Erschienen in:
31.07.2023 | Research
Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis—a prospective intervention study
verfasst von:
Nishant Chauhan, Shweta Mittal, Sanjay Tewari, Jyotsna Sen, Kuldip Laller
Erschienen in:
Clinical Oral Investigations
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Ausgabe 9/2023
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Abstract
Objective
The objective of this study is to investigate the effect of endodontic treatment on flow-mediated dilatation (FMD) and carotid intima-media thickness (c-IMT) in patients with apical periodontitis (AP).
Material and method
The study includes 32 young men having AP with a mean age of 25.78 years free from cardiovascular disease (CVD) and its risk factors, including periodontitis. All subjects underwent complete physical and dental examination, echocardiography, and ultrasound assessment of FMD on the brachial artery and c-IMT on the carotid artery at baseline and 12 months after the endodontic treatment. Data were analyzed using paired Student’s t-test and Pearson’s correlation coefficient (r) test using SPSS 26 version.
Results
Endodontic treatment leads to the improvement of FMD significantly from a pooled baseline value of 4.84 ± 1.55% to 7.68 ± 2.08% (p < 0.05). The study also depicts a statistically significant difference between c-IMT (mean = 0.62 ± 0.11 mm) before treatment as compared to 12 months after treatment (mean = 0.59 ± 0.11 mm) (p < 0.05).
Conclusion
Endodontic treatment leads to improved FMD and decreased c-IMT suggesting that treating AP can be help revert the early stages of CVD.
Clinical relevance
AP could be a potential etiological factor of future CVD and should be treated as soon as diagnosed.