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Archives of Orthopaedic and Trauma Surgery

Erschienen in:

01.07.2015 | Arthroscopy and Sports Medicine

Does intraoperative application of leukocyte-poor platelet-rich plasma during arthroscopy for knee degeneration affect postoperative pain, function and quality of life? A 12-month randomized controlled double-blind trial

verfasst von: Christian Duif, Tobias Vogel, Fatma Topcuoglu, Georgios Spyrou, Christoph von Schulze Pellengahr, Matthias Lahner

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 7/2015

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Abstract

Introduction

We aimed to identify the effects of intraoperative applied leukocyte-poor platelet-rich plasma (LP-PRP) during knee arthroscopy for degenerative lesions involving pain, function and quality of life.

Methods

We performed a randomized controlled, double-blind trial (RCT) including 58 patients for arthroscopic knee surgery for cartilage or meniscal degeneration with allocation into the LP-PRP (n = 24) or control group (n = 34). During arthroscopy, LP-PRP was injected intra-articular in the intervention group. At baseline, 6 weeks, 6 months and 12 months pain, function, and life quality were assessed.

Results

91 % of enrolled patients were available for 12 months follow-up. Pain was significantly lower in the LP-PRP group (VAS 0.9. vs. 2.3) at 6 (p = 0.008) but not at 12 months (VAS 1.0 vs. 1.6, p = 0.063). LP-PRP application improved the Lysholm Score at 6 (77.5 vs. 65.6, p = 0.033) and 12 months (83.2 vs.70.0, p = 0.007). Assessment of life quality (SF-36) concerning the physical component summary was significantly higher at 6 weeks (33.9 vs. 25.6, p = 0.001) and 6 months (29.9 vs. 27.1, p = 0.027) in the LP-PRP group but equal at 1 year (31.4 vs. 30.1, p = 0.438).

Conclusions

Intraoperative application of LP-PRP may enhance pain reduction and gain of knee function within 6–12 months compared to arthroscopy alone.

Level of evidence

II, randomized controlled clinical trial with reduced power.

ClinicalTrials.gov identifier

NCT02189408.

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Titel: Does intraoperative application of leukocyte-poor platelet-rich plasma during arthroscopy for knee degeneration affect postoperative pain, function and quality of life? A 12-month randomized controlled double-blind trial
verfasst von: Christian Duif
Tobias Vogel
Fatma Topcuoglu
Georgios Spyrou
Christoph von Schulze Pellengahr
Matthias Lahner
Publikationsdatum: 01.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Orthopaedic and Trauma Surgery / Ausgabe 7/2015
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-015-2227-5

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Abstract

Introduction

Methods

Results

Conclusions

Level of evidence

ClinicalTrials.gov identifier

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