Erschienen in:
01.09.2013 | Research Letter
DNA methylation in monozygotic quadruplets affected by type 1 diabetes
verfasst von:
Giulio Disanto, Jana Vcelakova, Julia Pakpoor, Ramyiadarsini I. Elangovan, Zdenek Sumnik, Tereza Ulmannova, George C. Ebers, Sreeram V. Ramagopalan, Kateřina Štechová
Erschienen in:
Diabetologia
|
Ausgabe 9/2013
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Excerpt
To the Editor: The concordance rate of monozygotic (MZ) twins is approximately 50% for type 1 diabetes and this, along with other evidence, supports a role played by both genetic and environmental factors in determining this disease [
1,
2]. The epigenome of a cell can be defined as the group of epigenetic marks, such as DNA methylation, that influence gene expression and are responsible for cell specific differentiation [
3]. Epigenetic marks are influenced by environmental agents and therefore provide a potential explanation of how environmental exposure can impact upon human health [
4]. The presence of DNA methylation differences in CD14
+ monocytes of MZ twins discordant for type 1 diabetes has recently been reported [
5]. We have further explored cell specific DNA methylation differences in diabetes in an unprecedented case of MZ quadruplets of which two individuals had diabetes, one was at a prediabetic stage and one was diabetes free. …
