nach oben

Environmental Health and Preventive Medicine

Erschienen in:

01.11.2012 | Regular Article

Effect of laughter on salivary flow rates and levels of chromogranin A in young adults and elderly people

verfasst von: Masahiro Toda, Hiroe Ichikawa

Erschienen in: Environmental Health and Preventive Medicine | Ausgabe 6/2012

Einloggen, um Zugang zu erhalten

Abstract

Objectives

Salivary chromogranin A (CgA) levels and salivary flow rates were measured to evaluate the stress relief effect of laughter on the young and the elderly.

Methods

Thirty healthy volunteers (15 aged 20–25 years; 15 aged 62–83 years) performed a serial arithmetic task for 15 min and then watched a comedy video for 30 min. On a different day, as a control, they watched a non-humorous video after performing a task similar to the first one. Saliva samples were collected immediately before and after the arithmetic task, 30 min after completing the task (immediately after watching the film), and 30 min after watching the film (60 min after completing mental task). Salivary CgA levels were determined by enzyme-linked immunosorbent assay.

Results

In the elderly group, salivary flow rates, which had declined by the end of the arithmetic task, were statistically significantly higher after watching the comedy video. In the young group, salivary CgA levels, which had increased by the end of the task, had statistically significantly declined after watching the comedy video. No such post-task changes were apparent in control results; in the young group, there was a statistically significant interprotocol difference in salivary CgA levels.

Conclusions

These findings suggest that laughter may relieve stress, particularly in the young people.

Bennett MP, Zeller JM, Rosenberg L, McCann J. The effect of mirthful laughter on stress and natural killer cell activity. Altern Ther Health Med. 2003;9:38–45.PubMed

Berk LS, Felten DL, Tan SA, Bittman BB, Westengard J. Modulation of neuroimmune parameters during the eustress of humor-associated mirthful laughter. Altern Ther Health Med. 2001;7:62–76.PubMed

Berk LS, Tan SA, Fry WF, Napier BJ, Lee JW, Hubbard RW, et al. Neuroendocrine and stress hormone changes during mirthful laughter. Am J Med Sci. 1989;298:390–6.PubMedCrossRef

Takahashi K, Iwase M, Yamashita K, Tatsumoto Y, Ue H, Kuratsune H, et al. The elevation of natural killer cell activity induced by laughter in a crossover designed study. Int J Mol Med. 2001;8:645–50.PubMed

Smith AD, Winkler H. Purification and properties of an acidic protein from chromaffin granules of bovine adrenal medulla. Biochem J. 1967;103:483–92.PubMed

Smith WJ, Kirshner N. A specific soluble protein from the catecholamine storage vesicles of bovine adrenal medulla. Mol Pharmacol. 1967;3:52–62.PubMed

Winkler H, Fischer-Colbrie R. The chromogranins A and B: the first 25 years and future perspectives. Neuroscience. 1992;49:497–528.PubMedCrossRef

Saruta J, Tsukinoki K, Sasaguri K, Ishii H, Yasuda M, Osamura YR, et al. Expression and localization of chromogranin A gene and protein in human submandibular gland. Cells Tissues Organs. 2005;180:237–44.PubMedCrossRef

Nakane H, Asami O, Yamada Y, Harada T, Matsui N, Kanno T, et al. Salivary chromogranin A as an index of psychosomatic stress response. Biomed Res. 1998;19:401–6.

10.

Nakane H, Asami O, Yamada Y, Ohira H. Effect of negative air ions on computer operation, anxiety, and salivary chromogranin A-like immunoreactivity. Int J Psychophysiol. 2002;46:85–9.PubMedCrossRef

11.

Baum BJ. Principles of saliva secretion. Ann N Y Acad Sci. 1993;694:17–23.PubMedCrossRef

12.

Gemba H, Teranaka A, Takemura K. Influences of emotion upon parotid secretion in human. Neurosci Lett. 1996;211:159–62.PubMedCrossRef

13.

Queiroz CS, Hayacibara MF, Tabchoury CP, Marcondes FK, Cury JA. Relationship between stressful situations, salivary flow rate and oral volatile sulfur-containing compounds. Eur J Oral Sci. 2002;110:337–40.PubMedCrossRef

14.

Uchida Y. A manual of the Uchida–Kraepelin psychodiagnostic test. Tokyo: Psychotechnological Institute; 1951.

15.

Kuraishi S, Kato M, Tsujioka B. Development of the Uchida–Kraepelin psychodiagnostic test in Japan. Psychologia. 1957;1:104–9.

16.

Oishi K, Kamimura M, Nigorikawa T, Nakamiya T, Williams RE, Horvath SM. Individual differences in physiological responses and type A behavior pattern. Appl Human Sci. 1999;18:101–8.PubMedCrossRef

17.

Sumiyoshi T, Yotsutsuji T, Kurachi M, Itoh H, Kurokawa K, Saitoh O. Effect of mental stress on plasma homovanillic acid in healthy human subjects. Neuropsychopharmacology. 1998;19:70–3.PubMedCrossRef

18.

Yasumasu T, Reyes del Paso GA, Takahara K, Nakashima Y. Reduced baroreflex cardiac sensitivity predicts increased cognitive performance. Psychophysiology. 2006;43:41–5.PubMedCrossRef

19.

Den R, Toda M, Nagasawa S, Kitamura K, Morimoto K. Circadian rhythm of human salivary chromogranin A. Biomed Res. 2007;28:57–60.PubMedCrossRef

20.

Nagasawa S, Nishikawa Y, Jun L, Futai Y, Kanno T, Iguchi K, et al. Simple enzyme immunoassay for the measurement of immunoreactive chromogranin A in human plasma, urine and saliva. Biomed Res. 1998;19:407–10.

21.

Morimoto K. Lifestyle and health. Jpn J Hyg. 2000;54:572–91.CrossRef

22.

Lorish CD, Maisiak R. The face scale: a brief, nonverbal method for assessing patient mood. Arthritis Rheum. 1986;29:906–9.PubMedCrossRef

23.

Bakke M, Tuxen A, Thomsen CE, Bardow A, Alkjær T, Jensen BR. Salivary cortisol level, salivary flow rate, and masticatory muscle activity in response to acute mental stress: a comparison between aged and young women. Gerontology. 2004;50:383–92.PubMedCrossRef

24.

Toda M, Morimoto K, Fukuda S, Hayakawa K. Lifestyle, mental health status and salivary secretion rates. Environ Health Prev Med. 2002;6:260–3.PubMedCrossRef

25.

Toda M, Morimoto K. Effect of lavender aroma on salivary endocrinological stress markers. Arch Oral Biol. 2008;53:964–8.PubMedCrossRef

26.

Esler M, Lambert G, Kaye D, Rumantir M, Hastings J, Seals DR. Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress. Biogerontology. 2002;3:45–9.PubMedCrossRef

27.

Fujimoto S, Nomura M, Niki M, Motoba H, Ieishi K, Mori T, et al. Evaluation of stress reactions during upper gastrointestinal endoscopy in elderly patients: assessment of mental stress using chromogranin A. J Med Invest. 2007;54:140–5.PubMedCrossRef

Titel: Effect of laughter on salivary flow rates and levels of chromogranin A in young adults and elderly people
verfasst von: Masahiro Toda
Hiroe Ichikawa
Publikationsdatum: 01.11.2012
Verlag: Springer Japan
Erschienen in: Environmental Health and Preventive Medicine / Ausgabe 6/2012
Print ISSN: 1342-078X
Elektronische ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-012-0279-5

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2012

Current status of and factors associated with social isolation in the elderly living in a rapidly aging housing estate community

Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat

Self-rated health as a comprehensive indicator of lifestyle-related health status

Lead in the Japanese living environment

Changes in mental health and quality of life with dental implants as evaluated by General Health Questionnaire (GHQ) and Health Utilities Index (HUI)

Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations