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Erschienen in: Health and Quality of Life Outcomes 1/2009

Open Access 01.12.2009 | Research

Do neurooncological patients and their significant others agree on quality of life ratings?

verfasst von: Johannes M Giesinger, Miriam Golser, Astrid Erharter, Georg Kemmler, Gabriele Schauer-Maurer, Guenter Stockhammer, Armin Muigg, Markus Hutterer, Gerhard Rumpold, Bernhard Holzner

Erschienen in: Health and Quality of Life Outcomes | Ausgabe 1/2009

Abstract

Introduction

Patients suffering from brain tumours often experience a wide range of cognitive impairments that impair their ability to report on their quality of life and symptom burden. The use of proxy ratings by significant others may be a promising alternative to gain information for medical decision making or research purposes, if self-ratings are not obtainable. Our study investigated the agreement of quality of life and symptom ratings by the patient him/herself or by a significant other.

Methods

Patients with primary brain tumours were recruited at the neurooncological outpatient unit of Innsbruck Medical University. Quality of life self- and proxy-ratings were collected using the EORTC QLQ-C30 and its brain cancer module, the QLQ-BN20.

Results

Between May 2005 and August 2007, 42 pairs consisting of a patient and his/her significant other were included in the study. Most of the employed quality of life scales showed fairly good agreement between patient- and proxy-ratings (median correlation 0.46). This was especially true for Physical Functioning, Sleeping Disturbances, Appetite Loss, Constipation, Taste Alterations, Visual Disorders, Motor Dysfunction, Communication Deficits, Hair Loss, Itchy Skin, Motor Dysfunction and Hair Loss. Worse rater agreement was found for Social Functioning, Emotional Functioning, Cognitive Functioning, Fatigue, Pain, Dyspnoea and Seizures.

Conclusion

The assessment of quality of life in brain cancer patients through ratings from their significant others seems to be a feasible strategy to gain information about certain aspects of patient's quality of life and symptom burden, if the patient is not able to provide information himself.
Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7525-7-87) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

GJ, GM, EA and HB were responsible for study design, conceptualization and writing of the manuscript as well as for data collection. MA, HM and SG were the treating neurologists and therefore in charge of patient recruitment and gave important input for medical content. GJ and KG performed the statistical analysis. RG and SMG helped to draft the manuscript. All authors read and approved the final manuscript.
Abkürzungen
CHES
Computer-based Health Evaluation System
CI95%
95% confidence interval
EORTC
European Organisation for Research and Treatment of Cancer
FACT-Br
Functional Assessment of Cancer Therapy - Brain
PRO
Patient-reported Outcome
QLQ-BN20
Quality of Life Questionnaire - Brain Cancer Module
QLQ-C30
Quality of Life Questionnaire - Core 30
QOL
Quality of Life
SD
Standard deviation
WHO
World Health Organisation

Introduction

The assessment of patient-reported outcomes (PRO) has become very common in oncological research and to a lesser degree in daily clinical routine. Information gathered through PRO-monitoring, especially data on quality of life (QOL), has proved to be useful in symptom management and evaluation of oncological treatment [15]. But to date the number of studies on QOL in patients with brain tumours is limited, although the limited curative options underline the importance of QOL.
Naturally, the assessment of PRO is restricted to patients having the ability to report on what they experience throughout the course of the disease. In patients with brain tumours the assessment of QOL can prove difficult not only due to physical condition but also because of cognitive impairments such as lack of concentration, thought disorder, communication deficits and visual disorders.
If during the course of the disease the patient's ability to report on his QOL and symptoms diminishes, ratings by others gain importance. Since significant others such as spouses, children or other family members are often intimately involved in patient care, their impression of a patient's well-being could contribute to symptom management and treatment evaluation if gathering information from the patient is not possible. In a research context proxy ratings may reduce drop out bias by allowing patients with progressive cognitive deterioration to remain in the study.
There is some evidence that significant others show agreement with patients' self-ratings on QOL for various types of cancer, although proxies tend to underrate QOL. Furthermore, agreement is lower for psychosocial issues and higher for physical symptoms [69].
This kind of proxy-ratings was also found to be more concordant with patients' self-ratings than ratings by physicians [10, 11]. Besides neurooncological patients, proxy-ratings have also been proven useful in many other patient groups that can not be assessed directly, e.g. in patients suffering from dementia [12] or in children [13].
Obviously, the usefulness of a proxy-approach to PRO-assessment depends strongly on the reliability of the rating in terms of agreement with the patient's self-rating. Therefore it is of interest whether or not self- and proxy-ratings correlate highly and whether or not there is a bias induced by proxies over- or underestimating patients' QOL.
The current study aimed to investigate the relation between ratings of patients and their significant others on QOL assessed with the EORTC QLQ-C30 and QLQ-BN20. Thus, we addressed the following questions:
1.) To what degree do self- and proxy-ratings on QOL correlate?
2.) Is there a systematic difference between self- and proxy-ratings on QOL?
3.) What percentage of ratings on QOL show strong agreement?

Methods

Sample

Patients with primary brain tumors treated at the neurooncological outpatient unit of Innsbruck Medical University were considered for participation in the study. Inclusion criteria were age between 18 and 80 years, fluency in German, no severe cognitive impairments, an expected survival time of at least 3 months and informed consent. As „severe cognitive impairment" we considered a degree of impairment not allowing the patient to report on his QOL. Exclusion criteria were very bad physical condition as rated by the treating physician and visiting the outpatient unit less than once a year. In addition to patients' ratings proxy-ratings from a significant other were collected. Significant others comprised (de facto) spouses, children (aged above 18 years), siblings or any person living with the patient. Informed consent was collected from participating significant others as well. The study was approved by the Ethics Committee of Innsbruck Medical University.

Procedure

Patients and their significant others were approached while waiting for their examination at the neurooncological outpatient unit. Data collection was done partly by a graduate psychology student and partly by nurses. After providing informed consent tablet-PCs presenting the EORTC QLQ-C30 and QLQ-BN20 on the screen were handed over to the patients and significant others along with instructions for the completion of the questionnaires. They filled in the questionnaires simultaneously and were asked to do so independently. The student or nurse supvervised data entry, escpecially with regard to possible communication between patient and significant other. As software tool for data collection we used a program called Computer-based Health Evaluation System [CHES, [14]]. CHES is a PC-program for the computerised assessment, calculation and presentation of psychosocial and medical data.

Assessment Instruments

EORTC QLQ-C30

The EORTC QLQ-C30 [15], an internationally validated and widely used cancer-specific QOL-instrument, assesses various facets of functioning, symptoms common in cancer patients and global QOL. The EORTC quality of life questionnaire suite has a modular structure consisting of a core questionnaire (EORTC QLQ-C30) and specific additional modules for cancer patients of different diagnostic groups. As a supplement two items concerning taste and smell alteration were added from the EORTC Quality of Life Group item bank ("Have you had problems with your sense of taste?" and "Did food and drink taste different from usual?"). This item bank covers all items included in the QLQ-C30 and its various modules. The two items on taste were summed to generate a novel subscale called the Taste Alterations subscale.
For collection of proxy-ratings the items were altered to refer to the patient in the third person, instead of the first person self-rating version.

EORTC QLQ-BN20

The Brain Cancer Module (EORTC QLQ-BN20 [16]) is a 20-item supplement for the QLQ-C30 to assess brain cancer-specific QOL issues. The module comprises the subscales Future Uncertainty, Visual Disorders, Bladder control, Motor Dysfunctions, Headaches, Communication Deficits, Seizures, Hair Loss, Itchy Skin and Weakness of Legs.
Again the wording of the items was altered to third person for proxy-ratings.

Statistical analysis

Patient and significant other scores on the QLQ-C30 and QLQ-BN20 were summarised as means and standard deviations. All scales were scored according to the EORTC guidelines along a possible range from 0 to 100 points.
T-tests for dependent samples were used to detect any systematic differences, while correlations between self- and proxy-ratings were carried out using the Pearson-correlation coefficient. 95%-confidence intervals were calculated for all correlation coefficients. Since correlations only reflect the strength of relation between ratings, but do not reflect systematic differences, the T-tests appeared to be more meaningful in determining rater agreement. Following recommendations of Osoba et al. [17] and King [18] we considered mean differences between patient and proxy ratings equal or below 5 points as an indicator of good rater agreement.
As an additional measure of agreement between patients and significant others we calculated the percentage of ratings with differences ≤5 points for each scale.
To demonstrate the extent of rater disagreement across the range of a scale we provide Bland and Altman plots [19].
Power analysis was done for detecting mean differences between patient and proxy ratings. A sample of 42 patient-proxy-pairs was found to be sufficient to detect a mean difference with an effect size of 0.44 (two-sided test, power = 0.80, alpha = 0.05).

Results

Sample characteristics

Between May 2005 and August 2007, 157 patients with primary brain tumors treated at the neurooncological outpatient unit of Innsbruck Medical University were eligible for participation in the study. The included patients were a sub-sample of a larger study on patient-reported outcome monitoring in neurooncologial patients. More details on data collection can be found in Erharter et al [20].
A total of 47 patients could not be included (19 patients were in very bad physical condition, 18 patients visited the outpatient unit less frequently than once per year, 4 patients did not provide informed consent, 3 patients were not fluent in German and 3 patients had severe visual disorders). Thus, data from 110 patients were available. Additional ratings from significant others could be collected for 42 patients (43 significant others refused participation, 25 patients did not bring a significant other with them), i.e. 42 paired ratings were available for statistical analysis. Details on sociodemographic and clinical variables are shown in Table 1.
Table 1
Descriptive statistics for sociodemographic and clinical data at baseline (N = 42)
Age (years)
Mean (SD)
47.5 (14.2)
Sex
Women
47%
 
Men
52%
Marital status
Single
12%
 
Partnership, marriage
81%
 
Divorced, seperated
2%
 
Widowed
5%
Housing situation
living alone
3%
 
living in partnership/with children and/or with children
86%
 
living with family of origin
7%
 
nursing home
3%
Education
Compulsory school
24%
 
Apprenticeship, professional school
41%
 
A-level
29%
 
University degree
6%
Employment status
Full time
31%
 
Part time
8%
 
Homemaker
19%
 
Training
3%
 
Retired
19%
 
Status of employee's illness
6%
 
Others
14%
Significant Other
Spouse
73%
 
Child
18%
 
Parent
6%
1%
 
Friend
3%
Duration of illness (months)
Mean (SD)
49.3 (47.8)
Tumor type
Meningioma
5%
 
Glioblastoma
16%
 
Astrocytoma
41%
 
Oligodendroglioma
24%
 
Ependymoma
3%
 
Other
11%
WHO-Grading
Grade I
0.0%
 
Grade II
45%
 
Grade III
35%
 
Grade IV
21%
Previous surgery
no surgery/biopsy
46%
 
Partial resection
29%
 
Total resection
25%
Previous radiotherapy
 
63%
Previous chemotherapy
 
53%
Location of tumor
Right hemisphere
57%
 
Left hemisphere
43%

Agreement between self-ratings and proxy-ratings for the QLQ-C30

For 14 of the 16 subscales (including the Taste Alterations subscale) differences between patients' self-ratings and proxy-ratings by a significant other were below 5 points. Higher discrepancies were only found for Social Functioning (patient mean 8.7 points higher than proxy-mean) and Dyspnoea (patient mean 5.6 points higher than proxy-mean). Seven of the 16 subscales showed correlations between self- and proxy-ratings of at least 0.5. Coefficients were highest for Physical Functioning (r = 0.79) and Taste Alterations (r = 0.77) and lowest for Social Functioning (r = 0.26, not significant) and Pain (r = 0.28, not significant).
Accuracy, in terms of percentage of differences equal or below 5 points, was highest for Diarrhea (83%), Appetite Loss (71%) and Constipation (68%) and lowest for Emotional Functioning (14%), Fatigue (19%) and Social Functioning (21%). For 8 of the 16 scales the percentage of differences equal or below 5 points was at least 50%. For further details see Table 2 and Figure 1. To illustrate extent of rater agreement across the scale range Bland and Altman plots are shown for Physical Functioning (Figure 2a) and Social Functioning (Figure 2b).
Table 2
Agreement of patient- and proxy-ratings for the EORTC QLQ-C30
EORTC QLQ-C30
Patient Mean (SD)
Proxy Mean (SD)
Patient minus Proxy
effect size
t-value
p-value
Pearson-Correlation
(CI95%)
agreement (+/- 5 points)
Physical Functioning
77.6 (27.3)
74.3 (28.8)
3.3
0.12
t = 1.16;
p = 0.25
0.79*
(0.65-0.89)
36%
Social Functioning
69.8 (35.4)
61.1 (34.5)
8.7
0.25
t = 1.33;
p = 0.19
0.26
(-0.05-0.53)
21%
Role Functioning
63.5 (36.9)
62.7 (35.3)
0.8
0.02
t = 0.13;
p = 0.90
0.42*
(0.13-0.65)
31%
Emotional Functioning
59.5 (30.4)
61.8 (23.8)
-2.3
-0.08
t = -0.45;
p = 0.65
0.31*
(0.01-0.56)
14%
Cognitive Functioning
70.6 (31.2)
70.2 (27.7)
0.4
0.01
t = 0.08;
p = 0.94
0.36*
(0.06-0.60)
24%
Global QOL
63.8 (23.0)
62.0 (21.6)
1.8
0.08
t = 0.55;
p = 0.58
0.55*
(0.29-0.74)
24%
Fatigue
41.5 (32.6)
44.2 (29.3)
-2.7
-0.09
t = -0.50;
p = 0.62
0.40*
(0.11-0.64)
19%
Nausea/Vomiting
9.9 (16.9)
9.1 (20.9)
0.8
0.04
t = 0.24;
p = 0.81
0.35*
(0.05-0.60)
60%
Pain
15.9 (25.5)
19.5 (22.6)
-3.7
-0.14
t = -0.81;
p = 0.42
0.28
(-0.03-0.54)
39%
Dyspnoea
20.6 (31.2)
15.1 (22.3)
5.6
0.20
t = 1.19;
p = 0.24
0.40*
(0.11-0.64)
50%
Sleeping Disturbances
27.8 (32.0)
28.6 (30.0)
-0.8
-0.03
t = -0.17;
p = 0.87
0.51*
(0.25-0.71)
52%
Appetite Loss
15.9 (27.8)
19.0 (29.6)
-3.2
-0.11
t = -0.81;
p = 0.42
0.61*
(0.38-0.78)
71%
Constipation
15.8 (29.8)
15.8 (25.4)
0.0
0.00
t = 0.00;
p = 1.00
0.50*
(0.24-0.70)
68%
Diarrhea
7.3 (19.0)
11.4 (25.4)
-4.1
-0.17
t = -1.09;
p = 0.28
0.46*
(0.18-0.67)
83%
Financial Impact
22.2 (31.8)
19.8 (27.6)
2.4
0.08
t = 0.53;
p = 0.60
0.53*
(0.28-0.72)
60%
Taste Alterations
22.1 (34.7)
18.8 (32.5)
3.3
0.10
t = 0.93;
p = 0.36
0.77*
(0.62-0.88)
60%
*p < 0.05

Agreement between self-ratings and proxy-ratings for the QLQ-BN20

For 10 of the 11 scales of the brain tumour module mean differences between patients' self-ratings and proxy-ratings by a significant other were below 5 points. A higher discrepancy was only found for Seizures (patient mean 6.3 points higher than proxy mean).
Correlations between self- and proxy-ratings were at least 0.5 for 6 of the 11 scales. Coefficients were highest for Motor Dysfunction (r = 0.67) and Communication Deficits (r = 0.67) and lowest for Bladder Control (r = 0.14) and Seizures (r = 0.38).
Accuracy, in terms of percentage of differences equal or below 5 points, was highest for Seizures (81%), Hair Loss (78%) and Bladder Control (75%) and lowest for Future Uncertainty (29%), Drowsiness (38%) and Motor Dysfunction (44%). For 7 of the 11 scales the percentage of differences equal or below 5 points was at least 50%. For further details see Table 3 and Figure 3.
Table 3
Agreement of patient- and proxy-ratings for the EORTC QLQ-BN20
EORTC QLQ-BN20
Patient Mean (SD)
Proxy Mean (SD)
Patient minus Proxy
effect size
t-value
p-value
Pearson-Correlation
(CI95%)
agreement (+/- 5 point)
Future Uncertainty
28.3 (29.6)
31.1 (28.1)
-2.8
-0.10
t = -0.67;
p = 0.51
0.55*
(0.29-0.74)
29%
Visual Disorders
13.3 (16.5)
12.9 (19.9)
0.4
0.02
t = 0.16;
p = 0.88
0.58*
(0.34-0.76)
50%
Motor Dysfunction
21.1 (25.9)
21.8 (28.3)
-0.7
-0.02
t = -0.20;
p = 0.84
0.67*
(0.46-0.81)
44%
Communication Deficits
26.3 (28.1)
23.8 (33.4)
2.5
0.08
t = 0.64;
p = 0.53
0.67*
(0.46-0.81)
45%
Headaches
34.1 (35.7)
32.5 (34.9)
1.6
0.04
t = 0.32;
p = 0.75
0.59*
(0.35-0.77)
57%
Seizures
13.5 (30.4)
7.1 (17.3)
6.3
0.27
t = 1.43;
p = 0.16
0.38*
(0.09-0.62)
81%
Drowsiness
38.9 (32.9)
36.5 (30.2)
2.4
0.08
t = 0.45;
p = 0.65
0.42*
(0.13-0.65)
38%
Hair Loss
9.2 (18.5)
7.5 (19.2)
1.7
0.09
t = 0.57;
p = 0.57
0.52*
(0.26-0.72)
78%
Itchy Skin
12.8 (22.4)
14.5 (29.4)
-1.7
-0.07
t = -0.37;
p = 0.71
0.42*
(0.13-0.65)
64%
Weakness of Legs
25.0 (36.8)
21.7 (31.6)
3.3
0.10
t = 0.58;
p = 0.56
0.45*
(0.17-0.66)
60%
Bladder Control
10.0 (21.6)
6.7 (15.5)
3.3
0.18
t = 0.85;
p = 0.40
0.14
(-0.17-0.43)
75%
*p < 0.05
Bland and Altman plots are shown for Motor Dysfunction (Figure 2c) and Seizures (Figure 2d) to exemplify extent of rater agreement across the scale range.

Discussion

The comparison of patients' rating on their QOL with proxy-ratings obtained from their significant others is of importance to the decision whether or not these proxy-ratings are a useful measure, if patients' ability to report on his QOL diminishes due to physical or cognitive deterioration.
Our study found that for a considerable number of subscales of the EORTC QLQ-C30 and QLQ-BN20 proxy-ratings by significant others can be regarded as useful. This was especially true for Physical Functioning, Sleeping Disturbances, Appetite Loss, Constipation, Financial Impact and Taste Alterations. Worse rater agreement was found for Social Functioning, Emotional Functioning, Cognitive Functioning, Fatigue, Pain, Dyspnoea and Seizures. For these scales correlations as well as percentage of agreement (+/-5 points) were low. However, with the exception of Social Functioning and Dyspnoea means of patients' ratings and proxy-ratings were rather similar (less than 5 points difference).
The additional module QLQ-BN20 showed fairly good rater agreement for most scales. Worst agreement was found for Seizures and Bladder Control.
With reference to Osoba et al. [17] and King [18] we considered mean differences above 5 points as relevant rater disagreement. Taking this into account discrepancies between proxy- and self-ratings were rather insiginficant for most scales. No uniform pattern was found with respect to systematic under/over-rating by proxies.
Another important issue is the extent of rater-agreement across the scale range, especially with regard to generalisability of our results to patients in a poor condition. Analysis of Bland and Altman plots indicate that agreement is worst for the central section of a scale. This finding is probably a result of the fact that possible differences between raters are necessarily minimised by the limited range scale.
Overall, proxy-ratings performed somewhat better for more overt aspects of QOL such as physical symptoms, whereas ratings on social and psychological aspects showed less congruency.
A limitation of our study is the small sample size which did not allow to detect small mean differences between patient and proxy ratings. For the same reason, it was not possible to perform subgroup analyses on certain patient groups. In addition, patients in a very bad physical condition, would have been of importance to our study, as proxy-ratings are most useful in that patient group. However, due to ethical considerations it was not possible to include such, since burden caused by filling in both questionnaires was considered not acceptable for these patients. Another limitation of our study is the high rate of significant others refusing participation in the study.
The results for accuracy (percentage of mean differences equal or below 5 points) may have been affected by the number of items in a scale, more precisely the number of possible scores on a scale. Two contrary effects can be expected from this. On the one hand a low number of possible scores increases agreement due to chance, on the other hand if the distance between two possible scores is higher than 10 points (e.g. for scales containing one or two items) only exact agreement is taken into account by this accuracy parameter.
The study most similar to ours [6] found more pronounced mean differences for Physical Functioning, Role Functioning, Cognitive Functioning, Social Functioning and Fatigue (all between 5 and 10 points). With the exception of Physical Functioning, these scales showed also only a moderate proportion of exact agreement. A slight difference to our study was the use of a previous version of the QLQ-C30 in the study by Sneeuw et al. [6] that employed a dichotomous response format for the scales Physical Functioning and Role Functioning.
Proxies' relationship with the patient, age, gender and culture showed no significant association with rater agreement. But agreement was worse in patients with mental confusion, cognitive impairments and motor deficits. We think that the finding that rater agreement is low in patients with severe cognitive impairments should not be considered per se as an indication for inaccurate proxy rating. It might also reflect patients' inability to report on their condition. On the other hand, it may as well be difficult for proxies to understand the individual consequences of cognitive decline. Additional clinical variables as more objective criteria may be helpful in evaluating rater disagreement in this patient group.
In a recent study by Brown et al. [21] on rater agreement in patients with newly diagnosed high-grade gliomas proxy-ratings by a caregiver chosen by the patient himself also showed good congruence. As QOL-instrument this study employed the FACT-Br [22]. Correlation between patient-ratings and caregiver-ratings was 0.63 at baseline and 0.64 at 2 and 4 months follow-up, percentage of agreement (+/- 10 points on a scale ranging from 0 to 100) was 63-68% at the three assessment time points.
With regard to type of proxy-rating, proxy-raters can not only differ in their relation to the patient (significant other, treating physician, caregiver etc.) but also in the perspective they take towards the patient. Gundy and Aaronson [23] investigated whether or not there are differences in proxy-ratings if the proxy rates the patient taking the patient's perspective or if he makes his own assessment of the patient. No differences with regard to bias were found between both types of ratings, although it should be mentioned that the study might have been not sufficiently powered to detect possible differences between these types of ratings.
Taking our own findings and those from similar studies into account, the assessment of QOL in brain cancer patients through ratings from their significant others seems to be a feasible strategy to gain information about important aspects of a patient's QOL, if the patient is not able to provide information himself. However, in general rater agreement is lower for psychosocial issues compared to physical symptoms.
In a research context proxy ratings may allow to reduce bias from patients droping out of studies because of deteriorating health and in a clinical context proxy-ratings could contribute to medical decision making. Future research, should further evaluate the impact of patient and proxy characteristics on rater agreement and include further criteria for accuracy of proxy ratings.

Acknowledgements

We want to thank Jakob Pinggera, Stefan Zugal and Barbara Weber for help with software programming. Furthermore, we want to thank Elisabeth Huber and Theresia Kindl for help with data collection. Thanks also to an anonymous referee for helpful comments on this manuscript. The project was partly funded by the "Jubiläumsfond" of the Austrian National Bank.
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://​creativecommons.​org/​licenses/​by/​2.​0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

GJ, GM, EA and HB were responsible for study design, conceptualization and writing of the manuscript as well as for data collection. MA, HM and SG were the treating neurologists and therefore in charge of patient recruitment and gave important input for medical content. GJ and KG performed the statistical analysis. RG and SMG helped to draft the manuscript. All authors read and approved the final manuscript.
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Metadaten
Titel
Do neurooncological patients and their significant others agree on quality of life ratings?
verfasst von
Johannes M Giesinger
Miriam Golser
Astrid Erharter
Georg Kemmler
Gabriele Schauer-Maurer
Guenter Stockhammer
Armin Muigg
Markus Hutterer
Gerhard Rumpold
Bernhard Holzner
Publikationsdatum
01.12.2009
Verlag
BioMed Central
Erschienen in
Health and Quality of Life Outcomes / Ausgabe 1/2009
Elektronische ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-7-87

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