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Clinical Orthopaedics and Related Research®
Erschienen in: Clinical Orthopaedics and Related Research® 6/2010

01.06.2010 | Basic Research

Distribution of Lubricin in the Ruptured Human Rotator Cuff and Biceps Tendon: A Pilot Study

verfasst von: Tadanao Funakoshi, MD, PhD, Scott D. Martin, MD, Thomas M. Schmid, PhD, Myron Spector, PhD

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 6/2010

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Abstract

Background

Lubricin is a lubricant for diarthrodial joint tissues and has antiadhesion properties; its presence in the (caprine) rotator cuff suggests it may have a role in intrafascicular lubrication.

Questions/Purposes

To preliminarily address this role, we asked: (1) What is the distribution of lubricin in human ruptured supraspinatus and biceps tendons? (2) What are the potential cellular sources of lubricin?

Methods

We obtained seven torn rotator cuff samples and four torn biceps tendon samples from 10 patients; as control tissues, we obtained the right and left supraspinatus tendons from each of six cadavers. Specimens were fixed in formalin and processed for immunohistochemical evaluation using a monoclonal antibody for lubricin.

Results

We found lubricin as a discrete layer on the torn edges of all of the ruptured supraspinatus and biceps tendon samples. None of the transected edges of the tissues produced during excision of the tissues showed the presence of lubricin. Lubricin was found in 3% to 10% of the tendon cells in the cadaveric controls and in 1% to 29% of the tendon cells in the torn supraspinatus and biceps tendon samples.

Clinical Relevance

The lubricin layer on the torn edges of ruptured human supraspinatus and biceps tendons may interfere with the integrative bonding of the torn edges necessary for repair.
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Metadaten
Titel
Distribution of Lubricin in the Ruptured Human Rotator Cuff and Biceps Tendon: A Pilot Study
verfasst von
Tadanao Funakoshi, MD, PhD
Scott D. Martin, MD
Thomas M. Schmid, PhD
Myron Spector, PhD
Publikationsdatum
01.06.2010
Verlag
Springer-Verlag
Erschienen in
Clinical Orthopaedics and Related Research® / Ausgabe 6/2010
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-009-1108-z

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