Background
Methods
Patients
Liver biopsy and pathological diagnosis
Laboratory assays
Statistical analyses
Results
Basic characteristics of enrolled patients
Immune Tolerant (n = 158) | Immune clearance (n = 133) | Low Replicative (n = 99) | HBeAg negativ hepatitis (n = 54) |
p value | |
---|---|---|---|---|---|
Age | 34 (28–42) | 31 (26–39) | 42 (32/49) | 43 (37–52) | <0.001a
|
Gender M/F | 92/66 | 94/39 | 58/41 | 39/15 | 0.053b
|
ALT IU/L | 40.5 (24–58.5) | 175 (103–356) | 22 (14–30) | 160 (112–391) | <0.001a
|
HBV DNA log IU/ml | 7.65(6.45–7.70) | 7.50 (6.65–7.69) | <2.70 (<2.70–2.73) | 5.81 (5.10–6.74) | <0.001a
|
HBsAg log IU/ml | 4.43 (3.54–4.76) | 3.96 (3.55–4.52) | 3.96 (3.56–4.51) | 3.28 (2.78–3.69) | <0.001a
|
HBeAg log COI | 2.97 (1.93–3.13) | 2.80 (2.12–3.08) | Negative | negative | – |
Necro-inflammation (G1:G2:G3) | 109:23:26 | 36:50:47 | 82:10:7 | 18:17:19 | <0.001a
|
Fibrosis: (S1, S2, S3, S4) | 84:38:16:20 | 33:48:20:32 | 65:13:10:11 | 13:15:12:14 | <0.001a
|
Liver HBsAg (0:1:2:3) | 1:29:71:57 | 3:30:44:56 | 20:38:25:16 | 2:13:22:17 | <0.001a
|
Liver HBcAg (0:1:2) | 78:50:30 | 85:38:10 | 96:2:1 | 49:5:0 | <0.001a
|
The level of HBcrAg and its relationship with other markers
Immune Tolerant (n = 159) | Immune clearance (n = 134) | Low Replicative (n = 99) | HBeAg negativ hepatitis (n = 54) | |||||
---|---|---|---|---|---|---|---|---|
r | P | r | P | r | P | r | P | |
HBcrAg | ||||||||
HBV DNA (log IU/ml) |
0.683
|
<0.001
|
0.397
|
<0.001
| 0.023 | 0.822 |
0.583
|
<0.001
|
HBeAg (log COI) |
0.761
|
<0.001
|
0.652
|
<0.001
| NA | NA | NA | NA |
HBsAg (log IU/ml) |
0.668
|
<0.001
|
0.521
|
<0.001
|
0.368
|
<0.001
| 0.296 | 0.03 |
ALT IU/L | −0.78 | 0.330 | 0.082 | 0.133 | 0.06 | 0.555 | 0.126 | 0.365 |
HBsAg | ||||||||
HBV DNA (log IU/ml) |
0.679
|
<0.001
|
0.608
|
<0.001
| 0.224 | 0.026 | 0.380 | 0.005 |
HBeAg (log COI) |
0.624
|
<0.001
|
0.456
|
<0.001
| NA | NA | NA | NA |
HBcrAg (log IU/ml) |
0.668
|
<0.001
|
0.521
|
<0.001
|
0.368
|
<0.001
| 0.296 | 0.030 |
ALT IU/L | −0.08 | 0.271 | 0.104 | 0.231 | 0.015 | 0.879 | −0.092 | 0.509 |
Multiple linear regression analysis of HBcrAg
Clinical Variables | Regression Coefficient | SE of Regression Coefficient | 95% CI |
P value | Multiple Regression Coefficient (R) | |
---|---|---|---|---|---|---|
Lower | Upper | |||||
Immune tolerant |
0.776
| |||||
logHBV DNA |
0.262
|
0.089
|
0.087
|
0.437
|
0.004
| |
logHBeAg |
0.751
|
0.104
|
0.546
|
0.956
|
1.99E-11
| |
Immune clearance |
0.664
| |||||
logHBV DNA | 0.164 | 0.085 | −0.005 | 0.333 | 0.057 | |
LogHBeAg |
0.697
|
0.086
|
0.527
|
0.867
|
3.35E-13
| |
E negative hepatitis |
0.583
| |||||
LogHBV DNA |
0.635
|
0.123
|
0.389
|
0.881
|
3.68E-6
|