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01.07.2014 | Original Article

Diagnostic value of ¹⁸F-FDG PET/CT for lymph node metastasis of esophageal squamous cell carcinoma

verfasst von: Hiroyuki Yamada, Masao Hosokawa, Kazuo Itoh, Toshinao Takenouchi, Yoshihiro Kinoshita, Tomohiro Kikkawa, Keita Sakashita, Shion Uemura, Yasunori Nishida, Takaya Kusumi, Shigeyuki Sasaki

Erschienen in: Surgery Today | Ausgabe 7/2014

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Abstract

Purpose

This study investigated the diagnostic accuracy of hybrid positron-emission tomography/computed tomography (PET/CT) for lymph node (LN) metastasis of esophageal cancer. We also investigated the correlation between the size of metastatic nests and the detection by PET/CT.

Methods

Two hundred and fifty-eight patients with esophageal squamous cell carcinoma who underwent esophagectomy with two- or three-field radical lymphadenectomy were analyzed retrospectively. We compared the diagnosis of preoperative PET/CT to the postoperative histopathological examination by each anatomical field (n = 1,231) in all 258 patients. The metastatic LNs resected from PET/CT positive fields were classified as belonging to the PET/CT-N-positive group (n = 229) and those from negative fields as belonging to the PET/CT-N-negative group (n = 352). The cross-sectional areas of metastatic nests were measured in each metastatic LN.

Results

Of the 1,231 fields, 275 (22 %) were positive for metastasis, including 581 LNs from 408 regional LN stations. The sensitivity and specificity of PET/CT examined by each anatomical field were 25.8 and 97.8 %, respectively. The median area of metastatic nests was 17.7 mm² in the PET/CT-N-positive group, and 7.7 mm² in the PET/CT-N-negative group (p < 0.001).

Conclusions

A significant correlation was suggested between the nest size and detection by PET/CT. Because of its low sensitivity, PET/CT alone is insufficient to determine the surgical procedures, especially when considering reduction surgery.

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Titel: Diagnostic value of 18F-FDG PET/CT for lymph node metastasis of esophageal squamous cell carcinoma
verfasst von: Hiroyuki Yamada
Masao Hosokawa
Kazuo Itoh
Toshinao Takenouchi
Yoshihiro Kinoshita
Tomohiro Kikkawa
Keita Sakashita
Shion Uemura
Yasunori Nishida
Takaya Kusumi
Shigeyuki Sasaki
Publikationsdatum: 01.07.2014
Verlag: Springer Japan
Erschienen in: Surgery Today / Ausgabe 7/2014
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0725-z

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Abstract

Purpose

Methods

Results

Conclusions

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