Background
Methods
Eligibility & Data Collection
Treatment technique
Statistical methods
Results
All Patients (n = 29) | Aspirators (n = 10) | Non-aspirators (n = 19) | p-value | |
---|---|---|---|---|
Median age | 54 (30–73) | 54 (31–67) | 54 (30–73) | 0.75 |
Dose (cGy) | 7000 (6400–7500) | 7175 (7000–7500) | 7000 (6400–7500) | 0.11 |
N (%) | N (%) | N (%) | ||
Sex | ||||
Male | 23 (79.3) | 7 (70.0) | 16 (84.2) | 0.63 |
Female | 6 (20.7) | 3 (30.0) | 3 (15.8) | |
Smoking | ||||
No | 23 (79.3) | 6 (60.0) | 17 (89.5) | 0.14 |
Yes | 6 (20.7) | 4 (40.0) | 2 (10.5) | |
Tumor Site | ||||
Oropharynx | 22 (75.9) | 9 (90.0) | 13 (68.4) | 0.065 |
Unknown Primary | 6 (20.7) | 0 | 6 (31.6) | |
Hypopharynx | 1 (3.5) | 1 (10.0) | 0 | |
T stage | ||||
T0 | 5 (17.2) | 0 | 5 (26.3) | 0.18 |
T1 | 8 (27.6) | 3 (30.0) | 5 (26.3) | |
T2 | 11 (37.9) | 4 (40.0) | 7 (36.8) | |
T3 | 4 (13.8) | 3 (30.0) | 1 (5.3) | |
T4 | 1 (3.5) | 0 | 1 (5.3) | |
N stage | ||||
N1 | 1 (3.5) | 0 | 1 (5.3) | 0.17 |
N2a | 3 (10.3) | 0 | 3 (15.8) | |
N2b | 21 (72.4) | 7 (70.0) | 14 (73.7) | |
N2c | 4 (13.8) | 3 (30.0) | 1 (5.3) | |
Stage | ||||
III | 2 (6.9) | 1 (10.0) | 1 (5.3) | 0.42 |
IVA | 26 (89.6) | 8 (80.0) | 18 (94.7) | |
IVB | 1 (3.5) | 1 (10.0) | 0 | |
Grade | ||||
1 | 1 (3.5) | 0 | 1 (5.3) | 0.44 |
2 | 9 (31.0) | 5 (50.0) | 4 (21.1) | |
3 | 9 (31.0) | 2 (20.0) | 7 (36.8) | |
Unknown | 10 (34.5) | 3 (30.0) | 7 (36.8) | |
p16 status | ||||
Positive | 14 (48.3) | 3 (30.0) | 11 (57.9) | 0.99 |
Negative | 1 (3.4) | 0 | 1 (5.3) | |
Unknown | 14 (48.3) | 7 (70.0) | 7 (36.8) |
Sample size | All Patients | Aspirators | Non-aspirators | AUC | Univariate p-value | Multivariate p-value |
---|---|---|---|---|---|---|
29 | 10 | 19 | ||||
Mean (sd) | Mean (sd) | Mean (sd) | ||||
Structure | ||||||
AE Folds | 6606 (679) | 7025 (398) | 6386 (700) | 0.753 | 0.025 | 0.025 |
Arytenoids | 5832 (1070) | 6419 (568) | 5523 (1152) | 0.737 | 0.045 | NS |
Glossoepiglottic fold | 7304 (459) | 7507 (289) | 7197 (500) | 0.668 | 0.096 | NS |
Cricoid cartilage | 5722 (975) | 6207 (616) | 5466 (1044) | 0.695 | 0.063 | NS |
Thyroid cartilage | 6406 (739) | 6841 (532) | 6178 (741) | 0.747 | 0.029 | NS |
Epiglottis | 6947 (611) | 7300 (406) | 6761 (626) | 0.747 | 0.032 | NS |
Suprahyoid epiglottis | 7178 (482) | 7422 (360) | 7050 (497) | 0.726 | 0.058 | NS |
Infrahyoid epiglottis | 6487 (840) | 6867 (573) | 6287 (901) | 0.711 | 0.085 | NS |
Total larynx | 6217 (823) | 6675 (504) | 5977 (866) | 0.747 | 0.038 | NS |
Supraglottic larynx | 6573 (754) | 6996 (446) | 6350 (795) | 0.732 | 0.037 | NS |
Subglottic larynx | 5571 (1062) | 6018 (638) | 5336 (1175) | 0.679 | 0.110 | NS |
Glottic larynx | 5834 (1074) | 6358 (634) | 5559 (1167) | 0.711 | 0.067 | NS |
Mean dose cutpoint (cGy) | Number (%) of aspirators above cutpoint (sensitivity) | Number (%) of non-aspirators below cutpoint (specificity) | Positive likelihood ratio: sensitivity/(100-specificity) | PPV(%)a | NPV(%)b | RRc | |
---|---|---|---|---|---|---|---|
Structure | |||||||
AE Folds | 6500 | 9/10 (90.0) | 13/19 (68.4) | 2.81 | 60.0 | 92.9 | 8.4 |
Arytenoids | 6000 | 8/10 (80.0) | 14/19 (73.7) | 3.04 | 61.5 | 87.5 | 4.9 |
Glossoepiglottic fold | 7000 | 10/10 (100.0) | 8/19 (42.1) | 1.73 | 47.6 | 100.0 | undefined |
Cricoid cartilage | 6000 | 7/10 (70.0) | 14/19 (73.7) | 2.66 | 58.3 | 82.4 | 3.3 |
Thyroid cartilage | 6450 | 9/10 (90.0) | 14/19 (73.7) | 3.42 | 64.3 | 93.3 | 9.6 |
Epiglottis | 7225 | 7/10 (70.0) | 14/19 (73.7) | 2.66 | 58.3 | 82.3 | 3.3 |
Suprahyoid epiglottis | 6810 | 10/10 (100.0) | 9/19 (47.4) | 1.90 | 50.0 | 100.0 | undefined |
Infrahyoid epiglottis | 6300 | 9/10 (90.0) | 12/19 (63.2) | 2.45 | 56.3 | 92.3 | 7.3 |
Total larynx | 6100 | 9/10 (90.0) | 13/19 (68.4) | 2.85 | 60.0 | 92.9 | 8.5 |
Supraglottic larynx | 6650 | 9/10 (90.0) | 13/19 (68.4) | 2.85 | 60.0 | 92.9 | 8.5 |
Subglottic larynx | 5750 | 7/10 (70.0) | 13/19 (68.4) | 2.66 | 53.9 | 81.3 | 2.9 |
Glottic larynx | 6100 | 8/10 (80.0) | 14/19 (73.7) | 2.81 | 61.5 | 87.5 | 4.9 |