET/CT in patients with suspected SI provided the following results: sensitivity 94.8% (95% CI 88.9–97.6%) and specificity 91.4% (95% CI 78.2–96.9%). The pooled LR+, LR− and DOR were 4.7 (95% CI 2.9–7.7), 0.11 (95% CI 0.07–0.16) and 63.4 (95% CI 28.9–139), respectively. No significant heterogeneity or publication bias was found.

Conclusion

¹⁸F-FDG PET/CT demonstrated a very good diagnostic performance in patients with SI and can be used in patients in which MRI cannot be performed or is non-diagnostic or inconclusive. Several studies underlined the value of ¹⁸F-FDG PET/CT in assessing the response to treatment in patients with SI. Overall, larger multicentre and prospective studies and cost-effectiveness analyses are warranted.

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Titel: Diagnostic performance of 18F-FDG PET/CT in patients with spinal infection: a systematic review and a bivariate meta-analysis
verfasst von: Giorgio Treglia
Mariarosa Pascale
Elena Lazzeri
Wouter van der Bruggen
Roberto C. Delgado Bolton
Andor W. J. M. Glaudemans
Publikationsdatum: 15.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 5/2020
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04571-6

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Diagnostic performance of ¹⁸F-FDG PET/CT in patients with spinal infection: a systematic review and a bivariate meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

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Abstract

Purpose

Methods

Results

Conclusion

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