Erschienen in:
01.04.2010 | Letter
DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies
verfasst von:
Hidehiko Sugino, Hooi-Ming Lee, Norihiro Nishimoto
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 2/2010
Einloggen, um Zugang zu erhalten
Excerpt
In a recent interesting review, Alex Clarke and Timothy Vyse described the genetics of rheumatic disease [
1]. In the past several years, genome-wide association studies (GWAS) have led to the identification of six high-risk rheumatoid arthritis (RA) susceptibility genes - namely,
CD244,
PADI4,
SLC22A2,
PTPN22,
CTLA4, and
STAT4 (summarized in [
2]).
In vitro studies using mutant alleles and cultured cells have revealed the individual upregulation of
CD244,
PADI4,
SLC22A2, and
PTPN22 [
2‐
6]; however, studies on the expression of RA susceptibility genes in RA patients are rare. We therefore investigated the expression of the above-mentioned six RA susceptibility genes in 112 RA patients using DNA microarray analysis. This study aims to clarify whether DNA microarray analysis and GWAS produce comparable results with respect to RA susceptibility genes. …