Background
Methods
Patient data
Number of patients | 12 |
---|---|
Gender | |
male/female | 3/9 |
Age (y) | |
median | 14 |
range | 3-76 |
Tumor type | |
germinoma | 1 |
recurrent medulloblastoma | 1 |
optic glioma | 2 |
ependymoma | 1 |
pilocytic astrocytoma | 2 |
meningioma | 5 |
Imaging and treatment planning
Evaluation
Statistical analysis and evaluation
Results
Target volume coverage
Dosimetric index | dISO | dISO-40 |
p
|
---|---|---|---|
Dmin [Gy(RBE)] | 46.4 (44.9÷47.6) | 46.0 (43.9÷47.1) | 0.791 |
Dnear-min [Gy(RBE)] | 48.5 (48.4÷48.9) | 48.6 (48.5÷48.9) | 0.068 |
Dmean [Gy(RBE)] | 50.4 (50.3÷50.5) | 50.4 (50.2÷50.5) | 0.204 |
Dnear-max [Gy(RBE)] | 52.2 (51.8÷52.6) | 52.1 (51.7÷52.3) | 0.021* |
Dmax [Gy(RBE)] | 53.8 (53.1÷55.7) | 54.3 (53.1÷55.4) | 0.126 |
CI95% [−] | 0.69 (0.45÷0.81) | 0.70 (0.49÷0.83) | 0.042* |
CI50% [−] | 0.30 (0.19-0.41) | 0.36 (0.22-0.47) | 0.002* |
Normal tissue and OAR sparing
Volume of interest/dosimetric index | Absolute difference | Relative percentage difference |
p
| ||
---|---|---|---|---|---|
Whole brain | |||||
Dnear-max [Gy(RBE)] |
0.1
| (−0.4÷3.0) |
0.3
| (−0.7÷8.5) | 0.013* |
Dmean [Gy(RBE)] |
1.0
| (0.5÷1.6) |
12.5
| (9.2÷16.0) | 0.001* |
V1% [%] |
6.9
| (4.1÷8.6) |
16.7
| (10.4÷21.0) | <0.001* |
V2% [%] |
6.3
| (3.4÷7.6) |
15.2
| (10.2÷19.9) | <0.001* |
V10% [%] |
4.0
| (2.4÷5.0) |
13.6
| (8.0÷18.4) | <0.001* |
V60% [%] |
1.1
| (0.2÷2.0) |
11.3
| (6.4÷16.4) | <0.001* |
V80% [%] |
0.4
| (0.1÷1.2) |
6.3
| (2.0÷12.1) | <0.001* |
V95% [%] |
0.0
| (−0.3÷0.3) |
1.3
| (−3.8÷7.0) | 0.212 |
Brainstem | |||||
Dnear-max [Gy(RBE)] |
0.0
| (−0.2÷1.1) |
0.0
| (−0.4÷2.1) | 0.173 |
Dmean [Gy(RBE)] |
2.9
| (1.0÷5.0) |
16.2
| (2.6÷30.9) | <0.001* |
V2% [%] |
9.6
| (0.0÷22.5) |
14.0
| (0.0÷27.0) | 0.002* |
V10% [%] |
7.9
| (0.6÷20.1) |
14.8
| (0.6÷31.1) | <0.001* |
V60% [%] |
5.5
| (2.0÷8.8) |
17.6
| (3.8÷34.4) | <0.001* |
V80% [%] |
2.5
| (0.3÷6.7) |
17.2
| (0.5÷40.0) | <0.001* |
V95% [%] |
0.6
| (−0.6÷2.7) |
9.1
| (−14.4÷30.7) | 0.017 * |
Chiasm | |||||
Dnear-max [Gy(RBE)] |
0.0
| (−1.5÷4.07) |
0.0
| (−2.9÷9.9) | 0.695 |
Dmean [Gy(RBE)] |
0.1
| (−1.2÷4.7) |
0.2
| (−2.5÷26.4) | 0.077 |
V2% [%] |
0.0
| (0.0÷14.6) |
0.0
| (0.0÷15.8) | 0.5 |
V10% [%] |
0.0
| (0.0÷13.6) |
0.0
| (0.0÷17.7) | 0.185 |
V60% [%] |
0.0
| (0.0÷13.3) |
0.0
| (0.0÷59.9) | 0.050 |
V80% [%] |
0.0
| (0.0÷7.0) |
0.0
| (0.0÷64.5) | 0.030* |
V95% [%] |
0.0
| (−5.1÷8.7) |
0.0
| (−158.5÷26.7) | 0.147 |
Left temporal lobe | |||||
Dnear-max [Gy(RBE)] |
1.1
| (−0.1÷5.3) |
2.7
| (−0.2÷18.0) | 0.001* |
Dmean [Gy(RBE)] |
1.3
| (0.5÷2.7) |
9.7
| (5.8÷27.4) | <0.001* |
V2% [%] |
6.2
| (0.8÷15.4) |
8.8
| (0.8÷38.2) | <0.001* |
V10% [%] |
4.7
| (1.4÷9.7) |
7.2
| (1.5÷40.0) | <0.001* |
V60% [%] |
1.2
| (0.0÷5.5) |
13.1
| (0.0÷63.9) | 0.002* |
V80% [%] |
0.4
| (−0.0÷4.0) |
11.3
| (−2.0÷33.3) | 0.003* |
V95% [%] |
0.0
| (−1.4÷1.2) |
5.7
| (−28.9÷50.0) | 0.380 |
Right temporal lobe | |||||
Dnear-max [Gy(RBE)] |
0.6
| (−0.2÷2.7) |
1.9
| (−0.4÷7.9) | 0.003* |
Dmean [Gy(RBE)] |
2.3
| (0.5÷3.0) |
15.4
| (7.0÷28.7) | <0.001* |
V2% [%] |
7.1
| (2.4÷16.5) |
12.1
| (2.5÷38.0) | <0.001* |
V10% [%] |
4.5
| (1.7÷12.9) |
11.5
| (2.0÷36.4) | <0.001* |
V60% [%] |
2.7
| (0.0÷6.9) |
20.7
| (0.0÷28.2) | 0.002* |
V80% [%] |
0.6
| (−0.0÷2.3) |
10.2
| (−4.8÷18.3) | 0.003* |
V95% [%] |
0.0
| (−0.8÷2.0) |
0.0
| (−10.3÷63.9) | 0.207 |
Left hippocampus | |||||
Dnear-max [Gy(RBE)] |
0.3
| (−0.1÷4.4) |
0.7
| (−0.3÷76.6) | 0.002* |
Dmean [Gy(RBE)] |
1.9
| (0.3÷5.3) |
10.0
| (0.8÷81.8) | 0.001* |
V2% [%] |
0.9
| (0.0÷15.0) |
0.9
| (0.0÷85.4) | 0.007* |
V10% [%] |
5.8
| (0.0 ÷18.5) |
6.6
| (0.0÷93.6) | 0.005* |
V60% [%] |
1.7
| (−0.2÷12.0) |
10.1
| (−0.2÷21.7) | 0.007* |
V80% [%] |
0.7
| (0.0 ÷13.1) |
9.9
| (0.0÷42.8) | 0.007* |
V95% [%] |
0.0
| (−0.3÷5.0) |
0.9
| (−3.7÷44.7) | 0.040* |
Right hippocampus | |||||
Dnear-max [Gy(RBE)] |
0.5
| (0.0÷2.3) |
1.0
| (0.0÷100.0) | <0.001* |
Dmean [Gy(RBE)] |
2.5
| (0.1÷4.2) |
12.9
| (4.9÷100.0) | <0.001* |
V2% [%] |
1.6
| (0.0÷19.4) |
2.4
| (0.0÷98.1) | 0.007* |
V10% [%] |
7.1
| (0.0÷14.9) |
9.5
| (0.0÷19.0) | 0.007* |
V60% [%] |
5.9
| (−0.2÷22.1) |
15.3
| (−184.6÷42.4) | 0.004* |
V80% [%] |
2.6
| (−0.0÷9.1) |
11.7
| (−16.7÷75.3) | 0.004* |
V95% [%] |
0.1
| (−0.5÷7.5) |
0.8
| (−14.3÷62.3) | 0.118 |
Left optic nerve | |||||
Dnear-max [Gy(RBE)] |
0.1
| (−0.9÷3.9) |
0.2
| (−2.0÷100.0) | 0.153 |
Dmean [Gy(RBE)] |
2.2
| (−0.3÷4.0) |
11.8
| (−0.7÷100.0) | 0.004* |
V2% [%] |
7.3
| (0.0÷17.7) |
11.0
| (0.0÷59.4) | 0.005* |
V10% [%] |
8.4
| (0.0÷16.8) |
13.7
| (0.0÷49.1) | 0.005* |
V60% [%] |
2.0
| (0.0÷7.1) |
5.9
| (0.0÷26.1) | 0.003* |
V80% [%] |
0.9
| (−2.1÷4.7) |
2.8
| (−41.6÷20.0) | 0.042* |
V95% [%] |
0.2
| (−11.0÷2.1) |
2.1
| (−42.9 ÷40.6) | 0.172 |
Right optic nerve | |||||
Dnear-max [Gy(RBE)] |
0.1
| (−0.6÷7.3) |
0.3
| (−1.2 ÷97.8) | 0.050 |
Dmean [Gy(RBE)] |
2.5
| (0.0÷5.1) |
12.5
| (0.0÷100.0) | 0.002* |
V2% [%] |
10.8
| (0.0÷25.7) |
14.3
| (0.0÷56.7) | 0.002* |
V10% [%] |
9.0
| (0.0÷18.2) |
13.2
| (0.0÷38.1) | 0.003* |
V60% [%] |
3.3
| (0.0÷7.8) |
11.6
| (0.0÷48.3) | 0.003* |
V80% [%] |
1.3
| (0.0÷7.1) |
8.4
| (0.0÷42.4) | 0.003* |
V95% [%] |
0.2
| (−1.2÷3.4) |
2.4
| (−57.4 ÷52.3) | 0.078 |