The purpose of this study was to determine the level of eHealth literacy skill and associated factors among internet user chronic patients in University of Gondar Comprehensive Specialized Hospital. The result showed that eHealth literacy skill was relatively low with 188 (46.5%) of the participants reporting high eHealth literacy skill. The result also shows 353 (87.3%) use of daily and several days a week internet use of participants with more than three fourth of them using it for browsing social medias like Facebook. Younger, educated and peoples from urban residence were more frequent users of internet. Educational status, occupation type, residence, self-reported health status, monthly salary, frequency of internet use, knowledge about the availability and importance of online resources, attitude toward using online resources and computer literacy level were statistically significant factors associated with eHealth literacy skill among internet user chronic patients in this study. This study also found that, the majority of respondents 268 (66.3%) were males and there was no significant chi square difference among the groups which is different from a study which revealed that males are superior internet users [
41]. This could be due to the fact that the participants in this study are all internet users. The mean age was 35.58 ± 14.8 years and when compared to elders, youngsters were more frequent internet users. This could be due to the internet penetration rate among youngsters which is related with internet using habit [
42].
when compared to studies conducted in other countries, the mean eHealth literacy score of chronic patients in this study was relatively lower and this could be due to the less internet penetration and economic berries in low-income countries like Ethiopia [
43‐
45]. The univariate analysis indicated that patient’s educational status, occupation type, permanent residence, self-reported health status, monthly salary, frequency of internet use, knowledge about the availability and importance of online health information resources, attitude towards using online sources and computer literacy level of participants were significantly associated with eHealth literacy skill with 95% confidence interval, (
p-value< 0.05). After adjustment for the covariates, except for two variables (residence and frequency of internet use) all the other predictor variables were significantly associated with eHealth literacy skill with
p-value< 0.05. See Table
2 for detail. Patients with diploma and above education level were 3.48 (CI: 1.54, 7.87) times more likely to have high eHealth literacy skill compared with those with primary and below education level (
p-value< 0.05). This finding is similar with other studies in different populations which underlined the need for capacity building and continuous educational support for chronic patients with lower educational status [
15,
46,
47]. Participants who works in governmental organizations were more likely to possess high eHealth literacy when compared to unemployed chronic patients with AOR: 1.73, 95%CI: (1.11, 2.68). This study also indicated that chronic patients living in urban setting are COR: 3.77 (95%CI: (1.88, 7.57) times more likely to possess high eHealth literacy skill compared to patients residing on rural setting. The finding seems obvious in most cases [
48,
49] but it is different in developed countries in which majority of rural patients have computer and internet connection in their home preferring internet for health information [
50‐
52]. Income was the other significant factor associated with eHealth literacy skill among chronic patients in which patients those who have a monthly income > 5500 ETB are more likely to have higher eHealth literacy skill compared with those who earn monthly income < 800 ETB with AOR:4.44, (95%CI, 1.32, 14.86),
P-value< 0.05. Higher income is highly associated with higher eHealth literacy skill in different studies [
53,
54]. In this study, patients who perceived their health status as good were 3.97 times more likely to have higher eHealth literacy skill with 95% CI: (1.38, 11.38) and
p-value< 0.05 compared to those who perceive their health status as bad. This finding is similar with other studies done elsewhere which argues the more likely possession of eHealth literacy skill by patients who perceive their health status as good [
30,
55,
56]. This could be due to the fact that peoples with perceived good health condition are more likely to be looking for possible medical treatment and preventive actions before their health get worse. Frequency of internet use was also the predictive variable with
p-value< 0.05 where chronic patients those who use internet on a daily basis are almost 3 (AOR: 2.96) times more likely to have high eHealth literacy skill when compared to those who use internet 1 day and less than 1 day a week with 95%CI: (1.08, 6.76). This finding is similar with different studies confirming that frequent internet users possess higher eHealth literacy skill [
15,
30,
57,
58]. In addition, higher computer literacy was also highly associated with higher eHealth literacy skill which is similar with studies done elsewhere [
59‐
61]. Knowledge regarding the availability and importance of health information and attitude toward using online resources were significant factors associated with eHealth literacy skill where patients with good knowledge and favorable attitude toward online resources are more likely to possess high eHealth literacy skill with AOR: 3.12, 95% CI: (1.61, 5.3) and AOR: 2.94, 95%CI: (1.07, 3.52) respectively. This finding was also in line with other studies [
62‐
65].