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Journal of Medical Systems
Erschienen in: Journal of Medical Systems 5/2011

01.10.2011 | Original Paper

Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis

verfasst von: Z. Y. Luo, F. Xu, T. J. Lu, B. F. Bai

Erschienen in: Journal of Medical Systems | Ausgabe 5/2011

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Abstract

To better understand the physical mechanism of leukocyte separation via microfluidics, a level set method was employed to analyze the coupled deformation-flow of individual leukocytes in microfluidic parabolic shear blood flow. The results show that: (1) Weber number and viscosity ratio have great effects on the deformation of single leukocyte, (2) difference between the deformation and motion behavior of different subtypes of leukocytes (i.e., granulocytes, lymphocytes, monocytes) was observed, and (3) the existence of a second leukocyte significantly changes the leukocyte deformation and motion. These results shed light on the understanding of the motion and deformation of leukocytes in microchannel flow and provide a theoretical foundation for separating lymphocytes via microfluidics.
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Metadaten
Titel
Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis
verfasst von
Z. Y. Luo
F. Xu
T. J. Lu
B. F. Bai
Publikationsdatum
01.10.2011
Verlag
Springer US
Erschienen in
Journal of Medical Systems / Ausgabe 5/2011
Print ISSN: 0148-5598
Elektronische ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-010-9502-3

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