Erschienen in:
01.09.2008 | Symposium: Molecular Genetics in Sarcoma
Editorial Comment: Cancer Biology – Lessons Learned From Sarcoma
verfasst von:
John H. Healey, MD, FACS, Bang H. Hoang, MD
Erschienen in:
Clinical Orthopaedics and Related Research®
|
Ausgabe 9/2008
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Excerpt
Sarcoma biology has been the foundation of our understanding the molecular, immunologic, and viral bases of cancer. In the premodern era of orthopaedics, before arthroplasty and arthroscopy, bone and soft tissue sarcoma research established basic concepts of cancer biology. Virtually every major advance in our understanding of how genetic code aberrations cause cancer originated in investigations of sarcoma. Retinoblastoma gene and osteogenic sarcoma [
1,
4], Rous sarcoma virus (src gene) [
7], Harvey and Kirsten sarcoma viruses (H-ras and V-ras) [
8], and Li-Fraumeni syndrome (p53) [
6], are important examples. Despite these contributions, during the last quarter-century most serious investigators focused on liquid (hematopoietic) cancers and eschewed the more difficult solid tumors. …