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Tumor Biology
Erschienen in: Tumor Biology 12/2015

01.12.2015 | Research Article

Effect of ERCC8 tagSNPs and their association with H. pylori infection, smoking, and alcohol consumption on gastric cancer and atrophic gastritis risk

verfasst von: Jing-jing Jing, Li-ping Sun, Qian Xu, Yuan Yuan

Erschienen in: Tumor Biology | Ausgabe 12/2015

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Abstract

Excision repair cross-complementing group 8 (ERCC8) plays a critical role in DNA repair. Genetic polymorphisms in ERCC8 may contribute to the risk of cancer development. We selected tag single nucleotide polymorphisms (tagSNPs) in Chinese patients from the HapMap database to investigate associations with gastric cancer and its precursors. Genomic DNA was extracted from 394 controls, 394 atrophic gastritis, and 394 gastric cancer cases in northern Chinese patients, and genotypes were identified using the Sequenom MassARRAY system. We found that the ERCC8 rs158572 GG+GA genotype showed a 1.651-fold (95 % confidence interval (CI) = 1.109–2.457, P = 0.013) increased risk of gastric cancer compared with the AA genotype, especially in diffuse type. Stratified analysis comparing the common genotype revealed significantly increased gastric cancer risk in males and individuals older than 50 years with rs158572 GA/GG/GG+GA genotypes, while individuals older than 50 years with rs158916 CT/CC+CT genotypes were less susceptible to atrophic gastritis. Haplotype analysis showed that the G-T haplotype was associated with increased risk of gastric cancer. Statistically significant interactions between the two ERCC8 tagSNPs and Helicobacter pylori infection were observed for gastric cancer and atrophic gastritis risk (P < 0.05). Smokers and drinkers with ERCC8 rs158572 GG+GA genotype were more susceptible to gastric cancer compared with non-smokers and non-drinkers homozygous for AA. Our findings suggested that ERCC8 rs158572 and rs158916, alone or together with environmental factors, might be associated with gastric cancer and atrophic gastritis susceptibility. Further validation of our results in larger populations along with additional studies evaluating the underlying molecular function is required.
Literatur
1.
Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212–36.CrossRefPubMed
2.
3.
4.
5.
Palli D, Polidoro S, D’Errico M, Saieva C, Guarrera S, et al. Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer. Mutagenesis. 2010;25:569–75.CrossRefPubMed
6.
Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, et al. Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343:78–85.CrossRefPubMed
7.
Berwick M, Vineis P. Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst. 2000;92:874–97.CrossRefPubMed
8.
Henning KA, Li L, Iyer N, McDaniel LD, Reagan MS, et al. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell. 1995;82:555–64.CrossRefPubMed
9.
Boraz RA. Cockayne’s syndrome: literature review and case report. Pediatr Dent. 1991;13:227–30.PubMed
10.
Laugel V, Dalloz C, Durand M, Sauvanaud F, Kristensen U, et al. Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. Hum Mutat. 2010;31:113–26.CrossRefPubMed
11.
Fousteri M, Mullenders LH. Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res. 2008;18:73–84.CrossRefPubMed
12.
Friedberg EC. How nucleotide excision repair protects against cancer. Nat Rev Cancer. 2001;1:22–33.CrossRefPubMed
13.
Costa RM, Chigancas V, Galhardo Rda S, Carvalho H, Menck CF. The eukaryotic nucleotide excision repair pathway. Biochimie. 2003;85:1083–99.CrossRefPubMed
14.
Stevnsner T, Muftuoglu M, Aamann MD, Bohr VA. The role of Cockayne syndrome group B (CSB) protein in base excision repair and aging. Mech Ageing Dev. 2008;129:441–8.CrossRefPubMedPubMedCentral
15.
Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell. 2003;113:357–67.CrossRefPubMed
16.
Fousteri M, Vermeulen W, van Zeeland AA, Mullenders LH. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell. 2006;23:471–82.CrossRefPubMed
17.
Groisman R, Kuruoka I, Chevallier O, Gaye N, Magnaldo T, et al. CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors in the Cockayne syndrome. Genes Dev. 2006;20:1429–34.CrossRefPubMedPubMedCentral
18.
D’Errico M, Parlanti E, Teson M, Degan P, Lemma T, et al. The role of CSA in the response to oxidative DNA damage in human cells. Oncogene. 2007;26:4336–43.CrossRefPubMed
19.
Frosina G. The current evidence for defective repair of oxidatively damaged DNA in Cockayne syndrome. Free Radic Biol Med. 2007;43:165–77.CrossRefPubMed
20.
Nardo T, Oneda R, Spivak G, Mortier L, Thomas P, et al. A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage. Proc Natl Acad Sci U S A. 2009;106:6209–14.CrossRefPubMedPubMedCentral
21.
Fleming ND, Agadjanian H, Nassanian H, Miller CW, Orsulic S, et al. Xeroderma pigmentosum complementation group C single-nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression-free survival in advanced ovarian cancer. Cancer. 2012;118:689–97.CrossRefPubMed
22.
Guillem VM, Cervantes F, Martínez J, Alvarez-Larrán A, Collado M, et al. XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia. Am J Hematol. 2010;85:482–6.CrossRefPubMed
23.
Tu H, Sun L, Dong X, Gong Y, Xu Q, et al. Serum anti-Helicobacter pylori immunoglobulin G titer correlates with grade of histological gastritis, mucosal bacterial density, and levels of serum biomarkers. Scand J Gastroenterol. 2014;49(3):259–66.CrossRefPubMed
24.
Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996;20:1161–81.CrossRefPubMed
25.
Hamilton S, Aaltonen L. World Health Organization classification of tumours. Pathology and genetics of turnouts of the digestive system. Lyon: IARC Press; 2000. p. 237–40.
26.
Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histoclinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49.PubMed
27.
Barrett JC. Haploview: visualization and analysis of SNP genotype data. Cold Spring Harb Protoc. 2009;4:pdb ip71.
28.
Gong YH, Sun LP, Jin SG, Yuan Y. Comparative study of serology and histology based detection of Helicobacter pylori infections: a large population-based study of 7,241 subjects from China. Eur J Clin Microbiol Infect Dis. 2010;29:907–11.CrossRefPubMed
29.
Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005;15:97–8.CrossRefPubMed
30.
31.
Trzyna E, Duleba M, Faryna M, Majka M. Regulation of transcription in cancer. Front Biosci (Landmark Ed). 2012;17:316–30.CrossRef
32.
Crepieux P, Leprince D, Flourens A, Albagli O, Ferreira E, et al. The two functionally distinct amino termini of chicken c-ets-1 products arise from alternative promoter usage. Gene Expr. 1993;3:215–25.PubMed
33.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.CrossRefPubMed
34.
Brenner H, Rothenbacher D, Arndt V. Epidemiology of stomach cancer. Methods Mol Biol. 2009;472:467–77.CrossRefPubMed
35.
Vauhkonen M, Vauhkonen H, Sipponen P. Pathology and molecular biology of gastric cancer. Best Pract Res Clin Gastroenterol. 2006;20(4):651–74.CrossRefPubMed
36.
37.
Compare D, Rocco A, Nardone G. Risk factors in gastric cancer. Eur Rev Med Pharmacol Sci. 2010;14:302–8.PubMed
38.
Sankari SL, Masthan KM, Babu NA, Bhattacharjee T, Elumalai M. Apoptosis in cancer—an update. Asian Pac J Cancer Prev. 2012;13:4873–8.CrossRefPubMed
39.
Brooks PJ. DNA damage, DNA repair, and alcohol toxicity—a review. Alcohol Clin Exp Res. 1997;21:1073–82.PubMed
40.
Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer. 2003;3:733–44.CrossRefPubMed
41.
42.
Toller IM, Neelsen KJ, Steger M, Hartung ML, Hottiger MO, et al. Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proc Natl Acad Sci U S A. 2011;108:14944–9.CrossRefPubMedPubMedCentral
Metadaten
Titel
Effect of ERCC8 tagSNPs and their association with H. pylori infection, smoking, and alcohol consumption on gastric cancer and atrophic gastritis risk
verfasst von
Jing-jing Jing
Li-ping Sun
Qian Xu
Yuan Yuan
Publikationsdatum
01.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3703-9

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